Efficient evidence selection for systematic reviews in traditional Chinese medicine by Yizhen Li, Zhe Huang, Zhongzhi Luan, Shujing Xu, Yunan Zhang, Lin Wu, Darong Wu, Dongran Han, Yixing Liu

“…Methods We integrated an established deep learning model (Evi-BERT combined rule-based method) with Boolean logic algorithms and an expanded retrieval strategy to automatically and accurately select potential evidence with minimal human intervention. The selection process is recorded in real-time, allowing researchers to backtrack and verify its accuracy. …”
Get full text

Epidemiology of Respiratory Pathogens in Children with Severe Acute Respiratory Infection and Impact of the Multiplex PCR Film Array Respiratory Panel: A 2-Year Study by Asmae Lamrani Hanchi, Morad Guennouni, Meriem Rachidi, Toufik Benhoumich, Hind Bennani, Mounir Bourrous, Fadl Mrabih Rabou Maoulainine, Said Younous, Mohamed Bouskraoui, Nabila Soraa

“…The most common viruses detected were HRV (n = 201) and RSV (n = 124), followed by PIV (n = 35) influenza A (n = 29) and human metapneumovirus (n = 27). Bacteria was found in 8.8% (n = 47), and Bordetella pertussis was the most detected. …”
Get full text

Glucose‐induced LINC01419 reprograms the glycolytic pathway by recruiting YBX1 to enhance PDK1 mRNA stability in hepatocellular carcinoma by Yanfang Liu, Junjiao Song, Qili Shi, Bing Chen, Wenying Qiu, Yizhe Liu, Shenglin Huang, Xianghuo He

“…These findings provide evidence for an unprecedented regulatory mechanism of LINC01419 involving metabolic reprogramming in human cancer. The newly identified LINC01419/YBX1‐PDK1 axis may represent a promising therapeutic target for HCC. …”
Get full text

Effectiveness of educational interventions to promote safe handling of pesticides: protocol for a systematic review and meta-analysis by Anne Cockcroft, Neil Andersson, Sergio Paredes-Solís, José Legorreta-Soberanis, Belén Madeline Sánchez-Gervacio, Víctor Manuel Alvarado-Castro, Miguel Flores-Moreno, Claudia Erika Rios-Rivera, Janet Saldaña-Almazán

“…Introduction Appropriate use of pesticides minimises harm to human health and the environment. Despite regulations and restrictions on use, however, many farmers still use highly toxic pesticides in ways that endanger their health and the environment. …”
Get full text

Anemia and associated factors among HIV/AIDS patients treated with antiretroviral therapy at Mizan-Tepi University Teaching Hospital, Southwest Ethiopia by Tadesse Adula Duguma, Teshale Worku, Mengistu Abayneh

“…Introduction Human immunodeficiency virus (HIV) and treatments given to HIV patients to reduce complications and fast disease progression, cause a series of hematological abnormalities. …”
Get full text

A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer by Peter Jung, Stefan P. Glaser, Jing Han, Alexandra Popa, Laura Pisarsky, Ningping Feng, Antonia Geyer, Franziska Haderk, Donat Alpar, Christopher Bristow, Susanne Schmittner, Paula-Elena Traexler, Mikhila Mahendra, Birgit Poehn, Poojabahen Gandhi, Roberto Fiorelli, Sanket Awate, Nicole Budano, Florian Martin, Christoph Albrecht, Barbara Drobits-Handl, Sathanandam S. Anand, Srinath Kasturirangan, Francesca Trapani, Norbert Schweifer, Joseph R. Marszalek, Ulrike Tontsch-Grunt, Mark Pearson, Timothy P. Heffernan, Norbert Kraut, Christopher P. Vellano, Juan Manuel García-Martínez

“…The limited clinical success of previous TRAILR2 agonistic agents, to date, has been ascribed to either poor efficacy or hepatotoxicity. TR2/CDH3 BAB is a human bispecific antibody that relies on binding both CDH3 and TRAILR2 on cell surfaces to achieve TRAILR2 hyperclustering and efficient apoptosis induction by TRAILR2 signaling selectively in CDH3-expressing tumor cells. …”
Get full text

Long non-coding RNA NEAT1 promotes ovarian granulosa cell proliferation and cell cycle progression via the miR-29a-3p/IGF1 axis by Lina He, Jie Lin, Zhengwen Qin, Qing Xu, Li Hao, Yanhong Fu, Xu Ran, Wei Chen

“…Methods We investigated the function of lncRNA NEAT1 in human ovarian granulosa-like tumor cells (KGN). The effects of NEAT1 overexpression or silencing on cell proliferation and cell cycle were evaluated using CCK-8 assays and flow cytometry. …”
Get full text

Morphometric and Molecular Characterization of Fasciola spp. in Livestock From Northwestern Provinces of Iran by Hossein Galavani, Saber Raeghi, Mehdi Karamian, Negin Torabi, Ali Haniloo

“…ABSTRACT Background Liver flukes from the genus Fasciola are the causative agents for human and livestock fascioliasis. Accurate identification of Fasciola spp. is essential to understanding the epidemiology of fascioliasis. …”
Get full text

Mitophagy mediated by HIF-1α/FUNDC1 signaling in tubular cells protects against renal ischemia/reperfusion injury by Wenjun Zhang, Chao Guo, Yi Li, Hao Wang, Huabing Wang, Yingying Wang, Tingting Wu, Huinan Wang, Gang Cheng, Jiangwei Man, Siyu Chen, Shengjun Fu, Li Yang

“…This study assessed the role of hypoxia-inducible factor 1α (HIF-1α)-mediated mitophagy in protection against RIRI in vitro and in vivo. The human tubular cell line HK-2 was used to assess hypoxia/reoxygenation (H/R)-induced mitophagy through different in vitro assays, including western blotting, immunofluorescence staining, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL), and reactive oxygen species (ROS) measurement. …”
Get full text

Dendritic cell maturation is induced by p53-armed oncolytic adenovirus via tumor-derived exosomes enhancing systemic antitumor immunity by Tomoko Ohtani, Shinji Kuroda, Nobuhiko Kanaya, Yoshihiko Kakiuchi, Kento Kumon, Masashi Hashimoto, Chiaki Yagi, Ryoma Sugimoto, Satoru Kikuchi, Shunsuke Kagawa, Hiroshi Tazawa, Yasuo Urata, Toshiyoshi Fujiwara

“…Exosomes (Exo53, Exo301, or Exo702) were isolated from conditioned media of human or murine pancreatic cancer cell lines (Panc-1, MiaPaCa-2, and PAN02) after treatment with Ad-p53, OBP-301, or OBP-702. …”
Get full text

Ecdysone receptor strongly influences larval–pupal–adult transition and melanization in Tuta absoluta by Xiaodi Wang, Jiajia Wu, Jianyang Guo, Nianwan Yang, Fanghao Wan, Zhichuang Lü, Wanxue Liu

“…The overuse of traditional pesticides negatively affects both human health and the environment. RNA interference (RNAi), based on double-stranded RNA (dsRNA) induction, can be beneficial in the control of Tuta absoluta; one of the key points of using this technique is the selection of target genes. …”
Get full text

Climate change and the sustainable use of medicinal plants: a call for “new” research strategies by Olha Mykhailenko, Olha Mykhailenko, Banaz Jalil, Lyndy J. McGaw, Javier Echeverría, Marce Takubessi, Marce Takubessi, Michael Heinrich, Michael Heinrich

“…Climate change and human activities severely impact the viability of plants and ecosystems, threatening the environment, biodiversity, and the sustainable development of plant-based products. …”
Get full text

The effects of glucose, nitrate, and pH on cultivation of Chlorella sp. Microalgae by H. Nouri, J. Mohammadi Roushandeh, A. Hallajisani, A. Golzary, S. Daliry

“…<strong>BACKGROUND AND OBJECTIVES: </strong>Bioenergy is a phenomenon that has attracted humans’ attention for about a century. The desirable biological properties of <em>chlorella sp.…”
Get full text

A novel placement method of a calibration‐free pH capsule for continuous wireless measurement of intragastric pH in horses by Evelyn Hodgson, Marthe Thirouin, Pranav Narayanan, Tallia‐Rume Romano, Jessica Wise, Stephanie Bond

“…A wireless capsule has been designed for continuous esophageal pH monitoring in humans. Objectives To (1) determine the feasibility and describe the methodology of measuring intragastric pH wirelessly in horses; and (2) determine attachment duration of the capsules. …”
Get full text

Association of cortical macrostructural and microstructural changes with cognitive performance and gene expression in subcortical ischemic vascular disease patients with cognitive... by Jing Huang, Runtian Cheng, Xiaoshuang Liu, Li Chen, Tianyou Luo

“…Moreover, the associations between the significant neuroimaging values and the cognitive scores and gene expression values from Allen Human Brain Atlas database were evaluated using partial least squares regression and partial correlation analysis. …”
Get full text

FadA antigen of Fusobacterium nucleatum: implications for ceRNA network in colorectal cancer and adenomatous polyps progression by Sama Rezasoltani, Elahe Shams, Moein Piroozkhah, Yaser Aidi, Mehdi Azizmohammad Looha, Parmida Bagheri, Roudabeh Behzadi Andouhjerdi, Amir Sadeghi, Leili Rejali, Ehsan Nazemalhosseini-Mojarad

“…According to our previous study to identify shared MicroRNA-Interaction-Targets (MITs) between ANXA2 and LINC00460, TargetScanHuman (V7.2) and miRDB databases have been used respectively. …”
Get full text

Electrochemical Detection of Dopamine with Graphene Oxide Carbon Dots Modified Electrodes by Omar Isaac Torres-Soto, Alejandro Vega-Rios, Rocio B. Dominguez, Velia Osuna

“…The assay of GOQDs-8/GCE sensor in normal human serum proved to be feasible for the practical determination of DA. …”
Get full text

Optimization of the Formulation of Rice Biscuits Supplemented with D. Edulis (L.) Powder Using Response Surface Methodology by Eliane Flore Eyenga, Hippolyte Tene Mouafo, Mercy Bih Loh Achu, Wilfred F. Mbacham, Sali Atanga Ndindeng

“…Trends in the food industry are nowadays directed towards the reduction of the level of trans fatty acids in food intended for human consumption. The present study was designed and aimed at valorizing Dacryodes edulis (L.) powder as a substitute for margarine in the production of functional rice biscuits. …”
Get full text

Benefit Analysis of Precursor Emission Reduction on PM2.5: Using CMAQ-RSM to Evaluate Control Strategies in Different Seasons by Chih-Rung Chen, Hsin-Chih Lai, Min-Chuan Hsiao, Hwong-wen Ma

“…Abstract PM2.5 pollution has been a major problem that threatens the environment and human health. To implement more effective management of this problem, the sensitivity of ambient PM2.5 reduction to precursors needs to be clarified. …”
Get full text

Fluorescence Lifetime Imaging for Quantification of Targeted Drug Delivery in Varying Tumor Microenvironments by Amit Verma, Vikas Pandey, Catherine Sherry, Taylor Humphrey, Christopher James, Kailie Matteson, Jason T. Smith, Alena Rudkouskaya, Xavier Intes, Margarida Barroso

“…Abstract Trastuzumab (TZM) is a monoclonal antibody that targets the human epidermal growth factor receptor 2 (HER2) and is clinically used for the treatment of HER2‐positive breast tumors. …”
Get full text