Age of Insomnia Onset Correlates with a Reversal of Default Mode Network and Supplementary Motor Cortex Connectivity by Emiliano Santarnecchi, Chiara Del Bianco, Isabella Sicilia, Davide Momi, Giorgio Di Lorenzo, Salvatore Ferrone, Giulia Sprugnoli, Simone Rossi, Alessandro Rossi

“…Chronic sleep deprivation, but most importantly early insomnia onset, seems to have a significant disruptive effect over the physiological negative correlation between DMN and SMA, a well-known fMRI marker of attention performance in humans. This suggests the need for more in-depth investigations on the prevention and treatment of connectivity changes and associated cognitive and psychological deficits in PI patients.…”
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ROCK Inhibitor-Induced Promotion of Retinal Pigment Epithelial Cell Motility during Wound Healing by Hiroyuki Kamao, Atsushi Miki, Junichi Kiryu

“…The aim of this study is to evaluate the effect of Rho-associated coiled-coil containing kinase (ROCK) inhibitor Y27632 on retinal pigment epithelial (RPE) cell motility during wound healing. Methods. Human RPE cells were cultured in media with and without 10 μM Y27632. …”
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Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms by Yue Xiao, Yingxuan Feng, Jianxin Zhao, Wei Chen, Wenwei Lu

“…Secondly, exploring microbiota biomarkers related to aging and discussing future possibility using dietary regime/components targeted to aging-related microbiota biomarkers promote human healthy lifespan. Thirdly, dietary intervention can effectively improve the imbalance of gut microbiota related to aging, such as probiotics, prebiotics, and postbiotics, but their effects vary among.…”
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Discovery of conserved peptide-MHC epitopes for directly alloreactive CD8+ T cells by Alexandra E. Hill, Eric T. Son, Moumita Paul-Heng, Chuanmin Wang, Shivanjali Ratnaseelan, Martina Denkova, Pouya Faridi, Asolina Braun, Anthony W. Purcell, Nicole A. Mifsud, Alexandra F. Sharland

“…Translating this approach to the human setting is achievable and will yield both critical insights into the fundamental basis of alloreactivity and powerful tools for immune monitoring in transplantation.…”
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Seroprevalence to herpesviruses in patients with primary brain gliomas by T. A. Zykova, O. I. Kit, E. E. Rostorguev, E. A. Shevyakova, N. S. Kuznetsova

“…Antibodies of classes M and G to herpes simplex virus types 1, 2 (HSV-1,2), cytomegalovirus (CMV), Epstein-Barr virus (EBV), human herpes virus type 6 (HHV-6) were determined by ELISA using JSC "Vector-Best" reagent kits.Results. …”
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Morphological and Molecular Characterization of Toxigenic Aspergillus flavus from Groundnut Kernels in Kenya by Robert O. Okayo, Darius O. Andika, Mathews M. Dida, George O. K’Otuto, Bernard M. Gichimu

“…Pathogenesis of Aspergillus flavus on important agricultural products is a key concern on human health due to the synthesis and secretion of the hazardous secondary metabolite, aflatoxin. …”
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Genomic analysis and antibiotic resistance of a multidrug-resistant bacterium isolated from pharmaceutical wastewater treatment plant sludge by Ningyu Sun, Hu Gao, Xinbo Zhang, Zeyou Chen, Anping Peng

“…Additionally, the N4 genome contained 187 genes associated with human disease and 249 virulence factors, underscoring its potential pathogenicity. …”
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Investigating the needs and barriers for prevention, control, and treatment of HIV/AIDS in transgender population: a systematic review of literature by Heshmatollah Sofimajidpour, Ghobad Moradi, Hojat Dehghanbanadaki, Marzieh Mahboobi, Mobin Azami, Parisa Khodakhah, Mohammad Aziz Rasouli, Yousef Moradi

“…Introduction The purpose of this systematic review was to identify the health needs related to prevention, control, and treatment of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) in transgender people from the perspective of transgender individuals and health policy-makers. …”
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Biodegradation of CAHs and BTEX in groundwater at a multi-polluted pesticide site undergoing natural attenuation: Insights from identifying key bioindicators using machine learning... by Feiyang Xia, Tingting Fan, Mengjie Wang, Lu Yang, Da Ding, Jing Wei, Yan Zhou, Dengdeng Jiang, Shaopo Deng

“…These contaminants pose serious risks to ecosystems and human health. Natural attenuation (NA) has emerged as a sustainable solution, with microorganisms playing a crucial role in pollutant biodegradation. …”
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sRrsR-Net: A New Low-Light Image Enhancement Network via Raw Image Reconstruction by Zhiyong Hong, Dexin Zhen, Liping Xiong, Xuechen Li, Yuhan Lin

“…Most existing low-light image enhancement (LIE) methods are primarily designed for human-vision-friendly image formats, such as sRGB, due to their convenient storage and smaller file sizes. …”
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Monitoring the Induction of Heat Shock Factor 1/Heat Shock Protein 70 Expression following 17-Allylamino-Demethoxygeldanamycin Treatment by Positron Emission Tomography and Optical... by Mikhail Doubrovin, Jian T. Che, Inna Serganova, Ekaterina Moroz, David B. Solit, Lyudmila Ageyeva, Tatiana Kochetkova, Nagavarakishore Pillarsetti, Ronald Finn, Neal Rosen, Ronald G. Blasberg

“…MicroPET imaging based on [ 124 I]iodide accumulation in pQHNIG70-transduced RG2 xenografts showed a significant 6.2-fold reporter response to 17-AAG, with a corresponding increase in tumor HSP70 and in tumor human sodium iodide symporter and green fluorescent protein reporter proteins. …”
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Electronic database of regulatory observations as a tool of public administration in the context of digitalization in construction by I. V. Karakozova, I. M. Lisitsyn, K. V. Boldyshev

“…There is a necessity to carry out several measurements at different sites to obtain averaged data, including due to the influence of the human factor in establishing fix points and forming a map of work operations, which creates the possibility of data falsification. …”
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Peripheral huntingtin silencing does not ameliorate central signs of disease in the B6.HttQ111/+ mouse model of Huntington's disease. by Sydney R Coffey, Robert M Bragg, Shawn Minnig, Seth A Ament, Jeffrey P Cantle, Anne Glickenhaus, Daniel Shelnut, José M Carrillo, Dominic D Shuttleworth, Julie-Anne Rodier, Kimihiro Noguchi, C Frank Bennett, Nathan D Price, Holly B Kordasiewicz, Jeffrey B Carroll

“…To study the relationship between peripheral huntingtin levels and striatal HD phenotypes, we utilized a knock-in model of the human HD mutation (the B6.HttQ111/+ mouse). We treated mice with ASOs from 2-10 months of age, a time period over which significant HD-relevant signs progressively develop in the brains of HttQ111/+ mice. …”
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Preparing for old age in a geragogic approach. The conceptual assumptions for gerontological education of people aged 50+ “Towards a dignified and successful old age” by Anna Maria Leszczyńska-Rejchert

“…Results Old age as a phase of human life is regarded in geragogy as a task of an individual. …”
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Exogenous selenium enhances cadmium stress tolerance by improving physiological characteristics of Artemisia argyi seedlings by Yaxin Yu, Yingbin Yang, Yu Guo, Meiqi Pan, Wenfang Hao

“…Abstract The contamination of Chinese medicinal materials with cadmium (Cd) is a pressing global issue that poses significant risks to human health. The beneficial effects of selenium (Se) have been established in improving plant growth and reducing Cd accumulation in plant under Cd stress. …”
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Weedy plants at Ugolnye Kopi Village, Anadyrsky District, Chukotka Autonomous Area by E. G. Nikolin

“…Penetration of adventive plant species, human satellites, into this area is very limited. …”
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Understanding the county-level relationship between population change and ecological environment quality dynamic in China, 2000–2020 by Mingxing Zhong, Qingqing Liu, Xinyue Hu

“…Global population growth has increasingly intensified human interferences with natural ecosystems. These interferences often exhibit complexity and diversity characteristics. …”
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Spatiotemporal dynamics and driving mechanism of eco-environmental quality in piedmont-oasis-desert ecotone based on long-term harmonized remote sensing ecological index- take Korl... by Junling He, Xifeng Ju, Chuqiao Han, Liming Liu, Haidong Zhang, Saitiniyazi Adilai, Chongbo Li

“…The degraded and essential stable areas were located in the northern and the southern, accounting for about 25% of the total area, and the overall fluctuation was low. (4) The spatiotemporal distribution results from the joint action of natural and human factors, the key factors were temperature, precipitation, and socio-economic development level. …”
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Research progress on the therapeutic roles and mechanisms of hydrogen-rich water in periodontitis by LIU Fushuang, WEI Xiaoxuan, ZHOU Jianpeng, WANG Jun

“…Therefore, further clinical studies are required to validate the therapeutic significance and optimal therapeutic regimen of HRW in human periodontitis. This article aims to review the therapeutic role and the underlying mechanisms of HRW in periodontitis.…”
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Mycotoxicological Assessment of Broiler Compound Feed: A Multi-Year Analysis of Five Mycotoxins in a Romanian Feed Mill by Dragoș Mihai Lăpușneanu, Silvia-Ioana Petrescu, Cristina-Gabriela Radu-Rusu, Mădălina Matei, Ioan Mircea Pop

“…Mycotoxins are secondary metabolites of filamentous fungi that cause massive agricultural losses worldwide and constitute a significant health problem for humans and animals. The aim of this five-year study was to investigate the contamination of compound feed for broiler chickens at all stages (starter, grower and finisher) from a feed mill in Romania with mycotoxins such as total aflatoxins (AFT), deoxynivalenol (DON), fumonisins (FUMs), ochratoxin A (OTA) and zearalenone (ZEN). …”
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