A Pooling Genome-Wide Association Study Identifies Susceptibility Loci and Signaling Pathways of Immune Thrombocytopenia in Chinese Han Population by Yanmei Xu, Jing Li, Wentao Yang, Xiaoli Tang, Bo Huang, Jing Liu, Jin Lin, Jing Zhang, Weiming Yang, Shuqi Li, Fan Sun, Libin Deng, Xiaozhong Wang

“…To extend the genetic evidence and to identify novel candidates of ITP, we performed a pooling genome-wide association study (GWAS) by IlluminaHumanOmniZhongHua-8 combining pathway analysis in 200 ITP cases and 200 controls from Chinese Han population (CHP). …”
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Conceptual basis of international jurisdiction by N. Yu. Rubanenko

“…These concepts reflect the goal of international criminal justice, which is the inevitability of punishment for serious violations of international law, since their commission threatens the security of all humanity.…”
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Beamline and Flight Comparisons of the ARMAS Flight Module With the Tissue Equivalent Proportional Counter for Improving Atmospheric Radiation Monitoring Accuracy by Brad “Buddy” Gersey, W. Kent Tobiska, William Atwell, Dave Bouwer, Leonid Didkovsky, Kevin Judge, Seth Wieman, Richard Wilkins

“…This work provides a method for significantly improving the accuracy of radiation measurements relevant to human tissue safety using a silicon detector that is easy to deploy and can report data in real time.…”
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Doctoral Education as an Institutional Resource for Training Research and Higher Education Personnel (Article 1) by B. I. Bednyi, A. A. Mironos, N. V. Rybakov

“…The authors note the insufficient information support for the programs aiming to develop doctoral education in Russia, as well as the lack of empirical data necessary to assess the effectiveness of Russian doctoral education in the reproduction of human resources for the research and education sector. …”
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Glutathione Peroxidase-1 Suppresses the Unfolded Protein Response upon Cigarette Smoke Exposure by Patrick Geraghty, Nathalie Baumlin, Matthias A. Salathe, Robert F. Foronjy, Jeanine M. D’Armiento

“…Expression of ER stress markers was investigated in fully differentiated normal human bronchial epithelial (NHBE) cells isolated from nonsmoking, smoking, and COPD donors and redifferentiated at the air liquid interface. …”
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18F-Fluorothymidine-Pet Imaging of Glioblastoma Multiforme: Effects of Radiation Therapy on Radiotracer Uptake and Molecular Biomarker Patterns by Sanjay Chandrasekaran, Andrew Hollander, Xiangsheng Xu, Joseph L. Benci, James J. Davis, Jay F. Dorsey, Gary Kao

“…Nude/athymic mice with human GBM orthografts were assessed by microPET imaging with 18F-FDG and 18F-FLT. …”
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Replication timing in Drosophila and its peculiarities in polytene chromosomes by T. D. Kolesnikova, O. V. Antonenko, I. V. Makunin

“…Comparison of genomic replication profiles revealed a significant similarity between Drosophila and other well-studi ed eukaryotic species, such as human. Early replication is often confined to intensely transcribed gene-dense regions characterized by multiple replication initiation sites. …”
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Design of an equilibrative nucleoside transporter subtype 1 inhibitor for pain relief by Nicholas J. Wright, Yutaka Matsuoka, Hyeri Park, Wei He, Caroline G. Webster, Kenta Furutani, Justin G. Fedor, Aidan McGinnis, Yiquan Zhao, Ouyang Chen, Sangsu Bang, Ping Fan, Ivan Spasojevic, Jiyong Hong, Ru-Rong Ji, Seok-Yong Lee

“…ENT1 is colocalized with A1R in mouse and human dorsal root ganglia, and the analgesic effect of our inhibitor is linked to A1R. …”
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Risk factors for inflammatory bowel disease: an umbrella review by Tingping Wu, Honghui Cheng, Jiamei Zhuang, Xianhua Liu, Zichen Ouyang, Rui Qian

“…The top ten risk factors were human cytomegalovirus (HCMV) infection, IBD family history, periodontal disease, poliomyelitis, campylobacter species infection, hidradenitis suppurativa, psoriasis, use of proton pump inhibitors, chronic obstructive pulmonary disease, and western dietary pattern.DiscussionIn conclusion, this umbrella review extracted 62 risk factors and 30 protective factors, most of which were related to underlying diseases, personal lifestyle and environmental factors. …”
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Wildfire Susceptibility Mapping using NBR Index and Frequency Ratio Model by Farzad Bolouk Heidari, Ramin Arfania

“…In this study, a fire hazard map for the Andika region of Iran was constructed by examining the correlation of past fires with the criteria of topography, meteorology, land cover, and human factors. The locations of eight-year fire points from 2013 to 2020 of Nova satellite sensor VIIRS were received and the fire map of each was constructed using the NBR (Normalized Burn Ratio). …”
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Cell-marking techniques for cell lineage tracing by A. M. Yunusova, N. R. Battulin

“…A zygote, the only totipotent cell of the developing organism, transforms into a complex, multicellular entity with billions (for humans) of highly specialized cells and tissues. Most adult tissues are maintained by a combination of highly dynamic processes of senescence, apoptosis and rejuvenation with new cells constantly arising from dispersed depots of stem cells. …”
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Magnetic Nanoparticle Based Nonviral MicroRNA Delivery into Freshly Isolated CD105+ hMSCs by Anna Schade, Paula Müller, Evgenya Delyagina, Natalia Voronina, Anna Skorska, Cornelia Lux, Gustav Steinhoff, Robert David

“…Genetic modifications of bone marrow derived human mesenchymal stem cells (hMSCs) using microRNAs (miRs) may be used to improve their therapeutic potential and enable innovative strategies in tissue regeneration. …”
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Portable wide-field digital imaging for screening of neonatal visual impairment causes in Rio de Janeiro, Brazil: a budget impact analysis by Andrea Zin, Lorena M Haefeli, Luiza M Neves, Ana Carolina Carioca Costa, Zilton Farias Meira de Vasconcelos, Marcia Pinto

“…Further health economic evaluations should be performed to verify the affordability of the implementation of this screening strategy in the Brazilian scenario, taking into account scarce human resources.…”
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Altered brain dynamics of facial emotion processing in schizophrenia: a combined EEG/fMRI study by Philippa Hüpen, Barbara Schulte Holthausen, Christina Regenbogen, Thilo Kellermann, Han-Gue Jo, Ute Habel

“…Abstract Facial stimuli are relevant social cues for humans and essential signals for adequate social interaction. …”
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A Retrospective Aspect at the Evaluations of a University Clinical Research Ethics Committee: The Unseen Reasons Behind the Disapproved Studies by Canan Uluoğlu, Ali Kağan Coşkun, Utku Aykan

“…Objective: The process of conducting medical research on human subjects is secured by a number of regulations from its planning phase through its publication as an original article. …”
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Oral Fusobacterium nucleatum resists the acidic pH of the stomach due to membrane erucic acid synthesized via enoyl-CoA hydratase-related protein FnFabM by Xiaocong Li, Shipeng Zhang, Huafang Sheng, Yan Zhen, Buling Wu, Zhuang Li, Dingqiang Chen, Hongwei Zhou

“…These results provide novel insights into the mechanisms underlying the oral bacteria survival in acidic environments and their potential to colonize the intestine; thus, shedding light on the oral-gut axis and its implications on human health.…”
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Selenium’s Role in Plant Secondary Metabolism: Regulation and Mechanistic Insights by Yan Zhou, Kaiqin Nie, Lulu Geng, Yixin Wang, Linling Li, Hua Cheng

“…Selenium (Se) is an indispensable trace element for humans and other animals. Various studies have demonstrated the beneficial effects of Se on plants, including the promotion of growth, accumulation of secondary metabolites, and enhancement of antioxidant capacity, thereby improving plant stress resistance. …”
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Improving Accuracy of Malaria Diagnosis in Underserved Rural and Remote Endemic Areas of Sub-Saharan Africa: A Call to Develop Multiplexing Rapid Diagnostic Tests by Rasheed O. Makanjuola, Andrew W. Taylor-Robinson

“…A primary drawback is that the vast majority of commercially available RDTs detect only one of the five species of human malaria, P. falciparum. While this is the main cause of infection in many areas, it excludes the possibility of infection with another parasite (P. vivax, P. ovale, P. malariae, and P. knowlesi) or of mixed infections containing different species. …”
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L’utilisation de la cartographie des valeurs sociales et culturelles comme outil dans l’adaptation aux changements climatiques : exemple d’un projet pilote à l’Île-du-Prince-Édouar... by Irene Novaczek, Josh MacFadyen, Darren Bardati

“…This method brings various knowledge fields together and creates the potential to compare and juxtapose normally invisible human relationships with scientific data on the predicted impacts of climate change. …”
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Assessing self-determined motivation for drinking alcohol via the Comprehensive Relative Autonomy Index for Drinking by Jimikaye Beck Courtney, Jimikaye Beck Courtney, Michael A. Russell, David E. Conroy, David E. Conroy

“…IntroductionSelf-Determination Theory (SDT) examines human motivation in multiple domains; however, the only existing measure assessing SDT-informed behavioral regulations for drinking focuses on responsible drinker behaviors, rather than drinking per se, which is important given the alignment between SDT and harm reduction approaches to alcohol use. …”
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