Nonsmall Cell Lung Carcinoma with Giant Cell Features Expressing Programmed Death-Ligand 1: A Report of a Patient Successfully Treated with Pembrolizumab by Shingo Nakayama, Mamoru Sasaki, Shojiroh Morinaga, Naoto Minematsu

“…A 69-year-old woman was diagnosed with NSCLC with multiple brain metastases. Histological evaluation of lung biopsy specimens revealed proliferation of pleomorphic giant tumor cells with poor cohesiveness, findings consistent with giant cell carcinoma. …”
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The canine blood-brain barrier in health and disease: focus on brain protection by Dimitri Bassalo, Stephen G. Matthews, Enrrico Bloise

“…We revise key anatomical, histological and functional aspects of the canine BBB and examine the role of the ABCB1/MDR1 gene mutation in specific dog breeds that exhibit reduced P-gp activity and disrupted drug brain pharmacokinetics. …”
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A Hybrid Ameloblastoma in Posterıor Mandible: A Case Report by Alper Sindel, Büşra Altunay, Gülay Özbilim, Öznur Özalp, Büşra Karasu

“…Objective: Hybrid ameloblastoma refers to the tumors that contain two or more different histologic types of ameloblastoma. Till date, only 49 cases of hybrid ameloblastoma with different combinations have been reported. …”
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Validation of a New Saliva Test for Helicobacter pylori Infection by OF Bathe, AJ Rae, P Zetler, IGM Cleator

“…Thirty-five patients (50%) had histological evidence of gastritis and, by using acridine orange stain, the bacterium was visualized in 25 patients (71%). …”
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Pelvic Desmoid Tumor: A Rare Case with Difficult Diagnosis and Treatment by Mariana Ormonde, Despoina Argyropoulou, Cândida Lourenço, João Bastos, Ana Quintas

“…The patient underwent an exploratory laparotomy for definite diagnosis and treatment, which led to right nephrectomy, hysterectomy, and right oophorectomy because of deep infiltration and difficult dissection. Definite histologic diagnosis revealed the presence of a pelvic desmoid tumor. …”
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Single-nucleus and spatial landscape of the sub-ventricular zone in human glioblastoma by Yamhilette Licón-Muñoz, Vanessa Avalos, Suganya Subramanian, Bryan Granger, Frank Martinez, Leopoldo A. García-Montaño, Samantha Varela, Drew Moore, Eddie Perkins, Michael Kogan, Stefano Berto, Muhammad O. Chohan, Christian A. Bowers, Sara G.M. Piccirillo

“…Here, we build a single-nucleus RNA-sequencing-based microenvironment landscape of the tumor mass and the SVZ of 15 patients and two histologically normal SVZ samples as controls. We identify a ZEB1-centered mesenchymal signature in the tumor cells of the SVZ. …”
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Elevated expression of ANTXR1 gene in tumors is a poor prognostic biomarker for patients with bladder cancer by L. S. Franco, S. Arunachalam, A. Chauhan, S. A. Kareff, P. L. Hallenbeck

“…In addition to the various roles TEM8 plays in oncogenesis, including angiogenesis, epithelial-to-mesenchymal transition, and cell migration, it has also been shown that the overexpression of the ANTXR1 gene in solid tumors correlates with poor prognostic indicators in several solid tumor histologies. As such, TEM8 has been identified as the target of novel oncologic therapies. …”
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Peripheral Nerve Repair with Cultured Schwann Cells: Getting Closer to the Clinics by Maria Carolina O. Rodrigues, Antonio Antunes Rodrigues, Loren E. Glover, Julio Voltarelli, Cesario V. Borlongan

“…Experimental studies provide evidence of functional, histological, and electromyographical improvement following transplantation of bone-marrow-derived cells in animal models of peripheral nerve injury. …”
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Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar by Prateek Kinra, V. Srinivas, Kavita Sinha, Vibha Dutta

“…Literature is limited to small series. Histologically, this tonsillar growth was composed of a squamous cell carcinoma (epithelial component) and a spindle cell sarcomatous component. …”
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False Positive Radioiodinated Metaiodobenzylguanidine (123I-MIBG) Uptake in Undifferentiated Adrenal Malignant Tumor by Hee Soo Jung, Seok Jun Moon, Yun Mi Kim, Hye Rim Kang, Seok Mo Lee, Soo Jin Jung, Seok Jin Choi, Tae Kyoon Kim, Min Jeong Kwon, Jeong Hyun Park, Soon Hee Lee

“…A final diagnosis of undifferentiated adrenal malignant tumor was rendered, instead of histologically malignant pheochromocytoma, despite the uptake of 123I-MIBG demonstrated by scintigraphy.…”
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Cavernous Breast Hemangioma Mimicking an Invasive Lesion on Contrast-Enhanced MRI by Menelaos Zafrakas, Panayiota Papasozomenou, Panayiotis Eskitzis, Demetrios Zouzoulas, Glyceria Boulogianni, Thomas Zaramboukas

“…A wide local excision was performed after 3 T MRI-guided hook wire localization and diagnosis of cavernous hemangioma was established histologically. Cavernous hemangioma is a rare breast lesion, with only few cases reported in the literature, and this is the first case with a presentation mimicking an invasive tumor on contrast-enhanced MRI.…”
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Noninvasive markers of inflammatory bowel disease activity by A. V. Nikitin, L. V. Vasilyeva, Anatoly A. Matiukhin

“…Original study included 67 patients with UC and CD in whom clinical and endoscopic activity of the disease with assessed by histological investigation of biopsy specimens. Blood serum cytokines: IL-4, IL-8, tumor necrosis factor α (TNF-α) and fecal calcium binding protein (calprotectin) were assessed. …”
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Lingual Fibrous Hyperplasia: Case Report and Literature Review by Edison Omar Sacaquirín Zhunio, Julián Alejandro Merel Guamán, Diana Priscila Llivichuzca Inga, Kevin Adrián Quishpe Peña

“…An excisional laser biopsy was performed and fibrous hyperplasia was confirmed histologically. This approach allowed precise therapeutic intervention and differential diagnosis against potentially malignant lesions such as oral leukoplakia. …”
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Sex differences in the relationship between body composition and MASLD progression in a murine model of metabolic syndrome by Laura Manjarrés, Aline Xavier, Leticia González, Camila Garrido, Flavia C. Zacconi, Katherine Rivera, Laura Parra, Alkystis Phinikaridou, Cecilia Besa, Marcelo E. Andia

“…Dimensionality reduction and clustering analyses identified distinct sex-specific MASLD phenotypes and progression patterns. Histological evaluations confirmed greater liver damage in males, evidenced by higher MAFLD Activity Scores. …”
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Calciphylaxis: Successful Management of a Rare Complication of Chronic Kidney Disease in Two Patients by Ibtissam Fares, Tarik Bouattar, Hadja Moussokoro Kone, Hajar Benzouina, Meryem Benbella, Naima Ouzeddoun, Rabia Bayahia, Loubna Benamar

“…In both patients, the diagnosis was confirmed histologically. Our two observations highlight the difficulty of the diagnosis and the complexity of the therapeutic management that has been personalized according to patient characteristics and clinical evolution. …”
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Hemangiopericytoma of the Breast: A Case Report and a Review of the Literature by Georgios Koukourakis, Evagelos Filopoulos, Kasiani Kapatou, Georgios Zacharias

“…The accurate diagnosis of HPC depends on the appropriate histological and immunohistochemical examination. Surgical resection is the treatment of choice and due to scarcity of cases and unpredictable biological behavior of these tumors long term follow-up may be warranted.…”
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Haemosiderotic Synovitis Secondary to Anticoagulant Use: An Unusual Mechanism of Failure of a Unicompartmental Knee Replacement by Jonathan Bartlett, Surjit S. Lidder, Andrew T. Bucknill

“…A left revision total knee arthroplasty was performed, and a diagnosis of haemosiderotic synovitis was made following histological analysis of intraoperative tissue samples. …”
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Toxicity of mercury (Hg) on survival and growth rate, hemato- and histopathological parameters ofOreochromis niloticus by Kukuh Nirmala, Yuni Puji Hastuti, Vika Yuniar

“…The aim of this study was to determine the influence of mercury in water on survival rate, growth rates, hematological, and histological parameters of Oreochromis niloticus. This study was conducted from Mei to June 2009. …”
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Prolapsed fallopian tube to the vagina after hysterectomy a year ago: A case report by Yu-Hsuan Lin, Huang-Ping Shen, Chih-Jen Tseng, Liang-Ying Wu, Li-Hsin Hsia

“…Differential diagnoses encompassed diverse pelvic pathologies, necessitating histological confirmation. Factors contributing to prolapse include poor vault closure and early sexual activity. …”
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Bronchial responses to substance P after antigen challenge in the guinea-pig: in vivo and in vitro studies by E. Boichot, V. Lagente, G. Le Gall, C. Carré, J. M. Mencia-Huerta, P. Braquet, A. Lockhart, N. Frossard

“…However, in vitro, the contractile responses of the tracheal smooth muscle to substance P were similar between groups of guinea-pigs, in respect to the presence or absence of the epithelium and/or phosphoramidon. Histological studies showed an accumulation of eosinophils in the tracheal submucosa after antigen challenge and intact epithelial cells. …”
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