Bone Formation by Sheep Stem Cells in an Ectopic Mouse Model: Comparison of Adipose and Bone Marrow Derived Cells and Identification of Donor-Derived Bone by Antibody Staining by Kristian Kjærgaard, Chris H. Dreyer, Nicholas Ditzel, Christina M. Andreasen, Li Chen, Søren P. Sheikh, Søren Overgaard, Ming Ding

“…Origin of new bone was assessed using human vimentin (HVIM) antibody staining. Results. …”
Get full text

Physicochemical Properties and Bioreactivity of Sub‐10 μm Geogenic Particles: Comparison of Volcanic Ash and Desert Dust by Ines Tomašek, Julia Eychenne, David E. Damby, Adrian J. Hornby, Manolis N. Romanias, Severine Moune, Gaëlle Uzu, Federica Schiavi, Maeva Dole, Emmanuel Gardès, Mickael Laumonier, Clara Gorce, Régine Minet‐Quinard, Julie Durif, Corinne Belville, Ousmane Traoré, Loïc Blanchon, Vincent Sapin

“…We assessed cellular responses (cytotoxic and pro‐inflammatory effects) to acute particle exposures (24 hr) in monocultures at the air‐liquid interface using two types of cells of the human airways: BEAS‐2B bronchial epithelial cells and A549 alveolar type II epithelial cells. …”
Get full text

Spatial and Temporal Variability of Extreme Hydroclimatic Events in the Bani River Basin by Fousseini Kouyaté, François Kossi Guédjé, Assane Ndiaye, Orou Moctar Ganni Mampo

“…Severe hydroclimatic events affect ecosystems and human livelihoods, creating significant challenges for managing water resources. …”
Get full text

Development and characterization of orthotopic patient-derived xenograft models of peritoneal metastatic mucinous appendiceal adenocarcinoma by I. Ito, V.K. Pattalachinti, A.M.G. Yousef, S. Chowdhury, M.M. Fanaeian, E. Haque, B.B. Gunes, M. Yousef, E.R. Salle, M.A. Zeineddine, S. Ji, R. Li, W. Wang, B.A. Helmink, M.W. Taggart, M.G. White, K.F. Fournier, N.W. Fowlkes, J.P. Shen

“…Comparison of histological, immunohistochemical, and molecular analyses including both RNA and DNA sequencing revealed that the PDX models recreate many of the features of metastatic AAs, but also displayed several differences between paired PDX and human tumors, highlighting the intratumoral heterogeneity of AAs within each patient. …”
Get full text

Induced mesenchymal stem cells generated from periodontal ligament fibroblast for regenerative therapy by Hemanathan Vembuli, Sheeja Rajasingh, Patrick Nabholz, Jefferson Guenther, Brian R. Morrow, Margaret M. Taylor, Marziyeh Aghazadeh, Vinoth Sigamani, Johnson Rajasingh, Johnson Rajasingh, Johnson Rajasingh

“…In this study, we generated induced pluripotent stem cells (iPSCs) using a safe, nonviral and mRNA-based approach from human periodontal ligament fibroblasts (PDLF), an easily accessible cell source. …”
Get full text

Bacterial community assembly of specific pathogen-free neonatal mice by Elizabeth A. Kennedy, James S. Weagley, Andrew H. Kim, Avan Antia, Anna L. DeVeaux, Megan T. Baldridge

“…Abstract Background Neonatal mice are frequently used to model diseases that affect human infants. Microbial community composition has been shown to impact disease progression in these models. …”
Get full text

Evaluation of the Antitumor Effects of Platinum-Based [Pt(η1-C2H4-OR)(DMSO)(phen)]+ (R = Me, Et) Cationic Organometallic Complexes on Chemoresistant Pancreatic Cancer Cell Lines... by Erika Stefàno, Luca Giulio Cossa, Federica De Castro, Erik De Luca, Viviana Vergaro, Giulia My, Gianluca Rovito, Danilo Migoni, Antonella Muscella, Santo Marsigliante, Michele Benedetti, Francesco Paolo Fanizzi

“…In this work, we evaluated the antiproliferative and antimigratory activities of the two organometallic compounds, [Pt(η1-C2H4-OMe)(DMSO)(phen)]Cl (1) and [Pt(η1-C2H4-OEt)(DMSO)(phen)]Cl (2), on three human pancreatic ductal adenocarcinoma cell lines with different sensitivity to cisplatin (Mia PaCa-2, PANC-1, and YAPC). …”
Get full text

Identification of as a Susceptibility Locus for Kawasaki Disease in Patients Younger than 6 Months of Age by Hea-Ji Kim, Sin Weon Yun, Jeong Jin Yu, Kyung Lim Yoon, Kyung-Yil Lee, Hong-Ryang Kil, Gi Beom Kim, Myung-Ki Han, Min Seob Song, Hyoung Doo Lee, Kee Soo Ha, Sejung Sohn, Ryota Ebata, Hiromichi Hamada, Hiroyuki Suzuki, Yoichiro Kamatani, Michiaki Kubo, Kaoru Ito, Yoshihiro Onouchi, Young Mi Hong, Gi Young Jang, Jong-Keuk Lee

“…We performed an age-stratified genome-wide association study using the Illumina HumanOmni1-Quad BeadChip data (296 cases vs. 1,000 controls) and a replication study (1,360 cases vs. 3,553 controls) in the Korean population. …”
Get full text

Efficacy of unified protocol for transdiagnostic treatment of emotional disorders in adolescents (UP-A) in China: protocol for a randomised controlled trial by Xue Gao, Lu Liu, Mei-Rong Pan, Hai-Mei Li, Yu-Feng Wang, Xue-Ying Liu, Zhong-Fang Fu, Qiujin Qian

“…The findings may contribute to providing an effective and feasible transdiagnostic intervention in Chinese clinical settings.Ethics and dissemination This trial has been approved by the Ethics and Clinical Research Committees of Peking University Sixth Hospital and will be performed under the Declaration of Helsinki with the Medical Research Involving Human Subjects Act (WMO). The results will be disseminated in a peer-reviewed journal and a conference presentation.Trial registration number ChiCTR2300069354.…”
Get full text

PTOV1 exerts pro-oncogenic role in colorectal cancer by modulating SQSTM1-mediated autophagic degradation of p53 by Yongli Fan, Yuqin Li, Xia Luo, Shiqi Xiang, Jia Hu, Jingchun Zhan, Weilong Chang, Rui Deng, Xianwen Ran, Yize Zhang, Yudie Cai, Weiwei Zhu, Huifen Wang, Zhibo Liu, Di Wang

“…Results Here, we revealed that PTOV1 was highly expressed in human CRC tissues, especially at advanced stages, and associated with reduced survival time among CRC patients. …”
Get full text

Subseasonal Prediction of Heat‐Related Mortality in Switzerland by Maria Pyrina, Ana M. Vicedo‐Cabrera, Dominik Büeler, Sidharth Sivaraj, Christoph Spirig, Daniela I. V. Domeisen

“…Abstract Heatwaves pose a range of severe impacts on human health, including an increase in premature mortality. …”
Get full text

Seroprevalence and Risk Factors of Toxoplasma gondii Infection among Domestic Ruminants in East Hararghe Zone of Oromia Region, Ethiopia by Berhanu Tilahun, Yacob Hailu Tolossa, Getachew Tilahun, Hagos Ashenafi, Shihun Shimelis

“…In conclusion, T. gondii infection is common and widespread among the domestic ruminants of the study area, indicating the potential transmission to humans from these animals when they are used as a source of food. …”
Get full text

GWAS of a soybean breeding collection from South East and South Kazakhstan for resistance to fungal diseases by A. Zatybekov, S. Abugalieva, S. Didorenko, A. Rsaliyev, Y. Turuspekov

“…In Kazakhstan the area under soybean is increasing every year, helping to solve the problem of protein deficiency in human nutrition and animal feeding. One of the main problems of soybean production is fungal diseases causing yields losses of up to 30 %. …”
Get full text

VisGraphVar: A benchmark generator for Assessing Variability in Graph Analysis Using Large Vision-Language Models by Camilo Chacon Sartori, Christian Blum, Filippo Bistaffa

“…Geometric structures, particularly graphs with their inherent flexibility and complexity, serve as an excellent benchmark for evaluating these models’ predictive capabilities. While human observers can readily identify subtle visual details and perform accurate analyses, our investigation reveals that state-of-the-art LVLMs exhibit consistent limitations in specific visual graph scenarios, especially when confronted with stylistic variations. …”
Get full text

Hepatoprotective potential of Tamarindus indica following prenatal aluminum exposure in Wistar rat pups by Helen Ruth Yusuf a , Sunday Abraham Musa a , Abel Nosereme Agbon , Ejike Daniel Eze , Akeem Ayodeji Okesina , Ismail Onanuga , Theophilus Pius , Victor Archibong , Mario Edgar Fernandez Diaz , Juma John Ochieng , Nicholas Kusiima , Bot Yakubu Sunday , Ibe Michael Usman

“…Over time, the use of plant-derived agents in the management of various human health conditions has gained a lot of attention. …”
Get full text

Normative Database of Spatiotemporal Gait Metrics Across Age Groups: An Observational Case–Control Study by Lianne Mobbs, Vinuja Fernando, R. Dineth Fonseka, Pragadesh Natarajan, Monish Maharaj, Ralph J. Mobbs

“…Introduction: Gait analysis is a vital tool in the assessment of human movement and has been widely used in clinical settings to identify potential abnormalities in individuals. …”
Get full text

Editorial by Jörg Tremmel, Edward Page, Konrad Ott

“…Combined with other inertias integral to the climate system, the bulk of the expected harm to humans from climate change will be felt by future generations…”
Get full text

Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition by Antonino Glaviano, Hannah Si-Hui Lau, Lukas M. Carter, E. Hui Clarissa Lee, Hiu Yan Lam, Elena Okina, Donavan Jia Jie Tan, Wency Tan, Hui Li Ang, Daniela Carbone, Michelle Yi-Hui Yee, Muthu K. Shanmugam, Xiao Zi Huang, Gautam Sethi, Tuan Zea Tan, Lina H. K. Lim, Ruby Yun-Ju Huang, Hendrik Ungefroren, Elisa Giovannetti, Dean G. Tang, Tullia C. Bruno, Peng Luo, Mads Hald Andersen, Bin-Zhi Qian, Jun Ishihara, Derek C. Radisky, Salem Elias, Saurabh Yadav, Minah Kim, Caroline Robert, Patrizia Diana, Kurt A. Schalper, Tao Shi, Taha Merghoub, Simone Krebs, Anjali P. Kusumbe, Matthew S. Davids, Jennifer R. Brown, Alan Prem Kumar

Get full text

Evaluation of Urban Composite Carbon Sink Value: A Case Study of Shenyang by Tiemao SHI, Di WANG, Yu TANG, Peiying LI

“…This is because human activities such as urban construction, transportation, and industrial production can have both positive and negative impacts on carbon sink. …”
Get full text

Navigating healthcare pathways: Cascade of prevention and care for chronic viral hepatitis in asylum seekers and refugees. A multicenter analysis in Northern Italy by Beatrice Formenti, Roberto Benoni, Jacopo Testa, Giulia Bertoli, Giacomo Stroffolini, Maria Grazia Pizzi, Barbara Menzaghi, Niccolò Ronzoni, Paola Magro, Issa El Hamad, Carla Scolari, Angiola Spinetti, Serena Zaltron, Francesco Castelli, Valentina Marchese, Alberto Matteelli

Get full text