Relationship between inherited genetic variation and survival from colorectal cancer stratified by tumour location by Christopher Wills, Katie Watts, Amy Houseman, Timothy S. Maughan, David Fisher, Nada A. Al-Tassan, Richard S. Houlston, Valentina Escott-Price, Jeremy P. Cheadle

“…We investigated the relationship between Phosphatidylinositol 4-Kinase Type 2 Beta (PI4K2B) expression in colorectal tumours and survival in 597 patients from The Human Protein Atlas (THPA). We also analysed 3 SNPs previously associated with survival by anatomical site. …”
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Unaccountable counting: the folly of incorporating open ocean carbon sinks in Nationally Determined Contributions by Berger, Manon, Comte, Adrien, Kwiatkowski, Lester, Bopp, Laurent

“…However, it should be noted that this anthropogenic carbon uptake results from the physical and biogeochemical properties of water masses, rather than from human management practices. Additionally, the EEZ oceanic carbon sink is already considered in estimates of remaining carbon budgets to meet the goals of the Paris Agreement. …”
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Effect of afzelin on inflammation and lipogenesis in particulate matter-stimulated C. acnes-treated SZ95 sebocytes by Ji Yeon Hong, Yong Hee Choi, Yoon Jin Roh, Mi-Kyung Lee, Christos C. Zouboulis, Kui Young Park

“…However, its effects on the molecular aspects of inflammation and lipogenesis in SZ95 sebocytes has not been investigated.ObjectiveThis study aimed to (i) investigate inflammatory and sebum secretion changes when a Cutibacterium acnes-treated immortalized human sebocyte cell line (SZ95) is exposed to particulate matter (PM) and (ii) examine the effects of afzelin on these.MethodsTo investigate the effect of afzelin on PM- and C. acnes-treated SZ95 sebocytes, we injected heat-killed C. acnes into SZ95 cells to induce acne-like status. …”
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Mechanistic insights into Rho/MRTF inhibition-induced apoptotic events and prevention of drug resistance in melanoma: implications for the involvement of pirin by Bardees M. Foda, Bardees M. Foda, Annika E. Baker, Annika E. Baker, Annika E. Baker, Łukasz Joachimiak, Marzena Mazur, Richard R. Neubig, Richard R. Neubig, Richard R. Neubig

“…Upregulation of Rho/MRTF signaling in human and mouse melanomas causes resistance to targeted therapies. …”
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Assessment of ecological environment quality and their drivers in urban agglomeration based on a novel remote sensing ecological index by Fangyuan Lu, Chen Zhang, Haoyu Cao, Xibin Wang, Tong Zheng, Zhenfang Huang

“…This index comprehensively characterizes key environmental factors, including greenness, heat, wetness, air quality, and human activity. The NRSEI is then used to assess the Ecological Environmental Quality (EEQ) of the Yangtze River Delta Urban Agglomeration (YRDUA) over the period from 2012 to 2021. …”
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An optimized deep-forest algorithm using a modified differential evolution optimization algorithm: A case of host-pathogen protein-protein interaction prediction by Jerry Emmanuel, Itunuoluwa Isewon, Jelili Oyelade

“…The performance of the optimized deep forest model was evaluated on human-Plasmodium falciparum protein sequence datasets using 10-fold cross-validation. …”
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Exploring the role of spiritual leadership among nurse colleagues: an associative analysis of its impact on passion and altruism by Huda Gaber Hamzaa, Mohamed Hussein Ramadan Atta, Heba Mostafa Ali Taha, Mervat Amin Sayed, Asmaa Kamal Ahmed, Ahmed Abdellah Othman, Nadia Mohamed Ibrahim Wahba

“…Abstract Background Spiritual leadership emphasizes that nurses encounter situations that require compassion, empathy, and a deep understanding of the human experience. Passion can drive nurses' motivation, engagement, and commitment to patient care. …”
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In Vitro Susceptibility and Florfenicol Resistance in Citrobacter Isolates and Whole-Genome Analysis of Multidrug-Resistant Citrobacter freundii by Wangxiao Zhou, Qianqian Chen, Changrui Qian, Kai Shen, Xinyi Zhu, Danying Zhou, Wei Lu, Zhewei Sun, Hongmao Liu, Kewei Li, Teng Xu, Qiyu Bao, Junwan Lu

“…Sequencing and comparative analysis of the plasmids from a multidrug-resistant C. freundii isolate named R47 showed that the floR-containing region in the plasmid pR47-54 was a truncated transposon-like structure and could be found on both plasmids and chromosomes of bacteria of either animal or human origin. Furthermore, a range of antimicrobial and metal resistance genes associated with mobile genetic elements could be identified in pR47-54 and the other plasmid pR47-309 of C. freundii R47. …”
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Letter and Person Recognition in Freeform Air-Writing Using Machine Learning Algorithms by Huseyin Kunt, Zeki Yetgin, Furkan Gozukara, Turgay Celik

“…Air-writing is an emerging form of human-computer interaction that enables text entry through hand movements in the air. …”
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Transcriptional analysis of murine biliary atresia identifies macrophage heterogeneity and subset-specific macrophage functions by Kyle D. Gromer, Shang-Yang Chen, Gaurav Gadhvi, Liang Feng, Colin Shearn, Swati Antala, Swati Antala, Joshua B. Wechsler, Carla M. Cuda, Cara L. Mack, Ronald J. Sokol, William J. Janssen, Richard M. Green, Harris Perlman, Deborah R. Winter, Sarah A. Taylor, Sarah A. Taylor

“…Transcriptional similarities between murine BA and human cholestatic macrophages may enable translation of future mechanistic studies to new macrophage subset-specific therapies.…”
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Quantitative evaluation of essential amino acids and omega-3 long-chain polyunsaturated fatty acids from global marine bivalve aquaculture by Karsoon Tan, Peng Xu, Leiheng Huang, Cong Luo, KhaiHang Choong, Zexin Li, Yu Guo, Kit-Leong Cheong

“…The rapid growth of the human population and urbanization has significantly increased the demand for animal proteins. …”
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Predicting the Clinical Outcome of Triple-Negative Breast Cancer Based on the Gene Expression Characteristics of Necroptosis and Different Molecular Subtypes by Peng Luo, Zhaoqi Shi, Changshou He, Guojun Chen, Ji Feng, Linghua Zhu, Xiangyang Song

“…It helps to regulate different biological processes regarding human cancer. Nevertheless, studies that determine the impact of death on triple-negative breast cancer (TNBC) are scarce. …”
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Antibacterial Efficacy Comparison of Electrolytic and Reductive Silver Nanoparticles Against <i>Propionibacterium acnes</i> by Suparno Suparno, Rita Prasetyowati, Khafidh Nur Aziz, Anggarwati Rahma, Eka Sentia Ayu Lestari, Siti Chaerani Nabiilah, Deby Grace

“…<b>Background:</b> The aim of this study was to develop an electrolysis system to produce silver nanoparticles free from toxic gases, as the most common reduction and electrolysis techniques produce nitrogen dioxide (NO₂) as a byproduct, which is harmful to human health. The new electrolysis system used two identical silver plate electrodes, replacing silver and carbon rods, and used water as the electrolyte instead of silver nitrate (AgNO₃) solution since AgNO₃ is the source of NO₂. …”
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High and Low Taxa Specificity of Rhizosphere Bacteria Communities of Mangrove (Rhizophora mucronata) from Kuala Langsa and Telaga Tujuh Island, East Aceh by Siti Maysaroh, Meutia Samira Ismet, Rita Andini, Nurlita Anggraini, Beginer Subhan

“…This research examines sediment from rehabilitated and natural areas to understand how human and natural factors shape bacterial communities.The DNA sequence was analyzed using Next-Generation Sequencing (NGS), which targeted the 16S bacterial region in the V3-V4 rDNA. …”
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ARTIFICIAL INTELLIGENCE AS A METHODOLOGICAL INNOVATION IN THE TRAINING OF FUTURE DESIGNERS: MIDJOURNEY TOOLS by Ivan M. Tsidylo, Chele Esteve Sendra

“… Applications of artificial intelligence are used in almost all spheres of human activity. Their use in the educational process at all levels of education is no exception. …”
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Exposure to high-temperature and high-humidity environments associated with cardiovascular mortality by Yalan Wu, Xiangrong Feng, Jinmei Li, Mengjun Li, Yao Wang, Weihui Lu, Huanhuan Luo

“…These findings suggest that exacerbated dyslipidemia caused by long-term HTH environment exposure may be a key risk factor for CVD-related mortality in middle-aged and elderly individuals and suggest research directions into the effects of HTH environments on human health.…”
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High Virulence and Antifungal Resistance in Clinical Strains of Candida albicans by Eric Monroy-Pérez, Gloria Luz Paniagua-Contreras, Pamela Rodríguez-Purata, Felipe Vaca-Paniagua, Marco Vázquez-Villaseñor, Clara Díaz-Velásquez, Alina Uribe-García, Sergio Vaca

“…To study the expression of virulence and azole resistance genes in 39 clinical strains of C. albicans, we used a model of infection of human vaginal epithelial cells with C. albicans strains isolated from Mexican women with vulvovaginal candidiasis (VVC). …”
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Evaluation of the Antioxidant and Cytotoxic Activities on Cancer Cell Line of Extracts of Parasitic Plants Harvested in Tunisia by Imen Ben Attia, Paolo Zucca, Flaminia Cesare Marincola, Mariella Nieddu, Alessandra Piras, Antonella Rosa, Antonio Rescigno, Mohamed Chaieb

“…However, in certain areas of the world, they are consumed by humans as food, and they can represent a source of valuable active ingredients of ethnomedical interest. …”
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Polymorphism in the TRP8 gene in Kyrgyz population: putative association with highland adaptation by V. N. Babenko, Ж. Т. Isakova, E. T. Talaibekova, D. A. Asambaeva, V. F. Kobzev, T. A. Potapova, M. I. Voevoda, A. A. Aldashev

“…The human TRPM8 gene encodes a receptor mediating cold sensitivity, and this fact points to its putative role in cold adaptation. …”
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Adapting to change: exploring the distribution dynamics of the alien and potentially invasive aphid species Cinara curvipes (Hemiptera: Aphididae) in the context of global warming by K. Wieczorek, A. Bugaj-Nawrocka, B. Borowiak-Sobkowiak, A. Endrestøl, H. P. Ravn, W. Solarz, R. Durak

“…Unique survival mechanisms, including the production of numerous winged morphs under overcrowded conditions, enable rapid dispersal facilitated by human-mediated transport, notably through the “Christmas trees” trade. …”
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