EZH2 Regulates Lipopolysaccharide-Induced Periodontal Ligament Stem Cell Proliferation and Osteogenesis through TLR4/MyD88/NF-κB Pathway by Pengcheng Wang, Huan Tian, Zheng Zhang, Zuomin Wang

“…LPS stimulation significantly promoted EZH2 and H3K27me3 expression in primary human periodontal ligament stem cells (PDLSCs). Targeting EZH2 prevented LPS-induced upregulation of the inflammatory cytokines and inhibition of cell proliferation and migration. …”
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Effects of brain renin- angiotensin system inhibition in ISIAH rats with inherited stress-induced arterial hypertension by L. O. Klimov, M. A. Ryazanova, L. A. Fedoseeva, A. L. Markel

“…It has been shown that a steady arterial pressure increase is often associated with changes in the functioning of the central (brain) RAS in various animal models of hypertensive disease and in humans. Nevertheless, it is still not completely clear whether these changes alone are sufficient for the formation of hypertensive status, and whether the components of the central RAS can be used as targets for the treatment of hypertensive disease. …”
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Biochemical Constituents of Phaleria macrocarpa (Leaf) Methanolic Extract Inhibit ROS Production in SH-SY5Y Cells Model by Ibrahim Maina Hassan, Wan Norhamidah Wan Ibrahim, Ferdaus Binti Mohamat Yusuf, Siti Aqlima Ahmad, Syahida Ahmad

“…Reactive oxygen species generation in mammalian cells profoundly affects several critical cellular functions, and the lack of efficient cellular detoxification mechanisms which remove these radicals may lead to several human diseases. Several studies show that ROS is incriminated as destructive agents in the context of the nervous system especially with advance in age leading to neurodegeneration. …”
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Liraglutide Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism via SHP1/AMPK Signaling Pathway by Peng Yu, Xi Xu, Jing Zhang, Xuan Xia, Fen Xu, Jianping Weng, Xiaoyang Lai, Yunfeng Shen

“…The effects of LR were examined on the high-fat diet-induced in vivo model in mice and in vitro model of NAFLD in human HepG2 cells. Liver tissues and HepG2 cells were procured for measuring lipid metabolism, histological examination, and western blot analysis. …”
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A preliminary evaluation of a fast, low-cost, and high-throughput nucleic acid extraction method for bacterial microbiota profiling in low-microbial biomass samples by Xiangning Bai, Simon Rayner, Linda Ellevog Skuggen, Kine Kragl Engseth, Pål Marius Bjørnstad, Marianne Dalland, Gregor D. Gilfillan, Magnar Bjørås, Andreas Matussek

“…Abstract The respiratory tract is colonized with low-density microbial communities, which have been shown to impact human respiratory health through microbiota–host interactions. …”
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New Bioactive Metabolites from the Thermophilic Fungus Penicillium sp. Isolated from Ghamiqa Hot Spring in Saudi Arabia by Raha Orfali, Shagufta Perveen

“…All isolated metabolites were studied for their antibiotic effect against several pathogenic bacteria and for their cytotoxicity against the lymphoma human cancer cell line HTB-176. Austinol 3 exhibited strong antibacterial activity against P. aeruginosa bacterial strain with an MIC value of 0.13 ± 0.4 µg·mL−1, whereas emodin 4 demonstrated significant cytotoxicity against the tested HTB-176 cell line with an IC50 value of 2 ± 7.6 µM, while the other compounds were moderate to inactive with IC50 ranging from 4.3 ± 0.25–22 ± 2.94 µM in this assay.…”
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A Linear Model to Estimate Faculty Member in The Iranian Medical Sciences Universities by bahram mohaghegh, niusha shahidi sadeghi, amir mohamadi, mohamad nazari, mohamad hosein salarianzadeh, amir ahamad akhavan, mohamad reza maleki, mostafa deilami, azam sadat hoseini, fatemeh talebi, ali akbar abedi, maasumeh faraj allahi

“…Background and Aim: Human resource planning of faculties in medical sciences universities is an important requirement to achieve the function of producing health workforce. …”
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Expression and Function of the Homeostatic Molecule Del-1 in Endothelial Cells and the Periodontal Tissue by Jieun Shin, Kavita B. Hosur, Kalyani Pyaram, Ravi Jotwani, Shuang Liang, Triantafyllos Chavakis, George Hajishengallis

“…Here we investigated additional novel mechanisms whereby Del-1 could interfere with neutrophil recruitment and inflammation. Treatment of human endothelial cells with Del-1 did not affect the expression of endothelial molecules involved in the leukocyte adhesion cascade (ICAM-1, VCAM-1, and E-selectin). …”
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Therapeutic Effect and Location of GFP-Labeled Placental Mesenchymal Stem Cells on Hepatic Fibrosis in Rats by Jiong Yu, Guangshu Hao, Dan Wang, Jingqi Liu, Xiaotian Dong, Yanni Sun, Qiaoling Pan, Yang Li, Xiaowei Shi, Lanjuan Li, Hongcui Cao

“…The present study was designed to investigate the effect of human placenta mesenchymal stem cells (hPMSCs) expressing green fluorescent protein (GFP) on carbon tetrachloride- (CCl4-) induced liver fibrosis in rats. …”
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Longitudinal mitochondrial bioenergetic signatures of blood monocytes and lymphocytes improve during treatment of drug-susceptible pulmonary tuberculosis patients by Bridgette M. Cumming, Kelvin W. Addicott, Fernanda Maruri, Fernanda Maruri, Vanessa Pillay, Rukaya Asmal, Sashen Moodley, Beatriz Barreto-Durate, Beatriz Barreto-Durate, Mariana Araújo-Pereira, Mariana Araújo-Pereira, Matilda Mazibuko, Zoey Mhlane, Nikiwe Mbatha, Khadija Khan, Senamile Makhari, Farina Karim, Lauren Peetluk, Alexander S. Pym, Mahomed Yunus S. Moosa, Yuri F. van der Heijden, Yuri F. van der Heijden, Yuri F. van der Heijden, Timothy S. Sterling, Timothy S. Sterling, Bruno B. Andrade, Bruno B. Andrade, Alasdair Leslie, Alasdair Leslie, Alasdair Leslie, Adrie J. C. Steyn, Adrie J. C. Steyn, Adrie J. C. Steyn

“…The impact of human pulmonary tuberculosis (TB) on the bioenergetic metabolism of circulating immune cells remains elusive, as does the resolution of these effects with TB treatment. …”
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The Product of Formal Innovation in Contemporary Interior Design Techniques by Muhammad JarAllah Tawfiq, Rouwaida Ra'ed Muhammad

“… The product of formal innovation has become a strategy in itself, and because the design development with a technical dimension has become a feature of human life, so the concerned institutions have been referring to this through architecture, including the interior spaces it contains, especially at the level of all materials and raw materials.Therefore, in recent years a phenomenon has emerged that is characterized by the innovation of new design techniques, as the interior designer began to realize the importance of innovation, renewal and development through aesthetic and creative data that takes into account the formation of a future vision in which factors concerned with technical development in contemporary interior design overlap, and by informing researchers about foreign design techniques .Therefore, the problem of the research study was formulated with the following question: Does the product of formal innovation have a role in contemporary interior design techniques? …”
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EPPTA: Efficient partially observable reinforcement learning agent for penetration testing applications by Zegang Li, Qian Zhang, Guangwen Yang

“…Automating pen‐testing through reinforcement learning (RL) facilitates more frequent assessments, minimizes human effort, and enhances scalability. However, real‐world pen‐testing tasks often involve incomplete knowledge of the target network system. …”
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Climatic impacts on mortality in pre-industrial Sweden by T. T. Chen, T. T. Chen, R. Edvinsson, K. Modig, H. W. Linderholm, F. C. Ljungqvist, F. C. Ljungqvist, F. C. Ljungqvist

“…<p>Climate variability and change, as well as extreme weather events, have notable impacts on human health and mortality. In historical times, the effect of climate on health and mortality was stronger than today, owing to factors such as poor housing and healthcare, along with the nutrition status that was meditated through climatic impacts on food production. …”
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Surface topography modulates initial platelet adhesion to titanium substrata by Cecilia Yan Guo, Raymond Mo, Hugh Kim

“…Platelets were isolated from human blood, washed, and seeded on to the 4 test surfaces; platelet adhesion was quantified by microscopy. …”
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In vitro investigating of anticancer activity of focuxanthin from marine brown seaweed species by M. Karkhane Yousefi, M. Seyed Hashtroudi, A. Mashinchian Moradi, A.R. Ghasempour

“…Moreover, the anticancer activity of fucoxanthin-containing extracts on breast cancer cells line and normal human skin fibroblast cells line was assessed by MTT [3-(4,5-dimethylthiazolyl)-2,5-diphenyl-tetrazolium bromide] assay to specify the cytotoxic effects. …”
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Detection and Whole-Genome Characteristics of <i>Bordetella trematum</i> Isolated from Captive Snakes by Magdalena Zając, Inga Bona, Magdalena Skarżyńska, Renata Kwit, Anna Lalak, Ewelina Skrzypiec, Emilia Mikos-Wojewoda, Paulina Pasim, Dominika Wojdat, Weronika Koza, Dariusz Wasyl

“…<i>Bordetella trematum</i> is a rare member of the genus <i>Bordetella</i>, primarily associated with human wound infections rather than respiratory diseases. …”
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A Review of the Engineering Properties of Metakaolin Based Concrete: Towards Combatting Chloride Attack in Coastal/Marine Structures by Deveshan L. Pillay, Oladimeji B. Olalusi, Paul O. Awoyera, Carlos Rondon, Ana María Echeverría, John Temitope Kolawole

“…Changing human lifestyle and increasing urbanisation are contributory factors to the high demand for concrete construction materials across the globe. …”
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The impact of genetic polymorphisms of IL28B gene on the efficacy of antiviral therapy of the chronic hepatitis C by using the standard Interferon-<i>α</i> by A. V. Lapshin, M. V. Mayevskaya, V. T. Ivashkin, P. O. Bogomolov, I. G. Nikitin, O. O. Znoyko

“…The studies of genetic polymorphisms of the regions of human genome demonstrates that the positive predictive value of IL28B polymorphisms among the patients with 1-st HCV genotype is higher than among the patients with 2nd and 3d genotypes. …”
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Genomic and transcriptomic insights into vitamin A-induced thermogenesis and gene reuse as a cold adaptation strategy in wild boars by Mingpeng Zhang, Aleksei Traspov, Jiawen Yang, Min Zheng, Veronika R. Kharzinova, Huashui Ai, Natalia A. Zinovieva, Lusheng Huang

“…Recent gene flow (<100 years) from RUA to RUE reflects human-mediated introductions. Cold-region wild boars exhibit strong selection signatures indicative of genetic adaptation to cold climates. …”
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Interleukin-32γ in the Control of Acute Experimental Chagas Disease by Yarlla L. L. Braga, José R. C. Neto, Arthur W. F. Costa, Muriel V. T. Silva, Marcos V. Silva, Mara R. N. Celes, Milton A. P. Oliveira, Leo A. B. Joosten, Fátima Ribeiro-Dias, Rodrigo S. Gomes, Juliana R. Machado

“…Our results indicate that the presence of human IL-32γ in mice infected with the Colombian strain of T. cruzi is important for infection control during the acute phase of Chagas disease.…”
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