Lower Urinary Tract and Gastrointestinal Dysfunction Are Common in Early Parkinson’s Disease by Daniel Martinez-Ramirez, Edna Sophia Velazquez-Avila, Alejandro Almaraz-Espinoza, Arnulfo Gonzalez-Cantú, Genaro Vazquez-Elizondo, Daniel Overa-Posada, Amin Cervantes-Arriaga, Mayela Rodriguez-Violante, Mirna Gonzalez-Gonzalez

“…The cohort was grouped into high and low dysautonomic scores. A regression model identified variables that independently explained dysautonomic scores in our early PD cohort. …”
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Revealing the mismatch in the response to warm-wetting climate of vegetation greenness and primary productivity using MODIS GPP/LAI in Nepal by Dongping Zhong, Lingwen Zeng, Ye Chen, Yingdong Tong, Nana Bai, Jia Sun, Dongdong Zhang, Yingchun Fu

“…Relative to low coupling degree in high and low elevation regions, a higher yet gradually decreasing coupling degree was demonstrated in the mid high regions of central Nepal. …”
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Impact of Systolic Blood Pressure Trajectories and Variability on Unexplained Early Neurological Deterioration Post‐Endovascular Treatment in Acute Ischemic Stroke Patients by Xuxuan Gao, Qiheng Wu, Yu Ma, Yueran Ren, Jiaying Chen, Xiaofei Lin, Lianghao Ye, Wei Song, Jiajia Zhu, Jia Yin

“…Two distinct SBP trajectories—high and low—were identified within 24 h post‐EVT. The high‐trajectory group, characterized by elevated mean SBP and increased SBP variability (SBPV), exhibited a significantly higher incidence of unexplained END (odds ratio [OR] = 3.28, p < 0.01). …”
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Standardization of the Agar Plate Method for Bacteriophage Production by Su Jin Jo, Young Min Lee, Kevin Cho, Seon Young Park, Hyemin Kwon, Sib Sankar Giri, Sung Bin Lee, Won Joon Jung, Jae Hong Park, Mae Hyun Hwang, Da Sol Park, Eun Jae Park, Sang Wha Kim, Jin Woo Jun, Sang Guen Kim, Ji Hyung Kim, Se Chang Park

“…This study aimed to standardize an agar plate method for high-mix, low-volume phage production, suitable for personalized phage therapy. …”
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The lysosome-related characteristics affects the prognosis and tumor microenvironment of lung adenocarcinoma by Wuguang Chang, Wuyou Gao, Yawei Wu, Bin Luo, Lekai Zhong, Leqi Zhong, Wenqian Lin, Zhesheng Wen, Youfang Chen

“…In vitro experiments have validated the function of CTSH in LUAD.ResultsThe risk signature contained seven key LAGs, and patients were categorized into high- and low-risk groups based on a specific calculation formula. …”
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Acute Severe Anaphylaxis in Nepali Patients with Neurotoxic Snakebite Envenoming Treated with the VINS Polyvalent Antivenom by Sanjib Kumar Sharma, Emilie Alirol, Anup Ghimire, Suman Shrestha, Rupesh Jha, Surya B. Parajuli, Deekshya Shrestha, Surya Jyoti Shrestha, Amir Bista, David Warrell, Ulrich Kuch, Francois Chappuis, Walter Robert John Taylor

“…Patients were enrolled in a randomised, double-blind trial of high vs. low dose antivenom, given by intravenous (IV) push, followed by infusion. …”
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Generation of Chicken IgY against SARS-COV-2 Spike Protein and Epitope Mapping by Yan Lu, Yajun Wang, Zhen Zhang, Jingliang Huang, Meicun Yao, Guobin Huang, Yuanyuan Ge, Peichun Zhang, Huaxin Huang, Yong Wang, Huiliang Li, Wen Wang

“…Chicken immunoglobulin Y (IgY) has the potential to be used as neutralizing antibody against respiratory infections, and its advantages include high avidity, low risk of adverse immune responses, and easy local delivery by intranasal administration. …”
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Small extracellular vesicles derived from miRNA-486 overexpressed dental pulp stem cells mitigate high altitude pulmonary edema through PTEN/PI3K/AKT/eNOS pathway by Changyao Wang, Zhuang Mao, Drolma Gomchok, Xue Li, Huifang Liu, Jingyuan Shao, Hu Cao, Guanzhen Xue, Lin Lv, Junzhao Duan, Tana Wuren, Hua Wang

“…The rat HAPE model was established by exposing subjects to a simulated high-altitude, low-oxygen environment within a specialized chamber. …”
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Application of Patient Version of General Practitioner Assessment of Cognition for Screening Elderly with Mild Cognitive Impairment in Community by YANG Ting, HE Jiali, SONG Linlin, LIU Wentao, GUI Chenfan, CHEN Xiao, XU Li, JIA Chengsen

“…In the MCI group, the order of cognitive impairment rate from high to low was delayed recall test, clock drawing test, time orientation and reporting events. …”
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Interplay between fecundity, sexual and growth selection on the spring phenology of European beech (Fagus sylvatica L.). by Oddou-Muratorio, Sylvie, Bontemps, Aurore, Gauzere, Julie, Klein, Etienne K

“…This study aims to investigate how these three components of selection on spring phenology may combine in European beech populations in contrasting environments (high versus low altitude). Methods: we monitored the timing of budburst (TBB) in 339 adult beech trees and estimated their fecundity using spatially explicit mating models. …”
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A Novel Cancer Stemness-Related Signature for Predicting Prognosis in Patients with Colon Adenocarcinoma by Wei Wang, Congrong Xu, Yan Ren, Shiwei Wang, Chunli Liao, Xiaoyan Fu, Haixia Hu

“…We identified 483 differently expressed genes (DEGs) between the high and low mRNAsi score groups. We developed a cancer stemness-related signature using fifteen genes (including RAB31, COL6A3, COL5A2, CCDC80, ADAM12, VGLL3, ECM2, POSTN, DPYSL3, PCDH7, CRISPLD2, COLEC12, NRP2, ISLR, and CCDC8) for prognosis prediction of COAD. …”
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An interactive, online decision aid assessing patient goals and preferences for treatment of aortic stenosis to support physician-led shared decision-making: Early feasibility pilo... by Megan Coylewright, Diana Otero, Brian R Lindman, Melissa M Levack, Aaron Horne, Long H Ngo, Melissa Beaudry, Hannah V Col, Nananda F Col

“…Initial treatment preferences were associated with low knowledge, high decisional conflict, and poor decision quality; final preferences were associated with high knowledge, low conflict, and high quality.<h4>Conclusions</h4>AVITA was endorsed by patients and clinicians, easy to use, improved shared decision-making quality and helped patients and clinicians arrive at a treatment that reflected patients' values.…”
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An Approach to Refining MODIS LAI Data Using a Fitting Scale Factor Time Series by Junxian Tang, Peijuan Wang, Rui Feng, Yang Li, Qing Li

“…The time series of scale factors derived from high- and low-purity pixels, differentiated by a 50% purity threshold, resulted in improved performance in adjusting the spring maize LAI compared to traditional remote sensing LAI data. …”
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Validation of a delirium predictive model in patients admitted to surgical intensive care units: a multicentre prospective observational cohort study by Kaweesak Chittawatanarat, Onuma Chaiwat, Sirirat Mueankwan, Sunthiti Morakul, Pitchaya Dilokpattanamongkol, Chayanan Thanakiattiwibun, Arunotai Siriussawakul

“…The optimum cut-off value to discriminate between a high and low probability of postoperative delirium in SICU patients was 115. …”
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The Multimessenger Contribution of Ultra-High-Energy Cosmic Rays from Gamma-Ray Bursts by Zhenjiang Li, Fangsheng Min, Yi Jin, Yiqing Guo

“…In the benchmark case with a jet opening angle of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>θ</mi><mi>j</mi></msub><mo>=</mo><mn>1</mn></mrow></semantics></math></inline-formula> and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>f</mi><mrow><mi>C</mi><mi>R</mi></mrow></msub><mo>=</mo><mn>1</mn></mrow></semantics></math></inline-formula>, we find that both high- and low-luminosity populations contribute to less than 10% of the UHECR spectrum. …”
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Identification of a New m6A Regulator-Related Methylation Signature for Predicting the Prognosis and Immune Microenvironment of Patients with Pancreatic Cancer by Tianle Zou, Dan Shi, Weiwei Wang, Guoyong Chen, Xianbin Zhang, Yu Tian, Peng Gong

“…Immune assays suggested a different immune infiltration pattern in patients with high- and low-risk scores. Moreover, we found that two immune-related genes, CTLA4 and TIGIT, were downregulated in high-risk patients. …”
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Predictive model for determining the indications for automated 3D ultrasound for screening patients at low risk of developing breast tumors by A. E. Garanina, A. V. Kholin

“…It is believed that 3D ultrasound has high reproducibility, low dependence on the operator, less time spent on obtaining images, and automatic three-dimensional reconstruction of the entire breast.Purpose of the study. …”
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Production de Pennisetum sp. et son utilisation pour la culture de Pleurotus ostreatus au Burundi by Prosper Kiyuku, Samuel Bigawa

“…As for as the results obtained in this study are concerned, we can deduce that the different varieties of Pennisetum sp. clones S1, S2, S3 and S4 can serve as culture substratum for mushrooms owing to their high or low productivity. This would provide mushroom producers with a supplementary source of substratum even in periods of shortage of other sources of agricultural substratum. …”
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Prognostic values of intracellular cell-related genes in esophageal cancer and their regulatory mechanisms by Wei Cao, Dacheng Jin, Weirun Min, Haochi Li, Rong Wang, Jinlong Zhang, Yunjiu Gou

“…Cox regression analysis was employed to identify prognostic genes, categorizing samples into high- and low-risk groups based on median risk scores. …”
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Spatial identification of regions exposed to multi-hazards at the pan-European level by T.-E. Antofie, T.-E. Antofie, S. Luoni, A. Tilloy, A. Sibilia, S. Salari, G. Eklund, D. Rodomonti, C. Bountzouklis, C. Corbane

“…We find that beyond population density, the income level (i.e. high, medium, low) is the primary driver that influences risk status at the local level, within both rural and urban areas. …”
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