Therapeutic benefit of the dual ALK/FAK inhibitor ESK440 in ALK-driven neuroblastoma by Seema Chugh, Jean C. Tien, Jennifer Hon, Carson Kenum, Rahul Mannan, Yunhui Cheng, Chi Chiang Li, Zainab I. Taher, Andrew D. Delekta, Pushpinder Singh Bawa, Ingrid J. Apel, Stephanie J. Miner, Xuhong Cao, Rohit Mehra, Saravana M. Dhanasekaran, Yuanyuan Qiao, Rajen Mody, Arul M. Chinnaiyan

“…ESK440 potently inhibited proliferation of NB cell lines, with increased sensitivity in cell lines harboring ALK aberrations. …”
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Tenofovir and Doravirine Are Potential Reverse-Transcriptase Analogs in Combination with the New Reverse-Transcriptase Translocation Inhibitor (Islatravir) Among Treatment-Experien... by Alex Durand Nka, Yagai Bouba, Wilfried Rooker Tsapi Lontsi, Davy-Hyacinte Gouissi Anguechia, Georges Teto, Aude christelle Ka’e, Ezechiel Ngoufack Jagni Semengue, Collins Ambe Chenwi, Désiré Takou, Lum Forgwei, Tatiana Anim-Keng Tekoh, Aurelie Minelle Kengni Ngueko, Bernadette Bomgning Fokou, Jeremiah Efakika Gabisa, Michel Carlos Tommo Tchouaket, Willy Leroi TognaPabo, Derrick Tambe Ayuk Ngwese, Jacky Njiki Bikoi, Daniele Armenia, Vittorio Colizzi, Marcel Yotebieng, Nicaise Ndembi, Maria-Mercedes Santoro, Francesca Ceccherini-Silberstein, Carlo-Federico Perno, Alexis Ndjolo, Joseph Fokam

“…The study population, with a median age of 40 years, showed a high prevalence of resistance to NRTIs (77.4%) and NNRTIs (49.2%). …”
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Adaptability of spring oat yield in the environments of the Near-Irtysh area in Omsk Province by P. N. Nikolaev, N. I. Aniskov, O. A. Yusova, I. V. Safonova

“…Russell) were ‘Orion’, ‘Irtysh 21’, ‘Tarsky 2’, ‘Pamyati Bogachkova’, ‘Irtysh 13’, ‘Skakun’ and ‘Sibirsky Gerkules’ with minimal nonlinear deviations from the regression line (0.1–0.3). High compensatory capacity (according to A. …”
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EGFR-Mutant Non-small Cell Lung Cancer: State-of-the-Art and Future Perspectives by Antonio Rossi, Ettore Mari

“…However, after an initial activity to first-line EGFR-TKI treatment, a disease progression is reported due to the presence of an intrinsic resistance or the onset of an acquired resistance. …”
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Population genetics studies of <i>Puccinia striiformis</i> f. sp. <i>tritici</i> in Dagestan and Northwestern Russia by E. L. Shaydayuk, D. R. Yakovleva, K. M. Abdullaev, V. P. Pyukkenen, E. I. Gultyaeva

“…The Yr5, Yr10, Yr15, Yr17, Yr24 and Yr26 genes manifested high effectiveness in both locations. In the field, immune responses were observed in the Avocet lines with the Yr5, Yr7, Yr8, Yr10, Yr15, Yr24 and YrAR genes, and in the differential cvs. …”
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Stability and Control of Surrounding Rock of a Trapezoidal Roadway Retained with Hard Roof Cutting by Shizhong Zhang, Chuangnan Ren, Xinyao Gao, Yongsheng Gao, Lianyi Nie, Shaodong Li, Moulie Jiang

“…Using top-cutting, the pressure relief reduced the roof stress from 6.73 MPa to 2.04 MPa, the high stress zone moved to the inside of the solid coal, and the roof slid and deformed along the top line, showing characteristics of a “large deformation on the top side”; and (3) high-strength long anchor cables were used to reinforce the roof on the cut top side. …”
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Optimization Study of Pneumatic–Electric Combined Braking Strategy for 30,000-ton Heavy-Haul Trains by Mingtao Zhang, Congjin Shi, Kun Wang, Pengfei Liu, Guoyun Liu, Zhiwei Wang, Weihua Zhang

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Can Electric Vehicle Charging Stations Be Carbon Neutral With Solar Renewables? by Alpaslan Demirci, Zafer Ozturk, Musa Terkes, Said Mirza Tercan, Recep Yumurtaci, Umit Cali

“…In line with sustainable energy and environmental targets, the share of electric vehicles in the automobile market is expected to reach 80%. …”
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Assessment of the Chemical Diversity and Functional Properties of Secondary Metabolites from the Marine Fungus <i>Asteromyces cruciatus</i> by María Paz González-Troncoso, Catalina Landeta-Salgado, Javiera Munizaga, Ruth Hornedo-Ortega, María del Carmen García-Parrilla, María Elena Lienqueo

“…Crude extracts of fungal biomass were analyzed for total phenolic content (TPC), antioxidant capacity (TAC), toxicity, and phenolic compound identification using ultra-high-performance liquid chromatography coupled with high-resolution electrospray ionization mass spectrometry (UHPLC-MS/MS). …”
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Assessment of Microbiological Indoor Air Quality in Cattle Breeding Farms by Justyna Szulc, Małgorzata Okrasa, Katarzyna Dybka-Stępień, Michael Sulyok, Adriana Nowak, Anna Otlewska, Bogumiła Szponar, Katarzyna Majchrzycka

“…In addition, the cytotoxicity of the dust to the human epithelial lung cell line was determined by using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay. …”
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Comparative analysis of phytonutrients of Moringa oleifera leaves from South Africa and Nigeria, and their antimicrobial and antioxidant potentials by UPLC-ESI-QToF-MS and OPLS-DA... by Jonathan Kayembe, Cosa Sekelwa, Kokoette Bassey

“…This study aimed to conduct a comparative analysis of the phytonutrients (nutrients protectors) or supplements, antioxidant, and antimicrobial potentials of M. oleifera leaves from Nigeria and South Africa to benchmark quality control protocols for commercial beverages such as Moringa porridge.MethodsStandard techniques, including high-performance liquid chromatography-photodiode array and ultra-high-performance liquid chromatography electrospray ionization quadruple time-of-flight mass spectrometry (UPLC-ESI-QToF-MS) and chemometrics orthogonal partial least square discriminant analysis (OPLS-DA) were employed for phytoconstituents fingerprinting. …”
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Prophylactic and therapeutic effects of EsV3 on atherosclerotic lesions in ApoE−/− mice by Yaze Wang, Hifumi Ohishi, Rongji Wu, Hui Liu, Rong Xu

“…Methods The study utilized a high-fat diet-induced ApoE−/− hyperlipidemic mouse model. …”
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Histologic and Endoscopic Similarity between Nodular Gastric Antral Vascular Ectasia and Gastric Hyperplastic Polyps Potentially Causing Treatment Delays by Pujitha Kudaravalli, Sheikh A. Saleem, Rachana Mandru, Sekou Rawlins

“…We herein, through this case, would like to highlight that high clinical suspicion is required to diagnose nodular GAVE. …”
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A practical guide to FAIR data management in the age of multi-OMICS and AI by Douaa Mugahid, Jared Lyon, Charlie Demurjian, Nathan Eolin, Charlie Whittaker, Mark Godek, Douglas Lauffenburger, Sarah Fortune, Stuart Levine

“…Multi-cellular biological systems, including the immune system, are highly complex, dynamic, and adaptable. Systems biologists aim to understand such complexity at a quantitative level. …”
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The Contemporary Critical Reception of Walter Pater: Retrospective and Proleptical Views by Geoffrey Sadock

“…By showing the shift from hostile modernism to a more open and inclusive conception of his literary persona, I explain why Pater is no longer dismissed as precieux and inconsequential by the guardians of High Culture (such as Eliot) but is recognized as an original who synthesized personal preoccupations and aesthetic/critical response to various art forms, nature, and persons. …”
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Three-dimensional diffractive acoustic tomography by Luca Menozzi, Tri Vu, Aidan J. Canning, Harshal Rawtani, Carlos Taboada, Marie Elise Abi Antoun, Chenshuo Ma, Jesse Delia, Van Tu Nguyen, Soon-Woo Cho, Jianing Chen, Theresa Charity, Yirui Xu, Phuong Tran, Jun Xia, Gregory M. Palmer, Tuan Vo-Dinh, Liping Feng, Junjie Yao

“…With its enhanced imaging performance and high accessibility, 3D-DAT may find broad applications in fundamental life sciences and biomedical research.…”
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Barriers to nurse-led delirium management in intensive care units: an integrative systematic review using COM-B model by Mokhtar Abdu Almoliky, Sameer Alkubati, Khalil Saleh, Salman Alsaqri, Saddam A. Al-Ahdal, Galal Albani, Mujeeb A. Sultan

“…As nurses are in the first confrontation line for delirium, their prospective in identifying barriers are essential in developing integrated strategies and clinical guidelines. …”
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A Label-Free Aptasensor for the Detection of Sulfaquinoxaline Using AuNPs and Aptamer in Water Environment by Zhaoyang Zhou, Xingyue Chen, Shuang Jiang, Zhuoer Chen, Sixian Wang, Yueyang Ren, Xiaodong Fan, Tao Le

“…The recoveries of this aptasensor in water samples ranged from 90 to 109.9%, which was quite in line with high-performance liquid chromatography. …”
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The concept of LERNEN as a cognitive dominant of the educational discourse (based on the material of German language textbooks) by V.E. Shukman, S.I. Dubinin

“…We found the ways of representing the concept of LERNEN as a large and crucial cognitive dominant and marking it with the help of the studied representatives associated with not only the modern educational discourse in the field of foreign languages learning, but also with the educational policy of Germany in general, which is highly relevant because of the high attraction and active influx of foreign students, tourists, and migrants to Germany. …”
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Closure of Full-thickness Macular Hole after Pars Plana Vitrectomy (23G) with Cataract Phacoemulsification, Artificial Intraocular Lens Implantation, and Silicone Oil Administratio... by Maria Stec, Mikołaj Kuźniak, Sebastian Sirek

“…The inverted internal limiting membrane flap technique emerged as a superior strategy for managing full-thickness macular holes, demonstrating high closure rates and improved visual acuity postoperatively. …”
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