Discovery of the bacterial HslV protease activators as lead molecules with novel mode of action by Aurangzeb Sana, Aurongzeb Muhammad, Shamim Shahbaz, Rashid Yasmeen, Khan Khalid Mohammed, Aziz Tariq, Alharbi Metab, Alasmari Abdullah F.

“…This bacterial complex is reflected as an attractive target for drug development due to its presence in disease-causing microorganisms and concurrent absence in humans. The objective of this research was to identify certain promising drug candidates that could excessively stimulate the HslV protease, leading to uncontrolled protein breakdown in the pathogens. …”
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Screening of Anti-Hair Loss Plant Raw Materials Based on Reverse Network Pharmacology and Experimental Validation by Jiajia Xu, Congfen He, Rui Tian

“…Licorice water extract (LWE), salvia miltiorrhiza water extract (SMWE), mulberry leaf water extract (MLWE), ephedra water extract (EWE) and curcumae radix water extract (CRWE) did not exhibit cytotoxicity on human dermal papilla cells (HDPCs). Through ALP staining, it was found that the expression of ALP in HDPCs treated with LWE, SMWE, MLWE, EWE and CRWE was enhanced. …”
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Trends in genome diversity of small populations under a conservation program: a case study of two French chicken breeds by Bortoluzzi, Chiara, Restoux, Gwendal, Rouger, Romuald, Desnoues, Benoit, Petitjean, Florence, Bosse, Mirte, Tixier-Boichard, Michèle

“…Livestock biodiversity is declining globally at rates unprecedented in human history. Of all avian species, chickens are among the most affected ones because many local breeds have a small effective population size that makes them more susceptible to demographic and genetic stochasticity. …”
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CircRNF13 enhances IGF2BP1 phase separation-mediated ITGB1 mRNA stabilization in an m6A-dependent manner to promote oral cancer cisplatin chemoresistance by Xuemeng Xu, Qiu Peng, Zongyao Ren, Yaqian Han, Xianjie Jiang, Zhu Wu, Shiming Tan, Wenjuan Yang, Linda Oyang, Xia Luo, Jinguan Lin, Longzheng Xia, Mingjing Peng, Nayiyuan Wu, Yanyan Tang, Hao Tian, Yujuan Zhou, Qianjin Liao

“…Many studies highlight the regulatory role of circular RNAs (circRNAs) in human cancers, suggesting their potential as cancer biomarkers. …”
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Advances in Hemodynamic Analysis in Cardiovascular Diseases Investigation of Energetic Characteristics of Adult and Pediatric Sputnik Left Ventricular Assist Devices during Mock Ci... by Alexander A. Pugovkin, Aleksandr G. Markov, Sergey V. Selishchev, Leonie Korn, Marian Walter, Steffen Leonhardt, Leo A. Bockeria, Olga L. Bockeria, Dmitry V. Telyshev

“…The need to simulate the operating conditions of the human body is a key factor in every study and engineering process of a bioengineering device developed for implantation. …”
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Construction and Characterization of Adenovirus Vectors Encoding Aspartate-β-Hydroxylase to Preliminary Application in Immunotherapy of Hepatocellular Carcinoma by Yujiao Zhou, Feifei Liu, Chengmin Li, Guo Shi, Xiaolei Xu, Xue Luo, Yuanling Zhang, Jingjie Fu, Aizhong Zeng, Limin Chen

“…Firstly, the total AAH mRNA was extracted from human HCC tissues; the cDNA was amplified by RT-PCR, verified, and sequenced after TA cloning. …”
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Gastrointestinal protozoa in pet cats from Anhui province: prevalence and molecular characterization by Hao Zhang, Xing Tong, Zhonghui Ma, Tao Zhang, Feng Wu, Qiong Wu, Congshan Yang, Chunyang Han

“…IntroductionTo investigate the prevalence of Tritrichomonas foetus, Pentatrichomonas hominis, Giardia intestinalis, Cryptosporidium, Microsporidium, and Sarcocystis in domestic cats in Anhui Province, China, and their potential role as zoonotic hosts for human infection, a total of 304 fecal samples from two different sources were screened for the presence of related pathogens.MethodsUsing microscopy, along with polymerase chain reaction (PCR) or nested PCR amplification, followed by genotyping through sequence analysis.ResultsThe infection rates of T. foetus, P. hominis, G. intestinalis, Cryptosporidium, Enterocytozoon bieneusi, and Sarcocystis were 5.6%, 0%, 1.7%, 0.7%, 2.6%, and 0%, respectively. …”
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Extracting Regular Building Footprints Using Projection Histogram Method from UAV-Based 3D Models by Yaoyao Ren, Xing Li, Fangyuqing Jin, Chunmei Li, Wei Liu, Erzhu Li, Lianpeng Zhang

“…Current techniques heavily rely on human expertise and involve repetitive, labor-intensive manual operations. …”
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Development and characterization of a chicory extract fermented by Akkermansia muciniphila: An in vitro study on its potential to modulate obesity-related inflammation by A. Chervet, R. Nehme, C. Defois-Fraysse, C. Decombat, C. Blavignac, C. Auxenfans, B. Evrard, S. Michel, E. Filaire, J.-Y. Berthon, A. Dreux-Zigha, L. Delort, F. Caldefie-Chézet

“…The anti-inflammatory and anti-obesity activities of C-Akm extract were studied by testing the extract (50 μg/mL) on the polarization of THP-1 into macrophages, the secretion of pro-inflammatory cytokines in LPS-stimulated PBMCs, and the secretion of leptin and adiponectin in adipospheroids derived from human adipose stem cells. Finally, the extract was examined in 3D co-culture model mimicking inflamed obese adipose tissue. …”
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Intensity of Oestrus Signalling Is the Most Relevant Indicator for Animal Well-Being in High-Producing Dairy Cows by Emanuel Garcia, Jan Hultgren, Pontus Fällman, Johanna Geust, Bo Algers, George Stilwell, Stefan Gunnarsson, Heriberto Rodriguez-Martinez

“…Avoidance distances were short (<1 m), reflecting good human-animal interaction. Visually-recorded standing oestrus yielded 4.8 fold higher odds of pregnancy, respectively 4.6-fold higher odds of calving. …”
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Factors involved in the development of hospital-acquired conditions in older patients in acute care settings: a scoping review by Mélanie Verdon, Thomas Agoritsas, Cécile Jaques, Sophie Pouzols, Cédric Mabire

“…Personal factors, medications, and the human and work environment were the most frequent subcategories of factors retrieved, whereas social factors, hydration and nutrition, and organizational factors were less common. …”
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Peri Cholecystectomy Bile Analysis for Fasciola hepatica Eggs in Sulaimani Teaching Hospital by Seerwan Hama Shareef, Taher Abdullah Hawramy, Osman jamal nasrulla, Karwn Hama amin, Dara Ahmed Mohammed, Raz Seerwan Hama

“…It is a widespread disease throughout the world; nearly (2.4 – 17) millions of people is infected. Human is an accidental final host by ingestion of contaminated plants and water by metacircaria. …”
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Scaling up of parenting support to prevent violence against children in Tanzania: insights from policymakers and service providers by Sabine van Tuyll van Serooskereken Rakotomalala, Kija Nyalali, Joyce Wamoyi, Onduru Gervas Onduru, Gerry Mshana, F. Marijn Stok, Mara A. Yerkes, John B. F. De Wit

“…Current factors hindering the scale-up include the lack of a common understanding of what evidence-based parenting programmes entail, inadequate provision of human and financial capital to implement the programmes using community resources and deeply engrained social norms around adultism and gender. …”
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MHD effect on peristaltic motion of Williamson fluid via porous channel with suction and injection by K. Chakradhar, K. Nandagopal, Vishnudasu Prashanthi, A. Parandhama, T. Somaiah, B.V. Sai Thrinath, Nainaru Tarakaramu, Ghulam Rasool, Dilsora Abduvalieva

“…These materials play a critical role in diagnosing underlying issues within human organs that rely on peristaltic pumping for fluid transfer, such as the stomach, intestines, and ureters. …”
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TNF Superfamily: A Growing Saga of Kidney Injury Modulators by Maria D. Sanchez-Niño, Alberto Benito-Martin, Sara Gonçalves, Ana B. Sanz, Alvaro C. Ucero, Maria C. Izquierdo, Adrian M. Ramos, Sergio Berzal, Rafael Selgas, Marta Ruiz-Ortega, Jesus Egido, Alberto Ortiz

“…TNF-related apoptosis-inducing ligand (TRAIL and its potential decoy receptor osteoprotegerin are the two most upregulated death-related genes in human diabetic nephropathy. TRAIL activates NF-kappaB in tubular cells and promotes apoptosis in tubular cells and podocytes, especially in a high-glucose environment. …”
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Spatiotemporal Changes and Trade-Offs/Synergies of Ecosystem Services in the Qin-Mang River Basin by Jiwei Zhao, Luyao Wang, Dong Jia, Yaowen Wang

“…The results show that: (1) driven by urbanization and economic development, the expansion of built-up areas has replaced cultivated land and forests, with 35,000 hectares of farmland lost, thereby increasing pressure on ESs; (2) ESs show an overall downward trend, habitat quality (HQ) has deteriorated, carbon storage (CS) remains stable but the area of low CS has expanded, and sediment delivery ratio (SDR) and water yield (WY) fluctuate due to human activities and climate influence; (3) the TOSs of ESs change dynamically, with strong synergies among HQ, CS, and SDR. …”
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Identification of two new genetic loci for high-resolution genotyping of Enterocytozoon bieneusi by Meng Xinan, Ou Yonglin, Jiang Wen, Guo Yaqiong, Xiao Lihua, Feng Yaoyu, Li Na

“…., the public health significance of E. bieneusi in animals, and sources of E. bieneusi infections in humans.…”
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Prevalence and Subtypes Distribution (ST10, ST14, ST25, ST26) of Blastocystis spp. in Anatolian Water Buffalo (Bubalus bubalis) in Van, Türkiye by Adnan Ayan, Burcak Aslan Celik, Ozgur Yasar Celik, Ali Bilgin Yilmaz, Ozlem Orunc Kilinc, Ozge Oktay Ayan

“…ABSTRACT Background Blastocystis spp. is one of the most common protozoa worldwide, living in the gastrointestinal tract of humans and many other animals. On the basis of the genetic heterogeneity of small subunit ribosomal RNA, at least 28 subtypes (ST1‐ST17, ST21 and ST23–ST32) are reported to exist in mammals and birds. …”
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Golgin Subfamily A Member 5 Is Essential for Production of Extracellular Matrix Proteins during TGF-β1-Induced Periodontal Ligament-Fibroblastic Differentiation by Hyun-Jin Kim, Seong-Min Kim, Min-Jeong Choi, Young-Joo Jang

“…Human periodontal ligament stem cells (hPDLSCs) can be differentiated into periodontal ligament- (PDL-) fibroblastic progenitors by treatment with low concentrations of transforming growth factor beta 1 (TGF-β1). …”
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Fibrin Glue Enhances Adipose-Derived Stromal Cell Cytokine Secretion and Survival Conferring Accelerated Diabetic Wound Healing by Ursula Hopfner, Matthias M. Aitzetmueller, Philipp Neßbach, Michael S. Hu, Hans-Guenther Machens, Zeshaan N. Maan, Dominik Duscher

“…Fibrin glue seeding leads to a significantly enhanced secretion of key cytokines (SDF-1, bFGF, and MMP-2) of human ASCs in vitro. IVIS imaging showed a significantly prolonged murine ASC survival in diabetic wounds and significantly accelerated complete wound closure in the fibrin glue seeded group. …”
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