LncRNA SNHG17 Contributes to Proliferation, Migration, and Poor Prognosis of Hepatocellular Carcinoma by Yue Luo, Junhao Lin, Jiakang Zhang, Zhenghui Song, Dayong Zheng, Fengsheng Chen, Xuefen Zhuang, Aimin Li, Xinhui Liu

“…Bioinformatics analysis and qRT-PCR were performed to detect the expression pattern of SNHG17 in HCC tissues, adjacent nontumorous tissues, and cell lines. The effect of SNHG17 on proliferation, migration, and apoptosis of HCC was investigated by knockdown and overexpressing SNHG17 in HCC cell lines. …”
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RNA-binding protein DAZAP1 accelerates the advancement of pancreatic cancer by inhibiting ferroptosis by Xinqing Wang, Hao Fan, Xiaoping Ye, Yu Hu, Yan Xiao, Ming Zhang, Yonghui Xu, Jianjun Song, Yongyun Luo

“…Abstract Background Pancreatic cancer (PC) is a highly aggressive malignancy with a poor prognosis due to its late-stage diagnosis and limited treatment options. …”
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Overexpression of the Synthetic Chimeric Native-T-phylloplanin-GFP Genes Optimized for Monocot and Dicot Plants Renders Enhanced Resistance to Blue Mold Disease in Tobacco (N. taba... by Dipak K. Sahoo, Sumita Raha, James T. Hall, Indu B. Maiti

“…KY14, a cultivar that is highly susceptible to infection by Peronospora tabacina. …”
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Maker: the return of the builders. A possible digital transition for Architecture by Sergio Pone

“…By establishing these lines of development, it would be possible to bring architecture close to the people and restore a central role for the designer in the making of buildings. …”
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Researches on the Influence of Blasting of Newly Built Tunnel on the Existing Tunnel Structure with Small Cross Angle by Xian Du, Qinghua Xiao, Congming Li, Qiang Xiong, Jianyou Yu

“…From the comparison of vibration velocity, lining stress, and the displacement of the existing tunnel structure, the blasting methods, surrounding rock condition, cross angle, and clear distance are proven to be the highly correlated factors for the dynamic response of the existing tunnel to blasting. …”
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Assessing in-vitro models for microglial development and fetal programming: a critical review by Steven Schepanski, Steven Schepanski, Gonza B. Ngoumou, Gonza B. Ngoumou, Claudia Buss, Claudia Buss, Claudia Buss, Claudia Buss, Georg Seifert, Georg Seifert

“…Key factors such as scalability, genetic and epigenetic fidelity, and physiological relevance are highlighted. Microglia cell lines are highly scalable but lack genetic and epigenetic fidelity. iPSC-derived microglia provide moderate physiological relevance and patient-specific genetic insights but face operational and epigenetic challenges inherent to reprogramming. 3D brain organoids, derived from iPSCs, offer an advanced platform for studying complex neurodevelopmental processes but require extensive resources and technical expertise. …”
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Upper Limits on Stellar Companions to the Kepler-34 and Kepler-35 Systems by Carlos Jurado, Lauren M. Weiss, Laura Daclison, Benjamin M. Tofflemire, Jerome A. Orosz, William F. Welsh

“…For Kepler-35, we rule out stellar masses of 0.13 M _⊙ at orbital periods of  ≲55 yr. Highly stable, extreme precision RV instruments, as well as improved methodologies in characterizing double-lined spectroscopic binaries that come with these new instruments, will provide an opportunity to push these mass limits lower in the future.…”
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The perspectives of metabolomics studies of potato plants by R. K. Puzanskiy, V. V. Yemelyanov, T. A. Gavrilenko, M. F. Shishova

“…In the future, potato metabolome studies might complete classical and molecular approaches to develop new lines and varieties.…”
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An Underdetermined Blind Source Separation Method with Application to Modal Identification by Gang Yu

“…This study finds that the TF energy belonging to different monotone modals can cluster into distinct straight lines. Meanwhile, we provide the detailed theorem to explain the clustering features. …”
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Inhibition of NLRP3 enhances pro-apoptotic effects of FLT3 inhibition in AML by Helene Sieberer, Michela Luciano, Diana Amend, Constantin Blöchl, Anna Eglseer, Alina Steinkellner, Sebastian Rieser, Ancuela Andosch, Philip Steiner, Laura Hummer, Peter W. Krenn, Hieu-Hoa Dang, Christian G. Huber, Fritz Aberger, Theresa Neuper, Jutta Horejs-Hoeck

“…Our findings reveal that NLRP3 inhibition induces cell cycle arrest as well as signs of senescence in multiple AML cell lines. In contrast, NLRP3 inhibition selectively induced apoptosis in FLT3 mutant AML cell lines, but not in FLT3 wild-type AML cells. …”
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The dysregulation of PARP9 expression is linked to apoptosis and DNA damage in gastric cancer cells. by Yating Li, Xing Wang, Xiaolong Liu, Xiangjie Li, Jianling Zhang, Yulan Li

“…<h4>Background</h4>Gastric cancer (GC) is a highly malignant gastrointestinal tumor characterized by difficult early diagnosis and poor prognosis. …”
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Defining Human Rights in Times of Covid: Human Rights Discourse in the UK and Devolved Legislatures by Anne Cousson

“…Focusing thus on political discourse rather than on the effective effects of Covid restrictions on human rights allows us to identify ideological fault lines. Indeed, the analysis shows a highly differentiated definition of human rights between political parties on the one hand and between the different nations on the other.…”
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CROSS-BORDER CO-OPERATION EUROREGIONS IN THE ROMANIAN DANUBE BORDER-ZONE by RADU SĂGEATĂ, MIHAELA PERSU

“…The Danube-lined Romanian frontier represents an axis of discontinuity between natural regions, each with its own distinct traits. …”
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Functional Analysis of Durum Wheat GASA1 Protein as a Biotechnological Alternative Against Plant Fungal Pathogens and a Positive Regulator of Biotic Stress Defense by Mohamed Taieb Bouteraa, Walid Ben Romdhane, Alina Wiszniewska, Narjes Baazaoui, Mohammad Y. Alfaifi, Anis Ben Hsouna, Miroslava Kačániová, Stefania Garzoli, Rania Ben Saad

“…To protect themselves against harmful invaders, they have evolved highly effective defense mechanisms, including the synthesis of numerous types of antimicrobial peptides (AMPs). …”
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Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stage by Diego Alem, César X. García-Laviña, Francisco Garagorry, Dardo Centurión, Joaquina Farias, Hany Pazos-Espinosa, María Noel Cuitiño-Mendiberry, Carolina Villadóniga, Susana Castro-Sowinski, Martín Fló, Federico Carrión, Brenda Iglesias, Kevin Madauss, Lucía Canclini

“…Subsequently, the amyloid proteome of the RT4 non-invasive and HT1197 invasive bladder cancer cell lines was identified and included oncogenes, tumor suppressors, and highly expressed cancer-related proteins. …”
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Chromothripsis in Treatment Resistance in Multiple Myeloma by Kyoung Joo Lee, Ki Hong Lee, Kyong-Ah Yoon, Ji Yeon Sohn, Eunyoung Lee, Hyewon Lee, Hyeon-Seok Eom, Sun-Young Kong

“…Recently, the term chromothripsis has emerged, which is the massive but highly localized chromosomal rearrangement in response to a one-step catastrophic event. …”
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A large synthetic dataset for machine learning applications in power transmission grids by Marc Gillioz, Guillaume Dubuis, Philippe Jacquod

“…The method allows one to generate arbitrarily large time series from the knowledge of the grid – the admittance of its lines as well as the location, type and capacity of its power generators – and aggregated power consumption data, such as the national load data given by ENTSO-E. …”
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Insights into the molecular mechanisms and nanoparticle-based therapies for gastric cancer: A review by Smarika Chauhan, Eswar Marcharla, Sneha Hariharan, Saranya Vinayagam, Thanigaivel Sundaram, Priya SD, Swamynathan Ganesan, Maximilian Lackner

“…Gastric cancer is characterized by the abnormal development of cells in the intestinal lining and is listed as the third leading cause of cancer-related deaths globally. …”
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At the Start of the Sarcomere: A Previously Unrecognized Role for Myosin Chaperones and Associated Proteins during Early Myofibrillogenesis by J. Layne Myhre, David B. Pilgrim

“…This paper will outline several lines of evidence that converge to build a model for Unc45b activity during early myofibrillogenesis.…”
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Revolutionizing precision medicine in oral squamous cell carcinoma: Harnessing 3D in vitro models for translation by Nitesh Buldak, Vishnu Priya Veeraraghavan, Ullas Mony

“…Oral squamous cell carcinoma (OSCC) is a highly aggressive neoplasm of the surface epithelium that arises from the mucosal lining of the mouth. …”
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