Multiple air pollutants exposure and leukaemia incidence in Tehran, Iran from 2010 to 2016: a retrospective cohort study by Narges Khanjani, Nino Künzli, Zahra Khorrami, Mohsen Pourkhosravani, Marzieh Eslahi, Maysam Rezapour, Mohammad Esmail Akbari, Heresh Amini, Seyed Mahmood Taghavi-Shahri, Koorosh Etemad

“…This study warrants conducting further research with individual human data and better control of confounding.…”
Get full text

Develop Reusable Carbon Sub‐Micrometer Composites with Record‐High Cd(II) Removal Capacity by Mengke Cui, Huiting Jiao, Shijie Yuan, Bin Dong, Zuxin Xu

“…Abstract Cd(II)‐induced pollution across diverse water bodies severely threatens ecosystems and human health. Nevertheless, achieving ultra‐efficient and cost‐effective treatment of trace amounts of heavy metals remains a major challenge. …”
Get full text

APBIO: bioactive profiling of air pollutants through inferred bioactivity signatures and prediction of novel target interactions by Eva Viesi, Ugo Perricone, Patrick Aloy, Rosalba Giugno

“…The proposed chemogenomic methodology enables the prediction of novel CTIs for known or similar compounds and targets through well-established and efficient ML models, deepening our insight into the molecular interactions and mechanisms that may have a deleterious impact on human biological systems.…”
Get full text

Epigallocatechin gallate (EGCG) modulates senescent endothelial cell-monocyte communication in age-related vascular inflammation by Sarvatit Patel, Kai Ellis, Kai Ellis, Corey A. Scipione, Jason E. Fish, Jason E. Fish, Jason E. Fish, Jason E. Fish, Kathryn L. Howe, Kathryn L. Howe, Kathryn L. Howe, Kathryn L. Howe, Kathryn L. Howe

“…This study determined how senescent ECs communicate with monocytes, whether extracellular vesicles (EVs) released from senescent ECs affect monocyte functions, and investigated the potential for epigallocatechin-3-gallate (EGCG), a flavonoid in green tea, to reverse these effects. Human umbilical vein endothelial cells (HUVECs) were treated with Etoposide (10 µM, 24 h) to induce senescence, followed by EGCG (100 µM, 24 h) treatment to evaluate its potential as a senotherapeutic agent. …”
Get full text

Particulate Pollution in Korhogo and Abidjan (Cote d’Ivoire) during the Dry Season by Sylvain Gnamien, Véronique Yoboué, Cathy Liousse, Money Ossohou, Sékou Keita, Julien Bahino, Silué Siélé, Lamine Diaby

“…Abstract Particulate pollution in West African cities seriously impacts public human health. Assessing the levels of pollution to which populations are exposed is problematic, as to date very few countries in Africa have an air quality monitoring network in place. …”
Get full text

Unraveling the spatiotemporal trends and source attribution of polycyclic aromatic hydrocarbons and oxygenated derivatives in Guangzhou agricultural ditch sediment by Shaomin Li, Weisong Chen, Yichen Liu, Haoyu Wang, Yongtao Li, Zhen Zhang, Xingjian Yang

“…Spatially, Pearson correlation and path analysis disclosed a linkage between OPAHs and high-molecular-weight PAHs and adjacent agricultural practices, whereas low-molecular-weight PAHs were associated with human and industrial operations. This disparity was linked to the restricted mobility of high-molecular-weight PAHs, rendering them particularly susceptible to proximal sources. …”
Get full text

Geological disaster risk assessment based on ecological niche model: A case study of Longhui County, Shaoyang City by Yun ZHANG, Feng ZI, Jiehua GUO, Yunjiang CAO, Jiuling DUAN, Zhigang GUO, Long TANG

“…The study considered various disaster-inducing factors and selected 13 assessment criteria from topography and geomorphology, geological structure, engineering geology of geotechnical bodies, and human engineering activities. The MaxEnt model is employed to establish the geological disaster hazard assessment model, while 7 assessment factors are selected from population distribution, economic background, environmental resources development, disaster prevention, and mitigation capacity. …”
Get full text

Extraction, Chemical Composition and Antidiabetic Potential of Crude Polysaccharides from Centella asiatica (L.) Urban by Meng Li, Muhammad Shahid, Xiaobin Zhang, Douglas Law, Mukram Muhammad Mackeen, Arnida Hani Teh, Ahmad Abdul Kareem Najm, Shazrul Fazry, Babul Airianah Othman

“…The global prevalence of diabetes mellitus (DM) is escalating, posing a significant challenge to human healthcare systems. In the present study, mineral and monosaccharide compositions, and antidiabetic potential of polysaccharide fractions separated from Centella asiatica (L.) leaves (CAL) were assessed. …”
Get full text

Exposure to perchlorate via drinking water from eight major water basins in China and its health risks across different age groups by Jia Lyu, Yongyan Chen, Lan Zhang, Xu Yan, Muyesaier Tudi

“…Considering the endocrine-disrupting properties of perchlorate, the possibility of perchlorate exposure to humans through drinking water has become a public health concern. …”
Get full text

Downregulation of TNF-α/TNF-R1 Signals by AT-Lipoxin A4 May Be a Significant Mechanism of Attenuation in SAP-Associated Lung Injury by Suhui Yu, Jianming Xie, Yukai Xiang, Shengjie Dai, Dinglai Yu, Hongwei Sun, Bicheng Chen, Mengtao Zhou

“…In vitro, we found that AT-Lipoxin A4 markedly suppressed protein expression in TNF-α signals in human pulmonary microvascular endothelial cell, such as tumor necrosis factor receptor-associated factor 2 (TRAF2), TNF-R1-associated death domain (TRADD), receptor-interacting protein (RIP), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin. …”
Get full text

Cytotoxic Constituents from the Rhizomes of Curcuma zedoaria by Omer Abdalla Ahmed Hamdi, Syarifah Nur Syed Abdul Rahman, Khalijah Awang, Norhanom Abdul Wahab, Chung Yeng Looi, Noel Francis Thomas, Sri Nurestri Abd Malek

“…The cytotoxic activity of hexane, dichloromethane, ethyl acetate, methanol, and the methanol-soxhlet extracts of Curcuma zedoaria rhizomes was tested on two human cancer cell lines (Ca Ski and MCF-7) and a noncancer cell line (HUVEC) using MTT assay. …”
Get full text

Characterization and Pharmacological Efficacy of Silver Nanoparticles Biosynthesized Using the Bark Extract of Garcinia Kola by Sunday Adewale Akintelu, Seyifunmi Charles Olugbeko, Femi Adekunle Folorunso, Abel Kolawole Oyebamiji, Aderonke Similoluwa Folorunso

“…The delinquent peril of bacterial infections affecting human kind is becoming unbearable. This study was embarked on to investigate the antimicrobial activity of biosynthesized silver nanoparticles (AgNPs) using Garcinia kola bark extract against some bacteria strains. …”
Get full text

The Effects of Tormentic Acid and Extracts from Callistemon citrinus on Candida albicans and Candida tropicalis Growth and Inhibition of Ergosterol Biosynthesis in Candida albicans by Chido Bvumbi, Godloves Fru Chi, Marc Y. Stevens, Molly Mombeshora, Stanley Mukanganyama

“…Candida albicans and Candida tropicalis are the leading causes of human fungal infections worldwide. There is an increase in resistance of Candida pathogens to existing antifungal drugs leading to a need to find new sources of antifungal agents. …”
Get full text

Expression Profile of Genes Potentially Associated with Adequate Glycemic Control in Patients with Type 2 Diabetes Mellitus by Sâmia Cruz Tfaile Corbi, Alliny Souza Bastos, Rafael Nepomuceno, Thamiris Cirelli, Raquel Alves dos Santos, Catarina Satie Takahashi, Cristiane S. Rocha, Silvana Regina Perez Orrico, Claudia V. Maurer-Morelli, Raquel Mantuaneli Scarel-Caminaga

“…In order to identify potential genes related to poorly/well-controlled patients with T2D, our strategy of investigation included a primary screen by microarray (Human Genome U133) in a small group of individuals followed by an independent validation in a greater group using RT-qPCR. …”
Get full text

Spatial Variability of Metals in Surface Water and Sediment in the Langat River and Geochemical Factors That Influence Their Water-Sediment Interactions by Wan Ying Lim, Ahmad Zaharin Aris, Mohamad Pauzi Zakaria

“…These results are important when making crucial decisions in determining potential hazardous levels of these metals toward humans.…”
Get full text

Novel candidate genes and genetic basis analysis of kernel starch content in tropical maize by Xiaoping Yang, Ranjan K. Shaw, Linzhuo Li, Fuyan Jiang, Xingming Fan

“…Abstract Background Starch is the most abundant carbohydrate in maize grains, serving as a primary energy source for both humans and animals, and playing a crucial role in various industrial applications. …”
Get full text

Influence of flavonoids’ lipophilicity on platelet aggregation by Babić Ivana, Bojić Mirza, Maleš Željan, Zadro Renata, Gojčeta Koraljka, Duka Ivan, Rimac Hrvoje, Jukić Irena

“…Flavonoids are natural polyphenolic compounds present in a wide spectrum of plants that have a beneficial effect on human health. In the context of cardiovascular diseases related to plaque and thrombus formation, flavonoids exhibit an anti-aggregatory effect. …”
Get full text

Exploring the Decision-making Process of Medical Students’ on Choosing Radiology as a Specialty in Northern Saudi Arabia: A Cross-sectional Study by Pakeeza Shafiq

“…Introduction: Radiology is an important medical field that provides non invasive insights into the human body. However, the decision-making process regarding speciality choice among medical students is influenced by various personal, educational and societal factors. …”
Get full text

Evaluation of Siemens Healthineers’ StrokeSegApp for automated diffusion and perfusion lesion segmentation in patients with ischemic stroke by Lynnet-Samuel J. Teichmann, Ahmed A. Khalil, Kersten Villringer, Jochen B. Fiebach, Stefan Huwer, Eli Gibson, Ivana Galinovic

“…Out of 56 subjects meeting DEFUSE 2/3 criteria in the cohort, it correctly identified mechanical thrombectomy candidates with a sensitivity of 82.1% (95% CI: 63.1–93.9%) and a specificity of 96.4% (95% CI: 81.7–99.9%).ConclusionThe Siemens Healthineers’ StrokeSegApp provides accurate automated segmentation of ischemic stroke lesions, comparable to human experts as well as similar commercial software, and shows potential as a reliable tool in clinical decision-making for stroke treatment.…”
Get full text

Modulation of the high concentration viscosity of IgG1 antibodies using clinically validated Fc mutations by Joel Heisler, Daniel Kovner, Saeed Izadi, Jonathan Zarzar, Paul J. Carter

“…Here, we studied the effect of a panel of common and clinically validated Fc mutations on the viscosity of two closely related humanized IgG1, κ antibodies, omalizumab (anti-IgE) and trastuzumab (anti-HER2). …”
Get full text