The ABC transporter A7 modulates neuroinflammation via NLRP3 inflammasome in Alzheimer’s disease mice by Irene Santos-García, Pablo Bascuñana, Mirjam Brackhan, María Villa, Ivan Eiriz, Thomas Brüning, Jens Pahnke

“…Methods We developed the first humanized, Cre-inducible ABCA7 flx knock-in mouse model, crossbred it with the APPPS1-21 β-amyloidosis model, and generated constitutive ABCA7ko and microglia Cx3cr1-specific conditional ABCA7ko AD mice. …”
Get full text

Autophagy activation in response to cigarette smoke: Exploring the disparity in laryngeal cancer incidence and outcomes between sexes in South Korea by Min Ji Kim, Jisu Hong, Hyo Won Chang, Yun-Hee Lee, Jun-Pyo Myong, Ah Ra Jung, Yoon Se Lee, Minsu Kwon

“…The changes in autophagy-related markers were analyzed after exposure to human vocal fold fibroblast (hVFF) and cigarette smoke extract (CSE). …”
Get full text

Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes by Yong Li, Steven A Rosenberg, Paul F Robbins, Zhiya Yu, Maria Parkhurst, Billel Gasmi, Nikolaos Zacharakis, Todd D Prickett, Jared J Gartner, Sri Krishna, Stephanie L Goff, Satyajit Ray, Frank J Lowery, Sivasish Sindiri, Alakesh Bera, Noam Levin, Sanghyun P Kim, Charles A Marquardt, Nolan R Vale, Lior Levy, Tiffany Benzine, Robert V Masi, Rafiqul Islam

“…Given their prevalence, mutant p53 or RAS were studied as models of human neoantigens. An in vitro stimulation method, termed “NeoExpand”, was developed to provide neoantigen-specific stimulation to TILs. 25 consecutive patient TILs from tumors harboring p53 or RAS mutations were subjected to NeoExpand.Results We show that neoantigenic stimulation achieved selective expansion of neoantigen-reactive TILs and broadened the neoantigen-reactive CD4+ and CD8+ TIL clonal repertoire. …”
Get full text

CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses by Alice Bergamini, Barbara Camisa, Attilio Bondanza, Fabio Ciceri, Chiara Bonini, Monica Casucci, Beatrice Greco, Camilla Bove, Silvia Arcangeli, Laura Falcone, Rita El Khoury, Anna De Lucia

“…To this aim, we took advantage of immunodeficient mice reconstituted with a human immune system (HuSGM3) and engrafted with the B-cell acute lymphoblastic leukemia cell line NALM-6, a model that allows to thoroughly study efficacy and toxicity profiles of CD19 CAR-T cell products.Results CD4 CAR-T cells showed superior proliferation and activation potential, which translated into stronger stimulation of myeloid cells, the main triggers of adverse events. …”
Get full text

Bioelectric stimulation outperforms brain derived neurotrophic factor in promoting neuronal maturation by María del Pilar Diego-Santiago, María Ujué González, Esther María Zamora Sánchez, Nuria Cortes-Carrillo, Carlos Dotti, Francesc Xavier Guix, Sahba Mobini

“…In this study, we demonstrate that ES outperforms BDNF in promoting neuronal maturation in human neuroblastoma SH-SY5Y. Additionally, we address the question regarding which ES parameters regulate biological responses. …”
Get full text

Association of self-reported dental caries with sex, lifestyle, and problematic Internet use among elementary school children in Japan by Masaaki Yamada, Michikazu Sekine, Takashi Tatsuse, Yukiko Yanai

Get full text

First detection of Culex tritaeniorhynchus in Western Australia using molecular diagnostics and morphological identification by Kimberly L. Evasco, Craig Brockway, Tamara Falkingham, Margaret Hall, Nerida G. Wilson, Abbey Potter

“…The findings are significant given the detection of the species coincides with the first significant outbreak of JEV activity on mainland Australia involving an estimated 45 human cases of Japanese encephalitis, 80 impacted commercial piggeries and widespread feral pig activity. …”
Get full text

Correlates of physical activity behaviour among nursing professionals: A systematic search and literature review by Amanda H Wilkerson, Hunter O Thomas, Vinayak K Nahar

Get full text

Klebsiella pneumoniae employs a type VI secretion system to overcome microbiota-mediated colonization resistance by Andrew S. Bray, Christopher A. Broberg, Andrew W. Hudson, Weisheng Wu, Ravinder K. Nagpal, Maidul Islam, Juan D. Valencia-Bacca, Fawaz Shahid, Giovanna E. Hernandez, Noah A. Nutter, Kimberly A. Walker, Emma F. Bennett, Taylor M. Young, Andrew J. Barnes, David A. Ornelles, Virginia L. Miller, M. Ammar Zafar

Get full text

Enhancing detection of STEC in the meat industry: insights into virulence of priority STEC by Mai-Lan Tran, Sabine Delannoy, Patrick Fach

“…Detection of Shiga toxin-producing Escherichia coli (STEC) presenting high risk of human infections is challenging. In France, the latest Anses opinion categorized STEC in four groups based on their association with severe forms of clinical infection. …”
Get full text

Bone Density, Geometry, and Mass by Peripheral Quantitative Computed Tomography and Bone Turnover Markers in Children with Diabetes Mellitus Type 1 by Maciej Jaworski, Elżbieta Wierzbicka, Edyta Czekuć-Kryśkiewicz, Paweł Płudowski, Maria Kobylińska, Mieczysaw Szalecki

Get full text

Clinical phenotype and trio whole exome sequencing data from a patient with glycogen storage disease IV in Indonesia(NCBI) by Ivan William Harsono, Yulia Ariani, Beben Benyamin, Fadilah Fadilah, Dwi Ari Pujianto, Cut Nurul Hafifah, Titis Prawitasari

Get full text

Attention-enhanced optimized deep ensemble network for effective facial emotion recognition by Taimoor Khan, Muhammad Yasir, Chang Choi

“…Facial emotion recognition (FER) is rapidly advancing, with significant applications in healthcare, human-computer interactions, and biometric security, driven by recent advances in artificial intelligence (AI), computer vision, and deep learning. …”
Get full text

Quality of Life Philosophy III. Towards a New Biology: Understanding the Biological Connection between Quality of Life, Disease, and Healing by Soren Ventegodt, Niels Jørgen Andersen, Joav Merrick

“…The source of the qualities (the qualia) characterizing the human being as a whole — like joy, love, motivation, consciousness, free will, wisdom, intuitive competence — is still practically unknown and scientifically unexplained, more than 50 years after science has turned itself towards these fundamental problems. …”
Get full text

Assessment of Water Quality and Heavy Metal Contamination in River Water and Fish Species from the Bangshi River, Tangail, Bangladesh by Mausumi Rehnuma, Jannatul Firdous Jui, Jannatul Hasna, Umme Habiba, Anamul Haque

“…These findings highlight potential risks to human health from consuming water and fish from the Bangshi River, underscoring the urgent need for improved pollution control strategies. …”
Get full text

Research Progress and Trends in Exercise Interventions for Mild Cognitive Impairment: A Bibliometric Visualization Analysis Using CiteSpace by Han Q, Kim SM

“…Qifeng Han,1 Sung Min Kim1– 4 1Department of Physical Education, Hanyang University, Seoul, Republic of Korea; 2Department of Sport Science, Hanyang University, Seoul, Republic of Korea; 3BK21 FOUR Human-Tech Convergence Program, Hanyang University, Seoul, Republic of Korea; 4Center for Artificial Intelligence Muscle, Hanyang University, Seoul, Republic of KoreaCorrespondence: Sung Min Kim, Department of Sport Science, Hanyang University, 222, Wangsimni-ro, Seongdong-gu, Seoul, Republic of Korea, Email minarthur@hanyang.ac.krPurpose: With the increasing global aging population, exercise interventions for mild cognitive impairment (MCI) have gained significant research attention. …”
Get full text

Second Trimester Abortion: A Dilation and Evacuation Simulation for Gynecologic Surgery and Obstetrics Residents by Kiley Hunkler, David Boedeker, Elizabeth Gill, Katelyn Simpkins, Katerina Shvartsman, Jill Brown, Sara Drayer

Get full text

Dephrasal adjectives in Polish – A case of syntax-inside-morphology by Joanna Kolbusz-Buda

Get full text

Molecular-Based Identification of Actinomycetes Species That Synthesize Antibacterial Silver Nanoparticles by Abebe Bizuye, Lashitew Gedamu, Christine Bii, Erastus Gatebe, Naomi Maina

“…Infectious diseases caused by antibiotic-resistant bacteria lead to a considerable increase in human morbidity and mortality globally. This requires to search potential actinomycete isolates from undiscovered habitats as a source of effective bioactive metabolites and to synthesis metabolite-mediated antibacterial silver nanoparticles (AgNPs). …”
Get full text

A prospective study on association between comprehensive lifestyle scores and cognitive function changes in community-dwelling older adults in Tianjin city by Muya ZHANG, Xian CAI, Liping ZU, Huichao ZHAO, Tianyu WANG, Chenyu LI, Jing YUAN, Fei MA

Get full text