655Val and 1170Pro ERBB2 SNPs in Familial Breast Cancer Risk and BRCA1 Alterations by Stefania Tommasi, Vita Fedele, Rosanna Lacalamita, Michele Bruno, Francesco Schittulli, David Ginzinger, Gery Scott, Serenella Eppenberger-Castori, Daniele Calistri, Silvia Casadei, Ian Seymour, Salvatore Longo, Gianluigi Giannelli, Brunella Pilato, Giovanni Simone, Christopher C. Benz, Angelo Paradiso

“…Human ERBB2 presents several SNPs. One of these, Ile655Val, introduces a structural change in the transmembrane region of ERBB2 and has been the focus of debate over its potential role as a susceptibility marker for breast cancer risk. …”
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Secretory phospholipase A2 inhibitory activity in Tragia hispida: A novel and promising therapeutic agent for dengue fever by D.V. Dayangi Hemalika, U.G. Chandrika, Ajita M. Abeysekera, Sameera R. Samarakoon, Ananda Wijewickrama, Gathsaurie Neelika Malavige

“…Furthermore, THB exhibited significant inhibition of sPLA2 activity in human serum from dengue patients (n = 31, p < 0.0001) than that exhibited by CAY 10590. …”
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Results of a modified Delphi consensus on the optimal testing pathway for oesophago-gastric cancer care in the UK by Philippe Taniere, Manuel Rodriguez-Justo, Naureen Starling, Wasat Mansoor, Thomas Bird, Martin Eatock

“…Given the level of agreement and that the stopping criteria were met, it was decided not to undertake further Delphi rounds.Conclusion The recommendations support the use of a reflex testing approach for human epidermal growth factor receptor 2, programmed death ligand 1 and microsatellite instability high/mismatch repair deficiency in patients diagnosed with OG cancer who are suitable for treatment with targeted therapy.…”
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Effect of Kinases in Extracellular Vesicles from HIV-1-Infected Cells on Bystander Cells by Gifty A. Mensah, Anastasia Williams, Pooja Khatkar, Yuriy Kim, James Erickson, Alexandra Duverger, Heather Branscome, Kajal Patil, Hafsa Chaudhry, Yuntao Wu, Olaf Kutsch, Fatah Kashanchi

“…As of 2023, there were 39.9 million people living with Human Immunodeficiency Virus type 1 (HIV-1). Although great strides have been made in treatment options for HIV-1, and our understanding of the HIV-1 life cycle has vastly improved since the start of this global health crisis, a functional cure remains elusive. …”
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Clinicopathological characteristics and long-term prognosis of triple-negative breast cancer patients with HER2-Low expression: a retrospective propensity score-matched cohort stud... by Xin Liu, Kaihua Zhao, Ziyan Zhang, Meiyan Liu, Hongwu Chu, Xiao Zou

“…Abstract Purpose The objective of the current research was to assess the clinicopathological characteristics and long-term prognosis of triple-negative breast cancer (TNBC) patients with human epidermal growth factor receptor 2 (HER2)-low status following breast surgery. …”
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Clinical Characteristics and Short-Term Outcomes of HIV Patients Admitted to an African Intensive Care Unit by Arthur Kwizera, Mary Nabukenya, Agaba Peter, Lameck Semogerere, Emmanuel Ayebale, Catherine Katabira, Samuel Kizito, Cecilia Nantume, Ian Clarke, Jane Nakibuuka

“…In high-income countries, improved survival has been documented among intensive care unit (ICU) patients infected with human immune deficiency virus (HIV). There are no data from low-income country ICUs. …”
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Interleukin-6 related signaling pathways as the intersection between chronic diseases and sepsis by Jie Yang, Lin Yang, Yanjiao Wang, Lu Huai, Bohan Shi, Di Zhang, Wei Xu, Di Cui

“…This article summarized the inflammatory mechanisms of IL-6 cross-talked with other mediators of some chronic diseases in vitro, animal models, and human experiments, leading to the activation of pathways and accelerating the progression of sepsis. …”
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Projecting Surface Water Area Under Different Climate and Development Scenarios by Mollie D. Gaines, Mirela G. Tulbure, Vinicius Perin, Rebecca Composto, Varun Tiwari

“…However, most projections of surface water dynamics focus on climate drivers using local‐scale hydrological models, with few studies accounting for climate and human drivers such as land‐use/land‐cover change. …”
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Unified Visual-Aware Representations for Data Analytics by Ladislav Peska, Ivana Sixtova, David Hoksza, David Bernhauer, Jakub Lokoc, Tomas Skopal

“…The visual representations serve for data analytics tasks performed by human users as well as serve for universal data representations used in machine learning models for automated tasks. …”
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Corrosion behavior of NiTi alloys fabricated by laser powder bed fusion in relation to the formed passive films in Hank's solution by Yi-Fan Zhang, Liang-Yu Chen, Yong Liu, Hong-Yu Yang, Jin-Hua Peng, Chuanbo Zheng, Lina Zhang, Lai-Chang Zhang

“…Varying the parameters of the L-PBF process may result in the NiTi alloys with different ratios of B2 and B19′ phases, thereby, the different corrosion performance in the human body. However, a dearth of research efforts remains dedicated to resolving this issue. …”
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Thrombin-Induced Calpain Activation Promotes Protease-Activated Receptor 1 Internalization by Alejandro Alvarez-Arce, Irene Lee-Rivera, Edith López, Arturo Hernández-Cruz, Ana María López-Colomé

“…Due to the irreversible nature of PAR1 activation, its inactivation must be efficiently regulated in order to terminate signaling. Using ARPE-19 human RPE cell line, we characterized thrombin-induced [Ca+2]i increase and demonstrated the calcium-dependent activation of μ-calpain mediated by PAR1. …”
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Comparative immobilization of lead, cadmium, and copper in soil using dead bacterial biomass and graphitic carbon nitride nanomaterials by Asifa Farooqi, Ejaz ul Haq, Hooria Ikram Raja, Hafiz Abdul Malik, Yousaf Shad Muhammad, Syed Hamza Safeer, Sohail Yousaf, Maximilian Lackner

“…Heavy metals (HM) are known to pose severe harm to the soil, crops, and human beings. The usefulness and efficiency of metal immobilization of Pb, Cd, and Cu ions using different doses of dead bacterial biomass (BM) and graphitic carbon nitride (g-C3N4) was evaluated and compared in spiked soil. …”
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The multidrug-resistant Candida auris, Candida haemulonii complex and phylogenetic related species: Insights into antifungal resistance mechanisms by Lívia S. Ramos, Pedro F. Barbosa, Carolline M.A. Lorentino, Joice C. Lima, Antonio L. Braga, Raquel V. Lima, Lucas Giovanini, Ana Lúcia Casemiro, Nahyara L.M. Siqueira, Stefanie C. Costa, Célia F. Rodrigues, Maryam Roudbary, Marta H. Branquinha, André L.S. Santos

“…The rise of multidrug-resistant (MDR) fungal pathogens poses a serious global threat to human health. Of particular concern are Candida auris, the Candida haemulonii complex (which includes C. haemulonii sensu stricto, C. duobushaemulonii and C. haemulonii var. vulnera), and phylogenetically related species, including C. pseudohaemulonii and C. vulturna. …”
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Cadaveric Study of Variations in the Course of Lateral Femoral Cutaneous Nerve: Insight to Prevent Injury by Nidhi MANGLA, Surbhi WADHWA, Sabita MISHRA, Sumit SURAL, Neelam VASUDEVA

“…Methods: Twenty five adult human formalin embalmed cadavers were dissected. …”
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A maturity model for Clinical Trials Management Ecosystem by Shruti Sehgal, E. Chris Pua, Svetlana Rojevsky, Michael J. Becich, Joshua Fehrmann, Boyd M. Knosp, Adam Wilcox, Jeffery C. Talbert, Catherine K. Craven, Justin Starren

“… Abstract Introduction: Managing clinical trials is a complex process requiring careful integration of human, technology, compliance, and operations for success. …”
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Determination of Irisin, Body Mass Index, and Other Biochemical Parameters in a Sample of Iraqi Type II Diabetic Patients by Takwa Al Koloob Ali Chachan, Huda Farhan, Shatha Hamed

“…On the other hand, its role in type 2 diabetic Mellitus [T2DM] in humans is uncertain. As a result, we investigated if irisin levels in T2DM patients were dysregulated and whether there was a link between serum irisin levels and anthropometric obesity indices and biochemical parameters. …”
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Optimized Adaptive Neuro-Fuzzy Inference System Using Metaheuristic Algorithms: Application of Shield Tunnelling Ground Surface Settlement Prediction by Xinni Liu, Sadaam Hadee Hussein, Kamarul Hawari Ghazali, Tran Minh Tung, Zaher Mundher Yaseen

“…Deformation of ground during tunnelling projects is one of the complex issues that is required to be monitored carefully to avoid the unexpected damages and human losses. Accurate prediction of ground settlement (GS) is a crucial concern for tunnelling problems, and the adequate predictive model can be a vital tool for tunnel designers to simulate the ground settlement accurately. …”
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Development of a Combined 2D-MGD TLC/HPTLC Method for the Separation of Terpinen-4-ol and α-Terpineol from Tea Tree, <i>Melaleuca alternifolia</i>, Essential Oil by Aimé Vázquez, Nurhayat Tabanca

“…This study showcases a combined 2D-MGD TLC/HPTLC method for the successful separation of TTO components of interest. While human error, limited separation, and the partial evaporation of volatile components may still present a challenge during the process, considerable recovery of mono- and sesquiterpenes was achieved. …”
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Acridine-2,4-Dinitrophenyl Hydrazone Conjugated Silver Nanoparticles as an Efficient Sensor for Quantification of Mercury in Tap Water by Imdad Ali, Ibanga Okon Isaac, Mahmood Ahmed, Farid Ahmed, Farhat Ikram, Muhammad Ateeq, Rima D. Alharthy, Muhammad Imran Malik, Abdul Hameed, Muhammad Raza Shah

“…In this context, mercury is a highly dangerous metal which poses serious impact on human health. In the present study, acridine- (ACR-) based silver nanoparticles (ACR-AgNPs) were prepared and employed as a nanosensor for effective detection and quantification of Hg2+ in tap water. …”
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Alkali metal salt modulated visible photocatalytic degradation of tetracycline hydrochloride by g-C3N4: Degradation pathway, mechanism and toxicity assessment by Yujie Jiao, Sujin Lu, Ru Li, Qikai Liu, Yongxia Ma, Fei Fu, Yaqi Mao, Yang Liu

“…The frequent occurrence of tetracycline antibiotics in natural water systems poses a substantial risk to aquatic ecosystems and human health. Achieving efficient degradation of tetracyclines in aqueous environments using visible light is therefore of critical importance. …”
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