Cross-agency working when conducting a pragmatic RCT for older victims of crime: our experiences and lessons learned by Marc Serfaty, Jessica Satchell, Gloria K. Laycock, Chris R. Brewin, Marta Buszewicz, Gerard Leavey, Vari M. Drennan, Jonathan Cooke, Anthony Kessel

“…However, as the VIP trial only managed to recruit 131 out of 226 participants, we hope our reflections will help those wishing to conduct research in this population. …”
Get full text

iPSC-derived exosomes as amphotericin B carriers: a promising approach to combat cryptococcal meningitis by Jingyu Zhao, Jingyu Zhao, Wei Fang, Yangjie Gao, Jiquan Chen, Guizhen Wang, Julin Gu

“…Its MIC against Cryptococcus was over eight times lower than conventional AmB, significantly reducing fungal burden in the mouse brain and lowering serum inflammatory factors.ConclusionThe iPSC-Exo/AmB complex is a promising therapeutic strategy that enhances AmB efficacy while reducing toxicity, offering new hope for treating CM and other refractory fungal infections of the central nervous system.…”
Get full text

Foreword

“…We sincerely thank the authors, reviewers, and contributors whose dedication made this issue possible and hope it inspires further exploration of Korean linguistics and culture.                                                                           …”
Get full text

Unveiling the psychosocial and academic implications of living with sickle cell disease among undergraduates in a private university in Nigeria by Olumide T. Adeleke, Olufemi Folaranmi, Yetunde Olasinde, Larry Ayuba, Oludamola V. Adeleke, Modupe M. Ojo-Rufai, Efeturi Agelebe, Oyelola E. Adeoye, Aderemi T. Olabode, Dolapo E. Ajala, Titilola S. Akingbola

“…Conversely, some SCD patients enjoy some social support from colleagues and family members which gives hope and succor to them during difficult times.ConclusionThis study reveals that undergraduates with SCD face various academic and psychosocial challenges that affect their overall performance. …”
Get full text

Fetal and neonatal cardiac tumor diagnosed as Tuberous Sclerosis associated rhabdomyomas resulting from novel pathogenic missense variant detected in TSC2 gene: A case report by Aya Kawasaki, MD, Hidefumi Tonoki, MD, PhD, Osamu Sasaki, MD, PhD, Yoko Matsushita, MD, PhD, Michiko Watari, MD, PhD, Nobuhiro Takahashi, MD, Satoko Fujieda, MD

“…We speculate that this new missense variant in TSC2 gene with 30% mosaicism will be associated to the milder phenotype of TS since the regression of the rhabdomyomas is the only manifestation in this patient. We hope that this case report might help clinicians and genetic counselors manage individualized surveillance plans for patients with TS.…”
Get full text

Your brain on art, nature, and meditation: a pilot neuroimaging study by Beatrix Krause-Sorio, Sergio Becerra, Prabha Siddarth, Stacey Simmons, Taylor Kuhn, Helen Lavretsky

Get full text

Do Complications After Pancreatoduodenectomy Have an Impact on Long-Term Quality of Life and Functional Outcomes? by Ajami Gikandi, BA, Zhi Ven Fong, MD, MPH, DrPH, Motaz Qadan, MD, PhD, Raja R. Narayan, MD, MPH, Thinzar Lwin, MD, MS, Carlos Fernández-del Castillo, MD, Keith D. Lillemoe, MD, Cristina R. Ferrone, MD

Get full text

Moxibustion Regulates the BRG1/Nrf2/HO-1 Pathway by Inhibiting MicroRNA-222-3p to Prevent Oxidative Stress in Intestinal Epithelial Cells in Ulcerative Colitis and Colitis-Associat... by Xuejun Wang, Haiyang Ji, Yanting Yang, Dan Zhang, Xiehe Kong, Xiaoying Li, Hongna Li, Yunqiong Lu, Guang Yang, Jie Liu, Huangan Wu, Jue Hong, Xiaopeng Ma

“…In previous studies, we have demonstrated that suppressing microRNA-222-3p (miR-222-3p) can protect against oxidative stress in IECs, which ameliorates colonic injuries in UC mice and prevents the conversion of UC to CAC. In this case, we hope to explore whether moxibustion can alleviate UC and CAC by inhibiting miR-222-3p based on mouse models of UC and CAC. …”
Get full text

Formulation and characterization of CMPI nanoparticles for enhanced targeting of brain nicotinic receptors by positive allosteric modulator by Rahma Aly, Shoukath Sulthana, Robert Beaudoin, Ayman K. Hamouda, Santosh Aryal

“…Given the superiority of the nanoparticulate system in drug delivery and the unique role of CMPI, we hope this study will help in the development of nAChR PAM formulations that have superior pharmacokinetic profiles, especially their brain bioavailability.…”
Get full text

The externalization of internal experiences in psychotherapy through generative artificial intelligence: a theoretical, clinical, and ethical analysis by Yuval Haber, Dorit Hadar Shoval, Inbar Levkovich, Dror Yinon, Karny Gigi, Oori Pen, Tal Angert, Zohar Elyoseph, Zohar Elyoseph

“…This study aimed to examine the clinical, ethical, and theoretical implications of integrating GenAI into the therapeutic space through a proof-of-concept (POC) of AI-driven externalization techniques, while emphasizing the essential role of the human therapist.MethodsTo this end, we developed two customized GPTs agents: VIVI (visual externalization), which uses DALL-E 3 to create images reflecting patients' internal experiences (e.g., depression or hope), and DIVI (dialogic role-play-based externalization), which simulates conversations with aspects of patients' internal content. …”
Get full text

Comprehensive Hematological and molecular Characterization of hemoglobin Hekinan [α27(B8)Glu→Asp(α1), HBA1:c.84G > T] in a Large Thai cohort by Amornchai Suksusut, Jidapa Jaitheang, Manussavee Prapphal, Pranee Sutcharitchan, Ponlapat Rojnuckarin, Noppacharn Uaprasert

“…These included 104 Hb Hekinan heterozygotes, 10 Hb Hekinan coexisting with α+-thalassemia, 3 Hb Hekinan with non-deletional α-variants, 6 Hb Hekinan with α0-thalassemia, 21 double heterozygote for Hb Hekinan and HbE, 3 Hb Hekinan with β-thalassemia trait, 1 triple heterozygotes (Hb Hekinan/α0-thalassemia/Hb E) and 1 quadruple heterozygote for Hb Hekinan/α+-thalassemia/Hb E/Hb Hope. Hb Hekinan was well-separated from Hb A using IEF but was frequently missed with HPLC. …”
Get full text

Relationship between cognitive impairment and hippocampal iron overload: A quantitative susceptibility mapping study of a rat model by Xi Deng, Meiru Bu, Jiali Liang, Yihao Sun, Liyan Li, Heishu Zheng, Zisan Zeng, Muliang Jiang, Bihong T. Chen

Get full text

The Voltage-Ear – An Anomaly in Photovoltaic Systems With Undersized Inverters by Ernst Wittmann, Claudia Buerhop-Lutz, Vincent Christlein, Jens Hauch, Christoph J. Brabec, Ian Marius Peters

“…We assume, that the voltage ear is a symptom of system design issues that can result in malfunctioning of inverters and hope that it will be useful as an indicator for identifying design and operation issues.…”
Get full text

Human Fat-Derived Mesenchymal Stem Cells Xenogenically Implanted in a Rat Model Show Enhanced New Bone Formation in Maxillary Alveolar Tooth Defects by Andrew Wofford, Austin Bow, Steven Newby, Seth Brooks, Rachel Rodriguez, Tom Masi, Stacy Stephenson, Jack Gotcher, David E. Anderson, Josh Campbell, Madhu Dhar

“…Translating this strategy to preclinical animal models provides hope for bone tissue engineering.…”
Get full text

A conceptual model and practical guidance for the development, administration, and evaluation of individualized therapies by Lucie Perillat, Lucie Perillat, Andrew McFadyen, Andrew McFadyen, Andrew McFadyen, Patricia Furlong, James Anderson, James Anderson, James Anderson

“…Bespoke therapies represent a promising tool to address a diverse range of genetic and acquired conditions, offering new hope where conventional treatments have fallen short. …”
Get full text

Use of Garden Design to Enhance Mental Health Among the Selected Health Facilities in Kabale Town: A Case Study of Makanga Health Facility. by Nayebare, Maria

“…Healing gardens should provide a sense of security and safety, incorporating elements like trees, flowers, fragrant plants, and shrubs to evoke a feeling of hope and relaxation. Therefore, one has to consider the balance between physical activities and passive experiences in the garden to maximize its benefits. …”
Get full text

Management of chimeric antigen receptor T-cell-related toxicity of a patient affected by cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome, follo... by G. Menardi, A. Castellino, C. Castellino, M. E. Bersia, E. Grande, G. Fraternali, M. Massaia, C. Fruttero

“…Brexucabtagene autoleucel, a US Food and Drug and European Medicines Agency-approved anti-CD19 chimeric antigen receptor T-cell therapy, marks a significant breakthrough offering hope in this challenging scenario. Case presentation This article presents an analysis of the management of short-term chimeric antigen receptor T-cell therapy-associated toxicities, focusing on a specific case of a patient with refractory mantle cell lymphoma. …”
Get full text

Epidemics In The 21st Century: A Multifaceted Challenge by Shawana Sharif

“…In the pursuit of a healthier, more resilient future, the role of medical professionals stands as a beacon of hope, steering us through the turbulent seas of epidemics with unwavering dedication and expertise. …”
Get full text

Editorial by Editor

“…We extend our heartfelt gratitude to the reviewers and contributors whose dedication and scholarly efforts have enriched this volume. We hope this issue inspires researchers, educators, policymakers, and professionals to explore and appreciate the relevance of Indigenous Knowledge in contemporary society. …”
Get full text

Tradition and Development of Lithuanian Terminology by Antanas Smetona

“…However, during this short period of time, due to the efforts of terminologists—both linguists and specialists in the subject areas - the Lithuanian terminology has successfully played its proper role in the Lithuanian language of science and technology. The hope is that the morbidly perceived internationality will not overshadow the Lithuanian language altogether and that the new winds of life will not hinder the development of Lithuanian terminology, which will continue to serve the intellectual life of the Lithuanian nation, despite “occasional setbacks”. …”
Get full text