Oral glucose tolerance testing as a complement to fasting plasma glucose in screening for type 2 diabetes: population-based cross-sectional analyses of 146 000 health examinations... by Patrik Wennberg, Mattias Brunström, Anna Rosén, Julia Otten, Andreas Stomby, Simon Vallin

“…Analyses were further stratified by age, sex and risk factor burden to identify groups at high or low risk of IGT and T2D on testing. The numbers needed to screen (NNS) to prevent one case of T2D through detection and treatment of IGT was estimated, combining prevalence numbers with average progression rates and intervention effects from previous meta-analyses.Results The prevalence of IGT ranged from 0.9% (95% CI 0.7% to 1.1%) to 29.6% (95% CI 27.4% to 31.7%), and the prevalence of T2D ranged from 0.06% (95% CI 0.02% to 0.11%) to 7.0% (95% CI 5.9% to 8.3%), depending strongly on age, sex and risk factor burden. …”
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Community credit scores and community socioeconomic deprivation in association with type 2 diabetes across an urban to rural spectrum in Pennsylvania: a case–control study by Jonathan Pollak, Melissa N Poulsen, Karen Bandeen-Roche, Katherine Moon, Joseph DeWalle, Annemarie G Hirsch, Brian S Schwartz, Lorraine Dean, Meghann Reeder

“…CCS was derived from Equifax VantageScore V.1.0 data and categorised as ‘good’, ‘high fair’, ‘low fair’ and ‘poor’. Individuals were geocoded and assigned the CCS of their residential community. …”
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Role of B7H4 and Fas in regulation of trophoblast cells and development of pre-eclampsia: a cross-sectional study by Xiujuan Dong, Cuicui Nie, Yanli Yin, Haixia Xu, Yanxia Zhang, Lihua Han, Congcong Xu

“…The chi-square test was used to evaluate differences in clinical characteristics between the high- and low-expression groups. The expression levels of B7H4 and Fas were analysed using western blotting and real-time quantitative polymerase chain reaction (RT-qPCR). …”
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Evaluating the impact of a tertiary multidisciplinary meeting in metastatic breast cancer: A prospective study by Belinda Sassé, Sammy Shaya, Jessica Nimmo, Katie Cao, Daphne Day, Katie Evans, Catherine Healy, Gwo-Yaw Ho, Gillian Kruss, Amelia McCartney, Linda Mojzisova, Ranjana Srivastava, Jennifer Tan, Mun Yee Tan, Kate Webber, Michelle White, Steven David, Marion Harris

“…Co-primary endpoints were proportion of plans changed pre/post-MDM and the proportion of high vs. low-impact changes. Estimates of time spent on the MDM and time savings were collected. …”
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Multiple eco-regions contribute to the seasonal cycle of Antarctic aerosol size distributions by J. Brean, D. C. S. Beddows, E. Asmi, A. Virkkula, A. Virkkula, L. L. J. Quéléver, M. Sipilä, F. Van Den Heuvel, T. Lachlan-Cope, A. Jones, M. Frey, A. Lupi, J. Park, Y. J. Yoon, R. Weller, G. L. Marincovich, G. L. Marincovich, G. C. Mulena, G. C. Mulena, R. M. Harrison, R. M. Harrison, M. Dall'Osto

“…“Nucleation” and “bursting” PNSDs occur 28 %–48 % of the time between sites, most commonly at the coastal sites of Marambio and King Sejong where air masses mostly come from the west and travel over extensive regions of sea ice, marginal ice and open ocean and likely arise from new particle formation. “Aitken high”, “Aitken low” and “bimodal” PNSDs occur 37 %–68 % of the time, most commonly at Dome C on the Antarctic Plateau, and likely arise from atmospheric transport and ageing from aerosol originating likely in both the coastal boundary layer and free troposphere. …”
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Dissection of the genetic basis and molecular mechanism of ovule number per ovary in oilseed rape (Brassica napus L.) by Muslim Qadir, Muslim Qadir, Muslim Qadir, Xinyi Lin, Farhan Nabi, Kishore Kumar Ashok, Xue-Rong Zhou, Qingbin Sun, Peiman Shi, Xinfa Wang, Jiaqin Shi, Hanzhong Wang

“…Phytohormone quantification of ovaries (at the ovule initiation stage) from two pools of high and low ONPO lines showed significant differences in the levels of nine sub-types of phytohormones, suggesting their important roles in regulating ovule number. …”
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Effect of the Floor Level on the Probability of a Neurologically Favorable Discharge after Cardiac Arrest according to the Event Location by Han Joo Choi, Hyung Jun Moon, Won Jung Jeong, Gi Woon Kim, Jae Hyug Woo, Kyoung Mi Lee, Hyuk Joong Choi, Yong Jin Park, Choung Ah Lee

“…This study aimed to compare the EMS response times and probability of a neurologically favorable discharge among patients who suffered an out-of-hospital cardiac arrest (OHCA) event while on a high or low floor at home or in a public place. This retrospective analysis was based on Smart Advanced Life Support registry data from January 2016 to December 2017. …”
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Repeated low-intensity noise exposure exacerbates age-related hearing loss via RAGE signaling pathway by Jianbin Sun, Na Sai, Tong Zhang, Chaoying Tang, Shuhang Fan, Qin Wang, Da Liu, Xianhai Zeng, Juanjuan Li, Weiwei Guo, Shiming Yang, Weiju Han

“…Our results indicated that noise-exposed mice exhibited accelerated age-related hearing loss spanning from high to low frequencies. Proteomics analysis revealed an upregulation in the receptor for the advanced glycation end-products (RAGE) signaling pathway, which was associated with an activated inflammatory response, vascular injury, and mitochondrial and synaptic dysfunction. …”
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Liver Biomarkers and Lipid Profiles in Mexican and Mexican-American 10- to 14-Year-Old Adolescents at Risk for Type 2 Diabetes by Ana Cecilia Fernández-Gaxiola, Roxana Valdés-Ramos, Kimberly Fulda, Ana Laura Guadarrama López, Beatriz E. Martínez-Carrillo, Susan F. Franks, Shane Fernando

“…We found differences by gender and between high and low risk for T2DM adolescents in all liver enzymes in both sites.…”
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Design of multifunctional interfaces on ceramic solid electrolytes for high-performance lithium-air batteries by Yunxin Shi, Ziyang Guo, Changhong Wang, Mingze Gao, Xiaoting Lin, Hui Duan, Yonggang Wang, Xueliang Sun

“…As a result, the DSCCE-based Li–air batteries possess high capacity/low voltage polarization (11,836 mA h g−1/1.45 V under 500 mA g−1), good rate performance (capacity ratio under 1000 mA g−1/250 mA g−1 is 68.2%) and long-term stable cell operation (∼300 cycles at 750 mA g−1 with 750 mAh g−1) in ambient air.…”
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A national cross-sectional study on latent profile analysis of occupational fatigue among Chinese nurses in the early post-COVID-19 era by Qiuyang He, Qiuyang He, Jianhua Ren, Jianhua Ren, Guoyu Wang, Guoyu Wang, Yonghong Wang, Yonghong Wang

“…The primary instruments utilized for data collection were the Occupational Fatigue Exhaustion Recovery Scale and the Effort-Reward Imbalance Questionnaire.ResultsThree distinct profiles of occupational fatigue were identified: a low fatigue/high recovery group (18.6%), a moderate fatigue/moderate recovery group (48.8%), and a high fatigue/low recovery group (32.6%). The vast majority of nurses reported experiencing moderate to high levels of occupational fatigue during the early stage of the post-coronavirus era. …”
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A study of impulsivity and adverse childhood experiences in a population health setting by Robert W. Read, Karen A. Schlauch, Gai Elhanan, Iva Neveux, Stephanie Koning, Takesha Cooper, Takesha Cooper, Joseph J. Grzymski, Joseph J. Grzymski

“…Kaplan–Meier survival estimates characterized the differences in the lifetime predicted probability between high and low impulsivity for major depressive disorder and essential hypertension. …”
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Uncovering molecular mechanisms of soybean response to 12C6+ heavy ion irradiation through integrated transcriptomic and metabolomic profiling by Honglei Ren, Bixian Zhang, Chunlei Zhang, Xiulin Liu, Xueyang Wang, Fengyi Zhang, Kezhen Zhao, Rongqiang Yuan, Ahmed M. Abdelghany, Sobhi F. Lamlom

“…Transcriptomic analysis identified a multitude of differentially expressed genes (DEGs), with 6013, 3588, and 340 genes significantly altered in high vs. control, low vs. control, and high vs. low-dose irradiation comparisons, respectively, while metabolomic profiling unveiled 445, 445, and 218 differentially expressed metabolites (DEMs) in analogous comparisons. …”
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Multi‑omics identification of a novel signature for serous ovarian carcinoma in the context of 3P medicine and based on twelve programmed cell death patterns: a multi-cohort machin... by Lele Ye, Chunhao Long, Binbing Xu, Xuyang Yao, Jiaye Yu, Yunhui Luo, Yuan Xu, Zhuofeng Jiang, Zekai Nian, Yawen Zheng, Yaoyao Cai, Xiangyang Xue, Gangqiang Guo

“…We used the PCD-genes model to observe differences between high and low CDI groups. The results showed that patients with SOC and a high CDI showed immunosuppression and hardly benefited from immunotherapy; therefore, trametinib_1372 and BMS-754807 may be potential therapeutic agents for these patients. …”
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Classifying problematic gaming using a latent profile approach based on personality traits in Chinese young adolescent by Jingyue Hao, Zhenjiang Liao, Qiuping Huang, Xinxin Chen, Shuhong Lin, Yongyan Shi, Yifan Li, Yin Tang, Xuhao Wang, Hongxian Shen

“…The medium-risk group sought enjoyable experiences, exhibiting traits that were intermediate between the high- and low-risk groups. High-risk gamers demonstrated elevated levels of neuroticism, accompanied by lower scores in other Big Five personality traits. …”
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Influence of Cardiorespiratory Fitness on PPARG mRNA Expression Using Monozygotic Twin Case Control by Marcos Roberto Queiroga, Ricardo Augusto Barbieri, Sandra Aires Ferreira, André Ducati Luchessi, Rosario Dominguez Crespo Hirata, Mario Hiroyuki Hirata, Eduardo Kokubun

“…Monozygotic twin pairs aged 11–18 years were grouped into discordant (D) and concordant (C) high and low VO2max groups. VO2max was determined by progressive maximal exercise test on treadmill with gas exchange analysis. …”
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Inflammatory microglia correlate with impaired oligodendrocyte maturation in multiple sclerosis by J. Q. Alida Chen, Dennis D. Wever, Niamh B. McNamara, Morjana Bourik, Joost Smolders, Jörg Hamann, Jörg Hamann, Inge Huitinga, Inge Huitinga

“…Here, we studied the relation between microglia activation and remyelination activity in MS.MethodsWe correlated regenerative (CD163+) and inflammatory (iNOS+) microglia with BCAS1+ oligodendrocytes, subdivided into early-stage (<3 processes) and late-stage (≥3 processes) cells in brain donors with high or low remyelinating potential in remyelinated lesions and active lesions with ramified/amoeboid (non-foamy) or foamy microglia. …”
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Evaluations of Morphometric Traits and Body Conformation Indices of Horse Ecotypes Reared in the Highlands of Bale Eco‐Region, Ethiopia by Mesay Guyo, Melaku Tareke, Andualem Tonamo, Diriba Bediye, Girma Defar

“…The correlations of body conformation indices ranged from very high to low, with positive and negative associations for functional capabilities. …”
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Identification of Immune-Related lncRNA Pairs and Construction and Validation of a New Prognostic Signature of Colon Cancer by Minxian Xu, Qing Li, Jianfang Zhang, Hui Xie

“…Based on the optimal cutoff value of the ROC curve of the signature, colon cancer patients were divided into the high- and low-risk groups. Then, the signature was evaluated by clinicopathological features, tumor-infiltrating immune cells, checkpoint-related biomarkers, targeted therapy, and chemotherapy. …”
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Integration of histone modification-based risk signature with drug sensitivity analysis reveals novel therapeutic strategies for lower-grade glioma by Jingyuan Wang, Shuai Yan

“…We further conducted comprehensive analyses of molecular mechanisms, immune microenvironment, and drug sensitivity associated with the risk stratification.ResultsWe identified distinct histone modification patterns across five major cell populations in LGG and developed a robust 20-gene HMRS from 129 candidate genes that effectively stratified patients into high- and low-risk groups with significantly different survival outcomes (training set: AUC = 0.77, 0.73, and 0.71 for 1-, 3-, and 5-year survival; P < 0.001). …”
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