Lower vicine content reduces the reproductive yield performance in faba bean (Vicia faba L.) by Sadhan Debnath, Mayank Rai, Wricha Tyagi, Sujan Majumder, Ng. Tombisana Meetei

“…However, vicine-convicine remain as potential threats for “favism” in human beings. In this study, 189 diverse faba bean accessions have been evaluated for yield component traits and vicine content in seeds followed by a correlation study. …”
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The in vitro anticancer effects of FS48 from salivary glands of Xenopsylla cheopis on NCI-H460 cells via its blockage of voltage-gated K+ channels by Xiong Weichen, Fan Huizhen, Zeng Qingye, Deng Zhenhui, Li Guanhui, Lu Wancheng, Zhang Bei, Lai Shian, Chen Xin, Xu Xueqing

“…The present study aims to reveal the effects of FS48 on the Kv channels and the NCI-H460 human lung cancer cells through patch clamp, MTT, wound healing, transwell, gelatinase zymography, qRT-PCR and WB assays. …”
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Use of D-Squame^® as a Minimally Invasive Technique to Evaluate Skin Immune Response Biomarkers in Canine Atopic Dermatitis by Marion Mosca, Nadège Milhau, Mélanie Legain, Adrien Idée, Xavier Langon, Didier Pin

“…Tape stripping has been shown to be a reliable technique to study biomarkers in the stratum corneum (SC) in humans. The aim of this study was to assess the immune response and identify biomarkers in the SC of dogs with canine AD using D-squame^® as a minimally invasive technique. …”
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Exploratory analysis of a Novel RACK1 mutation and its potential role in epileptic seizures via Microglia activation by Sai Zhang, Zhaofei Dong, Jing Guo, Ze Li, Hong Wu, Linming Zhang, Fuli Min, Tao Zeng

“…Our findings reveal that the RACK1-p.L206P mutation significantly enhances proliferation, migration, phagocytic ability, and inflammatory activation in human microglia, which in turn affects neuronal excitability and synaptic function, culminating in typical seizure symptoms in the seizures. …”
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Analysing the effect of Quinalphos pesticide on fish health through molecular docking studies and their eradication by photocatalytic degradation using Fe/S/TiO2 nanocomposite by Anisha Russelraj, Sibmah Stalin, Kirupa Jino

“…Quinalphos is one of the most common organophosphorous pesticide especially used in agricultural fields bring about a great impact in environment thereby affecting the health of aquatic organisms and humans. Among the various type of method that has been implemented, photocatalytic reaction is considered as the most relevant technique for the removal of toxic organic contaminants. …”
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Methicillin-Resistant Staphylococcus aureus: Docking-Based Virtual Screening and Molecular Dynamics Simulations to Identify Potential Penicillin-Binding Protein 2a Inhibitors from... by Motahareh Masumi, Fatemeh Noormohammadi, Fatemeh Kianisaba, Fatemeh Nouri, Mohammad Taheri, Amir Taherkhani

“…This study suggests that kaempferol 3-rutinoside-7-sophoroside and rutin may be considered as drug candidates for therapeutic aims in several human infections associated with MRSA. Nevertheless, in vitro and in vivo confirmations are warranted.…”
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Vedolizumab for inflammatory bowel diseasesI by Igor L. Khalif, M. V. Shapina

“…The vedolizumab is anti-α4β7-integrin humanized class IgG1 antibodies which suppresses migration of leukocytes in intestinal tissue, interfering thereby with development of pathologic inflammation. …”
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Experimental opisthorchiasis: a study of blood cells, hematopoiesis and startle reflex in laboratory animals by D. F. Avgustinovich, I. A. Orlovskaya, L. B. Toporkova, G. B. Vishnivetskaya, A. V. Katokhin, M. N. Lvova, E. V. Kashina, N. P. Bondar, N. A. Feofanova, V. A. Mordvinov

“…One of the species of the family Opisthorchiidae, Opisthorchis felineus (O. felineus), causes severe disturbances in humans and animals, and so it is the subject of important research studies. …”
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Promising new drugs and therapeutic approaches for treatment of ovarian cancer—targeting the hallmarks of cancer by Julia Hillmann, Nicolai Maass, Dirk O. Bauerschlag, Inken Flörkemeier

“…Department of Health and Human Services, 2024)) for new drugs on the basis of their mechanisms of action and identified new target approaches. …”
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Knowledge, Attitude, and Practice Regarding High Salt Intake and Association With Hypertension Among Rural Women in Chandpur District of Bangladesh by Pradip Chandra, Aminul Islam, Shahara Robertson, Abu‐Al‐Rafe, Md. Abu Sayed, Afra Anjum Ahona, Mst. Nadira Parvin, Pradip Sen Gupta

“…ABSTRACT Background and Aims The human body requires a relatively little quantity of sodium to transmit nerve impulses, contract and relax muscles, and maintain appropriate water and mineral balance and which is typically added from diets. …”
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Chromosome 1 Sequence Analysis of C57BL/6J-Chr1KM Mouse Strain by Fuyi Xu, Tianzhu Chao, Yiyin Zhang, Shixian Hu, Yuxun Zhou, Hongyan Xu, Junhua Xiao, Kai Li

“…Further functional annotation identified 155 genes harboring potentially functional variants, among which 27 genes have been associated with human diseases. We then performed sequence similarity and Bayesian concordance analysis using the SNPs identified on Chr 1 and their counterparts in three subspecies, Mus musculus domesticus, M. m. musculus, and M. m. castaneus. …”
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Investigative genetic genealogy practices warranting policy attention: Results of a modified policy Delphi. by Christi J Guerrini, Louiza Kalokairinou, Jill O Robinson, Whitney Bash Brooks, Stephanie M Fullerton, Sara Huston, Jacklyn Dahlquist, Diana Madden, Norah Crossnohere, Nicola Campoamor, John F P Bridges, Amy L McGuire

“…A technique known as investigative genetic genealogy (IGG) was first introduced to criminal investigations in 2018, and it has since been used by U.S. law enforcement to help identify hundreds of criminal perpetrators and unidentified human remains. As expertise in IGG grows, policymakers have shown interest in regulating it. …”
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Prostanoid Receptor Subtypes and Its Endogenous Ligands with Processing Enzymes within Various Types of Inflammatory Joint Diseases by Mohammed A. Al-Madol, Mohammed Shaqura, Thilo John, Rudolf Likar, Reham Said Ebied, Magdi M. Salih, Sascha Treskatsch, Michael Schäfer, Shaaban A. Mousa

“…Our findings show a distinct expression profile of EP receptor subtypes and PGE2 as well as the corresponding processing enzymes in human synovium that modulate the inflammatory process in JT, OA, and RA patients.…”
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Frequency of Trypanosoma cruzi Infection in Synanthropic and Wild Rodents Captured in a Rural Community in Southeast of Mexico by Ivonne Hernández-Cortazar, Karla Cecilia Amaya Guardia, Marco Torres-Castro, Karla Acosta-Viana, Eugenia Guzmán-Marín, José Israel Chan-Pérez, Antonio Ortega-Pacheco, Roger I. Rodríguez-Vivas, Rodrigo Medina-Pinto, Matilde Jiménez-Coello

“…The active and chronic infection of T. cruzi in synanthropic or wild rodents of the rural community of southern Mexico evidences the natural infection in these reservoirs which contribute to maintaining the agent in the wild and domestic environments and can represent a risk of infection for the human population when the vector is present.…”
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Differential Susceptibility to Propofol and Ketamine in Primary Cultures of Young and Senesced Astrocytes by Liang Huang, Ferit Tuzer, Abigail Murtha, Michael Green, Claudio Torres, Henry Liu, Shadi Malaeb

“…Oxidative stimulus was applied to commercially available fetal cell lines of human astrocytes in vitro to induce morphological changes in cellular senescence. …”
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Copy Number Variation of UGT 2B Genes in Indian Families Using Whole Genome Scans by Avinash M. Veerappa, Prakash Padakannaya, Nallur B. Ramachandra

“…We investigated the presence of CNVs in UGT2B genes in 31 members from eight Indian families using Affymetrix Genome-Wide Human SNP Array 6.0 chip. Results. Our data revealed >50% of the study members carried CNVs in UGT2B genes, of which 76% showed deletion polymorphism. …”
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Vaginal Dysplasia and HIV: An African American and Caribbean American Cohort Study by Lunthita M. Duthely, Jose A. Carugno, Cayla Y. Suthumphong, Erica B. Feldman, JoNell E. Potter

“…In the US, vaginal infections are more prevalent among Caribbean women, and these infections contribute to higher rates of Human Papilloma Virus (HPV). Given the high rate of anogenital cancers in the Caribbean and the high rates of HPV among Caribbean women in the US, we sought to describe the occurrence of VaIN in a cohort of Black non-Hispanic WLWH. …”
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An Enhanced Vehicle-to-Vehicle Wireless Power Transfer System for Electric Vehicle Applications Using a Reconfigurable Coil Approach by Venkatesan Ramakrishnan, Dominic Savio A, Mohammad Shorfuzzaman, Waleed Mohammed Abdelfattah

“…However, the conventional plug-in approach limits safety and human intervention aspects. Recent advancements in wireless power transfer (WPT) offer both convenience and reliable power exchange, making them the most suitable approach for V2V technology. …”
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Role of CD117 and mast cells in periodontal diseases: Histological and immunohistochemical study by Fatin L. Khaphi, Hanaa Ali Hussein, Oula Fouad Hameed, Huda Jassem Jebur, Zahra Kadhum Saeed

“…Thus, an increase in mast cells in human periodontal diseases suggests that these cells are crucial for developing chronic periodontitis. [ J Adv Biotechnol Exp Ther 2025; 8(1.000): 182-191]…”
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5-Fluorouracil-β-Cyclodextrin conjugates:Linker strategies to enhance the anticancer efficacy and reduce the side effects by Liangliang Hu, Ting Meng, Davies Marabada, Zhichao Jin, Qing Huang, Shijie Wei, Zhizhong Wang

“…The cytotoxicity assays on human colon cancer cell lines HT-29 and normal colon epithelial cells NCM-460 demonstrated that the IC50 value of the 5-FUBA-β-CD conjugate for the HT-29 cells was 38.72 ± 0.13 μM, indicating superior antitumor activity compared to both 5-FUBA-β-CD and 5-FU. …”
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