Targeting SLC4A4: A Novel Approach in Colorectal Cancer Drug Repurposing by Krunal Pawar, Pramodkumar P. Gupta, Pooran Singh Solanki, Ravi Ranjan Kumar Niraj, Shanker L. Kothari

“…Methods: The study utilized computational approaches, including receptor-based virtual screening and high-throughput docking, to identify potential SLC4A4 inhibitors. A model of the human SLC4A4 structure was generated based on CryoEM data (PDB ID 6CAA), and drug candidates from the DrugBank database were evaluated using two computational tools (DrugRep and CB-DOCK2). …”
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A girl with intragenic variants in MARS2 and a chondrodysplasia phenotype by Hiroyuki Iijima, Yuko Tsujioka, Yoshiyuki Tsutsumi, Gen Nishimura, Yasushi Okazaki, Kei Murayama, Mitsuru Kubota, Akira Ohtake

“…Background: The human mitochondrial methionyl-tRNA is crucial for mitochondrial translation, serving as both initiator and elongator in polypeptide chains. …”
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“Sichuanvirus”, a novel bacteriophage viral genus, able to lyse carbapenem-resistant Klebsiella pneumoniae by Juan Li, Qingqing Fang, Huan Luo, Yan Feng, Yu Feng, Zhiyong Zong

“…Abstract Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a severe threat for human health and urgently needs new therapeutic approaches. …”
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Dengue Virus NS1 Protein as a Diagnostic Marker: Commercially Available ELISA and Comparison to qRT-PCR and Serological Diagnostic Assays Currently Used by the State of Florida by Jason H. Ambrose, Shamala Devi Sekaran, Azliyati Azizan

“…These comparisons were made among a group of 21 human sera. Results. Nine of 14 (64.3%) DENV qRT-PCR+ samples were also DENV NS1+. …”
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Piezoelectric biomaterials for providing electrical stimulation in bone tissue engineering: Barium titanate by Huagui Huang, Kaizhong Wang, Xiangyan Liu, Xin Liu, Jinzuo Wang, Moran Suo, Hui Wang, Shuang Chen, Xin Chen, Zhonghai Li

“…Piezoelectric materials have the same piezoelectric effect as human bone, and they are able to deform in response to physiological movement, thus providing electrical stimulation to cells or damaged tissue without the need for an external power source. …”
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The Mitochondria-Targeted Antioxidant SkQ1 Downregulates Aryl Hydrocarbon Receptor-Dependent Genes in the Retina of OXYS Rats with AMD-Like Retinopathy by M. L. Perepechaeva, A. Yu. Grishanova, E. A. Rudnitskaya, N. G. Kolosova

“…It has been shown that SkQ1 reduces clinical signs of retinopathy in senescence-accelerated OXYS rats, which are a known animal model of human age-related macular degeneration (AMD). The aim of this work was to test whether SkQ1 affects transcriptional activity of AhR (aryl hydrocarbon receptor) and Nrf2 (nuclear factor erythroid 2-related factor 2), which are considered as AMD-associated genes in the retina of OXYS and Wistar rats. …”
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How Can the Protection of Important Agricultural Heritage Sites Contribute to the Green Development of Agriculture: Evidence from China by Li Mo, Song Chen, Shenwei Wan, Lei Zhou, Shiyuan Wang

“…The protection of agricultural heritage sites has become a global human responsibility and consensus. However, the potential effect of agricultural heritage sites on the green development of agriculture has currently been ignored. …”
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Phosphate-sensing mechanisms and functions of phosphate as a first messenger by Yuichi Takashi

“…Phosphate is an essential mineral for the human body, and around 85% of phosphate is present in bone as a constituent of hydroxyapatite, Ca10(PO4)6(OH)2. …”
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Comparison of the mechanical properties of different skin sites for auricular and nasal reconstruction by M. F. Griffin, B. C. Leung, Y. Premakumar, M. Szarko, P. E. Butler

“…Methods Using ten fresh human cadavers, the tensile Young’s Modulus of the skin from the forehead, forearm, temporoparietal, post-auricular and submandibular neck was assessed. …”
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The association between urinary lead concentration and the likelihood of kidney stones in US adults: a population-based study by Dan Liang, Chang Liu, Mei Yang

“…Abstract The negative effects of lead exposure on human health have attracted widespread attention. …”
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The Phytochemical Screening and Antioxidants Potential of Schoenoplectus triqueter L. Palla by Amir Hassan, Zakaria Akmal, Nawaz Khan

“…Over the centuries, humans use different types of therapeutic plants to treat several diseases. …”
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Hearing loss prevalence and burden of disease in China: Findings from provincial-level analysis by Yu Wang, Yang Xie, Minghao Wang, Mengdan Zhao, Rui Gong, Ying Xin, Jia Ke, Ke Zhang, Shaoxing Zhang, Chen Du, Qingchuan Duan, Fang Wang, Tao Pan, Furong Ma, Xiangyang Hu, Jing Ni

“…Without timely and effective rehabilitation, hearing loss may profoundly affect human life quality. China has a large population of hearing-impaired individuals, which imposes a heavy health burden on society. …”
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Microneedle technology for enhanced topical treatment of skin infections by Tingting Peng, Yangyan Chen, Xuanyu Luan, Wanshan Hu, Wentao Wu, Bing Guo, Chao Lu, Chuanbin Wu, Xin Pan

“…Skin infections caused by microbes such as bacteria, fungi, and viruses often lead to aberrant skin functions and appearance, eventually evolving into a significant risk to human health. Among different drug administration paradigms for skin infections, microneedles (MNs) have demonstrated superiority mainly because of their merits in enhancing drug delivery efficiency and reducing microbial resistance. …”
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Artificial Taste: Advances and Innovative Applications in Healthcare by Letao Wang, Yuzhang Li, Yao Zhang, Bin Zheng

“…Targeted original research papers were analyzed, with data extracted to address five key aspects: interface design, stimulation parameters, sensation verification results, applications to health problems, and potential side effects in human subjects. Results: A total of 19 relevant papers were identified. …”
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Blue elixir of youth and wellness: The multicomponent-multitarget paradigm of Curcuma caesia Roxb by Sabrina Burattini, Federico Gianfanti, Francesco Onesimo, Sabrina Donati Zeppa, Barbara Canonico, Mariele Montanari, Giovanna Panza, Daniele Lopez, Giosuè Annibalini, Fabiana Fanelli, Roberta Saltarelli, Michele Mari, Michele Retini, Riham Osman, Aghna Mariam, Matteo Micucci, Giovanni Caprioli, Agnese Santanatoglia, Deborah Agostini, Michela Battistelli

“…Through HPLC-ESI-MS/MS, the chemical analysis identified key phenolic compounds, including (−)-epicatechin, procyanidin B2, and p-coumaric acid. Human immortalized keratinocyte cell lines (HaCaT) were treated with CCRE in healthy and UVB-induced conditions to assess their impact on oxidative stress and aging. …”
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Inhibiting the alternative pathway of complement by reducing systemic complement factor B: Randomized, double-blind, placebo-controlled phase 1 studies with Sefaxersen by Michael L. McCaleb, Steven G. Hughes, Tamar R. Grossman, Ashley Frazer-Abel, Bill Jung, Lixuan Yin, Scott P. Henry, Brett P. Monia, Eugene Schneider, Richard Geary, Gary T. Brice

“…An over-active alternative complement pathway has been implicated in the pathophysiology of multiple diseases, including IgA nephropathy and geographic atrophy secondary to age related macular degeneration. In first-in-human double-blind, placebo-controlled phase 1 studies, the safety and pharmacodynamic effects of sefaxersen (RO7434656), a GalNAc-conjugated 2’-MOE antisense oligonucleotide targeting the complement factor B mRNA, was investigated. …”
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Chronic Kidney Disease in the Eastern Region of the State of Mexico: Implication of the Social Determinants of Health by Luis Enrique Hernández Gamundi, Donovan Casas Patiño, Alejandra Rodríguez Torres, Angélica Heredia Sánchez

“…<br /><strong>Conclusions:</strong> due to their impact on the way of living and caring for chronic kidney disease, the social determinants of health should be included transdisciplinary in public health policies, where not only epidemiology dictates the approach to renal patients, at this time mathematical models They are not applicable to groups, because social, cultural behaviors and the social determinants of health set the behavior patterns of human beings.…”
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Environmental Characteristics of Modern Systems of Domestic Use of Fuel. Part 1 by B. S. Soroka, V. V. Horupa

“…Under some compositions of burning mixture the correlation could be set as [NO2] &gt;&gt; [NO], resulting in great danger for the human health. With regard to the formation of particularly toxic NO2 effluents observed in some cases, an influence of the reaction temperature and the composition of the combustible mixture on the possibility of nitrogen dioxide formation in the combustion products have been analyzed. …”
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Spatial genetic characterization of the red fox (Vulpes vulpes) in the area between the Alps and the Central Dinaric Mountains by A. Devedžić, F. F. Urzi, B. Pokorny, G. Vengušt, D. Ž. Vengušt, F. Janžekovič, L. Velić, T. Eterović, B. K. Stroil, E. Bužan

“…Studying genetic diversity is crucial for the resilience and adaptability of populations, ensuring their survival amid environmental changes and human-induced pressures.…”
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Incremental Instance-Oriented 3D Semantic Mapping via RGB-D Cameras for Unknown Indoor Scene by Wei Li, Junhua Gu, Benwen Chen, Jungong Han

“…Scene parsing plays a crucial role when accomplishing human-robot interaction tasks. As the “eye” of the robot, RGB-D camera is one of the most important components for collecting multiview images to construct instance-oriented 3D environment semantic maps, especially in unknown indoor scenes. …”
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