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The potential synergistic effect of combining doxorubicin with vorinostat in urothelial carcinoma therapy
Published 2025-01-01“…Cleaved caspase 8, and γ-H2AX proteins in both cell lines are totally inhibited, and cleaved PARP is partially inhibited. …”
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2863
HPV16 <em>E6</em> Oncogene Contributes to Cancer Immune Evasion by Regulating PD-L1 Expression through a miR-143/HIF-1a Pathway
Published 2024-01-01“…According to our results, in the E6 knock out (E6KO) cell lines an increased expression of miR-143 was recorded, while a decrease in the expression of HIF-1a and PD-L1 was exhibited. …”
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2864
Expression and prognostic significance of the m6A RNA methylation regulator HNRNPC in HNSCC
Published 2025-02-01“…Knockdown of HNRNPC in the HNSCC cell lines HSC-3 and CAL-27 resulted in a significant decrease in proliferation, invasion, and malignant transformation abilities. …”
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2865
An amplification mechanism for weak ELF magnetic fields quantum-bio effects in cancer cells
Published 2025-01-01“…When exposed to magnetic fields, the first group exhibits high-amplitude oscillations, while the second group synchronizes to reach a whole-cell oscillation. …”
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2866
Synthesis of CF<sub>3</sub>-Indazoles via Rh(III)-Catalyzed C-H [4+1] Annulation of Azobenzenes with CF<sub>3</sub>-Imidoyl Sulfoxonium Ylides
Published 2025-01-01“…This protocol featured easily available starting materials, excellent functional group tolerance and high efficiency. Moreover, the antitumor activities of selected CF<sub>3</sub>-indazoles against human cancer cell lines were also studied, and the results indicated that several compounds displayed considerable antiproliferative activities.…”
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2867
NIPAL1 as a prognostic biomarker associated with pancreatic adenocarcinoma progression and immune infiltration
Published 2025-01-01“…Abstract Pancreatic adenocarcinoma (PAAD) is a highly malignant tumor in the digestive system, with an increasing incidence and mortality rate globally. …”
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2868
Food environments in the Pacific region and efforts to improve them: a scoping review
Published 2025-01-01“…Results: From the sixty-six included studies (of 2520 records screened), it was clear that food environments in the Pacific region are characterised by high availability and promotion of ultra-processed unhealthy foods. …”
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2869
Synthesis, Characterization, and Biological Studies of Organotin(IV) Derivatives with o- or p-hydroxybenzoic Acids
Published 2009-01-01“…Also complexes 1–6 were studied for their in vitro cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, and the results showed that the complexes have high activity against these cell lines with triphenyltin((IV) complex 4 to be the most active one.…”
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2870
Experimental investigation on the anti-detonation performance of composite structure containing foam geopolymer backfill material
Published 2025-01-01“…Explosion tests were conducted using several composite structure models, including a concrete lining structure (CLS) without foam geopolymer and six foam geopolymer composite structures (FGCS) with different backfill parameters, to study the dynamic response and wave dissipation mechanisms of FGCS under explosive loading. …”
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2871
A pipeline for processing hyperspectral images, with a case of melanin-containing barley grains as an example
Published 2024-07-01“…Visualization based on PCA, UMAP and ISOMAP methods, as well as the use of clustering algorithms, showed that a linear separation of grain samples with and without pigmentation could be performed with high accuracy based on hyperspectral data. The analysis revealed statistically significant differences in the distribution of median intensities for samples of images of grains with and without pigmentation. …”
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2872
NCAPD3‐mediated AKT activation regulates prostate cancer progression
Published 2025-02-01“…Abstract Despite therapeutic improvements in prostate cancer treatment, the recurrence and mortality rates are still high, and the underlying mechanisms still need further study. …”
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2873
Genome-wide identification and functional roles relating to anthocyanin biosynthesis analysis in maize
Published 2025-01-01“…Furthermore, the gene expression patterns of the ten highly expressed genes and their potential interacting transcriptional factors were analyzed across the four inbred lines. …”
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2874
TFE3 Regulates the Function of the Autophagy-Lysosome Pathway to Drive the Invasion and Metastasis of Papillary Thyroid Carcinoma
Published 2021-01-01“…Analysis of the clinicopathological characteristics of PTC patients showed that high TFE3 expression was significantly correlated with lymph node metastasis. …”
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2875
Evaluation of genetic trend in milk production of buffalo cattle in Colombia
Published 2023-11-01“…This decrease is attributed to the limited use of high-genetic-value sires in biotechnological programs and low selection intensity. …”
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2876
Repression of PFKFB3 sensitizes ovarian cancer to PARP inhibitors by impairing homologous recombination repair
Published 2025-01-01“…Abstract Background Ovarian cancer (OC), particularly high-grade serous ovarian carcinoma (HGSOC), is the leading cause of mortality from gynecological malignancies worldwide. …”
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2877
Role of outer membrane vesicles of hypervirulent Klebsiella pneumoniae isolated from bovine uterine discharge in pro-inflammatory dysregulation
Published 2025-03-01“…Furthermore, hvKP OMVs displayed varying cytotoxic effects on the L929 and THP-1 cell lines. Notably, incubating THP-1 cells with high con-centrations of hvKP OMVs inhibited IL-1β and TNF responses, indicating that these OMVs may not only facilitate the internalisation of the bacterium by THP-1 cells but also suppress the cells’ innate immune response to hvKP infection. …”
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2878
Factors accounting for limited sexual reproduction in a long-lived unisexual plant species
Published 2025-02-01“…Modelling environmental data at higher resolution, smaller scale and expanding geographic coverage to include more sporophyte occurrences, and comparing genetic diversity in sporophytic with non-sporophytic populations, are future lines of this research.…”
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Morphogenetic peculiarities of reproductive biology in sugar beet (Beta vulgaris L.) breeding
Published 2023-06-01“…Self-fertile plants isolated from these lines serve as sterility fixers, while the apomixis elements increased the ovule number, additional embryo sacs and embryos. …”
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Continuous-wave Laser on Er,Yb-Codoped Pentaborate Crystal
Published 2019-12-01“…The maximum value of absorption cross-section was determined to be 1.5·10–20 cm2 at 976 nm for polarization E//Ng . A number of narrow lines were observed in the absorption spectra in the 1425–1575 nm spectral range (transition 4I15/2 → 4I13/2 of erbium ions). …”
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