Ruxolitinib synergizes with regulatory T cells to improve inflammation but has no added benefits in decreasing albuminuria in SLE by Mi-Ae Lyu, Ximing Tang, Maria Gabriela Raso, Meixian Huang, Ke Zeng, Tara Sadeghi, Christopher R. Flowers, Simrit Parmar

“…The addition of ruxolitinib increases UCB-Treg cell persistence in peripheral blood in vivo and decreases the soluble form of human inflammatory cytokines including IFN-γ, TNF-α, and sCD40L in plasma along with improvement of skin lesions in SLE xenografts. …”
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Predictive factors for axillary pathological complete response to neoadjuvant therapy in elderly breast cancer patients by Yuying Wang, Rui Wang, Di Lu, Yaling Zeng, Xihui Tu, Shiwei Liu, Purong Zhang

“…The univariate analysis results showed that the initial clinical lymph nodes negative(cN0) stage, Human Epidermal Growth Factor Receptor 2(HER2) positivity and breast pathological complete response(bpCR) were significantly correlated with high apCR rates(all P < 0.05). …”
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Astrocyte-Derived Interleukin 11 Modulates Astrocyte–Microglia Crosstalk via Nuclear Factor-κB Signaling Pathway in Sepsis-Associated Encephalopathy by Dandan Zhu, Peng Wang, Xiyue Chen, Kaituo Wang, Yunsong Wu, Min Zhang, Jianhua Qin

“…In this study, we aim to investigate the molecular basis of the astrocyte–microglia crosstalk underlying SAE pathogenesis and also to explore the new therapeutic strategies targeting this crosstalk in this devastating disease. We established a human astrocyte/microglia coculture system on a microfluidic device, which allows real-time and high-resolution recording of glial responses to inflammatory stimuli. …”
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Synthesis and Evaluation of Cytotoxic Activity of RuCp(II) Complexes Bearing (Iso)nicotinic Acid Based Ligands by Bárbara Marques, Diogo M. Engrácia, João Franco Machado, Jaime A. S. Coelho, Filipa Mendes, Tânia S. Morais

“…The cytotoxicity of the complexes was evaluated in vitro in several human cancer cell lines, namely melanoma (A375), alveolar adenocarcinoma (A549), epidermoid carcinoma (A431), and breast cancer (MDA-MB 231). …”
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Dynamics and regulatory roles of RNA m6A methylation in unbalanced genomes by Shuai Zhang, Ruixue Wang, Kun Luo, Shipeng Gu, Xinyu Liu, Junhan Wang, Ludan Zhang, Lin Sun

“…Aberrant expression of m6A components appears in a variety of human diseases. RNA m6A modification in Drosophila has proven to be involved in sex determination regulated by Sxl and may affect X chromosome expression through the MSL complex. …”
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Characterization and Removal of Condensable Particulate Matter in Flue Gas Studied with Cold Electrode Electrostatic Precipitator by Wenting Liu, Bowen Zhao, Xin Wang, Jianyi Lu

“…This was further evidence of the environmental and human hazards of CPM. The removal of CPM is highly efficient with multi-field synergistic CE-ESP that combines temperature, electric, and concentration fields. …”
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Computer analysis of co-localization of transcription factor binding sites in genome by ChIP-seq data by A. I. Dergilev, A. M. Spitsina, I. V. Chadaeva, A. V. Svichkarev, F. M. Naumenko, E. V. Kulakova, E. R. Galieva, E. E. Vityaev, M. Chen, Y. L. Orlov

“…The computer program of the statistical data processing of gene location and chromatin domains that analyzes experimental data of site localization obtained by ChIP-seq in the mouse genome and the human genome has been developed. The presence of preferences at position of transcription factor binding sites of various types has been revealed, the distances between the nearest groups of TF binding sites Oct4, Nanog, Sox2 and TF binding sites n-Myc and c-Myc have been calculated using this program. …”
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AcfA Regulates the Virulence and Cell Envelope Stress Response of <i>Vibrio parahaemolyticus</i> by Huan Liu, Huayu Lei, Juanjuan Cao, Zhaobang Xie, Yile Shi, Yanni Zhao

“…<i>Vibrio parahaemolyticus</i> is a ubiquitous inhabitant of estuarine and marine environments that causes vibriosis in aquatic animals and food poisoning in humans. Accessory colonizing factor (ACF) is employed by <i>Vibrio</i> to assist in the colonization and invasion of host cells leading to subsequent illnesses. …”
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Sources of PM2.5 Oxidative Potential during Haze and Non-haze Seasons in Chiang Mai, Thailand by Pitakchon Ponsawansong, Tippawan Prapamontol, Kittipan Rerkasem, Somporn Chantara, Kraichat Tantrakarnapa, Sawaeng Kawichai, Guoxing Li, Cao Fang, Xiaochuan Pan, Yanlin Zhang

“…These results suggest that during haze episodes, higher levels of PM2.5 and its chemical compositions play a crucial role on OP, particularly DTTv activity, which may induce oxidative stress in human body.…”
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Pharmacological Preconditioning Improves the Viability and Proangiogenic Paracrine Function of Hydrogel-Encapsulated Mesenchymal Stromal Cells by Francesco K. Touani, Melanie Borie, Feryel Azzi, Dominique Trudel, Nicolas Noiseux, Shant Der Sarkissian, Sophie Lerouge

“…Bone marrow MSCs from rat (rMSC) and human (hMSC) origin were preconditioned for 1 hour with celastrol 1 μM or vehicle (DMSO 0.1% v/v), then encapsulated within a chitosan-based thermosensitive hydrogel. …”
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Derivation and Verification of the Relationship between Ablation Index and Baseline Impedance by Zheng Cai, Sainan Li, Qi Zhang, Chenyuan Wang, Zhen Jin, Ming Fu, Shuai Zhang, Ming Liang, Zulu Wang, Yaling Han

“…Under different baseline impedances and corresponding powers, the swine hearts were ablated for 30 s in simulated human circumstances. The baseline impedances, the lesion dimensions, and AIs were recorded. …”
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Comprehensive health risk assessment of urban ambient air pollution (PM2.5, NO2 and O3) in Ghana by Boansi Adu Ababio, Gerheart Winfred Ashong, Thomas Peprah Agyekum, Blessed Adjei Yeboah, Marian Asantewah Nkansah, Jonathan Nartey Hogarh, Michael Kweku Commeh, Edward Ebow Kwaansa-Ansah, Kwabena Dabie, Felix Adulley, Eldad Boansi, Lorenda Sarbeng, Birago Adu Ababio, Maame Serwaa Boapea, Nana Kwabena Oduro Darko, Meshach Kojo Appiah

“…The study assessed urban air quality and evaluated both carcinogenic and non-carcinogenic health risks associated with human exposure to ambient air pollutants. Alarmingly, our findings revealed the yearly median PM2.5 concentrations (50.79–67.97 µg m−3) to be significantly higher than the WHO recommendation of 5 µg m−3. …”
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HER-SAFE study design: an open-label, randomised controlled trial to investigate the safety of withdrawal of pharmacological treatment for recovered HER2-targeted therapy-related c... by Robin Chung, James C Moon, Alexander R Lyon, Charlotte H Manisty, Muhummad Sohaib Nazir, Malcolm Walker, Peter Kellman, Benjamin Dowsing, Daniel Chen, Jessica Artico, Mark Westwood, Hakim-Moulay Dehbi, Rebecca Roylance, Tom Crake, Peter Schmid, Arjun Ghosh, Maria Sol Andres, Joanna Pedra, Orla Worn

“…Introduction A quarter of breast cancers show human epidermal growth factor-2 (HER2) overexpression, where targeted therapy dramatically improves survival. …”
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Laser-based 3D printing and optical characterization of optical micro-nanostructures inspired by nocturnal insects compound eyes by Bogdan Stefanita Calin, Roxana Cristina Popescu, Eugenia Tanasa, Irina Alexandra Paun

“…Abstract Nature offers unique examples that help humans produce artificial systems which mimic specific functions of living organisms and provide solutions to complex technical problems of the modern world. …”
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Pharmacodynamic Profiling of Amoxicillin: Targeting Multidrug-Resistant Gram-Positive Pathogens <i>Staphylococcus aureus</i> and <i>Staphylococcus pseudintermedius</i> in Canine Cl... by Syed Al Jawad Sayem, Ga-Yeong Lee, Muhammad Aleem Abbas, Seung-Chun Park, Seung-Jin Lee

“…The rising threat of antimicrobial resistance (AMR) is a global concern in both human and veterinary medicine, with multidrug-resistant (MDR) pathogens such as <i>Staphylococcus aureus</i> and <i>Staphylococcus pseudintermedius</i> presenting significant challenges. …”
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Attitudes towards persons with disabilities vs. personality traits of Polish students by Iwona Radlińska, Marta Kożybska, Arkadiusz Prajzner, Łukasz Krzywoszański, Beata Karakiewicz

“…ObjectiveThe study aimed to establish the relationship between attitudes towards persons with disabilities and personality traits among Polish students, and whether sociodemographic factors moderate this.MethodsA cross-sectional self-report online survey was conducted on 595 Polish students, aged 18–29, from different fields of study: 1) natural science and engineering technology; 2) social science and humanities; 3) medical and health sciences; 4) law, economics, and management. …”
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Efficacy of Fetal Wharton’s Jelly Mesenchymal Stem Cells-Derived Small Extracellular Vesicles in Metabolic Syndrome by Illayaraja Krishnan, Magdalene Tan Mei Ling, Min Hwei Ng, Jia Xian Law, Mohd Rafizul Mohd Yusof, Thavachelvi Thangarajah, Zalina Mahmood, Nurul Izzati Uda Zahli, Shathiya Rajamanickam, Baskar Subramani, Yogeswaran Lokanathan

“…In addition, sEVs preparations improved inflammation and hemorrhage in the lung and mineralisation in the renal of the treated group. Conclusions: Human fetal WJMSCs-derived sEVs preparations improve all the clusters of MetS in rats except AC and could be further explored as a treatment for MetS.…”
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Blinding assessment in randomised sham-controlled trials of acupuncture:protocol for a systematic survey by Ling Li, Xin Sun, Jiali Liu, Minghong Yao, Yong Fu, Jiahui Yang, Xiaochao Luo

“…The objectives of this study are the following: (1) to investigate the proportion and study characteristics of sham-controlled trials reporting on blinding assessment, (2) to assess the blinding effectiveness of different types of sham acupuncture, (3) to investigate the relationship between blinding effectiveness and effect sizes in acupuncture RCTs.Methods and analysis We will search PubMed and EMBASE from inception to 1 January 2025 to identify RCTs that compared acupuncture with sham acupuncture in humans with any disease or symptom, with no restrictions on language. …”
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Lentinan's effect on gut microbiota and inflammatory cytokines in 5-FU-induced mucositis mice by Xiaoxiao Zhang, Liang Wang, Asif Iqbal Khan, Ata Ur Rehman, Kavish Hasnain Khinsar, Yi Xin

“…Abstract Chemotherapeutic therapies for cancer are frequently associated with cytotoxic side effects that can be harmful to human health, including the development of intestinal mucositis (IM). …”
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Pharmacological effects of fibroblast growth factor 21 are sex-specific in mice with the <em>lethal yellow</em> (A^y) mutation by E. N. Makarova, T. V. Yakovleva, N. Yu. Balyibina, K. O. Baranov, E. I. Denisova, A. D. Dubinina, N. A. Feofanova, N. M. Bazhan

“…Mutations in the MC4R gene are the most common cause of monogenic obesity in humans. Fibroblast growth factor 21 (FGF21) is a promising antiobesity agent, but its effects on melanocortin obesity are unknown. …”
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