Metformin versus insulin in glycemic control in pregnancy (MevIP): a randomized clinical trial protocol by Carolina Freitas Alves Amaral-Moreira, Daiane Sofia Morais Paulino, Belmiro G. Pereira, Patricia Moretti Rehder, Fernanda G. Surita

“…Abstract Background Gestational diabetes is one of the most prevalent diseases in pregnancy, with an incidence of 5 to 18% in Brazil, and is associated with high morbidity rates. The first-line treatment is insulin, although some recent studies have indicated that metformin might also be effective. …”
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The Resuscitation, Equilibrium and De-escalation (RED) strategy: a phased, personalized hemodynamic support in children with sepsis by Jaime Fernández-Sarmiento, Sushitra Ranjit, L. Nelson Sanchez-Pinto, Vinay M. Nadkarni, Roberto Jabornisky, Niranjan Kissoon

“…Fluid boluses are a common first-line treatment for actual and relative hypovolemia. …”
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Investigation of the antioxidant properties of extracts of spent coffee grounds by Milić Anita S., Tepić-Horecki Aleksandra N., Škaljac Snežana B., Šumić Zdravko M., Cvetković Biljana R., Pavlić Branimir M., Jokanović Marija R.

“…By valorizing coffee waste, this research is in line with sustainability goals and offers a valuable approach to recycling food by-products.…”
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The assessment of chemical composition and biological activity of faba bean pods as a potential feed additive utilized in piglets nutrition by Inna Vlasova, Philip Krüsselmann, Yuliia Kostenko, Maciej Obrębski, Sebastian Granica, Wilfried Vahjen, Jürgen Zentek, Marcin Równicki, Jakub P. Piwowarski

“…Air-dried FBP from the cultivar ‘Bizon’ contained high levels of crude protein (144 g/kg), dietary fibre (413 g/kg), potassium (27.8 g/kg), and iron (126 mg/kg). …”
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Assessing genetic diversity and population structure of f4:f5 wheat genotypes using morphological and microsatellite markers under heat stress by Md. Zahid Hassan, M. Hasanuzzaman, Md. Jalil Uddin, Md Badsha Alomgir, Most. Salma Akter, Amorish Chandra Mohanto, Md. Omar Kayess

“…Two field experiments were carried out in 2019–20 and 2020–21 at the research fields of Genetics and Plant Breeding at Hajee Mohammad Danesh Science and Technology University, Dinajpur, Bangladesh, to identify heat-tolerant wheat advance lines. In F4 generation, 60 advanced lines were selected from a pool of 160 line and in the F5 generation, 16 lines were selected from the previous selection. …”
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Clinical Usefulness of the VS Classification System Using Magnifying Endoscopy with Blue Laser Imaging for Early Gastric Cancer by Yoshikazu Yoshifuku, Yoji Sanomura, Shiro Oka, Kazutaka Kuroki, Mio Kurihara, Takeshi Mizumoto, Yuji Urabe, Toru Hiyama, Shinji Tanaka, Kazuaki Chayama

“…Using the VS classification system, three highly experienced endoscopists (HEEs) and three less experienced endoscopists (LEEs) evaluated the demarcation line (DL), microsurface pattern (MSP), and microvascular pattern (MVP) within the endoscopic images of EGCs obtained using ME-BLI, assigning high-confidence (HC) or low-confidence (LC) levels. …”
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Epilation for minor trachomatous trichiasis: four-year results of a randomised controlled trial. by Esmael Habtamu, Saul N Rajak, Zerihun Tadesse, Tariku Wondie, Mulat Zerihun, Birhan Guadie, Teshome Gebre, Amir Bedri Kello, Kelly Callahan, David C W Mabey, Peng T Khaw, Clare E Gilbert, Helen A Weiss, Paul M Emerson, Matthew J Burton

“…<h4>Methodology/ principal findings</h4>1300 individuals with minor TT were recruited and randomly assigned to quality trichiasis surgery or repeated epilation using high quality epilation forceps by a trained person with good near vision. …”
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Tunable Filters Using Defected Ground Structures at Millimeter-Wave Frequencies by Kaushik Annam, Birhanu Alemayehu, Eunsung Shin, Guru Subramanyam

“…The DGSs are designed using co-planar waveguide (CPW) line structure on top of a barium strontium titanate (Ba_0.6Sr_0.4TiO₃) (BST) thin film. …”
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Environmental, economic and social trade-offs of membrane-based direct air capture technologies integrated with CO2 conversion using life cycle assessment by Tianhui Fan, Siyu Shen, Chun Yat (Benjamin) Sit, Paul J.A. Kenis, Andrew Chapman

“…Yet, the deployment of renewables alone may not be sufficient to restrict temperature increases in line with Paris Agreement targets. The emergence of carbon negative technologies to bridge this shortfall is needed and expected to overcome this gap. …”
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Metastatic pancreatic cancer now in remission: a case report and literature review by Charles W. Shi, Thomas J. VanderMeer, Anita Pudusseri

“…Abstract Pancreatic cancer is a highly aggressive malignancy with the majority of patients presenting at a late stage with unresectable or metastatic disease. …”
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Inhibition of the anti-apoptotic protein BCL2 in EML4-ALK cell models as a second proposed therapeutic target for non-small cell lung cancer. by Richard Junior Zapata Dongo, Diletta Fontana, Luca Mologni, Juan Enrique Faya Castillo, Stefany Fiorella Infante Varillas

“…We treated these cells with ABT-199, a selective BCL2 inhibitor, and found that models with high BCL2 expression exhibited resistance, while those with lower expression showed sensitivity to BCL2 inhibition. …”
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Detection and decontamination of Mycoplasma in cultured cells and viral strains by Glaucia Prado de Andrade, Natália Hettwer Pedroso, Alice Becker, Vinicius Soares dos Santos, Juciane Bonella, José Valter Joaquim Silva Júnior, Rudi Weiblen, Eduardo Furtado Flores

“…Overall, we detected a high frequency of Mycoplasma spp. contamination in cell cultures and viral strains and successfully applied drugs and protocols for decontamination.…”
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Glimepiride monotherapy versus combination of glimepiride and linagliptin therapy in patients with HNF1A-diabetes: a protocol for a randomised, double-blinded, placebo-controlled t... by Torben Hansen, Tina Vilsbøll, Filip Krag Knop, Alexander Sidelmann Christensen, Heidi Storgaard, Sofie Hædersdal

“…Sulfonylurea (SU) is used as a first-line therapy in HNF1A-diabetes. However, SU therapy may be problematic as it confers a high risk of hypoglycaemia. …”
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Land Subsidence in the Yangtze River Delta, China Explored Using InSAR Technique From 2019 to 2021 by Hongbo Jiang, Guangcai Feng, Yuexin Wang, Zhiqiang Xiong, Hesheng Chen, Ning Li, Zeng Lin

“…Despite the potential of interferometric synthetic aperture radar (InSAR) for monitoring LS, its application across vast delta regions may be hindered by complex data processing, high computational demands, and the need for standardized results. …”
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Interplay of swine acute diarrhoea syndrome coronavirus and the host intrinsic and innate immunity by Fei Zhao, Xiao Cong, Xiaobo Huang, Yi Zheng, Qin Zhao, Yiping Wen, Rui Wu, Senyan Du, Sanjie Cao, Feng Cong, Yiping Wang

“…SADS-CoV has a broad cell tropism with the capability to infect a wide variety of cells from human and diverse animals, which implicates its ability to hold high risks of cross-species transmission. The intracellular antiviral immunity, comprised of the intrinsic and innate immunity, represents the first line of host defence against viral infection prior to the onset of adaptive immunity. …”
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Growth performance and nutritional concentrations of two kale (Brassica oleracea var Acephala ) varieties in response to fertilizer types in Awka, Southeast Nigeria by Stella Muojiama, Uchenna Nwune, Gladys Ugo, Maryann Ezeh, Uchenna Ukwu

“…Purpose: Soil nutrient depletion is an endemic factor that constitutes one of the greatest limitations to crop production in the tropics. Identifying high yielding kale varieties that thrive best with the most cost-effective fertilizer type can help meet the nutritional deficits of most families in Africa in line with WHO recommendations. …”
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Defective homologous recombination and genomic instability predict increased responsiveness to carbon ion radiotherapy in pancreatic cancer by Brock J. Sishc, Janapriya Saha, Elizabeth M. Alves, Lianghao Ding, Huiming Lu, Shih-Ya Wang, Katy L. Swancutt, James H. Nicholson, Angelica Facoetti, Arnold Pompos, Mario Ciocca, Todd A. Aguilera, Michael D. Story, Anthony J. Davis

“…These findings suggest that PDAC tumors with HR pathway mutations or high replication stress are more likely to benefit from CIRT while minimizing normal tissue toxicity.…”
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Social Entrepreneurship in Providing Employment: the Experience of Poland and Ukraine by Oleksandr Shpykuliak, Diana Shelenko, Ivan Balaniuk, Аnna Diuk, Hennadii Mazur, Sergiy Balaniuk, Andrii Boichuk

“…Instead, hybrid structures such as social cooperatives or farming enterprises for veterans operate in line with certain social entrepreneurship criteria. …”
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Study on Microseismic Monitoring, Early Warning, and Comprehensive Prevention of a Rock Burst under Complex Conditions by Ke Ding, Lianguo Wang, Mei Yu, Wenmiao Wang, Bo Ren

“…After the implementation of this scheme, the energy and frequency of microseismic events monitored on-site changed gently, and 5305 working face was safely recovered to the stop line position. The scheme boasts a remarkable rock burst prevention and control effect.…”
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A Multivariate prediction model for amlodipine therapeutic efficacy in pediatric primary hypertension by Yao Lin, Hui Wang, Yaqi Li, Yang Liu, Yanyan Liu, Hongwei Zhang, Yanjun Deng, Lin Shi

“…Additionally, a nomogram model was established based on the four variables and evaluated by bootstrap internal validation with the c-statistic of 0.865 and the calibration curve being close to the ideal line (p &gt; 0.05).ConclusionA nomogram model with high predictive value for amlodipine therapeutic efficacy in pediatric PH was established. …”
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