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21881
Effects of endocrine disrupting chemicals, blood metabolome, and epigenetics on breast cancer risk: A multi-dimensional mendelian randomization study
Published 2025-02-01“…This study uses MR to investigate the effects of three types of EDCs, including bisphenols, parabens, and phthalates, on the risk of overall breast cancer and its subtypes—Luminal A, Luminal B, triple negative, human epidermal growth factor receptor 2-enriched, and estrogen receptor-positive/negative. …”
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21882
A sterol panel for rare lipid disorders: sitosterolemia, cerebrotendinous xanthomatosis and Smith-Lemli-Opitz syndrome
Published 2025-01-01“…A simple and rapid method to extract free sterols from human serum and quantitate their concentration using isotope-dilution liquid chromatography-tandem mass spectrometry (LC-MS/MS) without derivatization was developed. …”
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21883
Removal of Antibiotics from Real Hospital Wastewater by Cold Plasma Technique
Published 2021-01-01“…Hospital wastewater contains a complex mixture of bioactive substances and microorganisms that are deleterious to humans and aquatic animals. In this study, four antibiotics, namely, ofloxacin, ciprofloxacin, cefuroxime, and amoxicillin, respectively, from the wastewater of seven hospitals in Ho Chi Minh City, Vietnam, were monitored. …”
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21884
Susceptibility of Sardinella lemuru to emerging marine microplastic pollution
Published 2020-07-01“…While results from Canonical Correspondence Analysis of ingested microplastic data had no relationship with the standard lengths of the sardine and the masses of ingested food materials at varying size classes, the total number of ingested microplastics from 2014 to 2016 were directly correlated (r<sup>2</sup>=0.91, <em>p</em>=0.003) with the human population at the landing sites along the coastline of northern Mindanao.…”
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21885
Intratumoral <i>Fusobacterium nucleatum</i> in Pancreatic Cancer: Current and Future Perspectives
Published 2024-12-01“…<i>Fusobacterium nucleatum (Fn)</i>, an anaerobic Gram-negative bacterium primarily residing in the oral cavity, has garnered significant attention for its emerging role in several extra-oral human diseases and, lately, in pancreatic cancer progression and prognosis. …”
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21886
Modeling of magnetic vestibular stimulation experienced during high-field clinical MRI
Published 2025-01-01“…Using high-resolution micro-CT data of the human membranous labyrinth, we ensured anatomical accuracy. …”
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21887
Effects of Breast-Conserving Surgery Combined with Sentinel Lymph Node Biopsy on Breast Cosmetic Appearance and Systemic Stress of Patients with Breast Cancer
Published 2025-01-01“…No significant difference was observed between the two groups regarding human epidermal growth factor receptor-2 (HER-2) expression (p > 0.05). …”
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21888
Status of seawater intrusion in Mexico: A review
Published 2025-02-01“…This synthesis of seawater intrusion highlights the role of climate change, which directly links to human-induced pressures. The findings offer insights into coastal regions worldwide grappling with similar challenges from climate change and increasing water demand.…”
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21889
G Protein-Coupled Receptor 17 Inhibits Glucagon-like Peptide-1 Secretion via a Gi/o-Dependent Mechanism in Enteroendocrine Cells
Published 2024-12-01“…Here, we expressed the human GPR17 long isoform (hGPR17L) in GLUTag cells, a murine EEC line, and we used the GPR17 synthetic agonist MDL29,951 together with pharmacological probes and genetic approaches to quantitatively assess the contribution of GPR17 signaling to GLP-1 secretion. …”
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21890
Preparation and in vitro biological evaluation of strontium doped β-tricalcium phosphate scaffolds for alveolar bone tissue regeneration
Published 2025-01-01“…A range of strategies have been devised to boost the osteogenic differentiation capacity of various biomaterials. As a human trace element, strontium (Sr) plays a vital role in bone remodeling. …”
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21891
Metabolomics and Lipidomics Reveal the Metabolic Disorders Induced by Single and Combined Exposure of Fusarium Mycotoxins in IEC-6 Cells
Published 2025-01-01“…Deoxynivalenol (DON), fumonisin B<sub>1</sub> (FB<sub>1</sub>), and zearalenone (ZEN) are typical fusarium mycotoxins that occur worldwide in foodstuffs, posing significant health hazards to humans and animals. Single and combined exposure of DON, FB<sub>1</sub>, and ZEN leads to intestinal toxicity but the toxicology mechanism research is still limited. …”
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21892
The Role of ChatGPT and AI Chatbots in Optimizing Antibiotic Therapy: A Comprehensive Narrative Review
Published 2025-01-01“…However, challenges such as inconsistent handling of clinical nuances, susceptibility to unsafe advice, algorithmic biases, data privacy concerns, and limited clinical validation underscore the importance of human oversight and refinement. <b>Conclusions:</b> AI chatbots have the potential to complement antibiotic stewardship efforts by promoting appropriate antibiotic use and improving patient outcomes. …”
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21893
Prognostic significance of mast cell and microvascular densities in malignant peripheral nerve sheath tumor with and without neurofibromatosis type 1
Published 2019-03-01“…Recently, the essential role of mast cells in the tumor onset of neurofibromatosis type 1 (NF1)‐associated neurofibromas and MPNSTs was confirmed in both experimental and human studies. In this study, we investigate mast cell density (MCD), microvascular density (MVD), and proliferation index (Ki‐67) in MPNST. …”
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21894
AIM2 Mediates Inflammation-Associated Renal Damage in Hepatitis B Virus-Associated Glomerulonephritis by Regulating Caspase-1, IL-1β, and IL-18
Published 2014-01-01“…Following siRNA-mediated knockdown of AIM2 in HBV-infected and HBV-uninfected human glomerular mesangial (HGM) cells, expression of caspase-1, IL-1β, and IL-18 was detected by qRT-PCR and Western blot. …”
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21895
Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis
Published 2025-01-01“…Epigenetic age acceleration was observed in patients with IgG4-SC, but not in those with PSC or UC. meQTL analyses to identify genetic determinants of methylation revealed a strong human leucocyte antigen (HLA) signal in both PSC and IgG4-SC (HLA-DQB2, HLA-DPA1, HLA-F and HLA-DRA). …”
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21896
Intensification of Natural Disasters in the State of Pará and the Triggering Mechanisms Across the Eastern Amazon
Published 2024-12-01“…The detailed characterization of disasters on a municipal scale is relevant in terms of the scientific contribution applied to the strategic decision-making, planning, and implementation of public policies aimed at early risk management (rather than post-disaster response), which is critical for safeguarding human well-being and strengthening the resilience of Amazonian communities vulnerable to climate change.…”
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21897
EEG-based functional and effective connectivity patterns during emotional episodes using graph theoretical analysis
Published 2025-01-01“…These findings enhance our understanding of emotional processing and have practical applications in mental health, biomarker identification, and human-computer interaction.…”
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21898
Lipidomics-based association study reveals genomic signatures of anti-cancer qualities of pigmented rice sprouts
Published 2025-01-01“…This study offers valuable insights into the health-promoting potential of germinated rice sprouts as a rich dietary source of antioxidants beneficial to human health.…”
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21899
Use of digital data from open sources during the investigation of criminal offenses: certain aspects
Published 2024-06-01“…An analysis of national legislation, national judicial practice, the Berkeley protocol for conducting an investigation using open digital data (hereinafter referred to as the Berkeley Protocol), the practice of the European Court of Human Rights, the International Criminal Court and scientific research, based on which, by means of a synthesis, the basis of the problem was identified. …”
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21900
Science-based communication and education needed to improve forest carbon science, policy, and management outcomes
Published 2025-01-01“…Climate change is one of the most pressing issues facing humanity and forests are increasingly seen as a key pathway to mitigating and adapting to the climate crisis. …”
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