Safety, Tolerability, and Pharmacokinetics of NIM‐1324 an Oral LANCL2 Agonist in a Randomized, Double‐Blind, Placebo‐Controlled Phase I Clinical Trial by Andrew Leber, Raquel Hontecillas, Nuria Tubau‐Juni, Josep Bassaganya‐Riera

“…Through activation of LANCL2, NIM‐1324 modulates CD4+ T cells to bias signaling and cellular metabolism toward increased immunoregulatory function while providing similar support to phagocytes. In primary human immune cells, NIM‐1324 reduces type I interferon and inflammatory cytokine (IL‐6, IL‐8) production. …”
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Heterogeneity of Intermediate Care Organization Within a Single Healthcare System by Aaron S. Case, MD, MHS, Chad H. Hochberg, MD, MHS, Binu Koirala, PhD, MGS, BSN, RN, Eleni Flanagan, DNP, MBA, Souvik Chatterjee, MD, William N. Checkley, MD, PhD, Ayse P. Gurses, PhD, MS, MPH, David N. Hager, MD, PhD

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Molecular Characterization and Antibacterial Potential of Endophytic Fungal Isolates from Selected Mangroves along the Coastline of Kenya by Teresia Nyambura Wacira, Huxley Mae Makonde, Carren Moraa Bosire, Cromwell Mwiti Kibiti

“…The increasing emergence and re-emergence of resistant pathogenic microbes causes a health threat to the human population. Scientists have been striving to find novel bioactive compounds and drugs to overcome these obstacles. …”
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Exploring the solutions of tempered (κ,ϖ)-Hilfer hybrid implicit boundary value problem by Abdelkrim Salim, Sabri T.M. Thabet, Ava Sh. Rafeeq, Mohammad Esmael Samei, Imed Kedim, Miguel Vivas-Cortez

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Synthesis, Characterization, and Cytotoxicity Research of Sulfur-Containing Metal Complexes by Yanting Yang, Danqin Li, Mei Luo

“…In terms of application, the biological activity of complexes (I)–(III) in human cancer cell lines (lung cancer A549, liver cancer SMMC-7721, breast cancer MDA-MB-231, and colon cancer SW480) was tested using the MTS method. …”
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How does playfulness (re)frame the world? Evidence for selective cognitive and behavioral redirecting in times of adversity by Xiangyou Shen, Zoe Crawley

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Tumor-Derived Exosomal miR-29b Reduces Angiogenesis in Pancreatic Cancer by Silencing ROBO1 and SRGAP2 by Lihua Wang, Lei Yang, Tingting Zhuang, Xiuqing Shi

“…Transmission electron microscopy (TEM) and confocal microscopy were used to examine structural characteristics of the exosomes and verify their internalization by human umbilical vein endothelial cells (HUVECs). …”
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Relationship between landscape and river ecosystem services by M. Dede, S. Sunardi, K.C. Lam, S. Withaningsih

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جداسازی سلول‌های B با استفاده از نانوذرات مغناطیسی و بررسی اثر رنگ‌آمیزی سلول‌ها و مقدار نانوذرات بر جداسازی آن‌ها... by امیرحسین حقیقی

“…به‌منظور جداسازی هدفمند سلول‌های B، آنتی‌بادی FITC anti-human CD20 بااستفاده‌از EDC/NHS به نانوذرات، متصل و با فلوسایتومتری آنالیز شده‌است. …”
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Which social determinants of health have the highest impact in community oncology to advance patient care equity and improve health outcomes? A scoping review by Kayleigh R. Majercak, Emily F. Gorman, Nicholas J. Robert, Barbara Palmer, Henry Asante Antwi, C. Daniel Mullins

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Evaluating the dynamics of fee-free higher education in South Africa: a causal loop diagram approach  [version 3; peer review: 2 approved, 1 not approved] by Grace Kanakana-Katumba, Tlotlo Ramasu

“…Furthermore, the study aligns with global goals, particularly Sustainable Development Goals (SDGs) 4 (Quality Education), 8 (Decent Work and Economic Growth), and 10 (Reduced Inequalities), as well as the African Agenda 2063’s focus on human capital development. While the findings offer valuable recommendations for policymakers, further research is needed to explore longitudinal impacts of these reforms and expand comparative analyses with other nations implementing similar policies.…”
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Validation of the Italian Sense of Agency Scale and Its Relevance to Well-Being: An Iterative Bootstrap Approach by Simone Di Plinio, Claudia Greco, Simone Arnò, Marco Innamorati, Sjoerd J. H. Ebisch

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Investigation of Enterotoxigenic Coagulase-negative Staphylococci Isolated from Local and Imported Dairy Products; a Microbiological Study by Niyaz Sirwan Ali, Huner Hiwa Arif

“…Research interest in CNS has increased over the past decade following their implication in infections in animals and humans. This study was aimed to detect CNS isolated from 150 dairy products (yoghurt, several types of cheese, Lork, and Serezh) in Sulaimani and Halabja governorate. …”
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Paternal metabolic and cardiovascular programming of their offspring: A systematic scoping review. by Claudia Eberle, Michaela F Kirchner, Raphaela Herden, Stefanie Stichling

“…Epidemiological, clinical and experimental studies as well as human and animal model studies were included.<h4>Results</h4>From n = 3.199 citations, n = 66 eligible studies were included. …”
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Changes in IL-16 Expression in the Ovary during Aging and Its Potential Consequences to Ovarian Pathology by Jessica Ramirez, Pincas Bitterman, Sanjib Basu, Animesh Barua

“…In addition, we examined changes in nuclear expression of IL-16 expression with regards to exposure to follicle-stimulating hormone (FSH) by in vitro cell culture assays with human ovarian cancer cells. The frequencies of IL-16 expressing cells were significantly higher in ovarian stroma in women at early and late menopause as compared with premenopausal women (P<0.0001). …”
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Social activities and different intensities of physical activity among older adults in China: a population-based cohort study by Song Yang, Qi Zhang, Anhui Zhao, Dongye Lyu

“…IntroductionPopulation aging is an inevitable consequence of demographic transition and an important issue for human society in the 21st century. Physical activity is widely recognized as a critical factor for improving health, yet the specific impact of different intensities of physical activity on the health of older adults remains underexplored.MethodsThis study addresses this gap by analyzing data from the China Health and Retirement Longitudinal Survey (CHARLS), a nationally representative survey of a cohort of Chinese people (aged ≥45 years) from 150 counties or districts and 450 villages or urban communities across 28 provinces, who were selected by use of multistage stratified probability-proportionate-to-size sampling. …”
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Caption Generation Based on Emotions Using CSPDenseNet and BiLSTM with Self-Attention by Kavi Priya S, Pon Karthika K, Jayakumar Kaliappan, Senthil Kumaran Selvaraj, Nagalakshmi R, Baye Molla

“…The proposed work encapsulates the facial emotional features to produce more expressive captions similar to human-annotated ones with the help of Cross Stage Partial Dense Network (CSPDenseNet) and Self-attentive Bidirectional Long Short-Term Memory (BiLSTM) network. …”
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Jurisdictional immunity of the state: evolution of the doctrine by T. V. Stepanenko

“…At the present stage, the doctrine of jurisdictional immunity of a foreign state is on the threshold of a new period of development of the doctrine i.e. a period of further limitation of state immunity in favour of human rights, ensuring the necessary balance between state immunity and the right of an individual to access to court and a fair trial. …”
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An Effective Robust Total Least-Squares Solution Based on “Total Residuals” for Seafloor Geodetic Control Point Positioning by Zhipeng Lv, Guorui Xiao

“…However, the tracking point coordinates and acoustic ranging observations are inevitably contaminated by outliers because of human mistakes, failure of malfunctioning instruments, and unfavorable environmental conditions. …”
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Evaluation of Caries-Free Restorations Bonded with Various Adhesive Systems: In Vitro Study by Morakot Piemjai, Pareewan Chantarawej, Nobuo Nakabayashi

“…Previously frozen extracted human molars were used to prepare the Class V cavities at the CEJ on axial surfaces. …”
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