Systematic Analysis of E3 Ligase-Related Genes Identified UBE2L3 as a Prognostic Biomarker Associated With Drug Resistance in Acute Myeloid Leukemia by Ling C, Cao N, Wang H, Wan Y, Liang X, Guo J, Xiao M, Zhang Q, Zhai Z

“…Finally, the expression of UBE2L3 was verified in cell lines and clinical case specimens.Results: The model accurately predicted AML prognosis and identified the UBE2L3 gene within the model as a high-risk biomarker associated with drug resistance, significantly influencing AML outcomes.Conclusion: The high expression of UBE2L3 is a reliable biomarker for drug resistance and poor prognosis of acute myeloid leukemia.Keywords: E3 ubiquitin ligase, prognostic model, UBE2L3, acute myeloid leukemia, drug resistance…”
Get full text

Effect of axial elongation on anterior scleral thickness in myopia by Hui Yan, Jie Li, Cheng Wang, Cai-Qiu Mei

“…Results: The AST of the four diameter lines was highest at the scleral process and measured. …”
Get full text

The application of blockchain with a comparative approach and its impact on risk, flexibility and internal control evaluation by mohammadsadegh aminipoor, HamidReza GholamniaRoshan, azadeh kiapour, Iman Dadashi

“…Flexibility: Due to its distinctive method and technology, blockchain provides high flexibility against changes and organizational needs. …”
Get full text

Estimation and evaluation of iron reserves in the eastern area of Eileh1 mine, Razavi Khorasan province by Hamid Esmati Daroneh, Maryam Gholamzadeh

“…While this method offers numerous advantages, such as high accuracy due to the blocking of the deposit, it does have a drawback: in the case of low-grade deposits, the mixing of ore and tailings within the blocks tends to be high, leading to reserves being estimated slightly above their actual value. …”
Get full text

Breeding for Heat Tolerant Aromatic Rice Varieties and Identification of Novel QTL Regions Associated with Heat Tolerance During Reproductive Phase by QTL-Seq by Surangkana Chimthai, Sulaiman Cheabu, Wanchana Aesomnuk, Siriphat Ruengphayak, Siwaret Arikit, Apichart Vanavichit, Chanate Malumpong

“…Extremely high temperatures resulting from climate change have become a major challenge for increasing rice production. …”
Get full text

POPULATION GENETICS STUDY OF THE WHEAT LEAF RUST AGENT PUCCINIA TRITICINA IN DAGESTAN by E. I. Gultyaeva, E. L. Shaydayuk, K. M. Abdullaev

“…Using 20 almost  isogenic Thatcher lines (TcLr), 20 phenotypes (races) of the  pathogen were identified. …”
Get full text

Research on key technology and network deployment of fgOTN by LIAO Shangjin

“…With the development of 5G+ vertical industries and high-quality government-enterprise dedicated lines, the demand for fine particle business still maintains strong vitality. …”
Get full text

VACCIMEL, an allogeneic melanoma vaccine, efficiently triggers T cell immune responses against neoantigens and alloantigens, as well as against tumor-associated antigens by Ibel Carri, Ibel Carri, Erika Schwab, Juan Carlos Trivino, Erika M. von Euw, Morten Nielsen, Morten Nielsen, José Mordoh, María Marcela Barrio

“…VACCIMEL is a therapeutic cancer vaccine composed of four irradiated allogeneic human melanoma cell lines rationally selected to cover a wide range of melanoma tumor-associated antigens (TAA). …”
Get full text

Large-scale screening of HIV-1 T-cell epitopes restricted by 12 prevalent HLA-A allotypes in Northeast Asia and universal detection of HIV-1-specific CD8+ T cells by Yan Ding, Jialai Yan, Ling Huang, Jinhong Yu, Yandan Wu, Chuanlai Shen, Anning Fang

“…Furthermore, the HLA-A cross-restriction for each epitope candidate was identified through peptide competitive binding assays using 12 transfected HMy2.CIR cell lines.ResultsA total of 45 epitopes demonstrated high affinity, while 31 epitopes displayed intermediate affinity. …”
Get full text

Amorphous calcium phosphate-coated surfaces as a model for bone microenvironment in prostate cancer by Rebeca San Martin, Prijoyit Das, Tianchun Xue, Morgan Rose Brown, Renata Dos Reis Marques, Michael Essington, Adrian Gonzalez, Rachel Patton McCord

“…We also present modified protocols for subculturing cells and collecting nucleic acids and protein in high-calcium samples. Results: We find that prostate epithelial cell lines show increased adhesion and proliferation when cultured in these amorphous calcium surfaces, accompanied by independence from androgen starvation. …”
Get full text

Size Functions for the Morphological Analysis of Melanocytic Lesions by Massimo Ferri, Ignazio Stanganelli

“…This is mainly based on a qualitative assessment of asymmetry, performed by halving images by several lines through the center of mass, and comparing the two halves in terms of color, mass distribution, and boundary. …”
Get full text

Methodical approaches in experimental modelling of non-alcoholic fatty liver disease by N. V. Bivalkevich, Yu. K. Denisenko, T. P. Novgorodtseva

“…They include methionine choline-deficient diet, fructoseenriched diet and various variations of high-fat diet. At diet-induced NAFLD the liver undergoes a complex of histological and metabolic disorders to the high extent close to clinical symptoms of this disease in humans.Conclusion. …”
Get full text

Methods of yeast genome editing by A. S. Rozanov, V. N. Shlyahtun, L. A. Tekutieva, O. M. Son, S. V. Sizova, S. E. Peltek

“…It was sufficient for several decades before the development of high­throughput methods. Many high­throughput methods were developed in the second decade of the XXI century, including those used in genomics, transcriptomics, proteomics, metabolomics, interactomics, etc. …”
Get full text

Hypoxia and lipid metabolism related genes drive proliferation migration and immune infiltration mechanisms in colorectal cancer subtyping by Shansong Huang, Huiying Wang, Jiaqing Cao, Qiang Pang

“…The seven HLPG-based risk scoring model effectively stratified patients into high- and low-risk groups, with high-risk patients exhibiting significantly poorer survival outcomes. …”
Get full text

FOXP3 as a prognostic marker and therapeutic target in immunogenic cell death modulation for clear cell renal cell carcinoma by Jian Chen, Cheng Zhu, Yan He, Liping Huang, Weizhuo Wang, Shuaishuai Huang

“…Functional studies were conducted with FOXP3 knockdown in ccRCC cell lines to explore its impact on cell behavior. Results Eleven ICD-related genes were identified as key prognostic indicators in ccRCC, with high ICDS linked to worse survival outcomes. …”
Get full text

New genetic resources in wheat breeding for an increased grain protein content by O. P. Mitrofanova, A. G. Khakimova

“…Functional Gpc-B1 alleles have been introduced into commercial tetra- and hexaploid wheat cultivars, and it resulted in the creation of new highprotein and high-yield cultivars and series of nearly isogenic lines in different countries. …”
Get full text

Resource selection and survival of plains sharp‐tailed grouse at a wind energy facility by Carly S. Kelly, Chad W. LeBeau, Jeffrey L. Beck, Alex Solem, Hilary Morey, Kurt T. Smith

“…We found consistent selection for lower lengths of transmission lines across all life stages at the home range scale. …”
Get full text

Comparison of Analytic Hierarchy Process and Frequency Ratio Methods in Landslide Susceptibility Analysis: Example of Akçaabat and Düzköy districts of Trabzon province by Melek Dalkes, Mehmet Seren Korkmaz

“…Landslide susceptibility maps should be prepared in order to predetermine the areas with high landslide susceptibility in order to minimize the losses due to landslides. …”
Get full text

Dual Reporter Gene Imaging by Jiantu Che, Mikhail Doubrovin, Inna Serganova, Ludmila Ageyeva, Pat Zanzonico, Ronald Blasberg

“…RG2-pQCNIG cells expressed high levels of hNIS protein and showed high intensity of eGFP fluorescence compared with RG2 wild-type cells. …”
Get full text

Analysis of the transcriptional activity of model piggyBac transgenes stably integrated into different loci of the genome of CHO cells in the absence of selection pressure by L. A. Yarinich, A. A. Ogienko, A. V. Pindyurin, E. S. Omelina

“…Therefore, the identification of genomic loci ensuring a high level of protein production is very important. …”
Get full text