Machine vision-based detection of key traits in shiitake mushroom caps by Jiuxiao Zhao, Jiuxiao Zhao, Wengang Zheng, Wengang Zheng, Yibo Wei, Yibo Wei, Qian Zhao, Qian Zhao, Jing Dong, Jing Dong, Xin Zhang, Xin Zhang, Mingfei Wang, Mingfei Wang

“…In practical applications, this method improves the breeding process by rapidly and non-invasively assessing key traits such as the size and color of shiitake mushroom caps, which helps in efficiently screening strains and reducing human errors. Firstly, an edge detection model was established. …”
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Actinomycete-Derived Pigments: A Path Toward Sustainable Industrial Colorants by Blanca Hey Díez, Cristiana A. V. Torres, Susana P. Gaudêncio

“…The successful commercialization of actinomycete pigments can drive an industry-wide transition to environmentally responsible alternatives, offering substantial benefits for human health, safety, and environmental sustainability.…”
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The Role of Sulfur Emission from the Petroleum Industry on Ultrafine Particle Number Concentration in Singapore by Suyi Hou, Weihan Li, Liudongqing Yang, Guorong Chen, Yilin Zhang, Mikinori Kuwata

“…Abstract Ultrafine particles, defined as particles with a diameter (dp) smaller than 100 nm, serve as an important component of cloud condensation nuclei, in addition to impacting human health. The dominant sources of ultrafine particles include traffic emissions and nucleation. …”
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What makes health systems resilient? An analytical framework drawing on European learnings from the COVID-19 pandemic based on a multitiered approach by Thomas Czypionka, Markus Kraus, Miriam Reiss, Monika Riedel

“…Both sections are further divided into six building blocks that were adapted from the WHO health system framework: governance and leadership, information and research, financing, physical resources, human resources, and service delivery. An overarching component on contextual factors—subdivided into situational, structural, cultural and international factors—represents an important addition to the existing spectrum of resilience frameworks.Conclusions Foundations for a resilient health system must be laid in ‘normal’ times and in all areas of the health system. …”
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Willingness of end users to pay for e-waste recycling by H.T.T. Nguyen, C.-H. Lee, R.-J. Hung

“…<strong>BACKGROUND AND OBJECTIVES:</strong> The sheer volume of electrical and electronic waste (e-waste) has presently been generated in Vietnam, posing a growing concern regarding its impact can have on the environment and human health. Therefore, the need for developing policies and regulations towards the environmentally sound management of e-waste is becoming crucial. …”
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DIGITALISATION OF CRISIS MANAGEMENT AND RESOURCE BALANCING FOR EDUCATIONAL QUALITY ASSURANCE AT A DISPLACED UNIVERSITY by Oleksandr Spivakovsky, Daria Malchykova, Viktoria Yatsenko

“…The crisis management strategy at Kherson State University involved seeking a balance of resources (material, financial, human, communicational, managerial, and innovative) to ensure the proper quality of education. …”
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REDD1 expression in podocytes facilitates renal inflammation and pyroptosis in streptozotocin-induced diabetic nephropathy by Siddharth Sunilkumar, Sandeep M. Subrahmanian, Esma I. Yerlikaya, Allyson L. Toro, Edward W. Harhaj, Scot R. Kimball, Michael D. Dennis

“…In contrast with diabetic REDD1+/+ mice, diabetic REDD1−/− mice did not exhibit albuminuria, increased pro-inflammatory factors, or renal macrophage infiltration. In cultured human podocytes, exposure to hyperglycemic conditions promoted REDD1-dependent activation of NF-κB signaling. …”
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Multislice B1 Mapping Method Using Magnetic Resonance Composite Spin Echo Sequences and Simultaneous Echo Refocusing by Suchit Kumar, Kyu Chan Lee, Jong-Min Kim, Jeung-Hoon Seo, Chulhyun Lee, Chang-Hyun Oh

“…In addition, the proposed B1 mapping methods were compared to the multislice iterative signal intensity mapping method in both phantom and in vivo human experiments, and there was no remarkable difference between the two methods regarding the flip angle distribution in these experiments. …”
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Simulating the Tone River eastward diversion project in Japan carried out 4 centuries ago by J. Trošelj, J. Trošelj, N. Hanasaki

“…We show that it is possible to bridge two different disciplines, history, and numerical hydrological modeling to obtain a better understanding of human–water interactions. One limitation is that we only reconstructed historical land maps in the present study; the meteorological forcing inputs employed were identical to those of the 20th century. …”
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Tolterodine is a novel candidate for assessing CYP3A4 activity through metabolic volatiles to predict drug responses by Valentina Stock, Rebecca Hofer, Franziska Lochmann, Vera Spanke, Klaus R. Liedl, Jakob Troppmair, Thierry Langer, Hubert Gstach, Christian Dank, Chris A. Mayhew, Sarah Kammerer, Veronika Ruzsanyi

“…For the first time, we identify an isotopically unlabelled CYP3A4 substrate, tolterodine that leads to the formation of a non-toxic volatile metabolite, acetone, which could potentially be applied to monitor CYP3A4 activity in humans. In vitro biotransformation of tolterodine by HepG2 cells overexpressing CYP3A4, CYP2D6 or CYP2C9 was investigated by LC-MS analysis of cell culture supernatant for the non-volatile metabolite, N-dealkylated tolterodine, and PTR-ToF-MS analysis of the headspace for acetone. …”
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Strategies for H-score Normalization of Preanalytical Technical Variables with Potential Utility to Immunohistochemical-Based Biomarker Quantitation in Therapeutic Reponse Diagnost... by William E. Pierceall, Michele Wolfe, Jessica Suschak, Hua Chang, Yan Chen, Kam M. Sprott, Jeffery L. Kutok, Stella Quan, David T. Weaver, Brian E. Ward

“…To examine the effects of preanalytical fixation variation on biomarker quantitation and potential utility of candidate calibrators to address such issues, 6 surgically-resected human breast cancer patient specimens were divided into 6 portions and fixed under distinct conditions (fixation following resection in formalin for 2 hr, 8 hr or 48 hr, or held overnight at 4°C in buffered saline prior to formalin fixation for 2 hr, 8 hr, or 48 hr). …”
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Evaluating cognitive bias in clinical ethics supports: a scoping review by Louise Giaume, Antoine Lamblin, Nathalie Pinol, Frédérique Gignoux-Froment, Marion Trousselard

“…Our main result first shows an overview of bias related to the working human environment and to information gathering that concerns different types of CES. …”
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Factors associated with unplanned readmissions for patients with mental and behavioural disorders in China: a quantitative analysis by Sha Lai, Zechen Wang, Chi Shen, Junfei Feng, Yawei Huang, Xiaolong Zhang, Li Lu, Zhongliang Zhou

“…Hospital factors such as facility type and size, human resources, and revenue size were associated with unplanned readmissions only in specific subgroups. …”
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Association of high complement and low immunoglobulins with the clinical symptoms of patients with fibromyalgia by Satoshi Izuno, Masako Hosoi, Kozo Anno, Takahiro A. Kato, Nobuyuki Sudo, Kazufumi Yoshihara

“…Although chronic inflammation has been implicated in the immunological abnormalities of FM, there are few human studies on complement and immunoglobulins. …”
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Developmental deficits, synapse and dendritic abnormalities in a Clcn4 KO autism mice model: endophenotypic target for ASD by Seong Mi Lee, Yura Choi, Dayeon Kim, Ha Jin Jeong, Young Ho Do, Sohee Jung, Bomee Lee, Hyung Jun Choi, Suhyeon Kim, Jung-Min Oh, Songhee Jeon, Jinju Han, Yeni Kim

“…Additionally, Sholl analysis revealed a reduction in dendritic branching and neuronal projection length in both mouse and human CLCN4 KD neurons. Finally, the decreased phosphorylation of SYNAPSIN and expression of PSD95 along with dendrite abnormalities were restored after Risperidone treatment. …”
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Efficient method for identification of Escherichia coli strains isolated from various chicken (Gallus gallus domesticus) organs by V. P. Terletskiy, V. I. Tyshchenko, O. B. Novikova, E. D. Dzhavadov, I. Ya. Shakhtamirov, N. L. Adaev

“…Tracing of transmission routes and identification of pathogen sources are important issues in preventive measures aimed at controlling human and animal infectious diseases. A fast and accurate method for bacterial strain identification (genotyping) allows scientifically sound planning of preventive schemes. …”
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Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms by Mie Suzuki Okutani, Shinya Okamura, Tang Gis, Hitomi Sasaki, Suni Lee, Akiho Kashiwabara, Simon Goto, Mai Matsumoto, Mayuko Yamawaki, Toshiaki Miyazaki, Tatsuya Nakagawa, Masahito Ikawa, Wataru Kamitani, Shiro Takekawa, Koichi Yamanishi, Hirotaka Ebina

“…Furthermore, we confirmed the safety of BK2102 using transgenic (Tg) mice expressing human ACE2 (hACE2) that are highly susceptible to SARS-CoV-2. …”
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Kombucha Versus Vegetal Cellulose for Affordable Mucoadhesive (nano)Formulations by Ioana Popa-Tudor, Naomi Tritean, Ștefan-Ovidiu Dima, Bogdan Trică, Marius Ghiurea, Anisoara Cimpean, Florin Oancea, Diana Constantinescu-Aruxandei

“…The cytocompatibility and in vitro antioxidant activity of the nanocellulose-based hydrogels were investigated using human gingival fibroblasts (HGF-1, ATCC CRL-2014). …”
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Musikalisches Zitat als kulturelle Assoziation. Die ästhetische Bedeutung des musikalischen Zitats in der koreanischen Musik des 20. und 21. Jahrhunderts by Hee Sook Oh

“…In this respect, the quotation technique which has been shown to embody not only culture and human, but also history and society, plays a significant role in reflecting the identity as a Korean composer.…”
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Coactivation of Tie2 and Wnt signaling using an antibody–R-spondin fusion potentiates therapeutic angiogenesis and vessel stabilization in hindlimb ischemia by Byungtae Hwang, Min-Young Jeon, Ju-Hong Jang, Young-Lai Cho, Dong Gwang Lee, Jeong-Ki Min, Jangwook Lee, Jong-Gil Park, Ji-Hun Noh, Wonjun Yang, Nam-Kyung Lee

“…We identified a Tie2-agonistic antibody T11 that cross-reacted with the extracellular domain of human and mouse Tie2, and evaluated its ability to increase endothelial cell survival and tube formation. …”
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