The Role of Pentacyclic Triterpenoids in Non-Small Cell Lung Cancer: The Mechanisms of Action and Therapeutic Potential by Young-Shin Lee, Ryuk Jun Kwon, Hye Sun Lee, Jae Heun Chung, Yun Seong Kim, Han-Sol Jeong, Su-Jung Park, Seung Yeon Lee, Taehwa Kim, Seong Hoon Yoon

“…Lung cancer remains a major global health problem because of its high cancer-related mortality rate despite advances in therapeutic approaches. …”
Get full text

Inflammatory microglia correlate with impaired oligodendrocyte maturation in multiple sclerosis by J. Q. Alida Chen, Dennis D. Wever, Niamh B. McNamara, Morjana Bourik, Joost Smolders, Jörg Hamann, Jörg Hamann, Inge Huitinga, Inge Huitinga

“…For CD163+ microglia, however, no differences were observed between MS lesions and MS donor groups. In line with our hypothesis, we found that INOS+ microglia were significantly increased in PRDs compared to ERDs within remyelinated lesions. …”
Get full text

Use of key indicators to monitor sustainable development of rural areas by V. Shcherbak, L. Ganushchak-Yefimenko, O. Nifatova, N. Fastovets, G. Plysenko, L. Lutay, V. Tkachuk, O. Ptashchenko

“…Therefore, the using of key indicators for monitoring the sustainable development of rural areas provides an opportunity to take into account the specifics of sustainable development of different specialization branches of rural areas that will support high economic and social growth in the future.…”
Get full text

Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors by Romain Pacaud, Scott Thomas, Sibapriya Chaudhuri, Ann Lazar, Luika A. Timmerman, Pamela N. Munster

“…Methods We generated hypomorphic BRCA1 and BRCA2 variants of the HRR proficient triple negative breast cancer cell line MDA-MB-231. We compared therapeutic response features such as RAD51 focus formation, cell cycle fraction alterations, DNA damage accumulation, colony formation, and cell death of these and other cell lines with and without intrinsic BRCA1/2 mutations. …”
Get full text

Denervation procedure of the lateral epicondyle for refractory lateral epicondylitis by Misty Suri, MD, MS, Arjun Verma, BS, Collyn O’Quin, MD, Gregory Parker, MD, Kareem Mohamed, MD, Hunter Starring, MD, Daniel Yoo, MD

“…The PBPCNF denervation procedure affords patients a high level of postoperative functionality with a low incidence of sensory deficits.…”
Get full text

Study of antifungal susceptibility pattern of various Candida species with reference to conventional and automated methods in a tertiary care hospital by Paulami De, Rehena Sarkar, Raja Ray, Kumkum Bhattacharyya, Hasina Banu, Hirak Jyoti Raj

“…Result: Total Candida isolates were 100, among them near about half (43%) of the isolates were obtained from critical care unit followed by thoracic unit (17%), Ward (16%), trauma centre (15%), high dependency (7%) and 2% from outdoor. Maximum number of isolates came from central line catheter 43, followed by blood 19. other samples from where candida were isolated are urine 13, endotracheal aspirate 9, Pleural fluid 7, Bronchoalveolar lavage 3, Cerebrospinal Fluid 3 and Wound 3. …”
Get full text

Depth dependence of soil organic carbon additional storage capacity in different soil types by the 2050 target for carbon neutrality by C. Chirol, C. Chirol, G. Séré, P.-O. Redon, C. Chenu, D. Derrien, D. Derrien

“…<p>Land planning projects aiming to maximize soil organic carbon (SOC) stocks are increasing in number and scope, often in line with the objective to reach carbon neutrality by 2050. …”
Get full text

Biomass and Yield in Solanum lycopersicum Expressing a Synthetic Photorespiration Pathway by Laura Dougherty, Bret Cooper, James Bunce, Bryan Vinyard, John Stommel

“…The number of fruit was similarly greater (1.4- to 4.2-fold) in modified plants; however, average individual fruit weights were significantly less for all but one line. Among transformed lines, larger fruited lines had the lowest biomass, while the smaller fruited lines had the highest biomass. …”
Get full text

Comparative genomics reveals low levels of inter- and intraspecies diversity in the causal agents of dwarf and common bunt of wheat and hint at conspecificity of Tilletia caries an... by Somayyeh Sedaghatjoo, Bagdevi Mishra, Monika K. Forster, Yvonne Becker, Jens Keilwagen, Berta Killermann, Marco Thines, Petr Karlovsky, Wolfgang Maier

“…Despite the conspicuously different teliospore ornamentation of T. caries and T. laevis, a high degree of genomic identity and scarcity of species-specific genes indicate that the two species could be conspecific.…”
Get full text

The financial character of policing in Tunisia: collusions, extraversion and the criminalization of informality by Daniela Musina

“…Financial policing in the Global South nowadays takes largely shape through the combination of anti-money laundering (AML) and counter financing of terrorism (CFT) agendas, which are systematically and racially coupled to target Asian or African contexts and, as such, largely exclude money and profits benefitting high capital concentration contexts and actors that is usually laundered for tax evasion. …”
Get full text

Long-term outcome of photodynamic therapy with hexyl aminolevulinate, 5-aminolevulinic acid nanoemulsion and methyl aminolevulinate for low-risk Basal Cell Carcinomas by M. Salmivuori, M. Grönroos, T. Tani, J. Räsänen, E. Snellman, N. Neittaanmäki

“…The recurrent lesions were excised as second line treatment. No aggressive subtypes were reported, with only superficial or nodular growth in the final histopathological report. …”
Get full text

Reestablishment of Redox Homeostasis in the Nociceptive Primary Afferent as a Mechanism of Antinociception Promoted by Mesenchymal Stem/Stromal Cells in Oxaliplatin-Induced Chronic... by Anna Lethicia L. Oliveira, Gisele G. L. Santos, Renan F. Espirito-Santo, Gessica Sabrina A. Silva, Afrânio F. Evangelista, Daniela N. Silva, Milena B. P. Soares, Cristiane Flora Villarreal

“…The ultrastructural analysis of the sciatic nerve and DRG of OIPN mice revealed a high proportion of atypical mitochondria in both myelinated and unmyelinated fibers. …”
Get full text

Artrosis: ¿cambios degenerativos o cambios adaptativos? Consejos educativos breves en la consulta de atención primaria by Gema Izquierdo Enríquez, María Victoria García Espinosa, Isabel Prieto Checa, María Fernández de Paúl, Patricia Moreno Carrero, Silvia Fernanda García Vila

“…Moreover, there are no disease-modifying drugs or curative treatment at present; the basic or first-line treatment is non-pharmacological, based on education and physical exercise.The presence of degenerative changes in imaging tests is present in a high percentage of the general asymptomatic population, i.e. in those who have no pain or functional limitation, and this percentage increases progressively with age. …”
Get full text

Anti-colorectal cancer effect of total minor ginsenosides produced by lactobacilli transformation of major ginsenosides by inducing apoptosis and regulating gut microbiota by Yunjiao Shen, Yunjiao Shen, Yansong Gao, Ge Yang, Zijian Zhao, Yujuan Zhao, Lei Gao, Shengyu Li

“…The level of apoptosis and expression of various proteins in the tumor tissues were detected by immunohistochemistry and Western blot. High-throughput 16S rRNA sequencing was used to determine the alterations in the gut microbiota.ResultsIn vitro studies demonstrated that TMG significantly inhibited proliferation and promoted apoptosis in CT26.WT cells. …”
Get full text

Effectiveness of ‘Tackle Your Tics’, a brief, intensive group-based exposure therapy programme for children with tic disorders: study protocol of a randomised controlled trial by Danielle Cath, Annet Heijerman-Holtgrefe, Chaim Huyser, Cara Verdellen, Jolande van de Griendt, Laura Beljaars, Kees-Jan Kan, Ramón Lindauer, Pieter Hoekstra, Lisbeth Utens

“…Patient associations stress the need for more accessible high-quality treatments, also focusing on improving quality of life. …”
Get full text

A Dichotomy in the 1–24 GHz Parsec-scale Radio Spectra of Radio-quiet Quasars by Sina Chen, Ari Laor, Ehud Behar, Ranieri D. Baldi, Joseph D. Gelfand, Amy E. Kimball

“…The 8.4–23.6 GHz radio emission in the high- L / L _Edd objects may be weak due to more extended emission from a radiation-pressure-driven wind. …”
Get full text

Coal‐wall spalling prevention mechanism using advance‐grooving pressure relief in the large‐mining‐height working face of a shallow coal seam by Wang Hongwei, Feng Li, Zhao Zhouyan, Li Yanjun, Cao Peipei, Jiao Jianqiang, Jiang Baolin, Liu Yong

“…The results show that: During the mining process of large mining height working face in shallow buried coal seam, the step change of static response of coal wall is induced by the transient instability of roof structure, and the high abutment pressure is formed on the coal wall. …”
Get full text

Synergistic effect of porous structure and gradient structure in carbon foam to boost terahertz absorption by Xiao Sun, Lipeng Wu, Congli Zhou, Dun Lu, Shangzhi Chen, Mingduo Yang, Chaoyang Kuang, Wenjie Fu, Xuesong Li, Zhaoyun Duan, Qiye Wen

“…COMSOL simulation and transmission line model were applied to explore the formation mechanism and the gradient loss capabilities of gradient structure. …”
Get full text

Сandidate SNP-markers of rheumatoid arthritis that can significantly alter the affinity of the TATA-binding protein for human gene promoters by I. V. Chadaeva, D. A. Rasskazov, E. B. Sharypova, I. A. Drachkova, E. A. Oshchepkova, L. K. Savinkova, P. M. Ponomarenko, M. P. Ponomarenko, N. A. Kolchanov, V. A. Kozlov

“…According to the more powerful female immune system compared to the male one, the risk of developing RA in women is thrice as high, this risk decreases during breastfeeding and grows during pregnancy as well as after menopause in proportion to the level of sex hormones. …”
Get full text

Applicability of the complementary relationship of evapotranspiration for heterogeneous vegetation cover at boundary and plot scales by Chong Fu, Xiaoyu Song, Wanyin Wei, Qi Zhang, Lanjun Li, Xinkai Zhao, Pengfei Meng, Long Wang, Huaiyou Li

“…New hydrological insights for the region: Dynamic Scaling of the GCR could achieve high accuracy at boundary-scale watersheds (NSE=0.78) and different vegetation plots (NSE=0.79), indicating the universality and stability of the GCR, in line with the conclusions of previous large-scale studies. …”
Get full text