Beyond consciousness: Ethical, legal, and social issues in human brain organoid research and application by Masanori Kataoka, Takuya Niikawa, Naoya Nagaishi, Tsung-Ling Lee, Alexandre Erler, Julian Savulescu, Tsutomu Sawai

“…Despite the academic and societal attention on the possibility that human brain organoids may be conscious, we have identified diverse issues in human brain organoid research and applications. …”
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Detection of fungal sequences in human brain: rDNA locus amplification and deep sequencing by Rodrigo Leitao, Iam Ut Wan, Harry Chown, Thomas J. Williams, Matthew C. Fisher, Johanna Rhodes

“…In this study we adopted a nanopore-based sequencing approach to characterise the presence or absence of fungal genera in both human brain tissue and cerebrospinal fluid (CSF). We observed the presence of small fungal burden DNA in two AD brains and a control case (extensive amyloid angiopathy). …”
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Persistent homology based topological analysis on the gestalt patterns during human brain cognition process by Zaisheng LIU, Fei NI, Rongpeng LI, Honggang ZHANG, Chang LIU, Jiefang ZHANG, Songyun XIE

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Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening by Anand Ramani, Giovanni Pasquini, Niklas J. Gerkau, Vaibhav Jadhav, Omkar Suhas Vinchure, Nazlican Altinisik, Hannes Windoffer, Sarah Muller, Ina Rothenaigner, Sean Lin, Aruljothi Mariappan, Dhanasekaran Rathinam, Ali Mirsaidi, Olivier Goureau, Lucia Ricci-Vitiani, Quintino Giorgio D’Alessandris, Bernd Wollnik, Alysson Muotri, Limor Freifeld, Nathalie Jurisch-Yaksi, Roberto Pallini, Christine R. Rose, Volker Busskamp, Elke Gabriel, Kamyar Hadian, Jay Gopalakrishnan

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A short investigation of the effect of the selection of human brain atlases on the performance of ASD's classification models by Naseer Ahmed Khan, Xuequn Shang

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Clinical confocal laser endomicroscopy for imaging of autofluorescence signals of human brain tumors and non-tumor brain by Marlen Reichenbach, Sven Richter, Roberta Galli, Matthias Meinhardt, Katrin Kirsche, Achim Temme, Dimitrios Emmanouilidis, Witold Polanski, Insa Prilop, Dietmar Krex, Stephan B. Sobottka, Tareq A. Juratli, Ilker Y. Eyüpoglu, Ortrud Uckermann

“…Conclusion Label-free CLE imaging through an approved clinical device was able to visualize the characteristic autofluorescence patterns of human brain tumors and non-tumor brain tissue ex vivo and in situ. …”
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Direct real‐time intra‐operative imaging of human brain tumour vessels using intravital microscopy by Diogo Moniz Garcia, Emmanuel Gabriel, Alfredo Quinones‐Hinojosa

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Physical Activity Protects the Human Brain against Metabolic Stress Induced by a Postprandial and Chronic Inflammation by Leo Pruimboom, Charles L. Raison, Frits A. J. Muskiet

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Pregnancy entails a U-shaped trajectory in human brain structure linked to hormones and maternal attachment by Camila Servin-Barthet, Magdalena Martínez-García, María Paternina-Die, Luis Marcos-Vidal, Daniel Martín de Blas, Anna Soler, Olha Khymenets, Daniel Bergé, Gemma Casals, Pilar Prats, Oscar J. Pozo, Clara Pretus, Susana Carmona, Oscar Vilarroya

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Inactivation of the CMAH gene and deficiency of Neu5Gc play a role in human brain evolution by Yuxin Liu, Jinhong Li, Qicai Liu

“…The inactivation of CMAH and the loss of endogenous Neu5Gc may have played a role in human brain evolution by affecting neural conduction, neuronal development, and aging.…”
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Exploring in vivo human brain metabolism at 10.5 T: Initial insights from MR spectroscopic imaging by Lukas Hingerl, Bernhard Strasser, Simon Schmidt, Korbinian Eckstein, Guglielmo Genovese, Edward J. Auerbach, Andrea Grant, Matt Waks, Andrew Wright, Philipp Lazen, Alireza Sadeghi-Tarakameh, Gilbert Hangel, Fabian Niess, Yigitcan Eryaman, Gregor Adriany, Gregory Metzger, Wolfgang Bogner, Małgorzata Marjańska

“…Introduction: Ultra-high-field magnetic resonance (MR) systems (7 T and 9.4 T) offer the ability to probe human brain metabolism with enhanced precision. Here, we present the preliminary findings from 3D MR spectroscopic imaging (MRSI) of the human brain conducted with the world's first 10.5 T whole-body MR system. …”
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Author Correction: Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening by Anand Ramani, Giovanni Pasquini, Niklas J. Gerkau, Vaibhav Jadhav, Omkar Suhas Vinchure, Nazlican Altinisik, Hannes Windoffer, Sarah Muller, Ina Rothenaigner, Sean Lin, Aruljothi Mariappan, Dhanasekaran Rathinam, Ali Mirsaidi, Olivier Goureau, Lucia Ricci-Vitiani, Quintino Giorgio D’Alessandris, Bernd Wollnik, Alysson Muotri, Limor Freifeld, Nathalie Jurisch-Yaksi, Roberto Pallini, Christine R. Rose, Volker Busskamp, Elke Gabriel, Kamyar Hadian, Jay Gopalakrishnan

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Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity by Shuyang Yao, Arvid Harder, Fahimeh Darki, Yu-Wei Chang, Ang Li, Kasra Nikouei, Giovanni Volpe, Johan N. Lundström, Jian Zeng, Naomi R. Wray, Yi Lu, Patrick F. Sullivan, Jens Hjerling-Leffler

“…By integrating genomic insights from genome-wide association studies with a comprehensive single-cell transcriptomic atlas of the adult human brain, we prioritized specific neuronal clusters significantly enriched for the SNP-heritabilities for schizophrenia, bipolar disorder, and major depressive disorder along with intelligence, education, and neuroticism. …”
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Formalin Fixation as Tissue Preprocessing for Multimodal Optical Spectroscopy Using the Example of Human Brain Tumour Cross Sections by Mona Stefanakis, Anita Lorenz, Jörg W. Bartsch, Miriam C. Bassler, Alexandra Wagner, Marc Brecht, Axel Pagenstecher, Jens Schittenhelm, Barbara Boldrini, Sabrina Hakelberg, Susan Noell, Christopher Nimsky, Marcos Tatagiba, Rainer Ritz, Karsten Rebner, Edwin Ostertag

“…Nonfixed and formalin-fixed cross sections of different common human brain tumours were subjected to analysis of chemical variations using ultraviolet and Fourier-transform infrared microspectroscopy. …”
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Enhanced multiscale human brain imaging by semi-supervised digital staining and serial sectioning optical coherence tomography by Shiyi Cheng, Shuaibin Chang, Yunzhe Li, Anna Novoseltseva, Sunni Lin, Yicun Wu, Jiahui Zhu, Ann C. McKee, Douglas L. Rosene, Hui Wang, Irving J. Bigio, David A. Boas, Lei Tian

“…Abstract A major challenge in neuroscience is visualizing the structure of the human brain at different scales. Traditional histology reveals micro- and meso-scale brain features but suffers from staining variability, tissue damage, and distortion, which impedes accurate 3D reconstructions. …”
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Protective effects of berbamine against arginase-1 deficiency-induced injury in human brain microvascular endothelial cells by Xiaolan Wei, Weiwei Li, Zixuan Chen, Jintu Chen, Yun Chen, Jiangping Cai, Huasong Lin

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The frontal and posterior cortical areas involved in the non-spatial visual allocation of attention in the human brain: a functional neuroimaging study by Kristina Drudik, Kristina Drudik, Veronika Zlatkina, Elise B. Barbeau, Michael Petrides, Michael Petrides

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The Critical Role of YAP/BMP/ID1 Axis on Simulated Microgravity‐Induced Neural Tube Defects in Human Brain Organoids by Di Guo, Bin Yao, Wen‐Wei Shao, Jia‐Chen Zuo, Zhe‐Han Chang, Jian‐Xin Shi, Nan Hu, Shuang‐Qing Bao, Meng‐Meng Chen, Xiu Fan, Xiao‐Hong Li

“…In this study, the effects of stimulated microgravity (SMG) on the development of human brain organoids are investigated. SMG impairs N‐cadherin‐based adherens junction formation, leading to neural tube defects associated with dysregulated self‐renewal capacity and neuroepithelial disorganization in human brain organoids. …”
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Ultra high density imaging arrays in diffuse optical tomography for human brain mapping improve image quality and decoding performance by Zachary E. Markow, Jason W. Trobaugh, Edward J. Richter, Kalyan Tripathy, Sean M. Rafferty, Alexandra M. Svoboda, Mariel L. Schroeder, Tracy M. Burns-Yocum, Karla M. Bergonzi, Mark A. Chevillet, Emily M. Mugler, Adam T. Eggebrecht, Joseph P. Culver

“…Abstract Functional magnetic resonance imaging (fMRI) has dramatically advanced non-invasive human brain mapping and decoding. Functional near-infrared spectroscopy (fNIRS) and high-density diffuse optical tomography (HD-DOT) non-invasively measure blood oxygen fluctuations related to brain activity, like fMRI, at the brain surface, using more-lightweight equipment that circumvents ergonomic and logistical limitations of fMRI. …”
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Human Brain Microvascular Endothelial Cells and Umbilical Vein Endothelial Cells Differentially Facilitate Leukocyte Recruitment and Utilize Chemokines for T Cell Migration by Shumei Man, Eroboghene E. Ubogu, Katherine A. Williams, Barbara Tucky, Melissa K. Callahan, Richard M. Ransohoff

“…In this study, we compared two different endothelial cellular models: transfected human brain microvascular endothelial cells (THBMECs) and human umbilical vein endothelial cells (HUVECs). …”
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