Targeting the Fanconi Anemia Pathway to Identify Tailored Anticancer Therapeutics by Chelsea Jenkins, Jenny Kan, Maureen E. Hoatlin

“…The pathway contains an upstream multiprotein core complex that mediates the monoubiquitylation of the FANCD2 and FANCI heterodimer, and a downstream pathway that converges with a larger network of proteins with roles in homologous recombination and other DNA repair pathways. Selective killing of cancer cells with an intact FA pathway but deficient in certain other DNA repair pathways is an emerging approach to tailored cancer therapy. …”
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Genetic Correction of Sickle Cell Anemia and β-Thalassemia: Progress and New Perspective by Ajay Perumbeti, Punam Malik

“…Vector improvements to enhance the safety and efficiency of lentivirus vectors are being explored, while new strategies, including homologous recombination in induced pluripotent cells, for correction of sickle cell anemia have shown proof-of-concept in vitro. …”
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Distribution of bacterial DNA repair proteins and their co-occurrence with immune systems by Sumanth K. Mutte, Patrick Barendse, Pilar Bobadilla Ugarte, Daan C. Swarts

“…Here, we describe a stringent search strategy to identify DNA repair proteins and provide a systematic analysis of taxonomic distribution and co-occurrence of DNA repair proteins involved in RecA-dependent homologous recombination. Our results reveal the widespread presence of RecA, SSB, and RecOR proteins and phyla-specific distribution for the DNA repair complexes RecBCD, AddAB, and AdnAB. …”
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Opportunities for predictive proteogenomic biomarkers of drug treatment sensitivity in epithelial ovarian cancer by Trudy J. Philips, Britt K. Erickson, Stefani N. Thomas

“…A prominent example is the stratification of epithelial ovarian cancer (EOC) patients with homologous recombination deficiency (HRD) characterized by mutations in DNA damage repair genes such as BRCA1/2 for treatment with PARP inhibitors. …”
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Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein by Ioannis Papaioannou, J. Paul Simons, James S. Owen

“…In particular, we discuss the possibility and potential benefit of applying in combination two technical advances to repair aberrant APOE genes: (i) an engineered endonuclease to introduce a double-strand break (DSB) in exon 4, which contains the common, but dysfunctional, ε2 and ε4 alleles; (ii) an efficient and selectable template for homologous recombination (HR) repair, namely, an adeno-associated viral (AAV) vector, which harbours wild-type APOE sequence. …”
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Histopathology and proteomics are synergistic for high-grade serous ovarian cancer platinum response prediction by Oz Kilim, Alex Olar, András Biricz, Lilla Madaras, Péter Pollner, Zoltán Szállási, Zsofia Sztupinszki, István Csabai

“…This method outperforms the Homologous Recombination Deficiency (HRD) score in predicting platinum response and overall patient survival. …”
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DNA Damage Induced by Alkylating Agents and Repair Pathways by Natsuko Kondo, Akihisa Takahashi, Koji Ono, Takeo Ohnishi

“…., endnuclease xeroderma pigmentosum complementation group F-excision repair cross-complementing rodent repair deficiency complementation group 1), Fanconi anemia repair, and homologous recombination. A detailed understanding of how cells cope with DNA damage caused by alkylating agents is therefore potentially useful in clinical medicine.…”
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A Case of 17q21.31 Microduplication and 7q31.33 Microdeletion, Associated with Developmental Delay, Microcephaly, and Mild Dysmorphic Features by Adrian Mc Cormack, Juliet Taylor, Leah Te Weehi, Donald R. Love, Alice M. George

“…Analysis has shown that low-copy repeats (LCRs) have allowed chromosome regions throughout the genome to become hotspots for nonallelic homologous recombination to take place. Here, we report a case of a 7.5-year-old girl who manifests microcephaly, developmental delay, and mild dysmorphic features. …”
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The enigma of cancer polyploidy as deciphered by evolutionary cancer cell biology (ECCB) by Vladimir F. Niculescu, Eugenia R. Niculescu

“…As observed in amoebae, DNA double-strand breaks (DSBs) manifest in the homologous recombination (HR) genes of NG germlines and stem cell lineages when exposed to specific hyperoxic conditions, referred to as AMF hyperoxia, characterized by an oxygen content exceeding 6.0%. …”
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The unconventional Xer recombination machinery of Streptococci/Lactococci. by Pascal Le Bourgeois, Marie Bugarel, Nathalie Campo, Marie-Line Daveran-Mingot, Jessica Labonté, Daniel Lanfranchi, Thomas Lautier, Carine Pagès, Paul Ritzenthaler

“…Homologous recombination between circular sister chromosomes during DNA replication in bacteria can generate chromosome dimers that must be resolved into monomers prior to cell division. …”
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Aspergillus fumigatus ctf1–a novel zinc finger transcription factor involved in azole resistance by Xiao Gong, Heng Zhang, Wenxu Cheng, Zhangxuan He, Tianyan Ma, Tian Chen, Yi Sun

“…Here, we investigated the function of ctf1 (AFUA_1G03800), a gene encoding a C6 transcription factor. Homologous recombination replacement technology was employed to construct ctf1-knockout and revertant strains. …”
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CRISPR/Cas9-Based Protocol for Precise Genome Editing in Induced Pluripotent Stem Cells by Avinash Singh, Swathy Babu, Marcus Phan, Shauna Yuan

“…In our study, we observed that combining p53 inhibition with pro-survival small molecules yields a homologous recombination rate of over 90% when using CRISPR in human iPSCs. …”
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Cloning, expression pattern analysis, and vector construction of the BvNAC40 gene in sugar beet by FAN Ziqi, SUN Yaqing, LI Ningning, ZHANG Shaoying, LI Guolong

“…Overexpression vectors and virus-induced gene silencing (VIGS) vectors for BvNAC40 were constructed using homologous recombination. [Results] The CDS of BvNAC40 was 1 182 bp long, encoding 393 amino acids, which was classified within the NAC transcription factor family, with a transmembrane domain at the C-terminus. …”
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Integration of single-cell and bulk RNA-sequencing data to construct and validate a signature based on NK cell marker genes to predict immunotherapy response and prognosis in color... by Xiaoyu Qin, Wenjuan Xu, Jinxiu Wu, Ming Li

“…Furthermore, the signature was associated with the homologous recombination deficiency (HRD) and T-cell receptor (TCR) scores. …”
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Improved 11α-hydroxycanrenone production by modification of cytochrome P450 monooxygenase gene in Aspergillus ochraceus by Li Qianqian, Shi Li, Liu Yingying, Guan Shimin, Zhang Shuo, Cai Baoguo, Rong Shaofeng

“…A recombinant A. ochraceus strain MF010 with the high expression of CYP monooxygenase was then obtained through homologous recombination. The biocatalytic rate of this recombinant strain reached 93 % at 60 h without the addition of organic solvents or surfactants and was 17–18 % higher than that of the MF018 strain. …”
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Heterozygous mutation in BRCA2 induces accelerated age-dependent decline in sperm quality with male subfertility in rats by Yashiro Motooka, Hideaki Tanaka, Yuki Maeda, Misako Katabuchi, Tomoji Mashimo, Shinya Toyokuni

“…Abstract Tumor suppressor BRCA2 executes homologous recombination to repair DNA double-strand breaks in collaboration with RAD51, involving exon 11 and 27. …”
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Molecular pathways in reproductive cancers: a focus on prostate and ovarian cancer by Ayodeji Folorunsho Ajayi, Mega Obukohwo Oyovwi, Oyedayo Phillips Akano, Grace Bosede Akanbi, Florence Bukola Adisa

“…In ovarian cancer, high-grade serous carcinomas are characterized by mutations in TP53, BRCA1/2, and homologous recombination repair genes. PI3K and MAPK pathways are frequently activated, promoting cell proliferation and survival. …”
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RNA Sequencing Reveals the Differentially Expressed circRNAs between Stable and Unstable Carotid Atherosclerotic Plaques by Xueguang Lin, Ying Deng, Lujuan Ye, Bo Chen, Jindong Tong, Weijun Shi, Bo Wang, Bo Yu, Jingdong Tang

“…KEGG analysis revealed that the host genes of the upregulated circRNAs were primarily associated with protein processing in endoplasmic reticulum, lysine degradation, homologous recombination, epithelial cell signaling in Helicobacter pylori infection, and yersinia infection. …”
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A new strategy for the treatment of advanced ovarian cancer: utilizing nanotechnology to regulate the tumor microenvironment by Zixuan Xiong, Yichun Huang, Shulong Cao, Xuqun Huang, Haiyuan Zhang

“…In addition, NPs can regulate the non-immune TME by reducing apoptosis in AOC cells, inhibiting homologous recombination (HR) repair, reversing EMT, and achieving the effect of reversing drug resistance. …”
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Methods of yeast genome editing by A. S. Rozanov, V. N. Shlyahtun, L. A. Tekutieva, O. M. Son, S. V. Sizova, S. E. Peltek

“…For a long time, yeast genome engineering was based on the yeasts’ system of homologous recombination. It was sufficient for several decades before the development of high­throughput methods. …”
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