Leaflet: Operative Steps for Interventional Studies in Neuroscience by Maria Meringolo, Sergio Delle Monache, Giuseppina Martella, Antonella Peppe

“…Clinical trials are designed to assess the effects of drugs on humans, focusing on determining safety profiles, appropriate modes of administration, and comparative efficacy against placebos. …”
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Tailoring and characterization of bioactive graft material for alveolar bone preservation and regeneration in fresh extraction sockets of dog model by Ayat Hamdy, Manal Saad, Rania ElBackly, Samir Nouh, Himanshu Jain, Mona Marei

“…Tailored amorphous multiporous bioactive glass (TAMP -BG) was prepared and characterized for bioactivity and response of human alveolar bone marrow mesenchymal stem cells (hABMSCs). …”
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The Effects of Alpha Interferon on the Development of Autoimmune Thyroiditis in the NOD H2h4 Mouse by Yael Oppenheim, Grace Kim, Yoshiyuki Ban, Pamela Unger, Erlinda Concepcion, Takao Ando, Yaron Tomer

“…Alternatively, it is possible that αIFN did not induce thyroiditis in mice because, unlike in humans, in mice αIFN does not induce Th1 switching.…”
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Extracellular vesicles-derived miR-21 as a biomarker for early diagnosis and tumor activity in breast cancer subtypes by Claudia Omarini, Virginia Catani, Ilenia Mastrolia, Angela Toss, Federico Banchelli, Chrystel Isca, Daniele Medici, Ornella Ponzoni, Marco Brucale, Francesco Valle, Maria Cristina Baschieri, Roberto D’Amico, Valentina Masciale, Chiara Chiavelli, Federica Caggia, Carlo Augusto Bortolotti, Federico Piacentini, Massimo Dominici

“…The levels of miR-21 were higher in the MBC group than in the HD group (p = 0.029), mainly in those who were human epidermal growth factor receptor 2 (HER2)+ (p = 0.0005) and hormone receptor-positive (p = 0.036). …”
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An investigator-blinded, 24-month, parallel-group, non-inferiority study to compare aesthetic restorations in primary anterior teeth in a paediatric dental clinic: study protocol f... by Ana Paula Taboada Sobral, Elaine Marcilio Santos, Marcela Leticia Leal Gonçalves, Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Sandra Kalil Bussadori, Elza Padilha Ferri, Juliana Maria Altavista Sagretti Gallo, Thais Gimenez, José Carlos Pettorossi Imparato

“…Secondary outcomes will include tooth survival, longevity of restoration, quality of life, perception and satisfaction of the participants’ parents/guardians.Ethics and dissemination This protocol has been approved by the Human Research Ethics Committee of Universidade Metropolitana de Santos (protocol number: 6.019.297. …”
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Characteristics and Sources of Organic Aerosol Markers in PM2.5 by Zheng Li, Ruiwen Zhou, Yuanyuan Li, Min Chen, Yachen Wang, Tonglin Huang, Yanan Yi, Zhanfang Hou, Jingjing Meng, Li Yan

“…These results confirmed that biomass burning can significantly influence the concentrations and chemical compositions of OAs, thereby they can affect human health and atmospheric chemistry.…”
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A novel agricultural drought index based on multi-source remote sensing data and interpretable machine learning by Hao Chen, Ni Yang, Xuanhua Song, Chunhua Lu, Menglan Lu, Tan Chen, Shulin Deng

“…Drought is a frequent, destructive, and complex natural hazard, and seriously threatens eco-environment, socio-economy, and the health of human. Previous studies suggested that integrated multi-source remote sensing drought indices have the potential to comprehensively monitor drought conditions, however most existing integrated drought indices still have several limitations. …”
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MiR-25-3p regulates pulmonary arteriovenous malformation after Glenn procedure in patients with univentricular heart via the PHLPP2-HIF-1α axis by Junpei Kawamura, Munekazu Yamakuchi, Kentaro Ueno, Teruto Hashiguchi, Yasuhiro Okamoto

“…In addition, we investigated the tube formation, migration, and proliferation of human lung microvascular endothelial cells (HMVEC-L) transfected with miR-25-3p mimic, miR-25-3p inhibitor, or PHLPP2 small interfering RNA, and examined HIF-1α/VEGF-A signaling after hypoxic stimulation. …”
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Aberrant methylation of placental development genes in chorionic villi of spontaneous abortions with trisomy 16 by О. Yu. Vasilyeva, E. N. Tolmacheva, A. E. Dmitriev, Ya. A. Darkova, E. A. Sazhenova, T. V. Nikitina, I. N. Lebedev, S. A. Vasilyev

“…In humans, aneuploidy is incompatible with the birth of healthy children and mainly leads to the death of embryos in the early stages of development in the first trimester of pregnancy. …”
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The Development and Content of Movement Quality Assessments in Athletic Populations: A Systematic Review and Multilevel Meta-Analysis by Gyan A. Wijekulasuriya, Carl T. Woods, Aden Kittel, Paul Larkin

“…Abstract Background Despite their prominence in the sport and human movement sciences, to date, there is no systematic insight about the development and content of movement quality assessments in athletic populations. …”
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Clinical and Functional Characteristics of a Novel KLF11 Cys354Phe Variant Involved in Maturity-Onset Diabetes of the Young by Yujing Sun, Jingru Qu, Jing Wang, Ruxing Zhao, Chuan Wang, Li Chen, Xinguo Hou

“…Background. Mutations in human KLF11 may lead to the development of maturity-onset diabetes of the young 7 (MODY7). …”
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Study on the Application of a Photocatalytic Titanium Dioxide Coating on Glass Beads for the Treatment of Perfluorooctane Sulfonic Acid by Dao Duy Nam, Cao Thi Hong Hanh, Nghiem Minh Huyen, Dieu-Anh Van, Ha Vinh Hung, Vu Minh Trang, Vu Quang Minh, Nguyen Bich Ngoc, Vu Thi Thu Ha, Huynh Trung Hai

“…Perfluorooctanesulfonic (PFOS) acid is a persistent anthropogenic organic fluorinated compound ubiquitous in industrial applications and is resistant to conventional wastewater treatment methods. Human exposure to PFOS can cause adverse health effects. …”
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Exploring the efficacy of drought tolerant, IAA-producing plant growth-promoting rhizobacteria for sustainable agriculture by Malika Uzma, Atif Nisar, Atia Iqbal, Shahida Hasnain, Mohamed H. Mahmoud, Muhammad Abdul Rahim, Tehseen Gull, Roberto Castro-Muñoz, Eliasse Zongo

“…The growing human population and abiotic stresses pose significant threats to food security, with PGPR favorable as biofertilizers for plant growth and stress relief. …”
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Molecular determinants of Neu5Ac binding to a tripartite ATP independent periplasmic (TRAP) transporter by Parveen Goyal, KanagaVijayan Dhanabalan, Mariafrancesca Scalise, Rosmarie Friemann, Cesare Indiveri, Renwick CJ Dobson, Kutti R Vinothkumar, Subramanian Ramaswamy

“…N -Acetylneuraminic acid (Neu5Ac) is a negatively charged nine-carbon amino sugar that is often the peripheral sugar in human cell-surface glycoconjugates. Some bacteria scavenge, import, and metabolize Neu5Ac or redeploy it on their cell surfaces for immune evasion. …”
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Differentiating False Loss of Resistance from True Loss of Resistance While Performing the Epidural Block with the CompuFlo® Epidural Instrument by Pasquale Vaira, Michela Camorcia, Tiziana Palladino, Matteo Velardo, Giorgio Capogna

“…A CompuFlo® epidural instrument has been introduced to measure the pressure of human tissues in real time at the orifice of a needle and has been used as a tool to identify the epidural space. …”
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Mf-net: multi-feature fusion network based on two-stream extraction and multi-scale enhancement for face forgery detection by Hanxian Duan, Qian Jiang, Xin Jin, Michal Wozniak, Yi Zhao, Liwen Wu, Shaowen Yao, Wei Zhou

“…Abstract Due to the increasing sophistication of face forgery techniques, the images generated are becoming more and more realistic and difficult for human eyes to distinguish. These face forgery techniques can cause problems such as fraud and social engineering attacks in facial recognition and identity verification areas. …”
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Enhanced quantitative precipitation estimation through the opportunistic use of Ku TV-SAT links via a dual-channel procedure by L. Gelbart, L. Barthès, F. Mercier-Tigrine, A. Chazottes, C. Mallet

“…This technique provides rain measurements at a fine temporal resolution (a few tens of seconds) and with a spatial resolution of a few kilometres, which is a good compromise for human activities such as civil security (watershed monitoring, flash flood), agriculture or transport. …”
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Generation of microdissected DNA probes from metaphase chromosomes when chromosome identification by routine staining is impossible by K. S. Zadesenets, N. B. Rubtsov

“…Application of microdissected DNA libraries and DNA probes in numerous and various modern molecular cytogenetic studies showed them as an efficient and reliable tool in the analysis of chromosome reorganization during karyotypic evolution and in the diagnosis of human chromosome pathology. An important advantage of DNA probe generation by metaphase chromosome microdissection followed by sequence-independent polymerase chain reaction in comparison with the method of DNA probe generation using chromosome sorting is the possibility of DNA probe preparation from chromosomes of an individual sample without cell line establishment for the production of a large number of metaphase chromosomes. …”
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Addressing challenges in vector control: a review of current strategies and the imperative for novel tools in India’s combat against vector-borne diseases by Kuldeep Singh, Amit Sharma, Manju Rahi, Sanjeev Kumar Gupta, Gaurav Kumar, Rajendra Baharia, Sam Joy

“…The promising new vector control tools are insecticide-treated nets with synergist and/or pyrrole chlorfenapyr, alternatives/additions to synthetic pyrethroids like neonicotinoids, clothianidin for indoor residual spray, newer formulations such as Bacillus sphaericus for use in larvicides, attractive toxic sugar baits, especially to curtail outdoor transmission, endectocides like ivermectin for use in animals/humans, insecticidal paints, spatial repellents, insecticide-treated wearables and others. …”
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Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity by Dafei Chai, Junhao Wang, Jing Ming Lim, Xiaohui Xie, Xinfang Yu, Dan Zhao, Perry Ayn Mayson Maza, Yifei Wang, Dana Cyril-Remirez, Ken H. Young, Yong Li

“…Additionally, LNP-M effectively delivered DNA-encoded antigens, such as mouse PD-L1 and p53R172H, or monoclonal antibodies targeting mouse PD1 and human p53R282W. This approach inhibited tumor growth or metastasis in several mouse models. …”
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