A Dynamic Design Methodology for Large-Scale Complex Nonlinear Systems Based on Orthogonal Decomposition Technique by Qi-Bin Wang, Si-Yang Piao, Ming-Wei Piao, Peng Dang, Qiu-Ze Li, Jing-Ying Ren

“…On the premise of meeting the requirements of crossing over different speed grade dedicated lines and realizing the running operations on three-speed levels of 160/250/350 km/h, the self-adaptive higher-/high-speed bogies can conditionally satisfy the economic reprofiling requirements of wheelsets through the optimal routing planning.…”
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Comprehensive assessment to reveal the salt tolerance potential of cultivated eggplants and their wild relatives by Esra Cebeci, Hatice Filiz Boyaci, Sevinc Kiran, Sekure Sebnem Ellialtioglu

“…A plant with high proline accumulation displays greater tolerance under stress conditions. …”
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Informative EST-SSR markers for genotyping and intraspecific differentiation of Brassica oleracea var. capitata L. by M. N. Shapturenko, T. V. Pechkovskaya, S. I. Vakula, A. V. Jakimovich, Yu. M. Zabara, L. V. Khotyleva

“…Brassica oleraceae var. capitata L. is characterized by a high level of intraspecific heterogeneity due to some biological features that cause difficulties for breeding creating genetically homogenous forms and maintaining their genetic purity. …”
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Donor Identification, Genetic Diversity, Population Structure and Marker–Trait Association Analyses for Iron Toxicity Tolerance Using Rice Landraces by Debanjana Saha, Udit Nandan Mishra, Chittaranjan Sahoo, Seema Tripathy, Uttam Kumar Behera, Susmita Das, Chandrasekhar Sahu, Shiv Datt, Manoj Kumar Rout, Tanmaya Lalitendu Mohanty, Shakti Prakash Mohanty, Saumya Ranjan Barik, Ishwar Chandra Mohanty, Sharat Kumar Pradhan

“…This study investigated molecular diversity, genetic structure, and marker–trait associations for tolerance to iron toxicity in a panel of germplasm lines using microsatellite markers. The studied population showed a moderate to high degree of genetic diversity, as revealed by the estimated molecular diversity parameters and principal component, cluster and box plot analyses. …”
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Antiproliferative evaluation of various aminoquinoline derivatives by Zorc Branka, Rajić Zrinka, Perković Ivana

“…The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides, with IC50 values in low micromolar range against all tested cancer cell lines.…”
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S100A13-driven interaction between pancreatic adenocarcinoma cells and cancer-associated fibroblasts promotes tumor progression through calcium signaling by Liuyuan Xia, Xin Guo, Dong Lu, Yixin Jiang, Xiaohui Liang, Yiwen Shen, Jiayi Lin, Lijun Zhang, Hongzhuan Chen, Jinmei Jin, Xin Luan, Weidong Zhang

“…Gene expression analysis revealed that S100A13 was highly expressed in CAFs and correlated with poor prognosis. …”
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Graphene-based Electronically Tuneable Microstrip Attenuator by L. Pierantoni, D. Mencarelli, M. Bozzi, R. Moro, S. Bellucci

“…By applying the proper voltage through two high-impedance bias lines, the surface resistivity of graphene can be modified, thereby changing the insertion loss of the microstrip attenuator.…”
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The Adsorption of Pollutants from Aqueous Effluents Using a Two-Resistance Mass-Transfer Model by G. McKay, J.C. Kelly, I.F. McConvey

“…The second method, based on a pseudo-analytical solution, is applicable to operating lines and tie lines terminating at any point on the isotherm, but requires longer computational time. …”
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Les chemins de fer atmosphériques. Première partie by Paul Smith

“…It tries to suggest something of the high hopes and the debates which accompanied the new system before it turned out to be a technological dead-end. …”
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New avenues of preoperative evaluation before corneal refractive surgery during the COVID-19 pandemic by S.N. Sakhnov, O.A. Klokova, A.V. Piskunov, R.O. Damashauskas, M.S. Geidenrich, E.I. Dyakonova

“…</i> </p> <p> <i><b>Results</b>: refractometry produced by Visionix VX130+ is highly reproducible and stable. Mean spread of spherical equivalent was 0.22±0.22 D and mean spread of cylindrical equivalent was 0.23±0.16 D.…”
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Le réseau hydraulique à Pompéi (Italie) de l’époque des Samnites à Auguste (fin ive-fin ier s. av. J.-C.) by Federico Giletti

“…With respect to the supply to the archaic city in the early and middle Samnite era, the evidence shows the use and spread across the main urban area of deep artesian wells, designed to intercept and capture the water present in the subsoil of Pompeii’s high ground. In our current state of knowledge, it is possible to identify 28 wells which, though already in use in the Archaic period, were perfectly integrated into the urban organisation of the Samnite city, where they were mainly located in open spaces, at crossroads and along roads. …”
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Clinical and genetic drivers of oligo-metastatic disease in colon cancer by Alessandro Ottaiano, Mariachiara Santorsola, Roberto Sirica, Annabella Di Mauro, Antonella Di Carlo, Monica Ianniello, Francesco Sabbatino, Rosa Castiello, Francesca Del Peschio, Marco Cascella, Francesco Perri, Maurizio Capuozzo, Nicola Martucci, Edoardo Mercadante, Valentina Borzillo, Rossella Di Franco, Francesco Izzo, Vincenza Granata, Carmine Picone, Antonella Petrillo, Massimiliano Berretta, Salvatore Stilo, Luca Tarotto, Anna Chiara Carratù, Gerardo Ferrara, Madhura Tathode, Alessia Maria Cossu, Marco Bocchetti, Michele Caraglia, Guglielmo Nasti, Giovanni Savarese

“…. <70 years), gender (male vs. female), tumor side (right vs. left), metastatic involvement (more than one site vs. one site), response to first-line therapy (disease control vs. no disease control), and RAS/BRAF variants (wild-type vs. mutated) identified OMD vs. …”
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Unbiased identification of cell identity in dense mixed neural cultures by Sarah De Beuckeleer, Tim Van De Looverbosch, Johanna Van Den Daele, Peter Ponsaerts, Winnok H De Vos

“…To facilitate the validation of iPSC-derived cell culture composition, we have implemented an imaging assay based on cell painting and convolutional neural networks to recognize cell types in dense and mixed cultures with high fidelity. We have benchmarked our approach using pure and mixed cultures of neuroblastoma and astrocytoma cell lines and attained a classification accuracy above 96%. …”
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Assessing Soil Erosion by Agricultural and Forestry Production and Proposing Solutions to Mitigate: A Case Study in Son La Province, Vietnam by X. H. Nguyen, A. H. Pham

“…Soil is eroded in very high level (>50 ton·ha−1·year−1), accounting for 25.7% of the study area. …”
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Experimenter Effects on Pain Reporting in Women Vary across the Menstrual Cycle by Jacob M. Vigil, Jared DiDomenico, Chance Strenth, Patrick Coulombe, Eric Kruger, Andrea A. Mueller, Diego Guevara Beltran, Ian Adams

“…Background. Separate lines of research have shown that menstrual cycling and contextual factors such as the gender of research personnel influence experimental pain reporting. …”
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Engineering hydrophobicity and manufacturability for optimized biparatopic antibody–drug conjugates targeting c-MET by Andreas Evers, Simon Krah, Deniz Demir, Ramona Gaa, Desislava Elter, Christian Schroeter, Stefan Zielonka, Nicolas Rasche, Julia Dotterweich, Christine Knuehl, Achim Doerner

“…Optimal combinations of paratopes assembled into a biparatopic antibody have the capacity to mediate high-grade target cross-linking on cell membranes, leading to degradation of the target, as well as antibody and payload delivery in the case of an antibody-drug conjugate (ADC). …”
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The Multifaceted Roles of Myrrha in the Treatment of Breast Cancer: Potential Therapeutic Targets and Promises by Anwar Shams MD, MSc, PhD, Abdullah Ahmed Alzahrani, Taghreed A Ayash MSc, PhD, Shadi Tamur MD, FRCPC, FAAP, Majed AL-Mourgi MD, FRCS, FCCP, FACS

“…Consistently, breast cancer patients with high expression of this genes’ signature display poor survival outcomes. …”
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Lacticaseibacillus rhamnosus Fmb14 ameliorates hyperuricemia-induced hepatocyte pyroptosis via NLRP3 inflammasome cascade inhibition by Hongyuan Zhao, Xiaoyu Chen, Li Zhang, Fanqiang Meng, Libang Zhou, Zhaoxin Lu, Yingjian Lu

“…Cell free extracts of high dose L. rhamnosus Fmb14 treatment reduced the death rate of HepG2 cell lines from 24.1% to 14.9% by inhibiting NLRP3 recruitment, which was mainly activated by reactive oxygen species release and mitochondrial membrane potential disorder. …”
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Targeting chromosomally unstable tumors with a selective KIF18A inhibitor by Aaron F. Phillips, Rumin Zhang, Mia Jaffe, Ryan Schulz, Marysol Chu Carty, Akanksha Verma, Tamar Y. Feinberg, Michael D. Arensman, Alan Chiu, Reka Letso, Nazario Bosco, Katelyn A. Queen, Allison R. Racela, Jason Stumpff, Celia Andreu-Agullo, Sarah E. Bettigole, Rafael S. Depetris, Scott Drutman, Shinsan M. Su, Derek A. Cogan, Christina H. Eng

“…The strong biological rationale, robust preclinical data, and optimized compound properties enable the clinical development of a KIF18A inhibitor in cancers with high chromosomal instability.…”
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The molecular mechanism by which heat stress during the grain filling period inhibits maize grain filling and reduces yield by Xiaohu Li, Shilin Zhuge, Jiyuan Du, Peng Zhang, Xingyu Wang, Tianjian Liu, Donghui Li, Haoran Ma, Xinzheng Li, Yongxin Nie, Changjian Liao, Haiping Ding, Zhiming Zhang

“…High temperatures significantly impair plant growth and development by restricting maize grain filling; however, the molecular mechanisms underlying heat stress remain poorly understood. …”
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