IFN Regulatory Factor 1 Mediates Macrophage Pyroptosis Induced by Oxidized Low-Density Lipoprotein in Patients with Acute Coronary Syndrome by Min Guo, Rui Yan, Hongmei Yao, Liqin Duan, Meng Sun, Zheng Xue, Yongping Jia

“…The expression of IRF-1 in human PBMC-derived macrophages was analyzed. Then, overexpression and inhibition of IRF-1 was performed in macrophages from patients with ACS to explore the possible role and mechanism of IRF-1 involvement in macrophage pyroptosis. …”
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Mesenchymal stem cell-derived extracellular vesicles enriched with miR-124 exhibit anti-inflammatory effects in collagen-induced arthritis by Guo Zhonghua, He Mengyuan, Shi Dongliang, Zhang Zhongbo, Wang Lisha, Ren Bowen, Wang Yunfei, Wang Junjie, Yang Shaoxiang, Yu Hongchao

“…This study investigated the anti-inflammatory effects of human umbilical cord-derived MSC (hUCSC)-EVs overexpressing miR-124 in collagen-induced arthritis (CIA). hUCSCs were transfected with miR-124, and hUCSC-EVs were isolated and characterized. …”
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AutoMEX: Streamlining material extrusion with AI agents powered by large language models and knowledge graphs by Haolin Fan, Junlin Huang, Jilong Xu, Yifei Zhou, Jerry Ying Hsi Fuh, Wen Feng Lu, Bingbing Li

“…AutoMEX utilizes a knowledge graph (KG) derived from the scientific literature to enable LLMs to provide expert recommendations on material selection, process parameters, and design considerations, thereby improving accessibility and efficiency. With minimal human intervention, the framework encompasses a complete workflow, including CAD model generation, printing parameter recommendation, slicing, and machine operation. …”
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Ameliorative effect of liprotide-encapsulated vitamin D3 on blood glucose, calcium homeostasis, and vitamin D level in a vitamin D and calcium deficient rat model by Gemala Anjani, Reza Achmad Maulana, Sylvia Rahmi Putri, Faizah Fulyani, Ahmad Syauqy, Diana Nur Afifah, Fitriyono Ayustaningwarno, Refani Alycia Kusuma, Zulfatul Masruroh

“…Vitamin D3, recognized for its higher bioavailability and direct cell utilization, plays a vital role in the human body. Applying β-lactoglobulin with oleic acid (β-Lg-AO) as an encapsulating agent is anticipated to protect and enhance the transport of vitamin D3 to the gastrointestinal system. …”
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Widely Targeted Metabolomics Analysis Reveals Key Quality-Related Metabolites in Kernels of Sweet Corn by Ruichun Yang, Yunfeng Li, Yuanyuan Zhang, Jun Huang, Junjie Liu, Zimei Lin, Qinqin Yu, Aimin Wu, Bo Wang

“…And the essential amino acids for the human body, methionine and threonine, were highly accumulated in the high-quality cultivar. …”
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Magnolol induces cell death through PI3K/Akt‐mediated epigenetic modifications boosting treatment of BRAF‐ and NRAS‐mutant melanoma by Abdullah Al Emran, Brinda Reddy Chinna Chowdary, Farzana Ahmed, Heinz Hammerlindl, Antje Huefner, Nikolas K. Haass, Wolfgang Schuehly, Helmut Schaider

“…Here, we show that magnolol, a constituent of Magnolia officinalis, induced G1 arrest, apoptosis and cell death in BRAF‐ and NRAS‐mutant melanoma cells at low concentration, with no effect in BRAF‐ and NRAS wild‐type melanoma cells and human keratinocytes. This was confirmed in a 3D spheroid model. …”
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Development and Implementation of an IoT-Based Early Flood Detection and Monitoring System Utilizing Time Series Forecasting for Real-Time Alerts in Resource-Constrained Environmen... by Nik Nor Muhammad Saifudin Nik Mohd Kamal, Ahmad Anwar Zainuddin, Abu Ubaidah Shamsudin, Muhamad Syariff Sapuan, Muhammad Hazim Amin Samsudin, Mohammad Adam Haikal Zulkfli

“…Traditional flood monitoring systems have severe limitations, including reliance on human data gathering, a lack of real-time capabilities, expensive prices, and slow response times, particularly in developing countries. …”
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Impact of socio-demographic structure of the deaf people communities in prevalence of hereditary hearing loss by O. L. Posukh, M. S. Bady-Khoo, M. V. Zytsar, V. Yu. Mikhalskaia, S. A. Lashin, N. A. Barashkov, G. P. Romanov

“…Nevertheless, studies of sociodemographic and medical-genetic characteristics of deaf people’s contemporary communities are important for predicting the prevalence of inherited forms of deafness, as well as for understanding the impact of social factors on the evolutionary processes occurring in human populations.…”
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Protective effects of wogonin in the treatment of central nervous system and degenerative diseases by Qingan Fu, Qingyun Yu, Hongdan Luo, Zhekang Liu, Xiaowei Ma, Huijian Wang, Zhijuan Cheng

“…Despite extensive preclinical evidence, further clinical studies are warranted to confirm its efficacy and safety in humans. This review highlights the great therapeutic potential of wogonin in terms of CNS protection. …”
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Degradation of PCDD/Fs from incineration of waste at low temperatures for resource utilization of fly ash by Songxuan CHEN, Hao WANG, Dongwei ZHANG, Mengxiao LAN, Zhi SUN, Yuping GAO, Hongbin CAO

“…This includes polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), which are among the most toxic substances to humans and other living organisms. Low-temperature degradation technology has broad prospects in engineering applications due to the advantages of low technical difficulty and operating costs. …”
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The impact of COVID-19 pandemic on HIV and AIDS care provision in South Africa: an integrative literature review by James R. Seretlo, Thifhelimbilu I. Ramavhoya, Fhumulani M. Mulaudzi, Rodwell Gundo, Tintswalo V. Nesengani, Mamoeng N. Kgatla, Mmapheko D. Peu

“…Worldwide, the coronavirus (COVID-19) pandemic has negatively impacted healthcare services, including human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) care. …”
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How do we measure the costs, benefits, and harms of sharing data from biomedical studies? A protocol for a scoping review [version 2; peer review: 2 approved] by Lauren Maxwell, Ankur Krishnan, Priya Shreedhar

“…Introduction The benefits of sharing participant-level data, including clinical or epidemiological data, genomic data, high-dimensional imaging data, or human-derived samples, from biomedical studies have been widely touted and may be taken for granted. …”
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Relationship between androgen receptor and androgen receptor-related protein expression in breast cancers focusing on morphologically identified carcinoma with apocrine differentia... by Haruto Nishida, Ami Kato, Ryo Kaimori, Kazuhiro Kawamura, Tsutomu Daa

“…Abstract Breast cancer (BC) is classified based on the expression of histopathological markers, namely, estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor 2 (HER2). …”
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Comparison of Prevalence of Pre-Diabetes and Type-2 Diabetes Mellitus Between Athletes and Non-Athletes by Muhammad Irfan, Fatima Abid, Sassi Kanwal, Aliya Jafri, Padma Rathore, Noor un Nisa Memon

“… Background: Sports and Exercise activities are exceedingly advantageous for the human body and extremely helpful in decreasing the risks of diseases. …”
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Sonochemically Modified Lapindo Mud Using Sulfuric Acid for Efficient Adsorption of Phenol in Aqueous Media and Real Wastewater Samples by Karna Wijaya, Adyatma Bhagaskara, Maria Francia Mirabella Sani, Marini Fairuz Vebryana, Fernando Alvaro Pratama, Widuri Anggraeni, Amalia Kurnia Amin, Faturrahman Al Ramadhani, Aldino Javier Saviola

“…Pharmaceutical industrial wastewater frequently contains high amounts of phenolic substances, which pose severe threats to the ecosystem and human health. Therefore, efficient removal of these pollutants is urgently needed. …”
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Mallard Hybridization With Domesticated Lineages Alters Spring Migration Behavior and Timing by Nicholas W. Bakner, Nicholas M. Masto, Philip Lavretsky, Cory J. Highway, Allison C. Keever, Abigail G. Blake‐Bradshaw, Ryan J. Askren, Heath M. Hagy, Jamie C. Feddersen, Douglas C. Osborne, Bradley S. Cohen

“…ABSTRACT Introgressive hybridization, the interbreeding and gene flow between different species, has become increasingly common in the Anthropocene, where human‐induced ecological changes and the introduction of captively reared individuals are increasing secondary contact among closely related species, leading to gene flow between wild and domesticated lineages. …”
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Therapeutic efficacy of a potent anti-Venezuelan equine encephalitis virus antibody is contingent on Fc effector function by Jennifer L. Schwedler, Maxwell A. Stefan, Christine E. Thatcher, Peter R. McIlroy, Anupama Sinha, Ashlee M. Phillips, Christopher A. Sumner, Colleen M. Courtney, Christina Y. Kim, Dina R. Weilhammer, Brooke Harmon

“…To determine the role of Fc effector function in therapeutic efficacy against Venezuelan equine encephalitis virus (VEEV), we compared the potently neutralizing anti-VEEV human IgG F5 (hF5) Ab with intact Fc function (hF5-WT) or containing the loss of function Fc mutations L234A and L235A (hF5-LALA) in the context of VEEV infection. …”
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Eco-Friendly Adsorbent from Waste of Mint: Application for the Removal of Hexavalent Chromium by Fatima Khammour, Fatouma Mohamed Abdoul-Latif, Ayoub Ainane, Jalludin Mohamed, Tarik Ainane

“…A serious environmental disaster is looming on the horizon due to the indiscriminate release of heavy metals into the soil and wastewater from human industrial practices. In this study, waste mint (WM) was used to remove chromium(VI) from aqueous solution using batch experiments. …”
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Amphotericin B Encapsulation in Polymeric Nanoparticles: Toxicity Insights via Cells and Zebrafish Embryo Testing by Magno Maciel-Magalhães, Renata Jurema Medeiros, Nayara Cecília do Couto Guedes, Thais Morais de Brito, Gabriele Fátima de Souza, Beatriz Rodrigues Canabarro, Fausto Klabund Ferraris, Fábio Coelho Amendoeira, Helvécio Vinicius Antunes Rocha, Beatriz Ferreira de Carvalho Patricio, Isabella Fernandes Delgado

“…Zebrafish (<i>Danio rerio</i>) embryos were used as a valuable model for toxicity testing, especially because of their genetic similarity to humans and standardized developmental assessments. …”
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Stereotypes and social representations associated with pediatric surgeons among medical students, residents and physicians: a cross-sectional study by Coline Ducrot, Max Piffoux, Mathilde Payen, Sebastien Raux, Franck Rolland, Evan Gouy, Linh Nam Truong, Ariel Frajerman, Florent Vinchon, Nawale Hadouiri

“…The specialty is considered as wide, intense, meticulous, and demanding surgical specialty but also as hyperspecialized and confined to academic centers with a unique parent–child–surgeon relationship, embodying traits such as “empathy”, “humanity”, “passion”, “beautiful[ness]” and “honorab[ility]”. …”
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