A novel sustained-release agent based on disulfide-induced recombinant collagen hydrogels for the prevention and treatment of Schistosoma infections by Jie Wang, Lijun Song, Yuntian Xing, Yang Dai, Jinyuan Hu, Guoli Qu, Yongliang Xu, Xuren Yin, Derong Hang, Jianfeng Zhang, Chunrong Xiong, Liang Shi, Fei Xu

“…It represents a significant step forward in the fight against this disease and offers hope for more effective and safer treatments in the future.…”
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Overcoming hypoxia-induced breast cancer drug resistance: a novel strategy using hollow gold-platinum bimetallic nanoshells by Lian-Ying Zhang, Xiao-Tong Chen, Rong-Tian Li, Wei Meng, Guo-Qin Huang, Yong-Jian Chen, Feng-Jun Ge, Qun Zhang, Yu-Jun Quan, Cai-Tao Zhang, Yi-Fei Liu, Ming Chen, Jin-Xiang Chen

“…This study presents a novel strategy to tackle tumor proliferation and enhance tumor response to chemotherapy, offering hope for reversing in drug resistance in cancerous lesions. …”
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Impact of HER2 Expression on the Prognosis of Muscle-Invasive Bladder Cancer Patients Treated with Bladder-Preservation Comprehensive Therapy by Yatong Chen, Fei Luo, Tingji Zhang, Jian Li

“…The discovery of HER2 positivity in urothelial carcinoma and the development of anti-HER2 drugs have brought new hope for bladder preservation treatment in MIBC. …”
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Ketogenic diet and β-hydroxybutyrate in osteoporosis: current progress and controversy by Changfang Luo, Changfang Luo, Changfang Luo, Changfang Luo, Zhuojun Dai, Zhuojun Dai, Zhuojun Dai, Zhuojun Dai, Wanhong He, Wanhong He, Wanhong He, Wanhong He, Yanqiu He, Yanqiu He, Yanqiu He, Yanqiu He, Ping Yang, Ping Yang, Ping Yang, Ping Yang, Mengting Huang, Mengting Huang, Mengting Huang, Mengting Huang, Junle Li, Junle Li, Junle Li, Junle Li, Yong Xu, Yong Xu, Yong Xu, Yong Xu, Wei Huang, Wei Huang, Wei Huang, Wei Huang

“…The main purpose of this review is to summarize the current research progress and hope that more basic and clinical experiments will focus on the similarities and differences between ketogenic diet (KD) and BHB in osteoporosis.…”
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Association of immune-related adverse events with the outcomes of immune checkpoint inhibitors in patients with dMMR/MSI-H metastatic colorectal cancer by Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Francesca Corti, Elisabetta Fenocchio, Massimiliano Salati, Margherita Ambrosini, Michael J Overman, Lisa Salvatore, Rossana Intini, Priya Jayachandran, Javier Ros, Maria Elena Elez, Marwan Fakih, Aakash Tushar Shah, Rosalba Miceli, Monica Niger, Vincenzo Nasca, Giacomo Mazzoli, Francesco Barretta

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Construction of feature selection and efficacy prediction model for transformation therapy of locally advanced pancreatic cancer based on CT, 18F-FDG PET/CT, DNA mutation, and CA19... by Liang Qi, Xiang Li, Jiayao Ni, Yali Du, Qing Gu, Baorui Liu, Jian He, Juan Du

“…With the rapid development of radiomics, next-generation sequencing, and machine learning, there is hope to identify biomarkers that can predict the efficacy of transformative treatment for locally advanced pancreatic cancer through simple and non-invasive clinical methods. …”
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Moderate regular physical exercise can help in alleviating the systemic impact of schistosomiasis infection on brain cognitive function by Inssaf Berkiks, Inssaf Berkiks, Nada Abdel Aziz, Nada Abdel Aziz, Nada Abdel Aziz, Blessing Moses, Blessing Moses, Tiroyaone Brombacher, Tiroyaone Brombacher, Frank Brombacher, Frank Brombacher

“…Furthermore, our findings demonstrated the positive effects of physical activities on mitigating the cognitive burden of schistosomiasis, offering new hope for patients afflicted by this debilitating disease.…”
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Editorial by Jörg Tremmel, Marisa dos Reis, Joseph Burke, Raphaelle Schwarzberg (†)

“…Finally, we would like to thank our reviewers for their most helpful criticisms and advice in the preparation of this issue, which we hope provides the basis for much further discussion and thinking on the legal implementation of intergenerational justice. …”
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Editorial by Jörg Tremmel, Edward Page, Konrad Ott

“…The authors give three reasons why these nations should act alone: ability to act; responsibility to act; self-interest in acting. We hope you will enjoy the articles in our current issue. …”
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Educide amid conflict: the struggle of the Palestinian education system by Dalal Iriqat, Rula Alousi, Tahani Z. Aldahdouh, Alaa AlDahdouh, Iman Dankar, Dima Alburai, Mohamed Buheji, Abdo Hassoun

“…The study emphasizes the need for global support to restore these educational spaces, ensuring that education can continue to foster community strength, identity and hope within Gaza’s society amid conflict. Originality/value – This paper is original in its focus on the concept of “Educide” in Gaza, a term describing the systematic targeting and destruction of educational infrastructure as a means of cultural and societal erasure. …”
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Detection of alteration in carotid artery volumetry using standard-of-care computed tomography surveillance scans following unilateral radiation therapy for early-stage tonsillar s... by Efstratios Koutroumpakis, Mohamed A. Naser, Abdallah Sherif Radwan Mohamed, Salman A. Eraj, Andrea Jarre, Jay C. Shiao, Mona Kamal, Subha Perni, Jack P. Phan, William H. Morrison, Steven J. Frank, G.Brandon Gunn, Adam S. Garden, Anita Deswal, Jun-ichi Abe, David I. Rosenthal, Elie Mouhayar, Clifton D. Fuller

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Real-life study on the effectiveness and safety of sofosbuvir/velpatasvir-based antiviral agents for hepatitis C eradication in Chinese patients by Jiayi Wang, Lingyao Du, Dongmei Zhang, Chen Zhou, Yilan Zeng, Miao Liu, Xing Cheng, Xiaona Song, Han Chen, Ning Han, Enqiang Chen, Hong Tang

“…Background: Hepatitis C virus (HCV) eradication with sofosbuvir/velpatasvir (SOF/VEL) represents a significant advancement, offering hope for eliminating the virus in diverse patient populations. …”
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Panitumumab plus 5-fluorouracil and folinic acid or 5-fluorouracil and folinic acid alone as maintenance therapy in RAS wild-type metastatic colorectal cancer (PanaMa, AIO KRK 0212... by Arndt Stahler, Meinolf Karthaus, Stefan Fruehauf, Ullrich Graeven, Lothar Müller, Ludwig Fischer von Weikersthal, Karel Caca, Eray Goekkurt, Alexej Ballhausen, Greta Sommerhäuser, Annabel H.S. Alig, Swantje Held, Armin Jarosch, David Horst, Anke Reinacher-Schick, Stefan Kasper, Volker Heinemann, Sebastian Stintzing, Tanja Trarbach, Dominik P. Modest

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Surgical Treatment for Spinal Tuberculosis without Elevation of Inflammatory Biomarkers at the Initial Visit Mimicking Spinal Metastasis by Takuya Sakamoto, Hiroshi Takahashi, Junya Saito, Yasuo Matsuzawa, Yasuchika Aoki, Arata Nakajima, Masato Sonobe, Yorikazu Akatsu, Manabu Yamada, Yuki Akiyama, Tatsunori Iwai, Keita Yanagisawa, Yasuhiro Shiga, Kazuhide Inage, Sumihisa Orita, Yawara Eguchi, Satoshi Maki, Takeo Furuya, Tsutomu Akazawa, Masao Koda, Masashi Yamazaki, Seiji Ohtori, Koichi Nakagawa

“…Conservative treatment was chosen with the hope of a significant neurologic recovery; however, 9 months after the primary surgery, she returned to our hospital with reprogressive paraplegia. …”
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A Meta-Synthesis of the Integrated Model of Customer Value co-Destruction and Value co-Creation by Zohreh Dehdashti Shahrokh, Vahid Nasehifar, Mohammad Reza Karimi Alavijeh, Yazdan Rahmatabadi

“…Introduction The main problem that is trying to be addressed is that these sharing economy platform companies with the hope of successfully co-creating value start processing different ideas and expect to receive appropriate feedback from this, which leads to co-destruction for different reasons. …”
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Conscientious Objection Based on Patient Identity by John Dinelli

“…One may argue that theological virtues like faith, hope, and charity support the conscientious objection because physicians are virtuous when they are faithful, or loyal to their religious beliefs. …”
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Real-world outcomes with tisagenlecleucel in aggressive B-cell lymphoma: subgroup analyses from the CIBMTR registry by Frederick L Locke, Grant Schofield, Marcelo Pasquini, Matthew J Frigault, Cameron J Turtle, Stephen Lim, Brian Hill, Samantha Jaglowski, Caron A Jacobson, Gunjan Shah, Daniel J Landsburg, Michael Heim, Stephen Ronan Foley, Ron Ram, Peter A Riedell, Leslie L Popplewell, Ranjan Tiwari, Marta Majdan, Aisha Masood

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Sex and outcomes of patients with microsatellite instability-high and BRAF V600E mutated metastatic colorectal cancer receiving immune checkpoint inhibitors by Michael Hoffmeister, Hermann Brenner, Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Julien Taieb, David Tougeron, Robyn L Ward, Marco Vitellaro, Thierry André, Pierre Laurent-Puig, Jitendra Jonnagaddala, Francesca Bergamo, Raghav Sundar, Claire Gallois, Michael J Overman, Jakob Nikolas Kather, Lisa Salvatore, Romain Cohen, Rossana Intini, Priya Jayachandran, Miriam Koopman, Javier Ros, Marwan Fakih, Vincenzo Nasca, Giacomo Mazzoli, Jeanine M L Roodhart, Filippo Ghelardi, Elena Elez, Durgesh Wankhede, Marta Ligero, Joseph Zhao, Koen Zwart, Jeroen Derksen, Nicholas Hawkins, Javier Carmona

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Pierre et carrières dans la Saintonge antique : identification, usages et diffusion by Jacques Gaillard, Egle Conforto

“…The archaeologist cannot hope to identify the solution to these enigmas if they rely solely on limestone observation, using only the naked eye. …”
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Call for Papers: How attractive are political parties and trade unions to young people? by IF and FRFG

“…They enrol less often in parties, rendering the parties’ age-profiles all too often considerably older than the broader electorate that they hope to embrace (Bruter/Harrison 2009; Scarrow/Gezgor 2010). …”
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