LINC02389/miR-7-5p Regulated Cisplatin Resistance of Non-Small-Cell Lung Cancer via Promoting Oxidative Stress by Peng Ma, Wen Han, Cunying Meng, Xiaohong Tan, Pengfei Liu, Lei Dong

“…Results. LINC02389 was highly expressed in NSCLC tissues and was correlated with poor prognosis of NSCLC patients. …”
Get full text

ZNF169 promotes thyroid cancer progression via upregulating FBXW10 by Wen Luo, Qiyu Xiao, Ying Fu

“…Recovery assay in cells and animals were also performed to demonstrate the mechanism. Results ZNF169 was highly expressed in THCA tissues and cells lines compared with matched adjacent non-cancerous thyroid tissues or normal thyroid epithelial cell. …”
Get full text

Model Test and Back Analysis of Shield Tunnel Load Distribution in Soft Clay by Haoshuang Niu, Xiaolin Weng, Chao Tian, Deng Wang

“…That is, the error of load distribution of mode 2 (the combination of vertical load distribution and horizontal load parabolic distribution) is the lowest and is highly consistent with the measured value, which is the closest to the characteristics of the load pattern of the stratum.…”
Get full text

Renewable Human Cell Model for Type 1 Diabetes Research: EndoC-βH5/HUVEC Coculture Spheroids by James M. Porter, Michael Yitayew, Maryam Tabrizian

“…While native islets are the ultimate target of these drugs (either in situ or for transplantation), significant benefit can be difficult to ascertain due to the highly heterogeneous nature of individual donors and the overall scarcity of human islets for research. …”
Get full text

Path Coefficient, Genetic Divergent and Principal Component Analysis on Common Bean (Phaseolus Vulgaris L.) Genotypes in Sekota, North Western Ethiopia by Abebe Assefa, Dereje Mekonnen, Muluken Bantayehu

“…Therefore, this study was initiated with the objective of identifying superior lines for hybridization program, identify the traits that have direct and indirect effect on seed yield and to determine genetic similarity among genotypes using multivariate analysis on 64 genotypes using 8x8 simple lattice design at Aybra main research site during 2023 under rain fed conditions. …”
Get full text

Synthesis, Characterization, and Biological Evaluation of Gabapentinoid Hybrids with Isoindole-1,3(2H)-Dione Moiety as Potential Antioxidant, Antimicrobial, and Anticancer Agents by Mirna Jabbour, Mohammad Ammar Al-Khayat, Mahmoud Al-Ktaifani

“…Furthermore, we have studied the effect of compounds on proliferation, cell cycle, and cell death in two human cancer cell lines (Caco-2 and HCT-116). Results. Compounds 1, 3, and 4 exhibited a good free radical scavenging effect, and compound 3 is the most effective with IC50 value of 2.525 μmol/mL. …”
Get full text

LncRNA LOXL1-AS1 Promotes the Proliferation and Metastasis of Medulloblastoma by Activating the PI3K/AKT Pathway by Ran Gao, Rui Zhang, Cuicui Zhang, Yingwu Liang, Weining Tang

“…It was initially found that LOXL1-AS1 was significantly overexpressed in clinical medulloblastoma tissues compared with the adjacent noncancerous tissues. LOXL1-AS1 was also highly expressed in medulloblastoma at advanced stages and differentially expressed in a series of medulloblastoma cell lines. …”
Get full text

NAT10 promotes ovarian cancer cell migration, invasion, and stemness via N4-acetylcytidine modification of CAPRIN1 by Yang Song, Min Cheng

“…The expression of NAT10 and CAPRIN1 in OC cells lines were measured using quantitative real-time polymerase chain reaction and immunoblotting. …”
Get full text

Cloning and expression characterisation of LiDXS2 gene in Oriental Lily (Lilium 'Sorbonne') by Yu Jiaxuan, Wu Nana, Fu Ruyu, Xue Lili, Zhang Jinzhu, Dong Jie, Yang Tao, Fan Jinping

“…Analysis of homologous sequences showed that it contains two highly conserved regions, WDVGHQ and IAEQHA, which were closely related to Ginkgo DXS2 protein and Periwinkle DXS protein. …”
Get full text

Valproic Acid Enhances Venetoclax Efficacy in Targeting Acute Myeloid Leukemia by Renshi Kawakatsu, Kenjiro Tadagaki, Kenta Yamasaki, Yasumichi Kuwahara, Tatsushi Yoshida

“…Therefore, new strategies to enhance the effect of venetoclax are highly sought. Valproic acid (VPA), commonly used for epilepsy, has also been studied for potential applications in AML treatment. …”
Get full text

JWST Discovery of a Very Fast Biconical Outflow of Warm Molecular Gas in the Nearby Ultraluminous Infrared Galaxy F08572+3915 NW by Kylie Yui Dan, Jerome Seebeck, Sylvain Veilleux, David Rupke, Eduardo Gonzalez-Alfonso, Ismael Garcia-Bernete, Weizhe Liu, Dieter Lutz, Marcio Melendez, Miguel Pereira Santaella, Eckhard Sturm, Francesco Tombesi

“…The outflowing H _2 material is slightly warmer (640–700 K) than the rotating disk material (460–520 K), perhaps due to shock heating in the highly turbulent outflowing material. This outflow shares the same kinematics and orientation as the sub-kiloparsec scale warm H _2 outflow traced by the rovibrational H _2 lines in Keck AO near-infrared IFS data. …”
Get full text

Proximity‐dependent biotinylation reveals an interaction between ubiquitin‐specific peptidase 46 and centrosome‐related proteins by Kazuma Yoshioka, Reiko Nakagawa, Chi Lieu Kim Nguyen, Hayate Suzuki, Kiyohiro Ishigaki, Seiya Mizuno, Tsukasa Okiyoneda, Shizufumi Ebihara, Kazuya Murata

“…Ubiquitin‐specific peptidase 46 (USP46), a deubiquitinase, is highly expressed in the brain and regulates neural functions. …”
Get full text

A novel conditional active biologic anti-EpCAM x anti-CD3 bispecific antibody with synergistic tumor selectivity for cancer immunotherapy by Gerhard Frey, Ana Paula G. Cugnetti, Haizhen Liu, Charles Xing, Christina Wheeler, Hwai Wen Chang, William J. Boyle, Jay M. Short

“…The CAB anti-EpCAM T-cell engagers displayed the anticipated bispecific binding properties and mediated the potent lysis of EpCAM-positive cancer cell lines through the recruitment of T cells in the tumor microenvironment. …”
Get full text

Ddx21 mutant peptide is an effective neoantigen in prophylactic lung cancer vaccines and activates long-term anti-tumor immunity by Zhe Zhang, Yimeng Xia, Yimeng Xia, Zhihong Wang, Yaxing Sun, Dan Pu, Yijia He, Ruixian Liu, Yanru Zhang, Yan Liu, Junzhi Yu, Shiyang Ning, Baisui Feng, Yaohe Wang, Na Wang

“…Our previous studies indicated that mice immunized with a prophylactic vaccine based on lung cancer cell lines KPL 160302S, derived from early-stage murine lung cancer tissues, exhibited a significantly extended survival period, with a strong anti-tumor immune response. …”
Get full text

Case report: Resolution of VIPoma-related symptoms with peptide receptor radionuclide therapy by Turgut Bora Cengiz, Raksha Kulkarni, Virginia Corbett, Nasrin V. Ghesani, Edward Wolin, Munir V. Ghesani

“…Two patients with VIPomas were admitted to the hospital with multiple prior hospital admissions after going through multiple lines of therapy. The first patient was a 47-year-old woman with a grade 2 pancreatic VIP-secreting NET. …”
Get full text

EIF4A3-induced circ_0022382 promotes breast cancer cell progression through the let-7a-5p/PI3K/AKT/mTOR signaling pathway and SLC7A11 axis by Wei Liu, Wei Liu, Jun Zhang, Jiawen Zhang, Yu Ye, Jianqin Zhu, Qiwen Yu, Tao Li, Tao Li, Xiaochun Sun, Huabiao Chen, Huabiao Chen

“…In this study, we explored the impacts of circRNAs on the progression of breast cancer cells.MethodsUsing bioinformatics analysis, we screened out one up-regulated circRNA in breast cancer, and its function and regulatory mechanisms were confirmed by quantitative real-time PCR, cell counting kit-8 experiment, migration assay, dual luciferase reporter assay, Kyoto Encyclopedia of Genes and Genomes enrichment analysis, cell immunofluorescence, clone formation assay, scratch wound healing experiment, RNA immunoprecipitation and subcutaneous tumor-bearing experiments.ResultsCirc_0022382 was highly expressed in breast cancer cell lines MDA-MB-231, MCF-7 as well as breast cancer tissues, and promoted the proliferative and migratory capacity of breast cancer cells. …”
Get full text

Keratinocyte differentiation factor 1 enhances cervical cancer cell viability and migration by activating the PI3K/AKT pathway by Chao Chen, Junhua Liao, Xingxing Sun

“…A PI3K inhibitor (LY294002) was used to detect the effect of KDF1 on the phosphoinositide 3-kinase (PI3K)/Protein Kinase B (AKT) pathway.Results KDF1 was highly expressed in cervical cancer tissues and cell lines (p < 0.01), and was significantly associated with poor prognosis (p < 0.05). …”
Get full text

In Vivo Distribution and Therapeutic Efficacy of Radioiodine-Labeled pH-Low Insertion Peptide Variant 3 in a Mouse Model of Breast Cancer by Min Zhang, Yue Xi, Hong Chen, Wangxi Hai, Biao Li

“…Extracellular acidity is a marker of highly aggressive breast cancer (BC). pH-low insertion peptides (pHLIPs) target the acidic tumor microenvironment. …”
Get full text

Resistance to viruses of potato: current status and prospects by S. S. Makarova, V. V. Makarov, M. E. Taliansky, N. O. Kalinina

“…Some new potato cultivars and lines resistant to many viruses have already been generated using either traditional breeding methods or genetic engineering. …”
Get full text

The consensus rye microsatellite map with EST-SSRs transferred from wheat by D. O. Vidakovic, D. Perovic, T. V. Semilet, A. Börner, E. K. Khlestkina

“…Microsatellite (SSR) markers with known precise intrachromosomal locations are widely used for mapping genes in rye and for the investigation of wheat-rye translocation lines and triticale highly demanded for mapping economically important genes and QTL-analysis. …”
Get full text