Post-Marketing Pharmacovigilance of Canakinumab from the FDA Adverse Event Reporting System (FAERS) by Weidong Zhang, Yunzhou Chen, Zeyu Yao, Mengling Ouyang, Minghui Sun, Shupeng Zou

“…<b>Background:</b> Canakinumab, a humanized anti-IL-1β monoclonal antibody, is known for its ability to suppress IL-1β-mediated inflammation. …”
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Web-based interventions for pregnant women with gestational diabetes mellitus: a systematic review and meta-analysis protocol by Ping Xu, Wei Zhang, Xiaojuan Wang, Dan Dan Chen, Pingping Guo, Yin Jin, Zhenzhen Xiang, Minna Mao, Qiong Zheng, Suwen Feng

“…We will conduct a qualitative synthesis for studies that cannot be quantitatively synthesised.Ethics and dissemination Ethics approval is not required for this review as no human participants will be involved. The results will be disseminated via a peer-reviewed journal or an academic conference.PROSPERO registration number CRD42022296625.…”
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Advancing treatment choices: CDK4/6 inhibitor switching in HR+/HER2- metastatic breast cancer by Paola Zagami, Angela Esposito, Beatrice Taurelli Salimbeni, Pier Paolo Maria Berton Giachetti, Roberta Scafetta, Matteo Lambertini, Massimo Di Maio, Giuseppe Curigliano, Carmen Criscitiello, Saverio Cinieri

“…Purpose: CDK4/6 inhibitors (CDK4/6i) use has revolutionized the treatment of hormone receptor-positive/human epidermal growth factor receptor 2 negative (HR+/HER2-) metastatic breast cancer. …”
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Design, Implementation and Environmental Impact of Cutoff Wall for Pollution Control in an Industrial Legacy Site by Lu Yu, Sichen Chen, Jinnan Wang, Zhihong Zhang, Yan Huang

“…Heavy metal-organic pollutants compound pollution at industrial legacy sites and have caused damage to the ecological environment and human health during recent decades. In view of the difficulty and high cost of post-contamination remediation, it is worth studying, and practically applying, cutoff walls to reduce the spread of pollution in advance. …”
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Exploring the anti-inflammatory effects of phytochemicals in attenuating interstitial cystitis-a literature review by Irfan Anjum, Ayesha Nasir, Faiza Naseer, Faiza Naseer, Ahsan Ibrahim, Bisma Rehman, Fawad Bashir, Qura Tul Ain

“…Sodium 2-mercaptoethane sulfonate (Mesna) has traditionally been employed in clinical practice to counter cyclophosphamide-induced cystitis in humans. However, cyclophosphamide has been employed in developing animal models of interstitial cystitis in in vivo studies. …”
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Protocol of the Nurses’ Mental Health Study (NMHS): a nationwide hospital multicentre prospective cohort study by Jiaxin Yang, Chongmei Huang, Shuiyuan Xiao, Xuting Li, Meng Ning, Zengyu Chen, Yusheng Tian, Qiang Yu, Yamin Chen, Ya-Min Li

“…Introduction Due to high workload, shift work and shortage of human resources, nurses are vulnerable to various mental health problems which are significantly related to their physical health, patient safety and healthcare quality. …”
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The comprehensive assessment of epigenetics changes during skin development by Li Lei, Ling Jiang, Yibo Hu, Menglu Chen, Jinhua Huang, Jing Chen, Qinghai Zeng

“…The transcriptomes of human skin samples from different ages or irradiated with different types and doses of UV light were analyzed using R (version 4.0.3) software. …”
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Tumor CEMIP drives immune evasion of colorectal cancer via MHC-I internalization and degradation by Ying Zhu, Jiao Li, Tao Zhang, Lei Zhao, Min Jin, Jinghua Ren, Jing Tang, Haihong Wang, Zhenyu Lin, Qing Liang, Ruiqi Li, Biying Zhang, Qingling Hua, Guojie Xu, Jiayuan Chen, Lanqing Wang, Dejun Zhang, Dandan Yu

“…In addition, the effect of CEMIP on tumor growth and the antitumor efficacy of targeting CEMIP in combination with ICB therapy were evaluated in murine models of colorectal cancer.Results We reported that CEMIP specifically downregulated the expression of MHC-I on the surface of murine and human colon cancer cells, hindering the cytotoxicity of CD8+ T cells. …”
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Under a not so white sky: visual impacts of stratospheric aerosol injection by Ansar Lemon, David W Keith, Steve Albers

“…We compare the simulated changes in color and brightness to experimental measurements of minimum thresholds humans can detect. The three aerosol types cause similar changes, except most notably the diamond aerosol increases brightness of the solar aureole by roughly three to five times less than do H _2 SO _4 or CaCO _3 . …”
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“Old” and “New” Trust in Higher Education by P. A. Ambarova, G. E. Zborovsky, N. V. Shabrova

“…They are important to design various academic practical experience oriented on the use of resource properties of trust with a view to developing the social and human capital of high school communities as well as to elaborate new social technologies for managing the processes of trust formation in the university.…”
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High Glucose with Insulin Induces Cell Cycle Progression and Activation of Oncogenic Signaling of Bladder Epithelial Cells Cotreated with Metformin and Pioglitazone by Daejin Kim, Byul-Nim Ahn, YeongSeok Kim, Dae Young Hur, Jae Wook Yang, Ga Bin Park, Jung Eun Jang, Eun Ju Lee, Min Jeong Kwon, Tae Nyun Kim, Mi Kyung Kim, Jeong Hyun Park, Byoung Doo Rhee, Soon Hee Lee

“…The cells derived from human bladder epithelial cells (HBlEpCs) were treated with metformin or pioglitazone with high glucose and insulin. …”
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Bradykinin B1 receptor signaling triggers complement activation on endothelial cells by Ingrid Lopatko Fagerström, Alexandra Gerogianni, Markus Wendler, Ida Arvidsson, Ashmita Tontanahal, Ann-Charlotte Kristoffersson, Fatimunnisa Qadri, Michael Bader, Michael Bader, Michael Bader, Michael Bader, Michael Bader, Diana Karpman

“…This study investigated if KKS activation induced complement activation on endothelial cells, and if activation was dependent on bradykinin B1 receptor (B1R) signaling.MethodsKKS was activated in normal human serum by kaolin or activated factor XII (FXIIa). …”
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Screening for schistosomiasis in a non-endemic setting: Accuracy of a rapid antibody test using finger prick blood by Margherita Ortalli, Bianca Granozzi, Michele Bacchiega, Concettina Di Lillo, Greta Roncarati, Silvia Stefania Longoni, Cristina Mazzi, Elisa Vanino, Zeno Bisoffi, Stefania Varani

“…Human schistosomiasis is a chronic neglected tropical disease caused by blood flukes of the genus Schistosoma, infecting 250 million people worldwide, mostly in sub-Saharan Africa. …”
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Complete Genome Sequence of Photobacterium damselae Subsp. damselae Strain SSPD1601 Isolated from Deep-Sea Cage-Cultured Sebastes schlegelii with Septic Skin Ulcer by Yongxiang Yu, Zheng Zhang, Yingeng Wang, Meijie Liao, Xiaojun Rong, Bin Li, Kai Wang, Jing Chen, Hao Zhang

“…Photobacterium damselae subsp. damselae (PDD) is a Gram-negative bacterium that can infect a variety of aquatic organisms and humans. Based on an epidemiological investigation conducted over the past 3 years, PDD is one of the most important pathogens causing septic skin ulcer in deep-sea cage-cultured Sebastes schlegelii in the Huang-Bohai Sea area and present throughout the year with high abundance. …”
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Design and assembly of plant-based COVID-19 candidate vaccines: reсent development and future prospects by E. A. Uvarova, P. A. Belavin, E. V. Deineko

“…This variant of the virus is characterized by a high degree of variability and, as the current situation with its spread across different regions of the globe shows, it can lead to a progressive spread of infection among the human population and become the cause of a pandemic. …”
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Comparative Effects of Crocin and Losartan on RAGE, TGF‐β, TNF‐α Gene Expression and Histopathological Changes of the Liver Tissue in Rats With Diabetes by Shahnaz Rajabi, Yaser Mohammadi, Hamid Kabiri‐rad, Mahdiyeh Rajabi‐moghaddam, Azam Rezaei Farimani

“…Conclusion Crocin may be a feasible therapeutic agent for treating diabetes and its symptoms when combined with pharmaceutical medications. Human research is still needed to reach clear conclusions.…”
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Cowpea cropping systems, traits preference and production constraints in the upper west region of Ghana: farmers' consultation and implications for breeding by Benjamin Karikari, Margaret Delle Maale, Ebenezer Anning, Daniel Brain Akakpo, Afishata Mohammed Abujaja, Isaac Kwahene Addai

“…Walp) is used primarily as food for humans and feed for animals. It is also used for soil management within a cropping system. …”
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Marker-assisted breeding of hybrid lines of <i>Triticum dicoccon</i> (Schrank) Schuebl. × <i>Triticum aethiopicum</i> Jakubz. with purple grain by P. I. Stepochkin, E. I. Gordeeva, Е. K. Khlestkina

“…Cereals whose grain contains antioxidants salutary for human health are promising for functional nutrition. …”
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Digital intervention promoting physical activity among obese people (DIPPAO) randomised controlled trial: study protocol by Bruno Pereira, Martine Duclos, Alexandre Mazéas, Aïna Chalabaev, Marine Blond

“…A mixed-model approach will be used to analyse the change in outcomes over time.Ethics and dissemination The research protocol has been reviewed and approved by the Local Human Protection Committee (CPP Ile de France XI, No 21 004-65219). …”
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Biogenic Amines and Aflatoxins in Some Imported Meat Products: Incidence, Occurrence, and Public Health Impacts by Fahad Dhafer Algahtani, Alaa Eldin Morshdy, Mohamed A. Hussein, Essam Said Abouelkheir, Adeniyi Adeboye, Andrea Valentine, Mohamed Tharwat Elabbasy

“…Since the beginning of humanity, the global burden of foodborne disease has had a decimating effect on populations, with biogenic amines (BAs) and aflatoxins in meat products implicated. …”
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