ERK5 Contributes to VEGF Alteration in Diabetic Retinopathy by Yuexiu Wu, Yufeng Zuo, Rana Chakrabarti, Biao Feng, Shali Chen, Subrata Chakrabarti

“…We investigated a novel pathway, namely extracellular signal regulated kinase 5 (ERK5) mediated signaling, in modulating glucose-induced vascular endothelial growth factor (VEGF) expression. Human microvascular endothelial cells (HMVEC) were exposed to glucose. …”
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Case studies in adaptation: centring equity in global health education during the COVID-19 pandemic and beyond by Anna Pancheshnikov, C Nicholas Cuneo, Wilfredo R Matias, Rebeca Cázares-Adame, Abner Gamaliel Santos López, Ryan M Paxton, Chi Chiung Grace Chen

“…Case 3: the Johns Hopkins Global Health Leadership Program adapted its curriculum into a hybrid online and in-person migrant health and human rights elective, collaborating with local organisations. …”
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Reconstructing the genetic structure of the Kazakh from clan distribution data by M. K. Zhabagin, О. Е. Balanovsky, Zh. M. Sabitov, A. Z. Temirgaliyev, A. T. Agdzhoyan, S. M. Koshel, Е. М. Ramankulov, E. V. Balanovska

“…Applying quasigenetic markers - non-biological traits which are nevertheless inherited in generations - is one of the research fields within human population genetics. For the West European, East European, and Caucasus populations, surnames are typical quasigenetic markers. …”
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GastroFuse-Net: an ensemble deep learning framework designed for gastrointestinal abnormality detection in endoscopic images by Sonam Aggarwal, Isha Gupta, Ashok Kumar, Sandeep Kautish, Abdulaziz S. Almazyad, Ali Wagdy Mohamed, Frank Werner, Mohammad Shokouhifar

“…To address these challenges, we introduced a specialized CNN-based architecture called GastroFuse-Net, designed to recognize human gastrointestinal diseases from endoscopic images. …”
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Genome-wide CRISPR-based screen identifies E2F transcription factor 1 as a regulator and therapeutic target of aristolochic acid-induced nephrotoxicity by Ziqi Liu, Huan Gao, Guoliang Li, Yongjiang Yu, Mengxing Cui, Honghao Peng, Xinchao Guan, Xue Zhang, Zhihan Zhang, Xiaoyu Shen, Shen Chen, Daochuan Li, Liping Chen, Yongmei Xiao, Wen Chen, Lili Liu, Qing Wang

“…To identify undiscovered key genes involved in AAI-induced renal toxicity, a genome-wide CRISPR library screen was conducted in the human kidney-2 (HK-2) cell line. Among the altered sgRNAs, a significant enrichment of those targeting the E2F transcription factor 1 (E2F1) gene was observed in surviving HK-2 cells in the AAI-treated group. …”
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Clinical evaluation and management of a 45-year-old man with confusion, psychosis, agitation, stereotyped behavior, and impaired speech by Xiaolin Deng, Paulo J. Negro, Patrick L. Jung, Christopher M. Marano, Stephanie Knight, Seshagiri R. Doddi, Nana Y. A. Nimo, Rachel M. LeMalefant, Drew A. Myers, Andrea K. Haake, Rebecca Chandler

“…Moreover, the fluctuation of the patient’s neuropsychiatric symptoms we observed during his hospitalization reflects the increased vulnerability of the human brain under sustained neurodegeneration.…”
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Infectivity in full-term placenta of Zika viruses with different lipid profiles by Eva Mazzetto, Alessio Bortolami, Davide Bovo, Matteo Stocchero, Elisa Mazzacan, Alessandra Napolitan, Valentina Panzarin, Maria Rosa Tran, Gianpiero Zamperin, Adelaide Milani, Andrea Fortin, Michela Bigolaro, Paola Pirillo, Matteo Pagliari, Claudia Zanardello, Giuseppe Giordano, Maria Teresa Gervasi, Eugenio Baraldi, Calogero Terregino, Carlo Giaquinto, Francesco Bonfante

“…Notably, ZIKV stock derived from mammalian cells showed a higher infectivity in immortalized villous trophoblasts and full-term placental explants of human origin. This increased infectivity was linked to enhanced fusion efficiency during the viral uncoating phase in trophoblast cells, as demonstrated using a lipophilic probe. …”
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Sociodemographic characteristics, occupational characteristics, motivational factors, and job satisfaction among primary health service practitioners by Di Liu, Huanyan Wang, Wenlin Zhang, Peixuan Chen, Yuqing Lin, Yujin Xie, Mingyang Zou, Debao Li, Ming Fang, Bingjie Hu, Lei Shi

“…Establishing scientific and reasonable research on the incentive mechanism at grassroots medical institutions can help stabilize the team, enhance staff satisfaction and work performance, and optimize human resource utilization.…”
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A growing degree day model determines the effect of temperature stress on diverse chickpea genotypes by Cara Jeffrey, Cara Jeffrey, Cara Jeffrey, Laura Ziems, Laura Ziems, Brent Kaiser, Brent Kaiser, Richard Trethowan, Richard Trethowan

“…Chickpeas are a globally crucial agricultural product, currently at risk due to human-induced climate change. There has been little research into the impact of heat stress on chickpea compared to other crops, but it is known that heat stress can cause up to 100% yield loss. …”
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Gross and applied anatomy pedagogical approaches in occupational therapy education: protocol for a scoping review by Emily S Ho, Anne Agur, Andrea Duncan, Erica Dove, Kelly Hennessy, Athena Kirou-Mauro, Lorna Aitkens

“…After title/abstract and full-text screening, included articles will be charted, collated and summarised.Ethics and dissemination This study will not involve human or animal subjects. Therefore, research ethics approval is not required. …”
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Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis by Junko Yoshida, Robert T. Wicks, Andrea I. Zambrano, Betty M. Tyler, Kashi Javaherian, Rachel Grossman, Yassine J. Daoud, Peter Gehlbach, Henry Brem, Walter J. Stark

“…We assessed the antiangiogenic effects of subconjunctival injection of Fc-endostatin (FcE) using a human vascular endothelial growth factor-induced rabbit corneal neovascularization model. …”
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Targeting transforming growth factor-β1 by methylseleninic acid/seleno-L-methionine in clear cell renal cell carcinoma: Mechanisms and therapeutic potential by Aseel O. Rataan, Yan Xu, Sean M. Geary, Yousef Zakharia, Eman S. Kamel, Youcef M. Rustum, Aliasger K. Salem

“…This study analyzed their expression in human ccRCC cell lines and patient tumor biopsies. …”
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Genetic and neurochemical profiles underlying cortical morphometric vulnerability to Parkinson’s disease by Su Yan, Jun Lu, Bingfang Duan, Hongquan Zhu, Tian Tian, Yuanyuan Qin, Yuanhao Li, Wenzhen Zhu

“…Then we performed gene-category enrichment and spatial correlation analyses to evaluate the specific correspondence between cortical alteration in PD and genetic expression from the Allen Human Brain Atlas and normative neurotransmitter atlases from Neuromaps. …”
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Rapid and Specific Detection of Escherichia coli O157:H7 in Ground Beef Using Immunomagnetic Separation Combined with Loop-Mediated Isothermal Amplification by Qin Yu, Puthiyakunnon Santhosh, Zhang Yiduo, Wu Xianbo, Boddu Swapna, Luo Binde, Fan Hongying

“…Escherichia coli O157:H7 is well known for many foodborne outbreaks that lead to fatal infections in human being worldwide. The objective of this study was to develop a rapid and sensitive method for detection of EHEC O157:H7 from ground beef using a method that combined immunomagnetic separation (IMS) with loop-mediated isothermal amplification (LAMP). …”
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Does heatwaves/above-average temperature increase interpersonal violent behavior? A scoping review by Daniela ACQUADRO MARAN, Gaia DIBIASE, Sofia FILIPPETTI, Riccardo SANDRETTO, Antonella VARETTO, Claudio Giovanni CORTESE, Elisabetta CARRARO

“…Future research is needed to better understand the relationship between heatwaves or above-average temperature and human health. Policymakers should implement programs to prevent violent behavior in terms of increased temperature adaptation and mitigation (e.g., promoting green spaces and reducing pollution) and at the level of individual city institutions, which can monitor the phenomenon and take action, such as increasing the presence of security personnel in anticipation of periods of highest temperatures.…”
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Prognostic Significance and Therapeutic Potential of SERPINE1 in Head and Neck Squamous Cell Carcinoma by Changyu Zhu, Heshu Liu, Zhixin Li, Yijun Shi, Jingyang Zhao, Yuping Bai, Qian Chen, Wei Li

“…It was observed that, particularly in human papillomavirus (HPV) negative HNSCC, SERPINE1 exhibited elevated expression levels, correlating with poorer prognosis. …”
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Does quercetin affect tendon healing? An experimental study in a rat model of Achilles tendon injury by Ahmet Yurteri, Numan Mercan, Zeliha Esin Çelik, Hakan Yaykaşlı, Ahmet Yıldırım

“…However, further clinical studies are needed to understand its effects on human tendon healing, as this is the first study of its kind.…”
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Folliculin Interacting Protein 1 (FNIP-1) expression and capillary density in gastrocnemius muscle tissue of mice after biological maturation period by Sinta Ayu Choiriyah, Bambang Purwanto, Viskasari Pintoko Kalanjati, Raden Argarini, Anisah Rosydiyah

“…The hormonal fluctuations play an important role in changing the characteristics of human body tissues during the biological maturity period. …”
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Spatial-temporal evolution of habitat quality in tropical monsoon climate region based on “pattern–process–quality” – a case study of Cambodia by Kang Junmei, Yang Fengshuo, Wang Jun, Liu Yang, Fang Dengmao, Jiang Chengcheng

“…The results show that (1) during 2000–2022, forest in Cambodia covered a wide range, showing a landscape pattern mainly distributed in the east and west. (2) The degree of fragmentation of impervious landscape pattern increased gradually from 2000 to 2022, indicating that it was seriously affected by human activities and natural factors, and with the increase in elevation and slope, the area of various types converted to impervious decreased. (3) During 2000–2022, high habitat quality areas were concentrated in Tonle SAP Lake in the east, southwest, and central part of Cambodia, while low habitat quality areas were concentrated in the central part. (4) Natural factors, socio-economic factors, policies, and regulations all have an impact on the change in land use pattern and habitat quality in Cambodia.…”
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Clinical and Epidemiological Characteristics of <i>Staphylococcus caprae</i> Infections in Catalonia, Spain by Javier Díez de los Ríos, María Navarro, Judit Serra-Pladevall, Sònia Molinos, Emma Puigoriol, Noemi Párraga-Niño, Glòria Pedemonte-Parramón, Luisa Pedro-Botet, Óscar Mascaró, Esteban Reynaga

“…<i>Staphylococcus caprae</i> is a coagulase-negative staphylococcus commonly associated with animals which can also be a zoonotic human pathogen. To date, there is little data available on <i>S. caprae</i> infections. …”
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