Omega-3 fatty acids: molecular weapons against chemoresistance in breast cancer by Vittoria Marchio, Giuseppina Augimeri, Catia Morelli, Adele Vivacqua, Cinzia Giordano, Stefania Catalano, Diego Sisci, Ines Barone, Daniela Bonofiglio

“…Highly targeted therapies have been developed for different subtypes of breast cancer, including hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-positive breast cancer. …”
Get full text

Enhancing student nurses’ ethical skills via simulation-based learning: barriers and opportunities by Richard M. Rasesemola, Manoko P. T. Molabe

“…Conclusion Barriers related to insufficient human resources and infrastructure made it almost impossible to facilitate ethics education among nursing students, especially during Covid-19 pandemic. …”
Get full text

Direct imaging of exoplanets: Legacy and prospects by Chauvin, Gael

“…On the timescale of a human Life, we may well be witnessing the first discovery of an exoplanet and the first detection of indices of life in the atmosphere of a nearby exo-Earth!…”
Get full text

Production of novel theranostic nano-vector based on superparamagnetic iron oxide nanoparticles/miR-497 targeting colorectal cancer by Asmaa M. Elfiky, May M. Eid, May El-Manawaty, Zeinab A. Elshahid, Elham Mohamed Youssef, Khaled Mahmoud

“…The data suggest that the mir-497 -loaded SPION@Ag@Cs nano-formulation could be a good candidate for the suppression of CTLA4in CRC human cell lines. Consequently, the targeting miR-497/CTLA4 axis is a potential immunotherapy treatment strategy for CRC.…”
Get full text

An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode by Xiaoying Jia, Xuping Jing, Ming Li, Minli Gao, Yao Zhong, Entao Li, Yang Liu, Rui Li, Guoqiang Yao, Qiaojie Liu, Minmin Zhou, Yuxia Hou, Linfeng An, Yibao Hong, Shanshan Li, Jiancun Zhang, Wei Wang, Kaiming Zhang, Peng Gong, Sandra Chiu

“…Importantly, treatment with HNC-1664 demonstrate anti-SARS-CoV-2 efficacy in infected K18-human ACE2 mice, with reduced viral titer and mortality, as well as improved lung injury. …”
Get full text

Studi Retrospektif Kanker Kulit di Poliklinik Ilmu Kesehatan Kulit dan Kelamin RS Dr. M. Djamil Padang Periode Tahun 2015-2017 by Silvia Wilvestra, Sri Lestari, Ennesta Asri

“…Faktor peningkatan radiasi sinar ultraviolet, faktor genetik, pola hidup yang tidak sehat, dan infeksi human papillomavirus dapat menjadi pencetus untuk timbulnya kanker kulit. …”
Get full text

A Review of Agricultural Film Mapping: Current Status, Challenges, and Future Directions by Mengmeng Zhang, Jinwei Dong, Quansheng Ge, Hasituya, Pengyu Hao

“…The accurate and timely agricultural film maps are expected to support effective land management, rationalize human land use behavior, and inform policy formulation for environmental sustainability.…”
Get full text

Anti-HER2 biparatopic antibody KJ015 has near-native structure, functional balanced high affinity, and synergistic efficacy with anti-PD-1 treatment in vivo by Zheng Wang, Yu Liu, Yunxia Xu, Lin Lu, Zhen Zhu, Baojie Lv, Xin Fang, Yao Tang, Jinhua Wang, Yu Cheng, Ying Hu, Junwen Lou, Peican Wu, Chendan Liu, Yanjun Liu, Xin Zeng, Qing Xu

“…Currently approved human epidermal growth factor receptor 2 (HER2)-targeted antibody therapies are largely derived from trastuzumab, including trastuzumab-chemotherapy combinations, fixed-dose trastuzumab-pertuzumab combinations, and trastuzumab antibody-drug conjugates. …”
Get full text

Hepatocyte-derived liver progenitor-like cells attenuate liver cirrhosis via induction of apoptosis in hepatic stellate cells by Xu Zhou, Wen-Ming Liu, Han-Yong Sun, Yuan Peng, Ren-Jie Huang, Cai-Yang Chen, Hong-Dan Zhang, Shen-Ao Zhou, Hong-Ping Wu, Dan Tang, Wei-Jian Huang, Han Wu, Qi-Gen Li, Bo Zhai, Qiang Xia, Wei-Feng Yu, He-Xin Yan

“…We have developed a strategy to effectively expand murine and human hepatocyte-derived liver progenitor-like cells (HepLPCs) in vitro. …”
Get full text

Antimicrobial Activity and Mode of Action of N-Heterocyclic Carbene Silver(I) Complexes by Giusy Castagliuolo, Michela Di Napoli, Tshering Zangmo, Joanna Szpunar, Luisa Ronga, Anna Zanfardino, Mario Varcamonti, Diego Tesauro

“…Silver drugs have played a vital role in human healthcare for the treatment of infections for many centuries. …”
Get full text

LC-MS-Based Global Metabolic Profiles of Alternative Blood Specimens Collected by Microsampling by Marlene N. Thaitumu, Daniel Marques De Sá e Silva, Philippine Louail, Johannes Rainer, Glykeria Avgerinou, Anatoli Petridou, Vassilis Mougios, Georgios Theodoridis, Helen Gika

“…<b>Results:</b> BµS devices, especially Mitra and Capitainer, provided equal or even superior information on the metabolic profiling of human blood based on the number and intensity of features and the precision and stability of some annotated metabolites compared to plasma. …”
Get full text

Aluminum-Induced Alterations in Purinergic System Parameters of BV-2 Brain Microglial Cells by Charles Elias Assmann, Vitor Bastianello Mostardeiro, Grazielle Castagna Cezimbra Weis, Karine Paula Reichert, Audrei de Oliveira Alves, Vanessa Valéria Miron, Margarete Dulce Bagatini, Taís Vidal Palma, Cinthia Melazzo de Andrade, Micheli Mainardi Pillat, Fabiano Barbosa Carvalho, Cristina Ruedell Reschke, Ivana Beatrice Mânica da Cruz, Maria Rosa Chitolina Schetinger, Vera Maria Melchiors Morsch

“…Aluminum (Al) is ubiquitously present in the environment and known to be a neurotoxin for humans. The trivalent free Al anion (Al3+) can cross the blood-brain barrier (BBB), accumulate in the brain, and elicit harmful effects to the central nervous system (CNS) cells. …”
Get full text

Exploring the operator experience in automated shuttles: Fatigue, attention, and gaze behaviour by Christer Ahlström, My Weidel, Anna Sjörs Dahlman, Ashleigh Filtness, Anna Anund

“…Automated shuttles provide a first look at future transportation, however, they still require on-board human operators for regulatory compliance and safety assurance. …”
Get full text

Effect of Chlorhexidine Treatment on Microleakage of Glass Ionomer, Giomer and Methacrylate-Based Composite Restorations in Class V Cavities by Ayşe Aslı Şenol, Seda Özmen, Büşra Karabulut Gençer, Bilge Tarçın, Pınar Yılmaz Atalı

“… Purpose: The aim of this in vitro study was to evaluate the effect of material selection and chlorhexidine digluconate (CHX) pretreatment on microleakage in Class V cavities restored with 3 different restorative materials.Materials and Methods: Thirty freshly extracted sound human molars were cleaned and stored in distilled water. …”
Get full text

A multimodal multistream multilevel fusion network for finger joint angle estimation with hybrid sEMG and FMG sensing by Zhouping Chen, Mohamed Amin Gouda, Longcheng Ji, Hong Wang

“…Finger joint angle (FJA) estimation, as a dynamic and fine-grained decoding mode, can support intuitive and natural human–machine interactions. This study is pioneering work dedicated to achieving accurate and clinically friendly FJA estimation. …”
Get full text

Revisiting the Metabolism of Donepezil in Rats Using Non-Targeted Metabolomics and Molecular Networking by Eun-Ji Park, Eui-Hyeon Kim, Ki-Young Kim, Ji-Hyeon Jeon, Im-Sook Song, So-Young Park, Kwang-Hyeon Liu

“…<b>Conclusions</b>: The metabolic characteristics of donepezil in rats were comparable to those in humans, indicating that a rat is a reliable model for studying donepezil metabolism. …”
Get full text

Users’ experiences of an online intervention for bipolar disorder: important lessons for design and evaluation by Richard Morriss, Steven H Jones, Fiona Lobban, Alyson L Dodd, Sara Mallinson, Martin Griffiths

“…Individual preferences and human contact were key factors for both trial design and engagement with an online intervention.Clinical implications Digital interventions should be co-produced, personalised, interactive and embedded as one component in a broader package of care.Trial registration number ISRCTN56908625; Post-results.…”
Get full text

Metallothionein II treatment mitigates rotenone-induced neurodegeneration in zebrafish models of Parkinson’s disease by Yong Hui Nies, Wei Ling Lim, Norwahidah Abd Karim, Mohamad Fairuz Yahaya, Seong Lin Teoh

“…This study explores the neuroprotective potential of exogenous human metallothionein 2 (hMT2) peptide in a rotenone-induced PD zebrafish model.MethodsAdult zebrafish were divided into four groups: control, rotenone-treated, hMT2 pre-treatment, and hMT2 co-treatment. …”
Get full text

Analysis of Melanin Concentration on Reflective Pulse Oximetry Using Monte Carlo Simulations by Maximilian Reiser, Oliver Amft, Andreas Breidenassel

“…We conclude that skin tone-adapted calibration should be applied to make reflective pulse oximeter applicable to any human, independent of skin pigmentation.…”
Get full text

Estimation of translational importance of mammalian mRNA nucleotide sequence characteristics based on ribosome profiling data by O. A. Volkova, Yu. V. Kondrakhin, R. N. Sharipov

“…A statistical analysis was carried out for revealing relationships between the human and mouse mRNA nucleotide sequence characteristics and ribosome profiling data. …”
Get full text