Methods for Extracting Immune-Response Modulating Agents of Plant Origin by Oksana V. Kozlova, Natalia S. Velichkovich, Elizaveta R. Faskhutdinova, Olga A. Neverova, Andrey N. Petrov

“…Numerous adverse factors may violate the human immune system and trigger various diseases. …”
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Targeting OAS3 for reversing M2d infiltration and restoring anti-tumor immunity in pancreatic cancer by Shaopeng Zhang, Ximo Xu, Kundong Zhang, Changzheng Lei, Yitian Xu, Pengshan Zhang, Yuan Zhang, Haitao Gu, Chen Huang, Zhengjun Qiu

“…OAS3 deficiency in macrophages substantially impairs IL-10highVEGF-AhighM2d polarization and their pro-tumor functions while enhancing the therapeutic efficacy of gemcitabine and anti-PD-L1 mAb in humanized mouse models. In conclusion, OAS3 presents as a promising immune therapeutic target for reversing IL-10highVEGF-AhighM2d infiltration and restoring CD8+T cell-mediated anti-tumor immunity in pancreatic cancer. …”
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Exploring the Role of Practice Managers in Dutch Oral Healthcare Practices by Joost CL den Boer, Wil JM van der Sanden, Katarina Jerković-Ćosić, Josef JM Bruers

“…In many cases, this PM was responsible for a large number of tasks within the sub-areas of care process, human resources, operational policy, and communication. …”
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Evaluation of bone development and organs in rat fetuses exposed to tartrazine by Osman Öztürk, Sümeyye Uçar, Züleyha Doğanyiğit, Aslı Okan Oflamaz, Evrim Suna Arıkan, Şükrü Ateş, Seher Yılmaz

“…Tartrazine has a negative effect on human health such as hyperactivity, allergies and asthma in children. …”
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Multimodal Assessment of Mental Workload During Automated Vehicle Remote Assistance: Modeling of Eye-Tracking-Related, Skin Conductance, and Cardiovascular Indicators by Fabian Walocha, Andreas Schrank, Hoai Phuong Nguyen, Klas Ihme

“…Similar to other control center positions, we expect the remote assistance tasks to exert high mental demands on the human operators. Therefore, we assessed impact of elevated mental workload during HAV remote assistance in a controlled environment in a user study (N = 37) with the goal of identifying cues to differentiate workload levels based on eye-tracking-related, skin conductance, and cardiovascular indicators. …”
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Step-by-Step: Insights on key marine organisms associated with coral reef benthic cover using Stepwise Multivariate Regression by Wee Hin Boo, Affendi Yang Amri, Then Amy Yee Hui, Chen Sue Yee, Hyde Julian

“…Coral reef ecosystems are severely threatened by human activities and climate change. However, the complexity of the ecosystem can complicate identification of significant ecological interactions between the organisms and the reef system. …”
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Biogenic silver nanoparticles produced by Trichoderma reesei inhibit SARS-CoV-2 infection, reduce lung viral load and ameliorate acute pulmonary inflammation by Marcus V.M.V. Amaral, Cláudia B. Carraro, Amanda C.C. Antoniêto, Mariana N. Costa, Thais F.C. Fraga-Silva, Ualter G. Cipriano, Rodrigo P.F. Abuná, Tamara S. Rodrigues, Ronaldo B. Martins, Andreia M. Luzenti, Glaucia R. Caruso, Priscyla D. Marcato, Vania L.D. Bonato, Dario S. Zamboni, Bergman M. Ribeiro, Sônia N. Báo, Joao S. da Silva, Flávio P. Veras, Roberto N. Silva

“…Additionally, AgNPs impair caspase-1 activation, lactate dehydrogenase release and IL-1β production by human monocytes. Moreover, our study reveals that AgNPs treatment significantly alleviated acute lung injury induced by SARS-CoV-2 infection in Syrian hamsters. …”
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POMA-C: A Framework for Solving the Problem of Precise Anesthesia Control Under Incomplete Observation Environment in Low-Income Areas by Yide Yu, Huijie Li, Dennis Wong, Anmin Hu, Jian Huo, Yan Ma, Yue Liu

“…Through comprehensive ablation experiments—where key observation dimensions are systematically reduced to simulate missing data—POMA-C demonstrates significantly higher decision accuracy and cumulative reward optimization compared to methods like Q-learning and human expertise, even in data-constrained environments. …”
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The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer’s disease by Xudong Sha, Jiayuan Lin, Kexin Wu, Jia Lu, Zhihua Yu

“…Lipid-droplet-accumulating microglia were identified in the aging mouse and human brain; however, little is known about the formation and role of lipid droplets in microglial neuroinflammation of Alzheimer’s disease (AD). …”
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Changes in basic composition and in vitro digestive characteristics of pork induced by frozen storage by Rui Wang, Yongqing Liu, Ying He, Caiping Feng, Xiufang Xia

“…IntroductionFrozen pork can reduce the quality of the meat and alter the digestibility and bioavailability of meat proteins in the human body. In this study, we investigated the changes in the basic composition during frozen storage and their effects on the structural properties of digestion products after protein digestion.MethodsThe impacts of frozen storage at different temperatures (−8, −18, −25, and −40°C) and for different times (1, 3, 6, 9, and 12 months) on the basic components and in vitro digestive characteristics of pork were evaluated.ResultsThe moisture, crude fat, and protein contents decreased with extended storage and increased temperature, whereas muscle juice loss increased (p < 0.05). …”
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Fish scale-inspired biomimetic nanocoatings on magnesium implants for vascularized bone regeneration in infected bone defects by Dan Li, Danni Dai, Jianrong Wang, Zhen Ai, Chao Zhang

“…Biodegradable magnesium (Mg)-based alloys are desirable for orthopedic implants due to the mechanical properties approximating those of human bone and the released Mg2+ ions essential to osteogenic activity. …”
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P-glycoprotein-independent cytotoxic effects of 5-aminopyrazole in L1210 leukemia cells by Lucia Sofrankova, Jana Spaldova, Pavol Stefik, Branislav Pavilek, Dusan Bortnak, Lucia Pavlikova, Ivana Zidekova, Daniel Vegh, Viktor Milata, Albert Breier, Zdena Sulova

“…Five derivatives (A1-A5), each containing perfluorinated methylbenzene at the N3 nitrogen of the pyrazole ring, were tested on murine lymphoblastic cell line variants: parental S cells (P-gp positive), R cells (vincristine-resistant and P-gp positive), and T cells (human P-gp transfected). Among these, A1 and A4 exhibited the strongest effects, especially in R cells, with lesser but similar effects observed in S and T cells. …”
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The influence of depth on the global deep-sea plasmidome by Melany Calderón-Osorno, Dorian Rojas-Villalta, Franck Lejzerowicz, Jorge Cortés, Maria Arias-Andres, Keilor Rojas-Jimenez

“…Our limited understanding of the deep-sea’s microbial ecology, especially its plasmidome, necessitates caution in human activities like mining. Such activities could have unforeseen impacts on this largely unexplored ecosystem.…”
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Asporin Reduces Adult Aortic Valve Interstitial Cell Mineralization Induced by Osteogenic Media and Wnt Signaling Manipulation In Vitro by Anisha Polley, Riffat Khanam, Arunima Sengupta, Santanu Chakraborty

“…Importantly, treatment with human recombinant Asporin protein reduces the mineralization level in osteogenic media-induced aortic valvular interstitial cells with the concomitant decreased level of Wnt/β-catenin signaling. …”
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Anatomical alterations: biparietal thinning in antiquity. Review of published cases and a new case by Nicol Rossetti, Roberta Fusco, Arianna Vanni, Francesca Garanzini, Alessandra Mazzucchi, Marta Licata

“…By presenting this new case, we aim to stimulate further research into biparietal thinning and similar cranial pathologies, enriching the broader narrative of human health evolution.…”
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<i>Vibrio cholerae</i> Gut Colonization of Zebrafish Larvae Induces a Dampened Sensorimotor Response by Isabella Cubillejo, Kevin R. Theis, Jonathan Panzer, Xixia Luo, Shreya Banerjee, Ryan Thummel, Jeffrey H. Withey

“…Cholera is caused by <i>Vibrio cholerae,</i> which colonizes the upper small intestine in humans once ingested. A growing number of studies suggest that the gut microbiome composition modulates animal behavior. …”
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Predicting Traffic Accident Risk in Seoul Metropolitan City: A Dataset Construction Approach by Ji-Woong Yang, Hyeon-Jin Jung, Tae-Wook Kim, Han-Jin Lee, Ellen J. Hong

“…In contemporary society, the rapid progression of urbanization and technological advancements has led to a substantial increase in the number of vehicles, consequently elevating the rate of traffic accidents. To minimize the human and economic losses resulting from these accidents, extensive research has been conducted over the past decades. …”
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Potensi Eugenol Fraksi Etil Asetat Bunga Cengkeh terhadap Proliferasi Kanker Serviks (HeLa Cell Line) by Fajri Rahendra Pratama, Annisa Permata Sari, Aprilia Susanti, Hasya Syakira, Amilia Salsabila, Dessy Arisanty

“…<p>Cervix cancer, also known as cervical cancer, is a type of cancer that is caused mainly by oncogenic Human Papillomavirus (HPV), which attacks the cervix. …”
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ELEVATED BLOOD LEAD LEVELS IN WOMEN OF REPRODUCTIVE AGE DUE TO LEADS EXPOSURE FROM CONTAMINATED WATER by Perdina Nursidika, Dedeh Kurnia, Ganthina Sugihartina

“…Background: Water quality can decrease due to population growth, domestic waste handling, climate, and human activities. Most of the people in Cimahi use well water for drinking and eating. …”
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The effect of two commonly consumed energy drinks on the bond strength of conventional and APC® brackets by Saya Mustafa Azeez, Omar Fawzi Chawshli

“…Materials and Methods: Sixty sound human premolars were divided into two groups of conventional and APC® brackets, and each group had three subgroups of control (artificial saliva), Wild Tiger and Red Bull storage. …”
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