Newcastle Disease Virus Displaying an Ectodomain of Middle East Respiratory Syndrome Coronavirus Spike Protein Elicited Robust Humoral and Cellular Immunity in Mice by Jaturawitt Prasopsiri, Kanjana Srisutthisamphan, Benjamas Liwnaree, Juggragarn Jengarn, Jarin Kramyu, Payuda Hansoongnern, Papon Muangsanit, Nathiphat Tanwattana, Challika Kaewborisuth, Suttipun Sungsuwan, Anan Jongkaewwattana, Nanchaya Wanasen

“…Background: Middle East Respiratory Syndrome Coronavirus (MERS-CoV) causes severe respiratory illness in humans and currently lacks an approved vaccine. The Newcastle disease virus (NDV) vector is a well-established, safe, and effective platform for vaccine development. …”
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Effects of starter cultures on the metabolite profile, antioxidant activities, and anti-aging properties of tapuy lees by Edward Kevin B. Bragais, Paul Mark B. Medina

“…Future studies should focus on clinical trials in humans to validate these findings and further explore the potential of tapuy lees as a natural, sustainable source of bioactive compounds.…”
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GTPase GPN3 facilitates cell proliferation and migration in non-small cell lung cancer by impeding clathrin-mediated endocytosis of EGFR by Linlin Xu, Jiankun Guo, Xinsheng Xie, Hailong Wang, Alan Jiang, Changhua Huang, Hua Yang, Shiwen Luo, Limin Chen

“…Abstract Small GTPases play a critical role as regulatory molecules in signaling transduction and various cellular processes, contributing to the development of human diseases, including cancers. GPN3, an evolutionarily conserved member of the GPN-loop GTPase subfamily classified in 2007 according to its structure, has limited knowledge regarding its cellular functions and molecular mechanisms. …”
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Profiling the diversity of the village chicken faecal microbiota using 16S rRNA gene and metagenomic sequencing data to reveal patterns of gut microbiome signatures by Mxolisi Nene, Mxolisi Nene, Nokuthula Winfred Kunene, Rian Pierneef, Rian Pierneef, Rian Pierneef, Khanyisile Hadebe

“…These genes primarily mediate antibiotic efflux and alteration.DiscussionThe detection of zoonotic bacteria such as Escherichia coli and Streptococcus spp. highlights potential health risks to humans through the food chain, emphasizing the importance of improved household hygiene practices. …”
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Assimilation of Sparse Continuous Near‐Earth Weather Measurements by NECTAR Model Morphing by I. A. Galkin, B. W. Reinisch, A. M. Vesnin, D. Bilitza, S. Fridman, J. B. Habarulema, O. Veliz

“…Associative memories mimic human capability to restore full information from its initial fragments. …”
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Comprehensive characterization of platelet function in dogs with hyperadrenocorticism by Sanggu Kim, Dohee Lee, Preeti Kumari Chaudhary, Hakhyun Kim, Byeong-Teck Kang, Soochong Kim

“…Hypercoagulation in HAC occurs in both humans and dogs. Platelets play a major role in thrombosis and hemostasis, but no study has investigated platelet function in dogs with HAC. …”
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A comparative study of polydopamine vs. glass ionomer cement for adhesion mechanisms on enamel and dentin using SEM and shear bond strength evaluation by Lakshmi Nidhi Rao, Soumyajit Sarkar, Aditya Shetty, Heeresh Shetty, Shraddha Shetty, Roshan Noor Mohamed, Sakeenabi Basha, Ajinkya Pawar, Mohmed Isaqali Karobari

“…This study aimed to compare the adhesive properties of PD and Glass Ionomer Cement (GIC) on enamel and dentin substrates, evaluating PD’s potential as an alternative adhesive in dental practice. A total of 120 human premolars were prepared, with 80 teeth allocated for Scanning Electron Microscopy (SEM) analysis and 40 teeth reserved for shear bond strength testing. …”
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MLL-AF4 upregulates 5-lipoxygenase expression in t(4;11) leukemia cells via the ALOX5 core promoter by Marius Hyprath, Maximilian Molitor, Ilona Schweighöfer, Rolf Marschalek, Dieter Steinhilber

“…Knockdown of the MLL-AF4 gene in the human B cell line SEM revealed that MLL-AF4 is an inducer of ALOX5 gene expression in leukemic cells with lymphoid properties. …”
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Tracking metal pollution from illegal gold mining: a health risk assessment in Edfu, Egypt by Kholoud M. AbdelMaksoud, Wael M. Al-Metwaly, Heba M. R. Hathout

“…The study aimed to assess the concentrations of carcinogenic agents and determine the potential human health risks associated with these agents in soil and fish samples collected within the city boundaries. …”
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Air pollution exposures in early life and brain development in children (ABC): protocol for a pregnancy cohort study by John Kinuthia, R Scott McClelland, Barbra A Richardson, Elizabeth Maleche-Obimbo, Brent R Collett, Sarah Benki-Nugent, Faridah H Were, Anne M Riederer, Michael Gatari, CJ Karr, Edmund YW Seto, Beatrice C Mutai, Susan Wamithi, Priscilla Wanini Edemba, Timothy V Larson, Julian D Marshall

“…Additional exposure assessment in a subset of the cohort includes residential indoor and outdoor air monitoring for fine particulate matter (PM2.5), carbon monoxide (CO), ultrafine particles (UFP) and black carbon (BC).Ethics and dissemination This study was approved by the Kenyatta National Hospital - University of Nairobi Ethics and Research Committee, and the University of Washington Human Subjects Division. Results are shared at annual workshops.…”
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ERK5 Contributes to VEGF Alteration in Diabetic Retinopathy by Yuexiu Wu, Yufeng Zuo, Rana Chakrabarti, Biao Feng, Shali Chen, Subrata Chakrabarti

“…We investigated a novel pathway, namely extracellular signal regulated kinase 5 (ERK5) mediated signaling, in modulating glucose-induced vascular endothelial growth factor (VEGF) expression. Human microvascular endothelial cells (HMVEC) were exposed to glucose. …”
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Case studies in adaptation: centring equity in global health education during the COVID-19 pandemic and beyond by Anna Pancheshnikov, C Nicholas Cuneo, Wilfredo R Matias, Rebeca Cázares-Adame, Abner Gamaliel Santos López, Ryan M Paxton, Chi Chiung Grace Chen

“…Case 3: the Johns Hopkins Global Health Leadership Program adapted its curriculum into a hybrid online and in-person migrant health and human rights elective, collaborating with local organisations. …”
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Reconstructing the genetic structure of the Kazakh from clan distribution data by M. K. Zhabagin, О. Е. Balanovsky, Zh. M. Sabitov, A. Z. Temirgaliyev, A. T. Agdzhoyan, S. M. Koshel, Е. М. Ramankulov, E. V. Balanovska

“…Applying quasigenetic markers - non-biological traits which are nevertheless inherited in generations - is one of the research fields within human population genetics. For the West European, East European, and Caucasus populations, surnames are typical quasigenetic markers. …”
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GastroFuse-Net: an ensemble deep learning framework designed for gastrointestinal abnormality detection in endoscopic images by Sonam Aggarwal, Isha Gupta, Ashok Kumar, Sandeep Kautish, Abdulaziz S. Almazyad, Ali Wagdy Mohamed, Frank Werner, Mohammad Shokouhifar

“…To address these challenges, we introduced a specialized CNN-based architecture called GastroFuse-Net, designed to recognize human gastrointestinal diseases from endoscopic images. …”
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Genome-wide CRISPR-based screen identifies E2F transcription factor 1 as a regulator and therapeutic target of aristolochic acid-induced nephrotoxicity by Ziqi Liu, Huan Gao, Guoliang Li, Yongjiang Yu, Mengxing Cui, Honghao Peng, Xinchao Guan, Xue Zhang, Zhihan Zhang, Xiaoyu Shen, Shen Chen, Daochuan Li, Liping Chen, Yongmei Xiao, Wen Chen, Lili Liu, Qing Wang

“…To identify undiscovered key genes involved in AAI-induced renal toxicity, a genome-wide CRISPR library screen was conducted in the human kidney-2 (HK-2) cell line. Among the altered sgRNAs, a significant enrichment of those targeting the E2F transcription factor 1 (E2F1) gene was observed in surviving HK-2 cells in the AAI-treated group. …”
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Clinical evaluation and management of a 45-year-old man with confusion, psychosis, agitation, stereotyped behavior, and impaired speech by Xiaolin Deng, Paulo J. Negro, Patrick L. Jung, Christopher M. Marano, Stephanie Knight, Seshagiri R. Doddi, Nana Y. A. Nimo, Rachel M. LeMalefant, Drew A. Myers, Andrea K. Haake, Rebecca Chandler

“…Moreover, the fluctuation of the patient’s neuropsychiatric symptoms we observed during his hospitalization reflects the increased vulnerability of the human brain under sustained neurodegeneration.…”
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Infectivity in full-term placenta of Zika viruses with different lipid profiles by Eva Mazzetto, Alessio Bortolami, Davide Bovo, Matteo Stocchero, Elisa Mazzacan, Alessandra Napolitan, Valentina Panzarin, Maria Rosa Tran, Gianpiero Zamperin, Adelaide Milani, Andrea Fortin, Michela Bigolaro, Paola Pirillo, Matteo Pagliari, Claudia Zanardello, Giuseppe Giordano, Maria Teresa Gervasi, Eugenio Baraldi, Calogero Terregino, Carlo Giaquinto, Francesco Bonfante

“…Notably, ZIKV stock derived from mammalian cells showed a higher infectivity in immortalized villous trophoblasts and full-term placental explants of human origin. This increased infectivity was linked to enhanced fusion efficiency during the viral uncoating phase in trophoblast cells, as demonstrated using a lipophilic probe. …”
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Sociodemographic characteristics, occupational characteristics, motivational factors, and job satisfaction among primary health service practitioners by Di Liu, Huanyan Wang, Wenlin Zhang, Peixuan Chen, Yuqing Lin, Yujin Xie, Mingyang Zou, Debao Li, Ming Fang, Bingjie Hu, Lei Shi

“…Establishing scientific and reasonable research on the incentive mechanism at grassroots medical institutions can help stabilize the team, enhance staff satisfaction and work performance, and optimize human resource utilization.…”
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Imaging pathology in archived cornea with Fuchs’ endothelial corneal dystrophy including tissue reprocessing for volume electron microscopy by Sayo Maeno, Philip N. Lewis, Robert D. Young, Yoshinori Oie, Kohji Nishida, Andrew J. Quantock

“…Specimens were archived full-thickness human corneal tissue, removed during graft surgery, that had been fixed, stained and embedded by conventional processing methods for examination by transmission electron microscopy more than 40-years previously. …”
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A growing degree day model determines the effect of temperature stress on diverse chickpea genotypes by Cara Jeffrey, Cara Jeffrey, Cara Jeffrey, Laura Ziems, Laura Ziems, Brent Kaiser, Brent Kaiser, Richard Trethowan, Richard Trethowan

“…Chickpeas are a globally crucial agricultural product, currently at risk due to human-induced climate change. There has been little research into the impact of heat stress on chickpea compared to other crops, but it is known that heat stress can cause up to 100% yield loss. …”
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