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21861
The Mitochondria-Targeted Antioxidant SkQ1 Downregulates Aryl Hydrocarbon Receptor-Dependent Genes in the Retina of OXYS Rats with AMD-Like Retinopathy
Published 2014-01-01“…It has been shown that SkQ1 reduces clinical signs of retinopathy in senescence-accelerated OXYS rats, which are a known animal model of human age-related macular degeneration (AMD). The aim of this work was to test whether SkQ1 affects transcriptional activity of AhR (aryl hydrocarbon receptor) and Nrf2 (nuclear factor erythroid 2-related factor 2), which are considered as AMD-associated genes in the retina of OXYS and Wistar rats. …”
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21862
Comparison of the mechanical properties of different skin sites for auricular and nasal reconstruction
Published 2017-04-01“…Methods Using ten fresh human cadavers, the tensile Young’s Modulus of the skin from the forehead, forearm, temporoparietal, post-auricular and submandibular neck was assessed. …”
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21863
Microneedle technology for enhanced topical treatment of skin infections
Published 2025-03-01“…Skin infections caused by microbes such as bacteria, fungi, and viruses often lead to aberrant skin functions and appearance, eventually evolving into a significant risk to human health. Among different drug administration paradigms for skin infections, microneedles (MNs) have demonstrated superiority mainly because of their merits in enhancing drug delivery efficiency and reducing microbial resistance. …”
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21864
Artificial Taste: Advances and Innovative Applications in Healthcare
Published 2025-01-01“…Targeted original research papers were analyzed, with data extracted to address five key aspects: interface design, stimulation parameters, sensation verification results, applications to health problems, and potential side effects in human subjects. Results: A total of 19 relevant papers were identified. …”
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21865
Blue elixir of youth and wellness: The multicomponent-multitarget paradigm of Curcuma caesia Roxb
Published 2025-02-01“…Through HPLC-ESI-MS/MS, the chemical analysis identified key phenolic compounds, including (−)-epicatechin, procyanidin B2, and p-coumaric acid. Human immortalized keratinocyte cell lines (HaCaT) were treated with CCRE in healthy and UVB-induced conditions to assess their impact on oxidative stress and aging. …”
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21866
Inhibiting the alternative pathway of complement by reducing systemic complement factor B: Randomized, double-blind, placebo-controlled phase 1 studies with Sefaxersen
Published 2025-03-01“…An over-active alternative complement pathway has been implicated in the pathophysiology of multiple diseases, including IgA nephropathy and geographic atrophy secondary to age related macular degeneration. In first-in-human double-blind, placebo-controlled phase 1 studies, the safety and pharmacodynamic effects of sefaxersen (RO7434656), a GalNAc-conjugated 2’-MOE antisense oligonucleotide targeting the complement factor B mRNA, was investigated. …”
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21867
Spatial genetic characterization of the red fox (Vulpes vulpes) in the area between the Alps and the Central Dinaric Mountains
Published 2024-11-01“…Studying genetic diversity is crucial for the resilience and adaptability of populations, ensuring their survival amid environmental changes and human-induced pressures.…”
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21868
Incremental Instance-Oriented 3D Semantic Mapping via RGB-D Cameras for Unknown Indoor Scene
Published 2020-01-01“…Scene parsing plays a crucial role when accomplishing human-robot interaction tasks. As the “eye” of the robot, RGB-D camera is one of the most important components for collecting multiview images to construct instance-oriented 3D environment semantic maps, especially in unknown indoor scenes. …”
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21869
Cryopreserved Umbilical Cord Mesenchymal Stem Cells Show Comparable Effects to Un-Cryopreserved Cells in Treating Osteoarthritis
Published 2025-01-01“…But it is unclear whether cryopreservation reduces the therapeutic effects of human umbilical cord mesenchymal stem cells (hucMSCs) on osteoarthritis (OA). …”
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21870
Comprehensive multi-omics analysis showed that CDC6 is a potential prognostic and immunotherapy biomarker for multiple cancer types including HCC
Published 2025-03-01“…Methods: Explored CDC6 mRNA and protein expression in normal human tissues and tumors using TCGA, GTEx, and HPA. …”
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21871
The Clinical Significance of High Antimicrobial Resistance in Community-Acquired Urinary Tract Infections
Published 2020-01-01“…The emergence and spread of multidrug-resistant (MDR) bacteria are increasing, representing one of the biggest threats for human health. The objective of our study was to describe antimicrobial patterns of resistance and identify risk factors associated with MDR uropathogens. …”
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21872
Microblog discourse analysis for parenting style assessment
Published 2025-02-01“…It facilitates the identification of suicide risk factors among microblog student users, and enables timely interventions to prevent suicides, which enhances human wellbeing and saves lives.…”
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21873
Development and Validation of Rabies Health Education Module (RaHEM) for Dog Owners in Kelantan, Malaysia: An ADDIE Model
Published 2025-01-01“…Despite the availability of effective vaccines for both humans and animals, the persistence of rabies-related fatalities underscores the need for enhanced public education strategies. …”
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21874
Instance maps as an organising concept for complex experimental workflows as demonstrated for (nano)material safety research
Published 2025-01-01“…Application of the InstanceMaps tool (described herein) to research workflows of increasing complexity is presented to demonstrate its utility, starting from (i) documentation of a nanomaterial’s synthesis, functionalisation, and characterisation, over (ii) assessment of a nanomaterial’s transformations in complex media, (iii) description of the culturing of ecotoxicity model organisms Daphnia magna and their use in standardised tests for nanomaterials ecotoxicity assessment, and (iv) visualisation of complex workflows in human immunotoxicity assessment using cell lines and primary cellular models, to (v) the use of the instance map approach for the coordination of materials and data flows in complex multipartner collaborative projects and for the demonstration of case studies. …”
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21875
Experimental study of the effects of siestas on the nocturnal sleep quality and thermal comfort levels under thermoneutral environment in summer
Published 2025-06-01“…It has been determined that siestas could potentially have both mental and physical influences on the human body. However, the effects of siestas on the nocturnal sleep quality and thermal comfort levels under thermoneutral environment had not yet been examined in detail. …”
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21876
Association between changes in genital immune markers and vaginal microbiome transitions in bacterial vaginosis
Published 2025-01-01“…Abstract Bacterial vaginosis (BV), characterized by an imbalance in the vaginal microbiota, is a prevalent condition among women of reproductive age and a risk factor for human immunodeficiency virus, sexually transmitted infections, and preterm birth. …”
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21877
Assessment of Hepatic Mineral Composition in Sheep, Cattle, Chicken, and Fish in Erbil City, Kurdistan Region-Iraq
Published 2021-07-01“…Therefore, it can be concluded that there are problems on animal and human health (due to high concentration of Pb and Ni) would be raised at present from the consumption of ovine, bovine, checkin, and fish slaughtered from the city of Erbil. …”
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21878
PROLIFERATION AND APOPTOSIS IN RAT MODELS OF ORAL SQUAMOUS CELL CARCINOMA INDUCED BY CAPSAICIN EXTRACT NANOPARTICLE GEL
Published 2023-11-01“…Capsaicin, a pungent phytochemical in red peppers, exhibits both anti-proliferative and potential pro-cancer effects on human cancer cell lines. Purpose: Determine the proliferation and apoptosis between five groups of rats induced OSCC. …”
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21879
Retrieval of NO2 Columns by Exploiting MAX-DOAS Observations and Comparison with OMI and TROPOMI Data during the Time Period of 2015–2019
Published 2022-05-01“…Exposure to high concentrations of NO2 has been reported to cause various health issues in humans. This study presents an intercomparison of NO2 retrieval settings using the Differential Optical Absorption Spectroscopy (DOAS) and based on the literature published over the last 20 years. …”
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21880
The effect of light-emitting diode-mediated photobiomodulation therapy on orthodontic tooth movement: A literature review
Published 2025-04-01“…Five studies were included in the review, comprising two animal studies (ages 10 and 12 weeks) and three human studies (ages ranging from 15 to 17 years). …”
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