Spatio-temporal changes of water quality variables in a highly disturbed river by Z. Abdollahi, A. Kavian, S.H.R. Sadeghi

“…Zanjanrud River, located in Zanjan Province, Iran, where recently faced human intervention needs a regular monitoring from upstream to downstream for sustainable management. …”
Get full text

Contribution of Aerosol Species to the 2019 Smoke Episodes over the East Coast of Peninsular Malaysia by Nur Nazmi Liyana Mohd Napi, Maggie Chel Gee Ooi, Mohd Talib Latif, Liew Juneng, Mohd Shahrul Mohd Nadzir, Andy Chan, Li Li, Samsuri Abdullah

“…Abstract Large-scale biomass burning (BB) emits large amounts of aerosols that lead to transboundary smoke events and adversely impacts human health, whilst causing societal and environmental issues. …”
Get full text

Test Performance of Plastic Waste Shredder Machine and Analyze the Quality of the Shredded Plastic Product Using the Taguchi Method by Adam - Kamil, Hendra Hendra, Sidik Susilo, Erny Listijorini, Hernadewita Hernadewita

“…This causes problems for the environment, humans, and others, especially in the waste treatment process. …”
Get full text

Antimicrobial and ADME properties of methoxylated, methylated and nitrated 2-hydroxynaphthalene-1 carboxanilides by Lucia Vrablova, Tomas Gonec, Tereza Kauerova, Michal Oravec, Izabela Jendrzejewska, Peter Kollar, Alois Cizek, Josef Jampilek

“…All the compounds were evaluated for antibacterial activities against Gram-positive and Gram-negative bacteria and mycobacteria. Cytotoxicity on human cells was also tested. Key results: Three compounds showed activity comparable to clinically used drugs. …”
Get full text

Elucidation of α-glucosidase inhibitory activity and UHPLC-ESI-QTOF-MS based metabolic profiling of endophytic fungi Alternaria alternata BRN05 isolated from seeds of Swietenia mac... by Piyush Kumar, Sai Anand Kannakazhi Kantari, Ranendra Pratap Biswal, Prasanth Ghanta, Malleswara Dharanikota

“…Molecular Dynamics (MD) simulations of 3’,4’,7-trihydroxyisoflavanone (THF) and alternariol 9-methyl ether (AME) from EQS, exhibiting high binding energies (-7.5 and -7 kcal/mol, respectively), were performed to investigate their interactions with human intestinal α-glucosidase. Results suggest THF possesses strong inhibitory potential, making it a promising candidate for diabetes management.…”
Get full text

USP39 phase separates into the nucleolus and drives lung adenocarcinoma progression by promoting GLI1 expression by Shaoxuan Cheng, Zhiyuan Qiu, Ziyi Zhang, Yuxuan Li, Yue Zhu, Yuxin Zhou, Yinghui Yang, Yaowen Zhang, Dian Yang, Yingqiu Zhang, Han Liu, Zhaoxia Dai, Shu-Lan Sun, Shuyan Liu

“…Deubiquitylating enzymes (DUBs) emerge as novel therapeutic targets against human cancers. However, the nucleolar phase separation of DUBs and association with lung cancer development have remained incompletely investigated till now. …”
Get full text

Eating "rubbish"? Exploring the herbal secrets of "Laji-He," a traditional herbal rice snack from southern China by Renchuan Hu, Qianyun Wang, Zhongxin Duan, Yunan Hu, Kedao Lai, Xiaohui Cai, Ya Peng, Binsheng Luo

“…This study aims to analyze the medicinal plant used in Laji-He and its implication in human medicine. Methods Ethnobotanical surveys and interviews were conducted in the Beibu Gulf region, covering local markets and communities. …”
Get full text

Helicobacter mastomyrinus infection induces autoimmune hepatitis in mice by Liqi Zhu, Yuanyuan Liang, Linghan Yang, Qihui Yang, Jun Yin, Tao Wang, Xiangming Xu, Quan Zhang

“…This model may serve as a novel animal model for the study of the pathogenesis and potential therapeutic strategies for human AIH.…”
Get full text

Performance of Bell Pepper (Capsicum annum) Under Different Grow Bag Media in Lalitpur District, Nepal by Sakuna Nepal, Pratibha Khatiwada, Pankaj Karki Dholi, Safal Adhikari

“…Promoting rooftop farming using suitable grow bag media is of utmost importance in densely populated cities like Lalitpur to sustain the human race. To assess the productivity and other economic characteristics of bell peppers, an experiment was conducted from Feb 2022 to Jun 2022 in different grow bag media on the premises of Vegetable Crop Development Centre, Khumaltar, Lalitpur. …”
Get full text

Association of ambient temperatures with suicide attempts and violence with the future projections under climate change scenarios: a nationwide time-stratified case-crossover study... by Jiwoo Park, Jieun Oh, Whanhee Lee, Yeonsu Kim, Jeong Ho Park, Ho Kim, Seungsik Hwang

“…Abstract Background Both climate change and intentional injuries (suicide attempts and violence) are recognized as crucial factors that affect human health. Previous studies revealed the association between ambient temperatures and deaths due to intentional injuries but mostly about the consequences of severe events. …”
Get full text

The association between Planetary Health Diet Index (PHDI) and chronic obstructive pulmonary disease (COPD): the mediating role of dietary inflammatory index (DII) by Hongyang Gong, Kaifeng Zhang, Seok Choi, Shaoqun Huang

“…PHDI is a dietary scoring system designed to balance human health and environmental sustainability by promoting increased consumption of plant-based foods and reduced intake of red meat, sugar, and highly processed foods. …”
Get full text

Intraperitoneal paclitaxel for patients with primary malignant peritoneal mesothelioma: a phase I/II dose escalation and safety study—INTERACT MESO by Job P van Kooten, Jacobus W A Burger, Cornelis Verhoef, Joachim G J V Aerts, Eva V E Madsen, Alexandra R M Brandt-Kerkhof, Stijn L W Koolen, Ron H J Mathijssen, Michelle V Dietz, Niels A D Guchelaar

“…Through this PAC, 8–16 weekly cycles of intraperitoneal chemotherapy will be administered.Ethics and dissemination The Central Committee on Research Involving Human Subjects (CCMO, The Hague, The Netherlands) and the Medical Research Ethics Committee (METC, Rotterdam, The Netherlands) have granted permission to carry out this study protocol. …”
Get full text

Causal relationship of familial hypercholesterolemia with risk of intestinal vascular disorders: A mendelian randomization study by Gang Wei, Cheng Zhang, Feng-Jie Shen, Hua-Qi Guo, Lin Liu

“…This study aims to investigate the cause-and-effect relationship of FH with risk of intestinal vascular diseases in human. Methods: A Mendelian randomization (MR) analysis was performed by extracting summary-level datasets for FH or FH concurrently with ischemic heart disease (IHD) and intestinal vascular diseases from the FinnGen study including 329,115, 316,290 and 350,505 individuals. …”
Get full text

Assessments of Antibacterial Effects of Aqueous-Ethanolic Extracts of Sida rhombifolia’s Aerial Part by Demeke Debalke, Mastewal Birhan, Amebaye Kinubeh, Muluken Yayeh

“…Because of this, searching of new treatment method is important from natural substances to against those infectious diseases in both human and animals’ aspects. Among those plants, Sida rhombifolia has various roles against those infectious diseases through its different phytochemical components. …”
Get full text

Identification of the Highly Polymorphic Prion Protein Gene (<i>PRNP</i>) in Frogs <i>(Rana dybowskii</i>) by Chang-Su Han, Sae-Young Won, Sang-Hun Park, Yong-Chan Kim

“…The origin of prion seeds is unclear, especially in non-human hosts, and this identification is pivotal to preventing the spread of prion diseases from host animals. …”
Get full text

House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model by Patricia Ramos-Ramírez, Jielu Liu, Sofia Mogren, Joshua Gregory, Malin Noreby, Anne Petrén, Ying Lei, Henric Olsson, Marianne van Hage, Jukka Kervinen, Lars Hellman, Cecilia Andersson, Gunnar Nilsson, Mikael Adner

“…As guinea pigs exhibit anatomical, physiological, and pharmacological features resembling human airways, including mast cell distribution and mediator release, we evaluated the effect of extracts from two common allergens, house dust mite (HDM) and cat dander (CDE), on histopathological changes and the composition of tryptase- and chymase-positive mast cells in the guinea pig lungs. …”
Get full text

Clinical Characteristics During and After COVID‐19 Infection Among Healthcare Workers During the First Wave of Omicron in Chongqing, China by Haoling Tang, Zhiwei Chen, Tianquan Huang, Pingping Yu, Qiao Tang, Yue Qiu, Yunling Xue, Jing Tang, Nan Cai, Hong Ren, Mingli Peng, Peng Hu

“…Conclusions The clinical manifestations observed in HCWs during and after Omicron infection displayed intricate patterns, shedding new light on the complex interplay between SARS‐CoV‐2 and humans.…”
Get full text

Opposing Effects of Omega-3 and Omega-6 Long Chain Polyunsaturated Fatty Acids on the Expression of Lipogenic Genes in Omental and Retroperitoneal Adipose Depots in the Rat by B. S. Muhlhausler, R. Cook-Johnson, M. James, D. Miljkovic, E. Duthoit, R. Gibson

“…This study aimed to determine the effect of varying dietary intake of the major n-3 PUFA in human diets, α-linolenic acid (ALA; 18 : 3n-3), on expression of lipogenic genes in adipose tissue. …”
Get full text

Air Quality of Bursa: Temporal and Spatial Evaluation of PM10, PM2.5, NO2 and SO2 Pollutants Using IDW Geostatistical Technique by Duygu Arıkan İspir, Ferruh Yıldız

“…One of the most significant environmental issues is air pollution. Human health is negatively impacted by this issue in addition to the environment. …”
Get full text

RNAi-based ALOX15B silencing augments keratinocyte inflammation in vitro via EGFR/STAT1/JAK1 signalling by Megan A. Palmer, Rebecca Kirchhoff, Claudia Buerger, Yvonne Benatzy, Nils Helge Schebb, Bernhard Brüne

“…Using a cytokine cocktail containing IL-17A, interferon-gamma and tumour necrosis factor-alpha to produce a psoriasis-like phenotype, a role for ALOX15B in human epidermal keratinocyte inflammation was investigated. siRNA-mediated silencing of ALOX15B increased CCL2 expression and secretion. …”
Get full text