Lipopolysaccharide alters CEBPβ signaling and reduces estradiol production in bovine granulosa cells by Mackenzie J. Dickson, I. Martin Sheldon, John J. Bromfield

“…The transcription factor CCAAT enhancer binding protein beta (CEBPβ) not only facilitates the transcription of LPS regulated cytokines, but also binds to the promoter region of CYP19A1 in humans, mice, and buffalo. We hypothesized that LPS alters CEBPβ signaling to reduce CYP19A1 expression, resulting in decreased estradiol secretion. …”
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Comparative Effects of Glenzocimab and Eptifibatide on Bleeding Severity in 2 Mouse Models of Intracranial Hemorrhage by Sébastien Dupont, Héloïse Lebas, Sabrina Mavouna, Eloïse Pascal, Astride Perrot, Adrien Cogo, Marie‐Charlotte Bourrienne, Carine Farkh, Mialitiana Solo Nomenjanahary, Véronique Ollivier, Fatima Zemali, Bernhard Nieswandt, Stéphane Loyau, Martine Jandrot‐Perrus, Eric Camerer, Jean‐Philippe Desilles, Mikael Mazighi, Yacine Boulaftali, Benoît Ho‐Tin‐Noé

“…Methods and Results The severity of ICH was assessed in mice humanized for glycoprotein VI treated or not with glenzocimab or eptifibatide at effective dose, in a model of primary ICH caused by unilateral striatal injection of collagenase type VII, and in a model of hyperglycemia‐induced hemorrhagic transformation of cerebral ischemia–reperfusion injury. …”
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Diabetes and gut microbiome by Kateřina Olša Fliegerová, Tiziana Maria Mahayri, Tiziana Maria Mahayri, Hana Sechovcová, Hana Sechovcová, Chahrazed Mekadim, Jakub Mrázek, Radka Jarošíková, Radka Jarošíková, Michal Dubský, Vladimíra Fejfarová, Vladimíra Fejfarová

“…Attention is focused on changes in the abundance of specific bacterial groups at different taxonomic levels in humans, and microbiome shift is also assessed in relation to geographic location, age, diet and antidiabetic drug. …”
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Understanding the impacts of drought on peanuts (Arachis hypogaea L.): exploring physio-genetic mechanisms to develop drought-resilient peanut cultivars by Sameer Pokhrel, Prasanna Kharel, Swikriti Pandey, Stephanie Botton, Gema Takbir Nugraha, Corley Holbrook, Peggy Ozias-Akins

“…Peanuts under drought stress exhibit higher levels of pre-harvest aflatoxin contamination, a toxic fungal metabolite detrimental to both humans and animals. One way to sustain peanut production in drought-prone regions and address pre-harvest aflatoxin contamination is by developing drought-tolerant peanut cultivars, a process that can be accelerated by understanding the underlying physiological and genetic mechanisms for tolerance to drought stress. …”
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First Report on the Frequency and Subtype Distribution of <i>Blastocystis</i> sp. in Extensively Reared Holstein-Friesian Cattle from Terceira Island, Azores Archipelago, Portugal by Sara Gomes-Gonçalves, Alexandra Silva, Guilherme Moreira, Nausicaa Gantois, Rubén Garcia Dominguez, Eric Viscogliosi, Magali Chabé, João R. Mesquita

“…However, the low frequency of <i>Blastocystis</i> sp. in this animal cohort possibly attributed to the extensive grazing system practiced on Terceira Island and the limited presence of zoonotic isolates, suggests a minimal risk of transmission from cattle to humans. This study highlights the importance of further research on the transmission dynamics of <i>Blastocystis</i> sp., particularly in regions with varying farming practices, to better understand its epidemiology and zoonotic potential.…”
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GC-MS analysis, antimicrobial and antiulcer evaluations of ginger-infused virgin coconut oil by Ibeabuchi Jude Ali, Okorie Ndidiamaka H, Adonu Cyril C, Omeh Romanus C, Obidiegwu Onyeka C, Okonkwo Raymond M, Okafor Judith O, Okoye Festus BC

“… Medicinal herb-infused oil is utilized in folkloric medicine due to its efficacy in ameliorating various diseases of humans; even with this evidence, most herbs are still underutilized and poorly investigated. …”
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Experimental study of mortar incorporating nano-magnetite on engineering performance and radiation shielding by Kunchariyakun Kittipong, Sinyoung Suthatip, MacKenzie Kenneth J. D., Pungkun Vithit, Raknarong Pakkamai, Teh Musofpar, Jekabaso Afham, Sittichan Narumol

“…These results indicate that the addition of nano-Fe3O4 to radiation-shielding mortar can potentially attenuate gamma rays rather than neutrons and lead to the development of materials for shielding radiation from radioactive storage facilities, thereby reducing the impact of this hazardous waste on humans and the environment.…”
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Isoleucine at position 137 of haemagglutinin acts as a mammalian adaptation marker of H9N2 avian influenza virus by Weiwei Ma, Chenyang Ren, Lin Shi, Bo Meng, Yali Feng, Ying Zhang

“…The H9N2 subtype of avian influenza virus (AIV) is widely distributed among poultry and wild birds and is also a threat to humans. During AIV active surveillance in Liaoning province from 2015 to 2016, we identified 10 H9N2 strains exhibiting different lethality to chick embryos. …”
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Anthelmintic activity of 1,10-phenanthroline-5,6-dione-based metallodrugs by Maria E. Cirino, Thainá R. Teixeira, Alessandro M. H. Silva, Ana C. C. Borges, Lucas Fukui-Silva, Luis G. Wagner, Christiane Fernandes, Malachy McCann, André L. S. Santos, Josué de Moraes

“…This study investigates the potential antiparasitic activity of 1,10-phenanthroline-5,6-dione (phendione) and its metal complexes, [Cu(phendione)3](ClO4)2.8H2O and [Ag(phendione)2](ClO4), against Schistosoma mansoni, the causative agent of intestinal schistosomiasis, and Angiostrongylus cantonensis, responsible for eosinophilic meningitis in humans. Additionally, the compounds were tested on Caenorhabditis elegans, a model organism for drug discovery. …”
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Adaptation of the sulfophosphovanillin method of analysis of total lipids for various biological objects as exemplified by <i>Drosophila melanogaster</i> by M. A. Eremina, N. E. Gruntenko

“…In recent decades the model object Drosophila melanogaster has been actively used in the study of the fundamental issues of lipid metabolism and its disorders, including obesity, as well as in the search for therapeutic goals for the treatment of metabolic disorders in humans. Quick and accurate quantification of lipid content is an important step in solving these problems. …”
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Presenting the model of social entrepreneurship in the development of rural tourism in the target villages of Gilan province by Fatemeh Doozandeh Ziabari, hamed fallah tafti, Mir Mohammad Asadi, Mahdi Basouli

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Special issue: Proceedings of the 15th ISIC - The Information Behaviour Conference, Aalborg, Denmark, August 26-29, 2024

“…Image data sharing in the social sciences and humanities Elina Late, Mette Skov, Sanna Kumpulainen Analysing humanities scholars’ data seeking behaviour patterns using Ellis' model Wenqi Li, Pengyi Zhang, Jun Wang Can ChatGPT provide health information as physicians do? …”
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End-to-End Architecture for English Reading and Writing Content Assessment Based on Prompt Learning by Su-Qin Wu, Ming-Yong Pang, Xue-Mei Sun, Xin-Jian Wang, Yun-Peng Ji

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Hiroshima and Nagasaki at 65 – A Reflection by Norimatsu Satoko

“…On countless occasions this year, sixty-five years after the Hiroshima and Nagasaki bombings, I have heard and read that hibakusha (atomic-bomb survivors) are dying away, and that we need to eliminate nuclear weapons from the face of the earth, for the future of humanity, to be sure, but also so that their dying wishes are fulfilled. …”
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Recurrence of Herpetic Keratitis after COVID-19 Vaccination: A Report of Two Cases by Ali Mahdavi Fard, Jeffrey Desilets, Sangita Patel

“…The COVID-19 vaccines work by generating both adaptive humoral and cellular immune responses in humans, including elevation of anti-spike neutralizing antibody titers, antigen-specific CD4+ and CD8+ T-cell responses, and increased levels of proinflammatory cytokines such as interferon gamma (IFNγ). …”
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A Decision Model Assessing the Owner and Contractor’s Conflict Behaviors in Construction Projects by Guangdong Wu, Huanming Wang, Ruidong Chang

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Aktivitas Anticandida Herba Krokot (Portulaca grandiflora) by Agus Purwanto, Ch. Endang Purwaningsih, Christiana Indriasari

“…Candidiasis is one of the most common fungal infections in humans. Candidiasis is an opportunistic infection caused by excessive growth of the genus Candida fungus, 70% of Candida infections are caused by Candida albicans. …”
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تحلیل و نقد کتاب The Generative Lexicon by زهرا روحی بایگی, غلام حسین کریمی دوستان

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Neurodiversity in Saudi Arabia: Towards quality education and reduced inequalities [version 2; peer review: 1 approved, 2 approved with reservations] by Borey Be, Alex S. M. Mhone, Ahmed Alduais, Ahmed Yahya Almakrob

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Creating Dissonance: Self-Tracking Devices and their Effects on Users by Xenia Schmidli

“…This argument serves as a continuation of the theory of self-extension through tracking devices and aims to further elaborate on the relation between humans and digital technology, especially in a fitness context. …”
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