CRISPR-based epigenetic editing of Gad1 improves synaptic inhibition and cognitive behavior in a Tauopathy mouse model by Lei Wan, Ping Zhong, Pei Li, Yong Ren, Wei Wang, Mingjun Yu, Henry Y. Feng, Zhen Yan

“…We confirmed that GABA synthesizing enzymes, GAD1 and GAD2, were significantly downregulated in prefrontal cortex (PFC) of AD human postmortem tissues. A tauopathy mouse model also had the significantly reduced expression of GABA-related genes, as well as the diminished GABAergic synaptic transmission in PFC pyramidal neurons. …”
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HLA-G Expression on Blasts and Tolerogenic Cells in Patients Affected by Acute Myeloid Leukemia by Grazia Locafaro, Giada Amodio, Daniela Tomasoni, Cristina Tresoldi, Fabio Ciceri, Silvia Gregori

“…Human Leukocyte Antigen-G (HLA-G) contributes to cancer cell immune escape from host antitumor responses. …”
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Lipid Mediator Informatics and Proteomics in Inflammation-Resolution by Yan Lu, Song Hong, Katherine Gotlinger, Charles Serhan

“…The automated system including databases and searching algorithms is crucial for prompt and accurate analysis of these lipid mediators biosynthesized from precursor polyunsaturated fatty acids such as eicosanoids, resolvins, and neuroprotectins, which play key roles in human physiology and many prevalent diseases, especially those related to inflammation. …”
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Dog–Owner Relationship and Its Association with Social Cognition in French Bulldogs by Lara Peterca, Elena Gobbo, Manja Zupan Šemrov

“…As understanding of pointing gestures is influenced by human–animal interaction, we used the Monash Dog Owner Relationship Scale (MDORS) to assess various aspects of the dog–owner relationship, including dog–owner interaction, emotional closeness, and negative aspects of dog ownership and measured salivary oxytocin levels. …”
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Prioritizing implementation solutions for the urban family physician policy in Iran: a multi-criteria decision-making study by Lida Shams, Mohammadreza Mobinizadeh, Taha Nasiri, Fatemeh Mohammadi

“…Results Main themes were identified, including financing, management, human resources, structure, culture building, payment mechanism information systems, monitoring & control, performance of insurance organisations, and implementation. …”
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An interval type-2 fuzzy AHP approach for success factors of green supply chain management by Davod Andalib Ardakani, Mehrdad Kiani, Ali Saffari Darberazi, Fatemeh Zamzam, Elham Mofatehzadeh

“…As a result of these steps, a comprehensive model was developed, comprising 30 factors categorized into six dimensions: green suppliers, green technology and expertise, green human resources, green products, green organization and communications, and green regulations and support. …”
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NADPH Oxidase Signaling Pathway Mediates Mesenchymal Stem Cell-Induced Inhibition of Hepatic Stellate Cell Activation by Haowen Qiao, Yu Zhou, Xingping Qin, Jing Cheng, Yun He, Yugang Jiang

“…To study the effect of human bone marrow-derived mesenchymal stem cells (hBM-MSCs) on activated HSCs, we used HSCs and the coculture systems to evaluate the inhibition of activated HSCs from the aspects of the apoptosis of activated HSCs. …”
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Investigation of paradoxical structures in Hafez's Ghazals by Maedeh Shegheft, Yadollah Shokri, Mohammad Rezaei, Rasool Rasoolipour

“…However, the two semantic and hybrid types of paradox in Hafiz's poetry not only serve as an instrumental or literary industry but also structurally form the inferior space between the two human-divine talents of Hafiz's poetry subjects. …”
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Special criminal investigation (in absentia): problematic issues of a defence counsel's participation by M. М. Kolomoitsev

“…In view of this, and in the context of ensuring such fundamental principles of criminal proceedings as the right to defence, adversarial proceedings, observance of human rights and freedoms, access to justice, etc., the author emphasises the need to amend the current criminal procedure legislation to ensure that the defence counsel can appeal against the investigating judge's decision to conduct a special pre-trial investigation The problematic issues of defence counsel's participation are characterised, and the inadmissibility of his/her formal participation in criminal proceedings is emphasised. …”
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XAI-Enhanced Machine Learning for Obesity Risk Classification: A Stacking Approach With LIME Explanations by Mohammad Azad, Md Faraz Kabir Khan, Sameh Abd El-Ghany

“…Overall, our approach contributes to advancing personalized interventions and bridging the gap between model complexity and human understanding.…”
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Chemical Composition of Cymbopogon flexuosus and C. winterianus Essential Oils and Their Insecticidal Potential Against the Coffee Berry Borer Hypothenemus hampei by Melally Giddegowda Venkatesha, Rudramuni Kiran

“…However, using these two chemicals may pose pesticide resistance, bioaccumulation, and a threat to human health and the environment. This study evaluated the chemical compositions of essential oils from Cymbopogon flexuosus and C. winterianus and their insecticidal potential against H. hampei as an alternative to endosulfan and methyl bromide. …”
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A Modified Wagner Stem Design Increases the Primary Stability in Cementless Revision Hip Arthroplasty by Julius M. Boettcher, MSc, Kay Sellenschloh, Dipl. Ing, Gerd Huber, Dr., Benjamin Ondruschka, Professor, Michael M. Morlock, Professor

“…Methods: Twenty fresh-frozen human femurs were implanted with either the established or the additional spline design, dynamically loaded and tested in a load-to-failure configuration. …”
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RETRACTED: Analysis of the Legal Framework Governing Gas Flaring in Nigeria’s Upstream Petroleum Sector and the Need for Overhauling by Olusola Joshua Olujobi

“…There are concerns that if nothing is done to curtail this menace, humans and the environment will be imperiled due to its negative consequences. …”
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Short-Term Restriction of Physical and Social Activities Effects on Brain Structure and Connectivity by Yajuan Zhang, Lianghu Guo, Zhuoyang Gu, Qing Yang, Siyan Han, Han Zhang

“…Our findings offer insights into the effects of isolation on the human brain, potentially informing rehabilitation mechanisms and interventions for individuals in similar conditions.…”
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Phytochemicals and Biological Properties of Azorean <i>Camellia sinensis</i> Black Tea Samples from Different Zones of Tea Plantation by Lisete Sousa Paiva, Ana Paula Dias, Madalena Hintze Motta, José António Bettencourt Baptista

“…The objective of this study was to investigate the biological properties of Azorean <i>C. sinensis</i> black tea from five different zones of tea plantation in order to select specific areas to cultivate tea rich in targeted compounds beneficial to human health. The free radical scavenging activity (FRSA), ferric reducing antioxidant power (FRAP), ferrous ion chelating (FIC) activities, total phenolic content (TPC), total flavonoid content (TFC), and tannins were determined by colorimetric methods, and catechin and theaflavin contents were analyzed by high-pressure liquid chromatography. …”
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The Function of SUMOylation and Its Role in the Development of Cancer Cells under Stress Conditions: A Systematic Review by Qi Zhao, Ying Ma, Zugui Li, Kexin Zhang, Minying Zheng, Shiwu Zhang

“…Malignant tumors still pose serious threats to human health due to their high morbidity and mortality. …”
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The influence of sustainable fertilization on the parameter of soil biogenicity, weight of 1000 grains and the yield of different maize genotypes by Cvijanović Gorica, Bajagić Marija, Stepić Vesna, Marinković Jelena, Mamlić Zlatica, Đurić Nenad, Nićin Slobodan

“…Land is one of the most important resources for humanity, so it is very important to protect it from degradation. …”
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A Semi-Automated Usability Evaluation Framework for Interactive Image Segmentation Systems by Mario Amrehn, Stefan Steidl, Reinier Kortekaas, Maddalena Strumia, Markus Weingarten, Markus Kowarschik, Andreas Maier

“…Specifically, when a precise segmentation result is desired for a small amount of given data sets, semi-automatic methods exhibit a clear benefit for the user. The optimization of human computer interaction (HCI) is an essential part of interactive image segmentation. …”
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A new future for dog breeding by Helle Friis Proschowsky, Maja Louise Arendt, Brenda N Bonnett, Camilla S Bruun, Irena Czycholl, Merete Fredholm, Dan O’Neill, James A Serpell, Peter Sandøe

“…We argue that newly invented designer breeds and mixed breeds also have worrying health and behavioural problems, and that the predictability of purebred dogs with respect to body size, basic behaviours, known need for grooming, disorder profiles and other attributes may well offer some benefits for a satisfying human-dog relationship seen from both sides. The optimal future seems to lie in the middle ground, where the future organised dog world (i.e. kennel and breed clubs or their successor organisations) will need to re-open the breed registries, remove wording from breed standards that currently promotes extreme conformation, support selection against disease-predisposing genotypes and phenotypes and refocus dog showing and breeding to promote health and appropriate behaviour.…”
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Phytoremediation of Oil-Contaminated Soil by <i>Tagetes erecta</i> L. Combined with Biochar and Microbial Agent by Xin Fang, Pufan Zheng, Haomin Wang, Kefan Wang, Cong Shi, Fuchen Shi

“…Crude oil pollution of soil is an important issue that has serious effects on both the environment and human health. Phytoremediation is a promising approach to cleaning up oil-contaminated soil. …”
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