Computational Analysis on Numerical Simulation of Internal Flow Physics for Pump as Turbine in Renewable Small Hydro Energy Generation by Du Jianguo, Daniel Adu, Emmanuel Acheaw, Shakir Hafeez, Eric Ofosu Antw

“…Energy contributes significantly in almost all aspects of human life as well as economic activities and plays a crucial role in the infrastructural development of a county to alleviate poverty. …”
Get full text

A zebrafish model of Ifih1-driven Aicardi–Goutières syndrome reproduces the interferon signature and the exacerbated inflammation of patients by Beatriz Bernal-Bermúdez, Beatriz Bernal-Bermúdez, Beatriz Bernal-Bermúdez, Alicia Martínez-López, Alicia Martínez-López, Francisco J. Martínez-Morcillo, Francisco J. Martínez-Morcillo, Francisco J. Martínez-Morcillo, Sylwia D. Tyrkalska, Sylwia D. Tyrkalska, Sylwia D. Tyrkalska, Teresa Martínez-Menchón, Teresa Martínez-Menchón, Teresa Martínez-Menchón, Pablo Mesa-del-Castillo, Pablo Mesa-del-Castillo, Pablo Mesa-del-Castillo, María L. Cayuela, María L. Cayuela, María L. Cayuela, Victoriano Mulero, Victoriano Mulero, Victoriano Mulero, Diana García-Moreno, Diana García-Moreno

“…In this study, we report the development of a transgenic zebrafish model of Type I interferonopathy overexpressing ifih1 carrying the mutation p.Arg742His (Tg(ifih1_mut)), corresponding to the human mutation p.Arg779His. RNA sequence analysis from Tg(ifih1_mut) larvae revealed a systemic inflammation and IFN signature upon a suboptimal poly I:C induction compared with wild-type larvae, confirming the phenotype observed in patients suffering from Type I interferonopathies. …”
Get full text

Gross and applied anatomy pedagogical approaches in occupational therapy education: protocol for a scoping review by Emily S Ho, Anne Agur, Andrea Duncan, Erica Dove, Kelly Hennessy, Athena Kirou-Mauro, Lorna Aitkens

“…After title/abstract and full-text screening, included articles will be charted, collated and summarised.Ethics and dissemination This study will not involve human or animal subjects. Therefore, research ethics approval is not required. …”
Get full text

Advances in Nucleic Acid Drugs and Gene Therapies based on Animal Models of Duchenne Muscular Dystrophy by LIU Siyu, LAI Yuezhao, GUO Wenting, CHEN Xuejin

“…The DMD gene, which encodes dystrophin, is the largest known gene in the human genome. Mutations in the DMD gene are highly diverse, including exon deletions, duplications, point mutations, and small insertions or deletions, posing significant challenges for treatment. …”
Get full text

Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis by Junko Yoshida, Robert T. Wicks, Andrea I. Zambrano, Betty M. Tyler, Kashi Javaherian, Rachel Grossman, Yassine J. Daoud, Peter Gehlbach, Henry Brem, Walter J. Stark

“…We assessed the antiangiogenic effects of subconjunctival injection of Fc-endostatin (FcE) using a human vascular endothelial growth factor-induced rabbit corneal neovascularization model. …”
Get full text

A new dimensionality reduction technique based on the Wavelet Transform for cancer classification by Lisardo Fernández, Mariano Pérez, Juan M. Orduña, José M. Alcaraz

“…Although the advent of methylation microarrays such as the HumanMethylation450 platform has greatly reduced the dimensionality of the problem from billions to 450K positions, this data size is still too large to be processed by machine learning algorithms for cancer prediction and classification. …”
Get full text

Review of the environmental and health risks of hydraulic fracturing fluids by Sara Makki, Elsa Maalouf, Alissar Yehya

“…The composition of hydraulic fracturing (HF) fluid poses risks to human health and the environment by impacting drinking water sources. …”
Get full text

Bioactive Molecules, Ethnomedicinal Uses, Toxicology, and Pharmacology of <i>Peltophorum africanum</i> Sond (Fabaceae): Systematic Review by Nkoana I. Mongalo, Maropeng V. Raletsena

“…Plants have long been used to treat serious illnesses in both humans and animals. A significant underappreciated medicinal tree, <i>Peltophorum africanum</i> Sond is utilized by many different ethnic groups to cure a wide range of illnesses. …”
Get full text

Antiplasmodial, Antitrypanosomal, and Cytotoxic Effects of Anthonotha macrophylla, Annickia polycarpa, Tieghemella heckelii, and Antrocaryon micraster Extracts by Aboagye Kwarteng Dofuor, Emmanuel Kofi Kumatia, Jersley Didewurah Chirawurah, Frederick Ayertey

“…Malaria and trypanosomiasis are protozoan diseases which pose a devastating challenge to human health and productivity especially, in Africa where their respective vectors (female Anopheles mosquito and tsetse fly) abound. …”
Get full text

Service delivery approaches related to hearing aids in low- and middle-income countries or resource-limited settings: A systematic scoping review. by Lauren K Dillard, Carolina M Der, Ariane Laplante-Lévesque, De Wet Swanepoel, Peter R Thorne, Bradley McPherson, Victor de Andrade, John Newall, Hubert D Ramos, Annette Kaspar, Carrie L Nieman, Jackie L Clark, Shelly Chadha

“…Innovative approaches for hearing aid service delivery can overcome many of the challenges related to access, including that of limited human resources trained to provide ear and hearing care. …”
Get full text

Targeting transforming growth factor-β1 by methylseleninic acid/seleno-L-methionine in clear cell renal cell carcinoma: Mechanisms and therapeutic potential by Aseel O. Rataan, Yan Xu, Sean M. Geary, Yousef Zakharia, Eman S. Kamel, Youcef M. Rustum, Aliasger K. Salem

“…This study analyzed their expression in human ccRCC cell lines and patient tumor biopsies. …”
Get full text

Calculation of Heat Exchange on the Surface of a Flexible Heat Exchanger for Use in Mobile Hospitals by I. L. Lokova, A. S. Kalinichenko

“…The analysis shows that human losses could be significantly less with rapid first aid. …”
Get full text

Genetic and neurochemical profiles underlying cortical morphometric vulnerability to Parkinson’s disease by Su Yan, Jun Lu, Bingfang Duan, Hongquan Zhu, Tian Tian, Yuanyuan Qin, Yuanhao Li, Wenzhen Zhu

“…Then we performed gene-category enrichment and spatial correlation analyses to evaluate the specific correspondence between cortical alteration in PD and genetic expression from the Allen Human Brain Atlas and normative neurotransmitter atlases from Neuromaps. …”
Get full text

Rapid and Specific Detection of Escherichia coli O157:H7 in Ground Beef Using Immunomagnetic Separation Combined with Loop-Mediated Isothermal Amplification by Qin Yu, Puthiyakunnon Santhosh, Zhang Yiduo, Wu Xianbo, Boddu Swapna, Luo Binde, Fan Hongying

“…Escherichia coli O157:H7 is well known for many foodborne outbreaks that lead to fatal infections in human being worldwide. The objective of this study was to develop a rapid and sensitive method for detection of EHEC O157:H7 from ground beef using a method that combined immunomagnetic separation (IMS) with loop-mediated isothermal amplification (LAMP). …”
Get full text

Does heatwaves/above-average temperature increase interpersonal violent behavior? A scoping review by Daniela ACQUADRO MARAN, Gaia DIBIASE, Sofia FILIPPETTI, Riccardo SANDRETTO, Antonella VARETTO, Claudio Giovanni CORTESE, Elisabetta CARRARO

“…Future research is needed to better understand the relationship between heatwaves or above-average temperature and human health. Policymakers should implement programs to prevent violent behavior in terms of increased temperature adaptation and mitigation (e.g., promoting green spaces and reducing pollution) and at the level of individual city institutions, which can monitor the phenomenon and take action, such as increasing the presence of security personnel in anticipation of periods of highest temperatures.…”
Get full text

Prognostic Significance and Therapeutic Potential of SERPINE1 in Head and Neck Squamous Cell Carcinoma by Changyu Zhu, Heshu Liu, Zhixin Li, Yijun Shi, Jingyang Zhao, Yuping Bai, Qian Chen, Wei Li

“…It was observed that, particularly in human papillomavirus (HPV) negative HNSCC, SERPINE1 exhibited elevated expression levels, correlating with poorer prognosis. …”
Get full text

Does quercetin affect tendon healing? An experimental study in a rat model of Achilles tendon injury by Ahmet Yurteri, Numan Mercan, Zeliha Esin Çelik, Hakan Yaykaşlı, Ahmet Yıldırım

“…However, further clinical studies are needed to understand its effects on human tendon healing, as this is the first study of its kind.…”
Get full text

Spacetimematter and quantum relations of affective e-motions by Jithya Merin Paul, Manali Karmakar

“…. • The proposed quantum-affective approach emerges from the foundation laid by Karan Barad through concepts like apparatus, agential realism, agential cut and difference to dissect the interactions of matter with the human/inhuman and the inherent multiplicity of e-motions involved in each emotive scenario.…”
Get full text

The Application of Fast Fourier Transform Filtering to High Spatial Resolution Digital Terrain Models Derived from LiDAR Sensors for the Objective Mapping of Surface Features and D... by Alberto González-Díez, Ignacio Díaz-Martínez, Pablo Cruz-Hernández, Antonio Barreda-Argüeso, Matthew Doughty

“…In this study, it is revealed that existing artefacts, derived from vegetation or human infrastructures, pose challenges in the units’ construction, and large physiographic units are better represented using low-pass filters, whereas detailed units are more accurately depicted with high-pass filters. …”
Get full text

Optimization and standardization of the work of a health care facility during a chemical accident by O.V. Hudoshyna, N.V. Kurdil

“…It is established that the special management group, which includes representatives of various services, is of decisive impor­tance in the effective management of a health care facility during a chemical incident: administration; communication department; security department; management of nurses and the department of infection control; human resources department; pharmacy; intensive care unit; department of engineering maintenance and repair; laboratory; kitchen; laundry; cleaning service and waste management. …”
Get full text