Balancing act: optimizing blue light for melanogenesis while minimizing cellular damage in primary human skin cells by Augustin C. Barolet, Augustin C. Barolet, Augustin C. Barolet, Augustin C. Barolet, Brice Magne, Brice Magne, Brice Magne, Karel Ferland, Karel Ferland, Karel Ferland, Natallia E. Uzunbajakava, Daniel Barolet, Daniel Barolet, Lucie Germain, Lucie Germain, Lucie Germain

“…Cellular metabolic activity was assessed using the AlamarBlue HS assay, α-Melanocyte-Stimulating Hormone (α-MSH) production by keratinocytes was quantified using ELISA, and Western blotting was used to assess pro-melanogenic factor expression in melanocytes.ResultsHigh blue light intensity (50 mW/cm2, 50 J/cm2) and UVA light (15 mW/cm2, 20 J/cm2) significantly reduced cellular metabolic activity, with a 0.86 ± 0.055 and 0.60 ± 0.031 (mean ± SD) fold decrease compared to their respective sham by day 7. …”
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Effects of flame retardant tributyl phosphate on early development of zebrafish by Yao LI, Jingying ZHU, Yao LI, Limei CHEN, Pengfei ZHU, Xinliang DING, Weijie ZHOU

“…The q-PCR results showed that the expression levels of HTP axis-related genes [thyroid hormone receptors (trα, \begin{document}$tr\beta $\end{document}), thyroglobulin (tg), and sodium/iodide co-transporter (nis)] were significantly down-regulated in the exposure groups, the expression level of transthyretin (ttr) was significantly up-regulated in the 0.02 μg·L−1 TBP group, and the iodothyronine deiodinase 2 (dio2) expression level was significantly down-regulated in the 0.02 μg·L−1 TBP group (P<0.05); the neurodevelopment-related gene acetylcholinesterase (ache) was significantly down-regulated in the exposure groups, and the expression levels of myelin basic protein (mbp) and Elav like neuron-specific RNA binding protein 3 (elavl3) were significantly down-regulated in the 0.02 μg·L−1 TBP group (P<0.05). …”
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Distinct mechanisms of electroacupuncture and manual acupuncture in modulating hypothalamic GnRH–tanycyte unit function of polycystic ovary syndrome by Yu Wang, Yicong Wang, Yuning Chen, Wenhan Lu, Xiaoyu Tong, Jiajia Li, Wenhao Gao, Rui Huang, Wei Hu, Yi Feng

“…Gonadotropin-releasing hormone (GnRH) neurons are pivotal in regulating hypothalamic endocrine function, whereas tanycyte, a specialized glial cell type, potentially contribute to this process. …”
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Cross-cultural adaptation of the simple Chinese version of the medication adherence reasons scale in patients undergoing adjuvant endocrine therapy for breast cancer by Lei Xu, Ping Li, Yan Hu, Weijie Xing, Jiajia Qiu, Xiaoju Zhang, Lingying Jia, Feng Jing, Ye Liu, Lili Li, Chunyang Lu

“…Inclusion criteria were: (a) female, (b) aged 18 years or older, (c) diagnosed with Stage I to III BrCa, (d) completed primary treatment for hormone receptor-positive BrCa and had been on AET for more than six months but less than five years, (e) proficient in Mandarin, and (f) provided informed consent. …”
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The comparative analysis of the influence of bisoprolol and carvedilol on the course of heart failure of ischemic origin in patients with concomitant atrial fibrillation and diabet... by N.M. Kulaiets, V.M. Kulaiets

“…The levels of thyroid-stimulating hormone, free triiodothyronine and free thyroxine, glucose, glycated hemoglobin, galectin-3, suppression of tumorigenicity 2 peptide, B-type natriu­retic peptide, N-terminal prohormone of brain natriuretic peptide were determined. …”
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Long-Term Results of Cabergoline Add-on Long-Acting Somatostatin Analogue Therapy in Acromegaly Patients by Mehmet Muhittin Yalçın, Gizem Bedir Keser, Meriç Coşkun, Afruz Babayeva, Emrah Çeltikçi, Mehmet Arda İnan, Emetullah Cindil, Aylar Poyraz, Ethem Turgay Cerit, Alev Eroğlu Altınova, Müjde Aktürk, Füsun Baloş Törüner, Mehmet Ayhan Karakoç, İlhan Yetkin

“…Patients were retrospectively evaluated in terms of age, gender, insulin-like growth factor-1 (IGF-1) values before and after cabergoline, disease duration, treatment dose, adenoma size, growth hormone level, and prolactin staining on pathologic examination. …”
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Effects of taurine on growth performance, body composition and physiological responses of western white shrimp, Litopenaeus vannamei broodstock by Vahid Morshedi, Mahmoud Nafisi Bahabadi, Mansour Torfi Mozanzadeh, Amin Oujifard, Naser Agh, Khalegh Maneii, Ahmad Qasemi, Nehzat Bakhshi, Hadi Ebrahimi, Rezvan Tamadoni, Shirin Hamedi, Reza Bagherpour, Fatemeh Solimani

“…Tau has been also implicated in osmoregulation, modulation of neurotransmitters, hormone release, and antioxidation. Materials and Methods: A 30-day feeding study was conducted to determine the effects of supplementing the Tau in the diet of broodstock western white shrimp. …”
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Decreased vitamin D increase the risk for subclinical hypothyroidism in individuals with T2DM: a cross-sectional study by Yaling Fang, Yaling Fang, Xin Wen, Hui You, Yueye Huang, Shen Qu, Xingchun Wang, Le Bu

“…In the higher VD group, free triiodothyronine (FT3) levels were significantly elevated (4.45 ± 0.93 vs. 4.95 ± 1.52 ng/mL, p &lt; 0.001), while total triiodothyronine (TT4) (104.84 ± 21.17 vs. 99.99 ± 23.64 ng/mL, p = 0.008) and thyroid stimulating hormone (TSH) (2.88 ± 7.03 vs. 2.06 ± 1.72 ng/mL, p = 0.046) levels were significantly reduced compared to the lower VD group. …”
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THE ORGANIZATION WORKS TO IMPROVE THE CLINICAL AND ECONOMIC OUTCOMES OF CARE FOR PROSTATE CANCER by O. I. Apolikhin, A. V. Sivkov, I. V. Chernishov, M. I. Katibov, O. V. Zolotukhin, I. A. Shaderkin, S. A. Leonov, D. A. Vojtko, M. Y. Prosyannikov

“…In case of detection of clinically insignificant PC assistance was provided at the level of ITC (active surveillance, watchful waiting, hormone therapy on the recommendations of the oncourologist of regional urology center).Results. …”
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Molecular evidence of the inhibitory potential of melatonin against sodium arsenite toxicity by Ramtin Farhadi, Marzieh Daniali, Maryam Baeeri, Reza Khorasani, Hamed Haghi-Aminjan, Mahdi Gholami, Mahban Rahimifard, Mona Navaei-Nigjeh, Mohammad Abdollahi

“…Recent studies on melatonin (MLT), a harmless hormone secreted in the body generally for induction of sleepiness, find many beneficial and positive effects. …”
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Antioxidant and Laxative Effects of Methanol Extracts of Green Pine Cones (<i>Pinus densiflora</i>) in Sprague-Dawley Rats with Loperamide-Induced Constipation by Hee-Jin Song, Ayun Seol, Jumin Park, Ji-Eun Kim, Tae-Ryeol Kim, Ki-Ho Park, Eun-Seo Park, Su-Jeong Lim, Su-Ha Wang, Ji-Eun Sung, Youngwoo Choi, Heeseob Lee, Dae-Youn Hwang

“…The other parameters, including the regulators for the adherens junction (AJ) and tight junction (TJ), and GI hormone secretion for laxative effects, were improved significantly in Lop+MPC-treated SD rats. …”
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Human hair biochar to remove malachite green dye and bisphenol-A contamination by M. Kamaraj, P. Kamali, R. Kaviya, K. Abishek, B. Navinkumar, T.G. Nithya, L.S. Wong, J. Aravind

“…Exogenous endocrine disruptors are responsible for interfering with reproduction and development because they can either stimulate or decrease endogenous hormone responses. This work explores the feasibility of human hair biochar as a potential adsorbent for possible solid waste management processes to minimize environmental pollution. …”
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Effect of SY009, a novel SGLT1 inhibitor, on the plasma metabolome and bile acids in patients with type 2 diabetes mellitus by Haoyi Yang, Yuwen Zhang, Yuxin Hong, Yuan Wei, Yuning Zhu, Lei Huang, Yuanxun Yang, Runbin Sun, Runbin Sun, Runbin Sun, Juan Li, Juan Li, Juan Li

“…We conducted untargeted and targeted metabolomics analyses on plasma samples from the phase Ib clinical study.ResultsUntargeted metabolomics revealed that, after SY009 treatment, there were differences in metabolic pathways, including primary bile acid biosynthesis; biosynthesis of unsaturated fatty acid; steroid hormone biosynthesis; purine metabolism; phenylalanine, tyrosine and tryptophan biosynthesis. …”
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Influence of ethnicity on cyclin-dependent kinase inhibitor efficacy and toxicity: A systematic review and meta-analysis by Roberto Buonaiuto, Aldo Caltavituro, Margherita Tafuro, Alessandra Longobardi, Giuliana Pavone, Pierluigi De Santis, Roberta Caputo, Carmine De Angelis, Lucia Del Mastro, Fabio Puglisi, Mario Giuliano, Grazia Arpino, Martina Pagliuca, Michelino De Laurentiis

“…Background: The combination of cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) with endocrine therapy (ET) is the standard of care for patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer (aBC). …”
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Outcomes in stage IIA versus stage IIB/III in the PALLAS trial [ABCSG-42/AFT-05/PrE0109/BIG-14-13]) by A. DeMichele, A. C. Dueck, D. Hlauschek, M. Martin, H. Burstein, G. Pfeiler, N. Zdenkowski, A. Wolff, M. Bellet-Ezquerra, E. Winer, M. Balic, K. Miller, M. Colleoni, D. Lake, G. Rubovsky, D. Cameron, J. Balko, C. F. Singer, Z. Nowecki, H. Iwata, N. Wolmark, K. A. Parraga, H. Rugo, G. G. Steger, T. Traina, G. Werutsky, D. Czajkowska, O. Metzger, S. El-Abed, K. P. Theall, R. D. Lu, P. O’Brien, C. Fesl, E. Mayer, M. Gnant

“…Patients diagnosed with stage II–III, hormone-receptor-positive, HER2/neu negative breast cancer within 12 months of diagnosis had completed all definitive therapy aside from endocrine therapy (started within 6 months prior to study entry) were eligible. …”
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Comparative transcriptome analysis reveals molecular mechanisms of resistance in Chinese cabbage to Plasmodiophora brassicae pathotype 11 by Yue Qiu, Yue Qiu, Yue Qiu, Jinhao Zhang, Jinhao Zhang, Chunju Deng, Chunju Deng, Jiasheng Yuan, Jiasheng Yuan, Bowen Wang, Bowen Wang, Han Meng, Han Meng, Mohamed Mohany, Liting Zeng, Liting Zeng, Lanfang Wei, Lanfang Wei, Waqar Ahmed, Guanghai Ji, Guanghai Ji

“…The resistant cultivar showed a pronounced activation of genes involved in hormone signaling, cell wall, secondary metabolism, redox state, and signaling process. …”
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Edible mushrooms as a potent therapeutics of subclinical thyroid dysfunction among adults, especially in obese individuals: a prospective cohort study by Juanjuan Zhang, Sabina Rayamajhi, Amrish Thapa, Ge Meng, Qing Zhang, Li Liu, Hongmei Wu, Yeqing Gu, Shunming Zhang, Tingjing Zhang, Xuena Wang, Zhixia Cao, Jun Dong, Xiaoxi Zheng, Xu Zhang, Xinrong Dong, Xing Wang, Shaomei Sun, Ming Zhou, Qiyu Jia, Kun Song, Kaijun Niu

“…SCTD was defined as abnormal serum thyroid-stimulating hormone levels and normal free thyroxine. Cox proportional hazards regression models were used to examine the association of edible mushrooms consumption with incident SCTD. …”
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Revealing the biological features of the axolotl pancreas as a new research model by Hui Ma, Hui Ma, Hui Ma, Guangcong Peng, Yan Hu, Binbin Lu, Binbin Lu, Yiying Zheng, Yingxian Wu, Weimin Feng, Yu Shi, Xiangyu Pan, Li Song, Ina Stützer, Yanmei Liu, Jifeng Fei, Jifeng Fei, Jifeng Fei

“…Differential gene expression analysis indicated a transition in global gene expression from pancreatic cell fate commitment and the cell cycle to glucose response, hormone synthesis, and secretion, following the development progression. …”
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Comparative Transcriptome Analyses Reveal the Mechanisms Underlying Waterlogging Tolerance in Barley by Juan Zhu, Haoxin Yin, Cong Cao, Chengqun Sun, Mengna Zhang, Yi Hong, Yuhang Zhang, Chao Lv, Baojian Guo, Feifei Wang, Rugen Xu

“…KEGG analysis showed that glycolysis/gluconeogenesis, the MAPK signaling pathway, plant hormone signaling, and galactose metabolism pathways were significantly enriched in the waterlogging-tolerant genotype TamF169 four days after waterlogging. …”
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Ovarian stimulation alternatives for in vitro production of embryos in water buffaloes by Alexis Bandeo, José Luis Konrad, Natalia Vallejos, Pablo Ponce, Marina J. Sansinena, Gustavo Crudeli, Pablo Maldonado-Vargas

“…The objective of this study was to evaluate the response to different hormonal stimulation treatments in buffalo donors, their effect on oocyte quality, and subsequent embryo production. …”
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