Unlocking the Potential of Receptor-Based Approaches in Diabetes Treatment by Mohsina Patwekar, Faheem Patwekar, J. Pavan Kumar, P. Dharani Prasad, Nazia Malik, A. Venkata Badarinath, Prashanth Parupathi, Konatham Teja Kumar Reddy, Selvaraja Elumalai, Zainul Abedeen Ab Samad

“…Healthcare professionals, researchers, politicians, and patients working together will pave the way to substantial improvements in the management of metabolic disorders including diabetes. In conclusion, hope for more efficient, individualized, and secure therapies may come from continuing research and breakthroughs in novel diabetes treatment targets. …”
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Through each other's eyes: initial results and protocol for the co-design of an observational measure of adolescent-parent interaction using first-person perspective by Nicky Wright, Rebecca M. Pearson, Rebecca M. Pearson, Danielle Crook, Danielle Crook, Alice Bond, Tom Jewell, Tom Jewell

“…“Trust” and “understanding” were most frequently reported as important adolescent-parent relationship constructs.ConclusionsThis work represents the first attempt to truly co-design a method to assess parenting in adolescence. We hope to develop an observational measure using novel technological methods that can be used across a range of research and therapeutic settings.…”
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The Upregulation of IL-1β Induced by Cisplatin Triggers PI3K/AKT/MMP9 Pathway in Pericytes Mediating the Leakage of the Blood Labyrinth Barrier by Yu M, Jiang WJ, Yu M, Zhou Z, Wang M, Li L

“…IL-1β and the PI3K-AKT pathway are promising therapeutic targets,offering hope for patients with CDDP-induced hearing loss. …”
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Outcomes of follicular lymphoma with leukemic phase in the modern era: results from a large multicenter study by Asaad Trabolsi, Sunwoo Han, Narendranath Epperla, Kaitlin Annunzio, Firas Baidoun, Muhamad Alhaj Moustafa, Dan Morgenstern-Kaplan, Peter Doukas, Frederique St-Pierre, Brittany McCall, Lindsey Fitzgerald, Jose Sandoval-Sus, Shivani Dalal, Isildinha M. Reis, Jennifer Rose Chapman-Fredricks, Seo-Hyun Kim, Cherry Au, Natalie B. Otto, Khaled Alhamad, Thomas Ollila, Reem Karmali, Geoffrey Shouse, Izidore S. Lossos, Juan Pablo Alderuccio

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Inhibitory effect of coriander (Coriandrum sativum L.) extract marinades on the formation of polycyclic aromatic hydrocarbons in roasted duck wings by Yajie Yu, Yiqun Cheng, Chong Wang, Suhong Huang, Yang Lei, Ming Huang, Xibin Zhang

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CMV Pancreatitis in an Immunocompromised Patient by Jaffer Ahmad, Najia Sayedy, Raghavendra Sanivarapu, Jagadish Akella, Javed Iqbal

“…Our case demonstrates the extent of dissemination of CMV in a severely immunocompromised patient by showing clear cut pancreatitis secondary to said viral infection with exclusion of other possible causes. Our hope is that clinicians will change their practice to include a more scrutinized study into causes of pancreatitis especially in their immunocompromised patients.…”
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TYRO3 blockade enhances anti-PD-1 therapy response by modulating expression of CCN1 in tumor microenvironment by Miso Park, Da-Sol Kuen, Keon Wook Kang, Yeonseok Chung, Jaewoo Park, Munkyung Choi, Yeonji Kim, Eun Chae Roh, Yong June Choi, Yoon Gyoon Kim, Sung Yun Cho

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Short- and long-term changes in neurological, behavioural, and blood biomarkers following repeated mild traumatic brain injury in rats—potential biological sex-dependent effects by Rodrigo Moraga-Amaro, Oscar Moreno, Jordi Llop, Marion Bankstahl, Marion Bankstahl, Jens P. Bankstahl

“…Understanding these differences could guide the diagnosis and treatment of CTE in a personalized manner, offering hope for more effective treatments in the future.…”
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Microneedle technology for enhanced topical treatment of skin infections by Tingting Peng, Yangyan Chen, Xuanyu Luan, Wanshan Hu, Wentao Wu, Bing Guo, Chao Lu, Chuanbin Wu, Xin Pan

“…Finally, the future development of biosensing MNs with easy-to-use and intelligent properties and MN-based wearable drug delivery for home-based therapy are prospected. We hope this review will provide valuable guidance for future development in MN-mediated topical treatment of skin infections.…”
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A video intervention to improve patient understanding of tumor genomic testing in patients with cancer by Deloris J. Veney, Lai Y. Wei, Amanda E. Toland, Carolyn J. Presley, Heather L. Hampel, Tasleem J. Padamsee, Clara N. Lee, William J. Irvin Jr, Michael J. Bishop, James J. Kim, Shelly R. Hovick, Leigha A. Senter, Daniel G. Stover

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Polish Historiography of Polish - Lithuanian Union of 20th Century by Mečislovas Jučas

“…There were no big debates on the reasons for the Lublin union: growing political activity of the Lithuanian nobility and its attempts to have equal rights with the Polish nobility, war between Lithuania and Moscow, and hope for the Polish nobility to realize old state rights, i.e., "executional attempt," and finally, the dominance and attractiveness of Polish culture. …”
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Barriers and facilitators to facility-based delivery in rural Zambia: a qualitative study of women’s perceptions after implementation of an improved maternity waiting homes interve... by Peter C Rockers, Godfrey Biemba, Davidson H Hamer, Nancy A Scott, Jeanette L Kaiser, Taryn Vian, Rachel M Fong, Thandiwe Ngoma, Jody R Lori, Michelle Munro-Kramer, Misheck Bwalya, Gertrude Musonda, Eden Ahmed Mdluli, Viviane Rutagwera Sakanga, Kayla J Kuhfeldt

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Evaluation of a Guided Chatbot Intervention for Young People in Jordan: Feasibility Randomized Controlled Trial by Anne Marijn de Graaff, Rand Habashneh, Sarah Fanatseh, Dharani Keyan, Aemal Akhtar, Adnan Abualhaija, Muhannad Faroun, Ibrahim Said Aqel, Latefa Dardas, Chiara Servili, Mark van Ommeren, Richard Bryant, Kenneth Carswell

“…Online questionnaires were administered at baseline (week 0) and postassessment (week 8) to assess depression (Hopkins Symptom Checklist-25 [HSCL-25]), anxiety (HSCL-25), functional impairment (WHO Disability Assessment Schedule [WHODAS] 2.0), psychological well-being (WHO-Five Well-Being Index [WHO-5]), and agency (State Hope Scale). Process evaluation interviews with stakeholders were conducted after the postassessment. …”
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Metal complexes in cells: from design of catalytic antioxidants to imaging metal ions and designing metal-based probes in X-ray fluorescence and IR-imaging, a multidisciplinary col... by Policar, Clotilde, Delsuc, Nicolas, Bertrand, Hélène Charlotte

“…After a brief overview, we will describe how metal-based probes can be developed, as trackers of organelles or tags, with application to mitochondria tracking and to the imaging of the Mn-based SOD mimics previously described.Overall, we hope this this story will provide an insight of what are bioinorganic chemistry and inorganic chemical biology, showing how artificial metal-based systems can be chemically designed, associated with their direct study in cells.…”
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Peer-assisted telemedicine hepatitis-C treatment for people who use drugs in rural communities: a mixed methods study by Kim Hoffman, Gillian Leichtling, Sarah Shin, Andrew Seaman, Tonhi Gailey, Hunter C. Spencer, P. Todd Korthuis

“…Innovative treatment models are needed that circumvent healthcare system barriers for people who use drugs (PWUD), particularly in rural areas. The Oregon HOPE TeleHCV study randomized PWUD living with HCV in rural Oregon to peer-facilitated and streamlined telemedicine HCV treatment (Peer TeleHCV) versus enhanced usual care (EUC) and assessed sustained virologic response at 12 weeks post treatment (SVR12). …”
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The Application of Bioreactors for Cartilage Tissue Engineering: Advances, Limitations, and Future Perspectives by Liwei Fu, Pinxue Li, Hao Li, Cangjian Gao, Zhen Yang, Tianyuan Zhao, Wei Chen, Zhiyao Liao, Yu Peng, Fuyang Cao, Xiang Sui, Shuyun Liu, Quanyi Guo

“…Tissue engineering (TE) has brought new hope for articular cartilage regeneration, as TE can provide structural and functional substitutes for native tissues. …”
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Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2 by Brigitta Buttari, Antonella Tramutola, Ana I. Rojo, Niki Chondrogianni, Sarmistha Saha, Alessandra Berry, Letizia Giona, Joana P. Miranda, Elisabetta Profumo, Sergio Davinelli, Andreas Daiber, Antonio Cuadrado, Fabio Di Domenico

“…The review highlights NRF2’s therapeutic implications for neurodegenerative diseases and cardiovascular conditions, emphasizing its role in improving proteostasis and redox homeostasis Additionally, it summarizes current research into NRF2 as a therapeutic target, offering hope for innovative treatments to counteract the effects of aging and associated diseases.…”
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Analisis Tren dan Perkiraan Pandemi COVID-19 di Indonesia Menggunakan Peramalan Metode Prophet :Sebelum dan Sesudah Aturan New Normal by Mawaddah Harahap, Ahmad Zaki Andika, Amir Mahmud Husein, Abdi Dharma

“…The results of a visual analysis of the spread of a pandemic are also presented in the hope that they will be useful as an insight into the development of the number of pandemic cases in Indonesia. …”
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Mortality Prediction Using SaO2/FiO2 Ratio Based on eICU Database Analysis by Sharad Patel, Gurkeerat Singh, Samson Zarbiv, Kia Ghiassi, Jean-Sebastien Rachoin

“…Using a machine-learning approach, we hope to demonstrate the relative mortality predictive capacities of S/F and P/F. …”
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A retrospective multicenter study on the efficacy and safety of disitamab vedotin monotherapy versus combination with anti-PD-1 immunotherapy in advanced gastric cancer by Shuailei Dong, Chen Wei, Xueting Wang, Xinyi Yang, Wei Shen, Shuyi Li, Jiye Xu, Yijie Ma, Liangyu Bie, Wenyue Yu, Ning Li

“…., PD-1 inhibitors) have provided new hope as an advanced gastric-cancer (GC) treatment. …”
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