In silico analysis of SNPs and miRNAs of KCTD13, CSDE1, SLC6A1 genes associated with autism spectrum disorder by Kübra Çoruh Kınalı, Ebru Özkan Oktay, Mesut Karahan

“…This data served as input for predictions, which were carried out using different computational tools like SIFT, PolyPhen-2, SNPs&GO, PROVEAN, MutationAssessor, PhD-SNP, PANTHER, SNAP-2, Meta-SNP, I-Mutant 2.0, MUpro, and Project HOPE. For miRNA analysis, the miRSNP and PolymiRTS tools were utilized. …”
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Motivations regarding continuing or terminating pregnancy in women with high-risk pregnancies: a scoping review by Mónica Antunes, Mónica Antunes, Ana Galhanas, Ana Lúcia Vitorino, Sara Palma, Sara Palma, Ana Frias, Ana Frias

“…Significant emotional and cognitive factors, particularly hope, also play a crucial role. The findings highlight the complexity of the decision-making process and provide a deeper understanding of the personal, social, and spiritual dimensions involved.ConclusionsMultiple factors shape the complex decisions of women with high-risk pregnancies. …”
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Advanced Learning Technologies for Intelligent Transportation Systems: Prospects and Challenges by Ruhul Amin Khalil, Ziad Safelnasr, Naod Yemane, Mebruk Kedir, Atawulrahman Shafiqurrahman, NASIR SAEED

“…By doing so, we aim to facilitate a deeper comprehension of the challenges and possibilities within this field. We hope that this effort will inspire further exploration of fresh perspectives and issues, which, in turn, will play a pivotal role in shaping the future of transportation systems.…”
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Influence of Mesalazine on Ferroptosis-Related Gene Expression in In Vitro Colorectal Cancer Culture by Joanna Słoka, Barbara Strzałka-Mrozik, Sebastian Kubica, Ilona Nowak, Celina Kruszniewska-Rajs

“…Thus, the discovery of safe inducers of ferroptosis, offering new hope in the struggle against CRC, remains crucial. …”
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Altered Functional Connectivity in Children with ADHD Revealed by Scalp EEG: An ERP Study by Chunli Chen, Huan Yang, Yasong Du, Guangzhi Zhai, Hesheng Xiong, Dezhong Yao, Peng Xu, Jianhua Gong, Gang Yin, Fali Li

“…On the one hand, when investigating the cortical activity, HCs recruited much stronger brain activity mainly in the temporal and frontal regions, compared to ADHD children; on the other hand, the brain network showed atypical enhanced long-range connectivity between the frontal and occipital lobes but attenuated connectivity among frontal, parietal, and temporal lobes in ADHD children. We hope that the findings in this study may be instructive for the understanding of cognitive processing in children with ADHD.…”
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A qualitative study exploring depressed participants’ experiences of receiving Augmented Depression Therapy (ADepT) by Rebecca Watson, Kim A Wright, Nigel Reed, Barney Dunn, Emily Widnall, Kalliopi Demetriou, Laura Warbrick, Katie Marchant, Nicole Geschwind, Isabella Magner-Parsons, Rachel Barter

“…Participants reported significant positive impacts of treatment on wellbeing, functioning and hope. Perceived mechanisms of change were reorienting to the positive, engaging with valued goals, taking a proactive life stance, gaining confidence and motivation for change, breaking down tasks into small steps, cultivating self-care and self-compassion, enhancing help seeking and interpersonal effectiveness, changing the relationship to depression, and rediscovering the self beyond depression.Conclusions Findings suggest that the wellbeing focus of ADepT is acceptable and leads to positive impacts, supports the logic model underpinning the intervention, and warrants continuation to a definitive trial.Trial registration number ISRCTN85278228.…”
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Bioactive milk-derived nutrient MFG-E8 ameliorates skeletal muscle atrophy induced by mitochondria damage in aging rats via activating the MAPK/ERK signaling pathway by Kaifang Guan, Xiaolin Liu, Weihong Lu, Yuhao Mao, Yirong Mao, Ying Ma, Rongchu Wang, Qiming Li

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A multidimensional Bayesian IRT method for discovering misconceptions from concept test data by Martin Segado, Aaron Adair, John Stewart, Yunfei Ma, Byron Drury, David Pritchard

“…While work remains to validate our findings, our hope is that future applications of this method could aid in the refinement of existing concept inventories or the development of new ones, enable the discovery of previously-unknown student misconceptions across a variety of disciplines, and—by leveraging the method's ability to quantify the prevalence of particular misconceptions—provide opportunities for targeted instruction at both the individual and classroom level.…”
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Rapid Heterotrophic Ossification with Cryopreserved Poly(ethylene glycol-) Microencapsulated BMP2-Expressing MSCs by Jennifer Mumaw, Erin T. Jordan, Corinne Sonnet, Ronke M. Olabisi, Elizabeth A. Olmsted-Davis, Alan R. Davis, John F. Peroni, Jennifer L. West, Franklin West, Yangqing Lu, Steven L. Stice

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Intravascular large B-cell lymphoma of the central nervous system with renal involvement: a case report and literature review by Jun Li, Zhaojiao Li, Yifeng Shi, Jiajie Chen, Heng Zhao, Xueye Mao, Shan Li, Huiying Wang, Qiang Meng, Lingchun Liu

“…Pathological biopsy is the gold standard for diagnosis. We hope that through this case, doctors can gain a deeper understanding of IVLBCL, enabling early diagnosis and timely treatment to improve prognosis.…”
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Infrared Image Enhancement: A Review by Qingwang Wang, Pengcheng Jin, Yuhang Wu, Liyao Zhou, Tao Shen

“…Based on these investigations, we have evaluated the performance of various representative infrared image enhancement methods, with the hope of providing a reference for future research. …”
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Analysing the scientific literature on transgender and gender diverse persons’ experiences with sexual and reproductive health care services from an intersectional perspective by Susan Heward-Belle, Sarah Ciftci, Renee Lovell

“…Best practices were identified including affirming, person-centred care, collaboration, trauma-informed care and leveraging informal support networks, which provide hope for improved service provision and design.…”
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Safety and efficacy of oral cancer vaccine B440 in patients with PD-1/PD-L1 inhibitor-resistant advanced urothelial cancer: a study protocol for a phase 1 multicenter, open-label,... by Junya Furukawa, Yasumasa Kakei, Sae Murakami, Hiroshi Kita, Hideto Ueki, Takuto Hara, Jun Teishima, Nobuyuki Hinata, Hideaki Miyake, Masato Fujisawa, Toshiro Shirakawa

“…Discussion If this trial shows B440 to be safe and effective, it may lead to a late phase randomized controlled trial in advanced urothelial cancer. Ultimately, we hope to provide a new treatment option for such patients. …”
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A lectin produced by a Streptomyces species targets mammalian pancreatic acinar cells in mice and humans by Janine C. Quijano, Honoka Natsuyama, Alonso Tapia, Karine Bagramyan, Jose A. Ortiz, Jacob Mares, Markus Kalkum, Yoko Fujita-Yamaguchi, Hsun Teresa Ku

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Investigation of Information Overload in Electronic Health Records: Protocol for Usability Study by Saif Khairat, Jennifer Morelli, Marcella H Boynton, Thomas Bice, Jeffrey A Gold, Shannon S Carson

“…By conducting a multisite, cross-sectional usability assessment of information overload in 2 leading EHRs, we hope to reveal mechanisms that explain information overload. …”
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‘It takes a village’: patient lived experiences of residential treatment for an eating disorder by Rebekah Rankin, Janet Conti, Lucie Ramjan, Phillipa Hay

“…Cutting across these main themes were participants’ encounters of barriers, setbacks and hope. Participant experiences of residential treatment were complex and multifaceted, marked by inherent ideological dilemmas that arose in balancing standardised treatment protocols with person-centred and recovery-oriented care. …”
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Recent advances in pancreatic α-cell transdifferentiation for diabetes therapy by Yanjiao Li, Yanjiao Li, Jinyu Zhu, Congyang Yue, Siyuan Song, Limin Tian, Yi Wang, Yi Wang, Yi Wang

“…Overall, the ability to convert α-cells into β-cells represents a transformative strategy for diabetes treatment, offering hope for more effective and sustainable therapies for patients with severe β-cell loss.…”
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The Pattern of the Relationship between Ethical Philosophies and Information Technology with the Ethical Behavior of Auditors: An Actors Network Theory (ANT) App by Hossein Rajabdorri, Hamidreza Vakilifard, Hojatolah Salari, Ali Amiri

“…Information technology (technical actors) also includes the integrated theory of acceptance and use of advanced technology (motivation, hope for effort, and social impact). The study's overall findings showed that the components of technical and human actors have a positive and significant effect on the development of ethical behaviour in auditors.Originality/Value: Considering the importance of systematizing ethical behaviour and preparing models appropriate to the country's environment, the findings of this study, with strong theoretical and practical support, can help to understand better and accelerate the implementation of auditors' ethical behaviour and human and technical actors and shows the influential role of each one clearly.…”
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Engaging health system, service and consumer representatives in the co-design of a multi-criteria decision-making framework for commissioning overweight and obesity programs and se... by Laura Thomas, Suzanne Robinson, Sharyn Burns, Helen Mitchell, Andrea Begley

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Women’s mental health in the doctoral context: Protective function of the psychological capital and academic motivation by Angel Deroncele-Acosta, Roger Pedro Norabuena-Figueroa, Emerson Damian Norabuena-Figueroa

“…Fourteen success factors for women’s mental health were identified and organized into four main approaches: Optimism, Hope, Resilience, and Self-efficacy. Conclusion: Limitations and future projections are discussed. …”
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