Therapeutic strategies for fungating and ulcerating breast cancers: A systematic review and narrative synthesis by Valentina Zagardo, Mandara Harikar, Gianluca Ferini

“…Results: The search identified 7917 studies, with 79 meeting the inclusion criteria: 62 case reports, 7 case series, and 10 cohort studies. Owing to high heterogeneity, a narrative synthesis was performed, categorizing treatment by year, molecular subtype, histology, and staging. …”
Get full text

A method for monitoring three dimensional surface deformation in mining areas combining SBAS-InSAR, GNSS and probability integral method by Qiuxiang Tao, Ruixiang Liu, Xuepeng Li, Tengfei Gao, Yang Chen, Yixin Xiao, Huzhen He, Yunguang Wei

“…Traditional synthetic aperture radar (InSAR) technology provides deformation components only along the line of sight (LOS) and often lacks sufficient effective data in vegetation-covered mining areas and mining subsidence centers. …”
Get full text

Integrated assessment of introduced red currant cultivars under the conditions of Tambov Province by O. S. Rodyukova

“…Collection testing was carried out in line with generally accepted techniques of variety studies and field experiments.Results. …”
Get full text

Optimizing Laser Capture Microdissection Protocol for Isolating Zone-Specific Cell Populations from Mandibular Condylar Cartilage by Aisha M. Basudan, Yanqi Yang

“…The 3′/m ratio means of GAPDH and β-Actin ranged between 1.11–1.56 and 1.41–2.12, respectively. These values are in line with the reported quality control requirements. …”
Get full text

Chemical Composition and Cytotoxic and Antioxidant Activities of Satureja montana L. Essential Oil and Its Antibacterial Potential against Salmonella Spp. Strains by Hanene Miladi, Rihab Ben Slama, Donia Mili, Sami Zouari, Amina Bakhrouf, Emna Ammar

“…The results revealed a significant cytotoxic effect of S. montana L. EO against A549 cell line and an important antioxidant activity. These findings suggest that S. montana L. …”
Get full text

Silk of the Indian meal moth Plodia interpunctella (Hübner, 1813) affects the human colon cancer cells by Nikodijević Danijela, Milutinović Milena, Radenković Nikola, Blagojević Stefan, Vasiljević Anđela, Jurišić Vladimir, Predojević Dragana, Vukajlović Filip, Pešić Snežana

“…The selective effect of silk indicates the presence of a high level of biocompatibility with normal human cells. …”
Get full text

Evaluation of Risk Factors of Peri-Implant Disease Using a New Manual Risk Assessment Model: A Clinical study by Mahima Jain, Mohd Shafiq Bin Shaffa’ee, Ashita Uppoor, Swati Pralhad, Sangeeta U. Nayak, Sharon Saldanha

“…Implants are being widely used as a treatment option and are considered the best line of treatment owing to their high level of predictability. …”
Get full text

Progress and prospects of research on wetland concession system by LIU Qianqian, XU Ruiliang, JIN Cheng, SUN Dongfang

“…[Results] The results show that: (1) Studies in China follow the line of object-relationship-mechanism, while international studies focus on concession-environmental-individual; (2) Studies in China have undergone three stages of change, with increasing policy guidance orientation. …”
Get full text

A Rare Case of Acute Methotrexate Toxicity Leading to Bone Marrow Suppression by Samreen Khuwaja, Matthew Lyons, Beenish Zulfiqar

“…Methotrexate is a first-line disease modifying antirheumatic drug used for the treatment of inflammatory arthritis. …”
Get full text

Performance assessment of ChatGPT 4, ChatGPT 3.5, Gemini Advanced Pro 1.5 and Bard 2.0 to problem solving in pathology in French language by Georges Tarris, Laurent Martin

“…Oppositely, all chatbots were outperformed by students to questions with a high discriminating power. Chatbot's scores were correlated to student discordance rates. …”
Get full text

Adaptability of the Cutter-Head of the Earth Pressure Balance (EPB) Shield Machine in Water-Rich Sandy and Cobble Strata: A Case Study by Chaodong Wan, Zhiyi Jin

“…This paper takes Chengdu Metro Line 6 in China as the engineering background; the studied area is typical of a water-rich sandy and cobble stratum with high content of cobble. …”
Get full text

Stability Analysis of a Weathered-Basalt Soil Slope Using the Double Strength Reduction Method by Xiaoliang Liu, Xin Chen, Mei Su, Shilin Zhang, Dengfeng Lu

“…The new method of double-strength finite element reduction presented in this paper is reasonable and feasible and is more in line with the actual situation of weathered-basalt soil slope instability in heavy rainfall areas.…”
Get full text

Mouse Mesenchymal Progenitor Cells Expressing Adipogenic and Osteogenic Transcription Factors Suppress the Macrophage Inflammatory Response by Natalie Fernandez, Heather Renna, Lauren McHugh, Katie Mazolkova, William Crugnola, Jodi F. Evans

“…Conversely, mesenchymal progenitors from the mouse aorta (mAo) support and contribute to the MΦ response under inflammatory conditions. We used cell lines with purported opposing immune-regulatory function, a bone marrow derived mesenchymal progenitor cell line (D1) and a mouse aorta derived mesenchymal progenitor cell line (mAo). …”
Get full text

Upregulation of HSP90α in the lungs and circulation in sarcoidosis by Takuma Isshiki, Takuma Isshiki, Takuma Isshiki, Motoko Sunakawa, Megan Vierhout, Megan Vierhout, Anmar Ayoub, Anmar Ayoub, Pareesa Ali, Pareesa Ali, Safaa Naiel, Safaa Naiel, Shion Miyoshi, Asghar Naqvi, Nathan Hambly, Kazuma Kishi, Kjetil Ask, Kjetil Ask, Martin R. J. Kolb

“…Extracellular HSP90α released from macrophages was examined in human primary cells and an immortalized cell line.ResultsMacrophages and granulomas in sarcoidosis-affected lungs showed high HSP90α expression. …”
Get full text

Acute fibrinous and organizing pneumonia after lung transplantation: A case report of treatment with infliximab and tocilizumab and literature review by Christophe Abellan, Foteini Ioakeim, Alessio Casutt, Benoit Lechartier, Zisis Balmpouzis, Samuel Rotman, Leslie Noirez, Isabelle Rochat, John-David Aubert, Angela Koutsokera

“…She developed severe pleuritic pain needing opioid treatment and died 4 months later. Conclusion: While high-dose systemic corticosteroids remain the first line of treatment, the use of anti TNF-α has shown promising results in case reports. …”
Get full text

Clinical Characteristics and Optimization of Empirical Antimicrobial Therapy for Febrile Neutropenia in Patients With Hematologic Malignancies by Cui Y, Liu X, Feng S

“…Effective treatment strategies require careful evaluation of local microbial epidemiology, risk factors for drug resistance, and predictors of poor prognosis. For high-risk FN patients, first-line antibiotic options include cefepime, PTZ, and carbapenems. …”
Get full text

The effect of the relative dose intensity of chemoradiotherapy on the effectiveness of therapy of locally advanced unresectable non-small cell lung cancer by A. E. Glukhareva, G. V. Afonin, I. V. Kolobaev, L. Yu. Grivtsova, S. A. Ivanov, A.  D.  Kaprin

“…To estimate the number of patients with the preservation of relative dose intensity (RDI) ≥ 80 % of first-line antitumor therapy in patients with unresectable non-small cell lung cancer (NSCLC), and to compare the effectiveness of therapy in groups with optimal and lower RDI.Patients and methods. …”
Get full text

A hepatocellular carcinoma model with and without parenchymal liver damage that integrates technical and pathophysiological advantages for therapy testing by Karina Benderski, Paul Schneider, Panayiotis Kordeves, Michael Fichter, Jenny Schunke, Federica De Lorenzi, Feyza Durak, Barbara Schrörs, Özlem Akilli, Fabian Kiessling, Matthias Bros, Mustafa Diken, Stephan Grabbe, Jörn M. Schattenberg, Twan Lammers, Alexandros Marios Sofias, Leonard Kaps

“…The model overexpressed key human HCC genes and showed high responsiveness to first-line treatment. Our model uniquely combines all the above-mentioned features, promoting its use towards HCC therapy testing.…”
Get full text

Development of an Enzyme-Linked Immunosorbent Assay Based on a Monoclonal Antibody for the Rapid Detection of Citrinin in Wine by Xingdong Yang, Yang Qu, Chenchen Wang, Lihua Wu, Xiaofei Hu

“…The cell line was injected intraperitoneally to prepare ascites. …”
Get full text

Research on the multi-agent motivation coupling evolution and synergy improvement for farmland ecological protection in China by Adila Ainiwaerjiang, Xueying Jin, Zhen Xie, Tian Tian, Yuxuan Dang

“…The temporal analysis of motivational shifts indicates a stabilizing trend among policy implementers and fluctuating efforts from agricultural producers. Spatially, high-value areas for policy implementers have experienced a significant decline, migrating from the left to the right of the Hu Line; whereas, high-value areas for agricultural producers have steadily decreased. …”
Get full text