Comparison of Concentration- and Homology-Dependent Effects of the Proinflammatory Cytokine Interleukin-1β (IL-1β) in a Bovine Chondrocyte Inflammation Model by Robert Ossendorff, Sarah Kurth, Su Wang, Max Jaenisch, Elio Assaf, Sebastian Scheidt, Kristian Welle, Christof Burger, Dieter C. Wirtz, Andreas C. Strauss, Frank A. Schildberg

“…Titration of IL-1β (100–0.1 ng/mL) was performed with both human and bovine recombinant protein in chondrocyte culture for 2 weeks. …”
Get full text

Salubrinal Regulates the Apoptosis of Adrenocortical Carcinoma Cells via the PERK/eIF2α/ATF4 Signaling Pathway by Lili Wu, Chunfeng Liang, Xuemei Huang, Xiujun Deng, Jiming Jiang, Zuojie Luo

“…In this study, we aimed to determine whether salubrinal (Sal), a selective activator of eukaryotic translation initiation factor 2 (eIF2α), can induce apoptosis of human adrenocortical carcinoma (ACC) cell via activating the PERK/eIF2α/ATF4 signaling pathway, and the potential mechanisms of this action were explored. …”
Get full text

Zero-Shot Remote Sensing Scene Classification Based on Automatic Knowledge Graph and Dual-Branch Semantic Correlation Supervision by Chao Wang, Jiajun Yang, Tanvir Ahmed, Yang Zhao, Tong Zhang, Bing Sun, Tao Xie, Jie Wang, Tianyu Chen

“…However, current graphs rely heavily on expert manual interpretation, making them susceptible to human biases and difficult to expand. They also lack quantitative description of the degree of spatial relationship associations and fail to adequately represent semantic information. …”
Get full text

Prognostic significance of programmed cell death 1 expression on CD8+T cells in various cancers: a systematic review and meta-analysis by Zhiyong Wan, Meng Cui, Jia Yang, Dan Liao, Junliang Chen, Fanmin Li, Yin Xiang, Zhiwei Cui, Yang Yang

“…Therefore, we conducted a meta-analysis to evaluate its prognostic value in human cancers.MethodsPRISMA reporting guidelines were strictly followed for conducting the current meta-analysis. …”
Get full text

Classification of Cigarette Types Using Computer Vision: An Analysis of Smoke Aggregation Features by Shishuan Guan, Lei Jiao, Zengyu Wang, Xiaofei Ji, Hongwei Zheng, Cunfeng Yu, Hongtao Li, Liwen Zheng, Shuaishuai Sun, Qiang Sun, Jun Li, Guangwei Jiang, Kezhi Wu, Erge Lin, Xinlong Zhang

“…Firstly, we constructed a 3D model experimental platform based on the human upper respiratory tract to create the cigarette smoke image dataset SmogAg. …”
Get full text

SVR model and OLCI images reveal a declining trend in phycocyanin levels in typical lakes across Northeast China by Changchun Song, Yipei Xu, Chong Fang, Chi Zhang, Zhuohang Xin, Zhihong Liu

“…Recently, the frequency of cyanobacterial blooms in lakes across Northeast China has noticeably increased, because of the combined effect of global climate change and human activities. Phycocyanin (PC), a distinctive pigment found in cyanobacteria, plays a pivotal role in detecting and predicting harmful cyanobacterial blooms. …”
Get full text

An evaluation on coping with stress of selcuk university faculty of veterinary medicine students: covid-19 pandemic process by Esra Çelik, Emine Merve Danış, Gökhan Aslım, Mustafa Agah Tekindal, Aşkın Yaşar

“…<b>Aim: </b>Declared as a pandemic by the World Health Organization on March 11, 2020, Covid-19 has raised significant psychological concerns and physical problems in humans. This study aimed to evaluate the relationship between the methods of coping with stress of the SUFVM students with socio-demographic characteristics, experiences during the Covid-19 pandemic process, and professional career concerns.…”
Get full text

Enzyme-responsive vitamin D-based micelles for paclitaxel-controlled delivery and synergistic pancreatic cancer therapy by Diana Peixoto, João M. Ravasco, Barbara Blanco-Fernandez, Francisco Veiga, Angel Concheiro, João Conde, Ana Cláudia Paiva-Santos, Carmen Alvarez-Lorenzo

“…PTX-loaded VD3 micelles also exhibited prominent cell internalization and induced a considerable cytotoxic synergistic effect against human PDAC cells (BxPC-3 cells) in 2D and 3D cell culture models compared with free PTX. …”
Get full text

Rice stable carbon and nitrogen isotope values as potential indicators of watering and manuring regimes by Rubi Wu, Rubi Wu, Eric J. Belfield, Yu Dong, Shangzong Feng, Xiangdong Fu, Nicholas P. Harberd, Fan Yang, Michael Charles, Amy Bogaard

“…Previous research on early rice in the Lower Yangtze River basin (LYRB) suggested shifts back and forth over time between wet and dry field conditions, and some application of animal dung and/or human feces as fertilizer. In this study, stable carbon and nitrogen isotope analysis was conducted on grains from rice of heritage landraces and modern varieties grown in a glasshouse pot experiment with three watering levels and two manuring levels, and from recent rice fields in China and South Korea including paddy and dry conditions, and with variable manuring histories. …”
Get full text

Permeability of the blood-brain barrier through the phases of ischaemic stroke and relation with clinical outcome: protocol for a systematic review by Helena Donato, Sara Bernardo-Castro, Lino Ferreira, João Sargento-Freitas

“…We will include randomised controlled trials, cohort, cross-sectional and case-controlled studies on humans that quantitatively assess the BBBP in stroke. …”
Get full text

Structural, Optical, Antibacterial, and Anticancer Properties of Cerium Oxide Nanoparticles Prepared by Green Synthesis Using Morinda citrifolia Leaves Extract by Abozer Y. Elderdery, Badr Alzahrani, Abdulrahim A. Alabdulsalam, Siddiqa M. A. Hamza, Ahmed M. E. Elkhalifa, Abdulaziz H. Alhamidi, Fehaid Alanazi, A. Mohamedain, Suresh Kumar Subbiah, Pooi Ling Mok

“…The anticancer properties of the green synthesized CeO2 NPs against human acute lymphoblastic leukemia (ALL) MOLT-4 cells were further explored by the meticulous study of their ability to diminish cancer cell viability (cytotoxicity), accelerate apoptosis, escalate intracellular reactive oxygen species (ROS) accumulation, decline the mitochondria membrane potential (MMP) level, modify the cell adhesion, and shoot up the activation of proapoptotic markers, caspase−3, −8, and −9, in the tumor cells. …”
Get full text

A new epidemic wave of Bordetella pertussis in paediatric population: impact and role of co-infections in pertussis disease by Rossana Scutari, Giulia Linardos, Stefania Ranno, Mara Pisani, Anna Chiara Vittucci, Luana Coltella, Luna Colagrossi, Velia Chiara Di Maio, Annamaria Sisto, Livia Mancinelli, Simona Landi, Sebastian Cristaldi, Massimiliano Raponi, Paola Bernaschi, Alberto Villani, Cristina Russo, Carlo Federico Perno

“…Rhinovirus, Metapneumovirus and Parainfluenza-virus were the most prevalent in our pediatric population. Co-infections of human bocavirus with B.pertussis were observed exclusively in patients with respiratory failure. …”
Get full text

Comparing the effect of addition of different supplements to sperm preparation media on intracytoplasmic injection outcome by Mohamed Ashraf Adly, Ahmed Samy Saad, Amoura Abou-El-Naga

“…Abstract Background  To assess the effectiveness of human sperm treated with an egg yolk-enhanced refrigeration group and to determine the protective effect of selenium supplementation in a laboratory setting, samples were prepared using the density gradient method as the standard preparation technique. …”
Get full text

Lateralization study of the basal ganglia, thalamus and supplying arteries in healthy individuals based on structure and connectivity analysis using 7.0T MRI by Hongqin Liang, Yawei Gu, Xiaoqi Yi, Li Kong, Jian Wang, Fajin Lv

“…The human cerebral cortex is known for its hemispheric specialization, which underpins a variety of functions and activities. …”
Get full text

Exploring the anti-metastatic potential of sunitinib and novel analogs in colorectal cancer: insights into HIF-1α mediated metastasis by Fatemeh B. Rassouli, Maryam M. Matin, Maryam M. Matin, Farzin Hadizadeh, Farzin Hadizadeh, Masoud Nejabat, Hossein Allahverdizadeh, Hamidreza Jamali, Shahin Gharedaghi, Halimeh Hassanzadeh

“…Due to the urgent demand for potent anti-metastatic agents, we aimed to determine the effects of sunitinib and novel analogs on the metastatic behavior of human CRC cells in hypoxic condition for the first time.MethodsFor in silico analyses, pathogenic targets of metastatic CRC were identified, PPI network was constructed and KEGG pathway enrichment analysis was conducted. …”
Get full text

Odyssey of environmental and microbial interventions in maize crop improvement by Alok Kumar Singh, Alok Kumar Singh, Alok Kumar Srivastava, Parul Johri, Manish Dwivedi, Radhey Shyam Kaushal, Mala Trivedi, Tarun Kumar Upadhyay, Nadiyah M. Alabdallah, Nadiyah M. Alabdallah, Irfan Ahmad, Mohd Saeed, Sorabh Lakhanpal

“…Maize (Zea mays) is India’s third-largest grain crop, serving as a primary food source for at least 30% of the population and sustaining 900 million impoverished people globally. The growing human population has led to an increasing demand for maize grains. …”
Get full text

Fall detection method based on spatio-temporal coordinate attention for high-resolution networks by Xiaorui Zhang, Qijian Xie, Wei Sun, Ting Wang

“…Abstract Fall behavior is closely related to the high mortality rate of the elderly, so fall detection has become an important and urgent research area in human behavior recognition. However, the existing fall detection methods, suffer from the loss of detailed action information during feature extraction due to the downsampling operation, resulting in subpar performance when detecting falls with similar behaviors such as lying and sitting. …”
Get full text

HEAL-Dengue: Hospital- based Exploration, Analysis and Learning about Dengue Outcomes (HEAL-D-ALDO) by Aijaz Zeeshan Khan, Omer Sabir, Adnan Hussain Shahid, Muhammad Bilal Basit, Syeda Arzinda Fatima Shah, Qamar Sajad

“… Background: Dengue Fever, also known as break-bone fever, is a viral illness and transmitted to humans by bites of infected Aedes aegypti and Aedes albopictus mosquitoes. …”
Get full text

Association between sleep duration and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis by Kasra Pirahesh, Ali Zarrinnia, Leila Nikniaz, Zeinab Nikniaz

“…Observational studies were included if they assess the association between sleep duration and NAFLD or compare the mean sleep duration between patients with NAFLD and healthy population. All studies done in humans without restriction on sex, age, and language were included. …”
Get full text

Lysine Reacts with Cholesterol Hydroperoxide to Form Secosterol Aldehydes and Lysine-Secosterol Aldehyde Adducts by George Wafula Wanjala, Arnold Nola Onyango, David Rasugu Abuga, John Kamathi Muchuna, Calvin Onyango, Moses Makayoto

“…Two cholesterol secosterol aldehydes, namely, 3β-hydroxy-5-oxo-5,6-secocholestan-6-al (secosterol A) and its aldolization product 3β-hydroxy-5β-hydroxy-B-norcholestane-6β-carboxyaldehyde (secosterol B), are highly bioactive compounds which have been detected in human tissues and potentially contribute to the development of physiological dysfunctions such as atherosclerosis, Alzheimer’s disease, diabetes, and cancer. …”
Get full text