Pharmacokinetic Evaluation of [C]CEP-32496 in Nude Mice Bearing BRAF Mutation-Induced Melanomas by Cuiping Jiang MMSc, Lin Xie MD, PhD, Yiding Zhang BSc, Masayuki Fujinaga PhD, Wakana Mori MSc, Yusuke Kurihara PhD, Tomoteru Yamasaki PhD, Feng Wang MD, PhD, Ming-Rong Zhang MD, PhD

“…CEP-32496, also known as RXDX-105 or Agerafenib, is a new orally active inhibitor for the mutated v-raf murine sarcoma viral oncogene homolog B1 (BRAF V600E ), which has attracted considerable attention in clinical trials for the treatment of human cancers. Here, we used carbon-11-labeled CEP-32496 ([ 11 C]CEP-32496) as a positron emission tomography (PET) radiotracer to evaluate its pharmacokinetic properties and explore its potential for in vivo imaging. …”
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11 Key Strategies in Using AI Chat GPT to Develop HOTS-Based Entrepreneurship Questionnaires by Almaida Vebibina, Rusijono Rusijono, Andi Mariono, Ahsan Muafa, Dydik Kurniawan, Ragil Sugeng Dewantoro, Dian Noer Asyari, Sussi Widiastuti, Jarot Suseno

“…This finding can be utilized by teachers as the latest generative model to increase the bank of diverse multiple-choice questions without replacing human expertise. …”
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Modern approaches to the therapy of computer visual syndrome by Zakharova M.A., Zh.G. Oganezova

“…However, doctors noted the growth of  pathological changes in the organs and systems of the human body, induced by work at the computer. It is computer syndrome, which includes changes in the skeleto-muscular system, carpal tunnel syndrome and computer vision syndrome (CVS). …”
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Double-blind, randomised, placebo-controlled trial to evaluate the effectiveness of late gestation oral melatonin supplementation in reducing induction of labour rates in nulliparo... by Miranda Davies-Tuck, Emily Callander, Mary Sharp, Scott W White, Dorota A Doherty, Jane Warland, Zoe Bradfield, Lesley Kuliukas, Monique Rose, Amber Pettitt, Kylie Ekin, JA Keelan

“…All data will be analysed by intention to treat.Ethics and dissemination The study is approved by the Western Australia Health Central Human Research Ethics Committee (RGS0000006283). …”
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Evaluation of a PCR-based lateral flow device for detecting Aspergillus and Candida species from clinical specimens by Ariff Khalid, Jacinta Santhanam, Mohd Nizam Tzar, Ang-Lim Chua, Sharifah Fadilah Abdul Wahid, Wan Rahiza Wan Mat, Raha Abd Rahman, Petrick Periyasamy

“…Results: The limits of detection of the multiplexed PCR were in the range of 5–100 CFU/mL for fungal spiked human blood samples. Against the clinical diagnosis of proven or probable IFDs, the findings show that the LFA system produced a high specificity of 99.4 % while the sensitivity was only moderate at 47.8 % due to the difficulty of extracting fungal DNA from blood samples. …”
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The combination of rAAV pseudo-lipid nanoparticle and triamcinolone acetonide enables multi-administration to liver by Chunmei Gan, Mi Leng, Yu Liu, Zhaoyue Zheng, Siwu He, Wen Qiao, Lin Xiao, Yao Xiao, Jingya Ye, Lixing Zhou, Jiao Zhou, Boduan Xiao, Wenxin Zhao, Jiamei Yang, Aohan Wu, Huiyuan Zhang, Hongbo Hu, Xiaobo Cen, Zhiyong Qian, Haohao Dong, C. Alexander Valencia, Lunzhi Dai, Hoi Yee Chow, Lei Zhang, Biao Dong

“…We showed successful but low efficient triple trafficking by LNP-rAAV2 carrying EGFP, human factor IX (hFIX), and luciferase (luc), due to its encapsulation characteristic. …”
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Biotechnological bases of the development of cloned pig embryos by A. V. Lopukhov, G. N. Singina, N. A. Zinovieva

“…Somatic cell nuclear transfer in pigs has a wide range of potential applications in various fields of human scientific and economic activities. However, the efficiency of producing cloned embryos in swine is still lower than that of other livestock species, in particular horses and cattle. …”
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CircWDR78 inhibits the development of colorectal cancer by regulating the miR-653-3p/RGS4 axis by Chu Hao, Yunju Pu, Jiunian Li, Zhi Zhong, Zhaohui Huang, Xue Wang

“…Abstract Background Colorectal cancer (CRC) stands as one of the most serious threats to human health, with its mortality rate increase during the past years. …”
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Factors Influencing Hospitalization Expenses Among Patients with Lung Cancer in China by Tingting Xu, Nan Jiang, He Chen, Jun Feng, Qiming Feng, Xianjing Qin, Jinmin Zhao, Hongda Gao

“…Lung cancer poses a serious threat to human health. The direct medical expense and indirect social economic burden caused by high morbidity and poor prognosis rate of malignant tumor are higher than other diseases around the world, especially in some developing countries such as China. …”
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Severe central nervous system injury in 9 children with COVID-19 by Peipei Zhang, Meiyun Xin, Yingge Bai, Xueyun Ren, Na Li

“…One child had lost his vital signs when admitted to hospital, and the remaining eight received hormonal shock, human immunoglobulin transfusion, antinainfection, cranial pressure reduction, and tracheal intubation, among others, during hospitalization. …”
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Clerodendrum volubile Ethanol Leaf Extract: A Potential Antidote to Doxorubicin-Induced Cardiotoxicity in Rats by Olufunke Esan Olorundare, Adejuwon Adewale Adeneye, Akinyele Olubiyi Akinsola, Daniel Ayodele Sanni, Mamoru Koketsu, Hasan Mukhtar

“…Overall, CVE may play a significant therapeutic role in the management of DOX-induced cardiotoxicity in humans.…”
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Super Typhoons Simulation: A Comparison of WRF and Empirical Parameterized Models for High Wind Speeds by Haihua Fu, Yan Wang, Yanshuang Xie, Chenghan Luo, Shaoping Shang, Zhigang He, Guomei Wei

“…As extreme forms of tropical cyclones (TCs), typhoons pose significant threats to both human society and the natural environment. To better understand and predict their behavior, scientists have relied on numerical simulations. …”
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Assessing dynamic coastal vulnerability to climate hazards: A geospatial approach in Kakinada District, Andhra Pradesh, India by Ganni Satya Venkata Sai Aditya Bharadwaz, Indrajit Pal, Chitrini Mozumder, Mokbul Morshed Ahmad

“…Overall, 598.32 km2 out of 1647.68 km2 exhibited moderate to very high vulnerability, highlighting the threats from coastal erosion and human encroachment. Significant coastal erosion was identified, with shoreline changes ranging from 604.35 to 1016.25 m over the past two decades, particularly in the southern district. …”
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A study looking at how missed somatropin injections affect growth in children with growth hormone deficiency: a plain language summary of publication by Jane Loftus, Bradley S. Miller, Craig S. Parzynski, Jose Alvir, Yong Chen, Priti Jhingran, Anu Gupta, Mitch DeKoven, Victoria Divino, Jenny Tse, Jing He, Michael Wajnrajch

“…Somatropin - a type of human growth hormone that can be made in a laboratory and used to treat growth hormone deficiency.…”
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Genome sequence and evaluation of safety and probiotic potential of Lacticaseibacillus paracasei LC86 and Lacticaseibacillus casei LC89 by Ting Chen, Yunjiao Zhao, Yunjiao Zhao, Yixuan Fan, Yao Dong, Zhonghui Gai

“…The oral LD50 for both LC86 and LC89 in mice was >2 × 1010 CFU/kg.ConclusionThe experimental results above demonstrated the probiotic characteristics and safety of LC86 and LC89, indicating their potential as candidates for probiotics for human and animal applications.…”
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Application of photodynamic therapy with 5-aminolevulinic acid and fractional CO2 laser for the management of recalcitrant plantar warts by Jiaoquan Chen, Xinyi Xie, Yingxue Liu, Fengyi Chen, Yeqing Gong, Bihua Liang, Yiling Wu, Shiqi He, Yueming Li, Huilan Zhu, Shaoyin Ma

“…Significance: Plantar warts, benign lesions on the soles of the feet, are caused by the human papillomavirus (HPV) infecting keratinocytes. …”
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Carbon Monoxide and Particulate Matter Concentrations inside the Road Tunnels of Guanajuato City, Mexico by Adrián Zamorategui-Molina, Norma L. Gutiérrez-Ortega, Juan Carlos Baltazar-Vera, Julio Del Ángel-Soto, David Tirado-Torres

“…However, exposure to elevated levels of carbon monoxide (CO) and particulate matter (PM), including PM2.5 and PM10 consisting of vehicle-emitted particles and resuspended dust, poses risks to human health. Hence, we monitored the CO, PM2.5, and PM10 concentrations; wind speed; and number of vehicles in three popular tunnels among pedestrians, all of which exhibited relatively high levels of pollution, in Guanajuato. …”
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Validating a novel measure for assessing patient openness and concerns about using artificial intelligence in healthcare by Bryan A. Sisk, Alison L. Antes, Sunny C. Lin, Paige Nong, James M. DuBois

“…Concern subscales assessed privacy, social justice, quality, human element of care, cost, shared decision‐making, and convenience. …”
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A broad spectrum Shigella vaccine based on VirG53 – 353 multiepitope region produced in a cell-free system by Girmay Desalegn, Charlotte Abrahamson, K. Ross Turbyfill, Lucy Pill-Pepe, Leslie Bautista, Chitradevi S. Tamilselvi, Dylan Dunn, Neeraj Kapoor, Barbara Sullinger, Matheo Herrera, Edwin V. Oaks, Jeff Fairman, Marcela F. Pasetti

“…The target antigen refinement and production improvement described here will facilitate the first-in-human studies.…”
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Design of a new class of broad-spectrum therapeutics targeted to drug-resistant bacteria by Amrutha Surendran, Agnes Turnbull, Allen Flockhart, Fern Findlay-Greene, Martyna Nowosielska, Donald Morrison, David J. Mincher, Samantha Donnellan

“…Key policy highlights Development of a novel class of antimicrobial compounds Drug screen against a WHO ‘high’ priority drug-resistant pathogen that poses the greatest threat to human health (methicillin-resistant Staphylococcus aureus) Drug screen against a surrogate for Mycobacterium tuberculosis, one of the leading causes of mortality worldwide.…”
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