Structure-Based Virtual Screening, Docking, ADMET, Molecular Dynamics, and MM-PBSA Calculations for the Discovery of Potential Natural SARS-CoV-2 Helicase Inhibitors from the Tradi... by Ahmed M. Metwaly, Alaa Elwan, Abdul-Aziz M. M. El-Attar, Sara T. Al-Rashood, Ibrahim H. Eissa

“…The obtained results give a huge hope to find a cure for COVID-19 through further in vitro and in vivo studies for the selected compounds.…”
Get full text

Profiles of systemic lupus erythematosus patients with co-existing sickle cell disease: a coincidence or true association? by Hakeem Babatunde Olaosebikan, Etseoghena Igebu, Adebukola Khairat Orolu, Gbenga Joshua Odunlami, Ilo Azizat Bamisebi, Akin Dada, Ebele Uche, Olufemi Adelowo

“…Conclusions Sickle cell disease and SLE should be considered in SCD with atypical clinical and labo­ratory features. We hope this report will raise diagnostic suspicion and prompt early diagnosis and treatment to prevent multiorgan damage that may ensue from such an association.…”
Get full text

Who freezes her eggs and why? psychological predictors, reasons, and outcomes of social egg freezing by Julia Jeannine Schmid, Seraina Weber, Ulrike Ehlert

“…Using SEF to actively shape one’s life and family planning was rather associated with positive psychological outcomes, whereas relying on SEF in the hope of personal and societal changes (e.g. improving fertility) was associated with negative outcomes. …”
Get full text

Targeting Cytokine-Mediated Inflammation in Brain Disorders: Developing New Treatment Strategies by Rahul Mallick, Sanjay Basak, Premanjali Chowdhury, Prasenjit Bhowmik, Ranjit K. Das, Antara Banerjee, Sujay Paul, Surajit Pathak, Asim K. Duttaroy

“…As research advances, the creation of personalized, cytokine-centered therapeutics has the potential to alter the therapy landscape for brain illnesses, giving patients hope for better results and a higher quality of life.…”
Get full text

Management of Oro-Antral Communication: A Systemic Review of Diagnostic and Therapeutic Strategies by Gianna Dipalma, Angelo Michele Inchingolo, Irma Trilli, Laura Ferrante, Angela Di Noia, Elisabetta de Ruvo, Francesco Inchingolo, Antonio Mancini, Stefan Cocis, Andrea Palermo, Alessio Danilo Inchingolo

“…Emerging techniques and minimally invasive procedures continue to improve patient outcomes, offering hope for more effective and sustainable solutions in complex cases.…”
Get full text

« Mon seul Shakespeare » by Jacques Nichet

“…In this paper, I also provide some explanations for my choices as a director as to casting, costumes, scenography, and rhythm of delivery. I hope these few pages will reflect the real pleasure we all took in staging Shakespeare’s play whose text so generously rewards those who approach it with a form of innocence!…”
Get full text

Understanding Psychological Wellbeing Among Iranian Healthcare Workers: The Role of Resilience and Social Capital by Maryam Akbari, Mohammad Hossein Kaveh, Rosanna Cousins, Hamidreza Mokarami, Mehdi Jahangiri, Changiz Rahimi Taghanaki

Get full text

Tumor-associated-fibrosis and active collagen-CD44 axis characterize a poor-prognosis subtype of gastric cancer and contribute to tumor immunosuppression by Yingqi Yang, Haohan Sun, Hongkai Yu, Luyao Wang, Chang Gao, Haokun Mei, Xiaomeng Jiang, Minghui Ji

“…By combining it with immune checkpoint inhibitors (ICIs), it may improve the efficacy of immunotherapy for gastric cancer and offer new hope for treatment.…”
Get full text

Biomimetic fabricated tubular graft in situ immobilized with peptides to restore the vascular structure and regulate the inflammation homeostasis through gastrodin coating by Shiwei Niu, Fan Li, Zhi Lin, Bo Chen, Lechun Lyu, Yongliang Jiang, Wanting Li, Jianlin Jiao, Yi Han, Di Lu, Lin Sun

“…The synthesis process was characterized, its biocompatibility, hierarchically cell induction capacity, anticoagulant effect and the ability to promote neovascularization were evaluated. In such way, we hope to prepare a biodegradable small-diameter artificial vascular for the clinical application.…”
Get full text

Enhancing antimicrobial resistance strategies: Leveraging artificial intelligence for improved outcomes by Aeshah M. Mohammed, Mohammed Mohammed, Jawad K. Oleiwi, Azlin F. Osman, Tijjani Adam, Bashir O. Betar, Subash C.B. Gopinath, Falah H. Ihmedee

“…This review explores the burgeoning role of artificial intelligence (AI) in revolutionizing AMR strategies, offering a beacon of hope for turning the tide against resistant pathogens. …”
Get full text

Cyclin-dependent protein kinases and cell cycle regulation in biology and disease by Ilenia Pellarin, Alessandra Dall’Acqua, Andrea Favero, Ilenia Segatto, Valentina Rossi, Nicole Crestan, Javad Karimbayli, Barbara Belletti, Gustavo Baldassarre

“…Finally, we discuss how CDKs inhibitors have become standard therapies in selected human cancers and propose novel ways of investigation to export their targeting from cancer to other relevant chronic diseases. We hope that the effort we made in collecting all available information on both the prominent and lesser-known CDK family members will help in identify and develop novel areas of research to improve the lives of patients affected by debilitating chronic diseases.…”
Get full text

Political Crisis in France: «Gilets Jaunes» and the End of the «First Period» of the Emmanuel Macron’s Governance by E. O. Obichkina

“…Dissatisfied people without any hope to be heard join the ranks of the mass spontaneous movement of «gilets jaunes», triggered by the introduction of the so-called «environmental» tax. …”
Get full text

About One Memorable Date in the History of Spain by G. I. Volkova

“…In 1714 the Catalans, being in the camp of the losers in the War of the Spanish Succession, finally lost any hope to gain independence. 300 years later, nationalists, who are in power now in Catalonia, want to take advantage of that memorable date by organizing a regional referendum in order to choose their own path of development. …”
Get full text

Molecular Characterization and Clinical Characteristics of m5C-Based RNA Methylation in Spinal Cord Injury: Validated by qPCR by Liang Cao, Wen Jun Pi, Qiang Zhang, Qing Li

“…This present study explored and discovered the close link between m5C regulators-related genes and SCI. We also hope our findings may contribute to further mechanistic and therapeutic research on the role of key m5C regulators after SCI.…”
Get full text

Novel Models for the Prediction of Left Atrial Appendage Thrombus in Patients with Chronic Nonvalvular Atrial Fibrillation by Do Van Chien, Pham Thai Giang, Pham Truong Son, Le Van Truong, Pham Nguyen Son

“…These models combine the CHA2DS2-VASc score with LA volume index and LA longitudinal strain parameters measured on speckle tracking echocardiography in the four-chamber view. We hope these simple models can help with decision-making in managing the antithrombotic treatment of such patients, whose risk of stroke cannot be determined solely based on the CHA2DS2-VASc score.…”
Get full text

Microstructural, Morphological, and Magnetic Effects of NiFe₂O₄ Shell Formation Around Nanospherical ZnFe₂O₄ Cores by Marija Šuljagić, Vuk Uskoković, Lukasz Kilanski, Sabina Lewinska, Abdul Khaliq, Anna Ślawska-Waniewska, Aleksandar Kremenović, Vladimir Pavlović, Dejan A. Jeremić, Ljubica Andjelković

“…First-row transition metal oxides have relatively modest magnetic properties compared to those of permanent magnets based on rare earth elements. However, there is a hope that this gap might be bridged via proper compositional and structural adjustments. …”
Get full text

Prevalence and Economic Impact of Acute Respiratory Failure in the Prehospital Emergency Medical Service of the Madrid Community: Retrospective Cohort Study by Ana María Cintora-Sanz, Cristina Horrillo-García, Víctor Quesada-Cubo, Ana María Pérez-Alonso, Alicia Gutiérrez-Misis

“…By achieving these objectives, we hope to inform efforts to address respiratory failure and establish a standardized methodology and framework that can facilitate expansion to a continuous community-wide registry in Madrid, driving advances in emergency care and care practices in these pathologies. …”
Get full text

A MALDI-ToF mass spectrometry database for identification and classification of highly pathogenic bacteria by Peter Lasch, Wolfgang Beyer, Alejandra Bosch, Rainer Borriss, Michal Drevinek, Susann Dupke, Monika Ehling-Schulz, Xuewen Gao, Roland Grunow, Daniela Jacob, Silke R. Klee, Armand Paauw, Jörg Rau, Andy Schneider, Holger C. Scholz, Maren Stämmler, Le Thi Thanh Tam, Herbert Tomaso, Guido Werner, Joerg Doellinger

“…The dataset contains a total of 11,055 spectra from altogether 1,601 microbial strains and 264 species and is primarily intended to improve the diagnosis of HPB. We hope that our MALDI-ToF MS data may also be a valuable resource for developing machine learning-based bacterial identification and classification methods.…”
Get full text

Operational research as a mechanism to improve treatment outcomes for drug-resistant TB in the WHO European Region by G.B. Migliori, O. Korotych, J. Achar, A. Ciobanu, G. Dravniece, M. Germanovych, E. Gurbanova, A. Hovhannesyan, N. Khachatryan, L. Kuksa, N. Lomtadze, M.L. Rich, A. Skrahina, A. Yedilbayev

“…This unique experience promoted further collaboration with national tuberculosis programmes, health authorities, experts and donors within and outside Europe, with a focus on implementing operational research and improving the quality of care in high TB burden countries of the region. In the hope of encouraging others to adopt this model, we have described the principles of the initiative, its strengths and weaknesses and next steps.…”
Get full text

Advances in Cell and Immune Therapies for Melanoma by Tanase Timis, Sanda Buruiana, Delia Dima, Madalina Nistor, Ximena Maria Muresan, Diana Cenariu, Adrian-Bogdan Tigu, Ciprian Tomuleasa

“…This review provides an overview of the requirement for advances in these medications, to mark a significant step forward in melanoma management, set to bring a fresh breath of hope for patients.…”
Get full text